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Found 321 with Last Name = 'cunningham' and Initial = 'a'
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM22416((3S,4R)-3-[(1,3-benzodioxol-5-yloxy)methyl]-4-(4-f...)
Affinity DataKi:  0.0400nMAssay Description:Binding inhibition towards human serotonin transporterMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50173715((+)3-((1S,2S)-2-Dimethylaminomethyl-cyclopropyl)-1...)
Affinity DataKi:  0.180nMAssay Description:In vitro binding inhibition towards human serotonin transporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50173715((+)3-((1S,2S)-2-Dimethylaminomethyl-cyclopropyl)-1...)
Affinity DataKi:  0.560nMAssay Description:Binding inhibition towards human serotonin transporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50173710(3-((1S,2S)-2-Dimethylaminomethyl-cyclopropyl)-1H-i...)
Affinity DataKi:  0.580nMAssay Description:Binding inhibition towards human serotonin transporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)
Affinity DataKi:  0.720nMAssay Description:Binding inhibition towards human serotonin transporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50173712(3-((1S,2S)-2-Dimethylaminomethyl-cyclopropyl)-1-et...)
Affinity DataKi:  1.80nMAssay Description:Binding inhibition towards human serotonin transporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50162700(3-(3-(dimethylamino)propyl)-1H-indole-5-carbonitri...)
Affinity DataKi:  2nMAssay Description:Binding inhibition towards human serotonin transporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50173717(((1S,2S)-2-(5-fluoro-1H-indol-3-yl)cyclopropyl)-N,...)
Affinity DataKi:  2.10nMAssay Description:Binding inhibition towards human serotonin transporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50173717(((1S,2S)-2-(5-fluoro-1H-indol-3-yl)cyclopropyl)-N,...)
Affinity DataKi:  2.10nMAssay Description:Binding inhibition towards human serotonin transporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50162708(3-(5-fluoro-1H-indol-3-yl)-N,N-dimethylpropan-1-am...)
Affinity DataKi:  4nMAssay Description:Binding inhibition towards human serotonin transporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50173706(3-((1R,2S)-2-Dimethylaminomethyl-cyclopropyl)-1H-i...)
Affinity DataKi:  5.70nMAssay Description:Binding inhibition towards human serotonin transporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50503346(CHEMBL4560254)
Affinity DataKi:  6.40nMAssay Description:Positive allosteric modulation of 5-HT2C receptor (unknown origin) assessed as increase in 5-HT-induced displacement of [3H]mesulergine by measuring ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50173713(3-((1S,2S)-2-Dimethylaminomethyl-cyclopropyl)-1-me...)
Affinity DataKi:  6.5nMAssay Description:Binding inhibition towards human serotonin transporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50173709(3-((1S,2S)-2-Dimethylaminomethyl-cyclopropyl)-1H-i...)
Affinity DataKi:  7.40nMAssay Description:Binding inhibition towards human serotonin transporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50173705((-)3-((1R,2R)-2-Dimethylaminomethyl-cyclopropyl)-1...)
Affinity DataKi:  8.90nMAssay Description:Binding inhibition towards human serotonin transporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50173714(CHEMBL364050 | [(1S,2S)-2-(7-Fluoro-1H-indol-3-yl)...)
Affinity DataKi:  10nMAssay Description:Binding inhibition towards human serotonin transporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50161646((1R)-8-chloro-2,3,4,5-tetrahydro-1-methyl-1H-3-ben...)
Affinity DataKi:  15nMAssay Description:Agonist activity at 5-HT2CR (unknown origin)More data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50173711((+)3-((1S,2R)-2-Dimethylaminomethyl-cyclopropyl)-1...)
Affinity DataKi:  17nMAssay Description:Binding inhibition towards human serotonin transporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50173703((-)[(1R,2S)-2-(5-Fluoro-1H-indol-3-yl)-cyclopropyl...)
Affinity DataKi:  24nMAssay Description:Binding inhibition towards human serotonin transporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50173703((-)[(1R,2S)-2-(5-Fluoro-1H-indol-3-yl)-cyclopropyl...)
Affinity DataKi:  24nMAssay Description:Binding inhibition towards human serotonin transporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50173701(CHEMBL194960 | [(1S,2S)-2-(6-Fluoro-1H-indol-3-yl)...)
Affinity DataKi:  38nMAssay Description:Binding inhibition towards human serotonin transporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50173704((-)[(1R,2R)-2-(5-Fluoro-1H-indol-3-yl)-cyclopropyl...)
Affinity DataKi:  41nMAssay Description:Binding inhibition towards human serotonin transporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50173716(CHEMBL194909 | [(1S,2S)-2-(4-Fluoro-1H-indol-3-yl)...)
Affinity DataKi:  59nMAssay Description:Binding inhibition towards human serotonin transporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM22416((3S,4R)-3-[(1,3-benzodioxol-5-yloxy)methyl]-4-(4-f...)
Affinity DataKi:  90nMAssay Description:Binding inhibition towards human norepinephrine transporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50173707((+)[(1S,2R)-2-(5-Fluoro-1H-indol-3-yl)-cyclopropyl...)
Affinity DataKi:  100nMAssay Description:Binding inhibition towards human serotonin transporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50161646((1R)-8-chloro-2,3,4,5-tetrahydro-1-methyl-1H-3-ben...)
Affinity DataKi:  112nMAssay Description:Agonist activity at 5-HT2AR (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2B(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50161646((1R)-8-chloro-2,3,4,5-tetrahydro-1-methyl-1H-3-ben...)
Affinity DataKi:  174nMAssay Description:Agonist activity at 5-HT2BR (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50173702(3-((1S,2S)-2-Dimethylaminomethyl-cyclopropyl)-1H-i...)
Affinity DataKi:  230nMAssay Description:Binding inhibition towards human serotonin transporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50173702(3-((1S,2S)-2-Dimethylaminomethyl-cyclopropyl)-1H-i...)
Affinity DataKi:  230nMAssay Description:Binding inhibition towards human serotonin transporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM22416((3S,4R)-3-[(1,3-benzodioxol-5-yloxy)methyl]-4-(4-f...)
Affinity DataKi:  400nMAssay Description:Binding inhibition towards human dopamine transporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)
Affinity DataKi:  440nMAssay Description:Binding inhibition towards human norepinephrine transporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50503222(CHEMBL4454100)
Affinity DataKi:  1.80E+3nMAssay Description:Displacement of [3H]-WIN35428 from recombinant human DAT expressed in HEK cell membranes after 90 mins by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)
Affinity DataKi:  1.90E+3nMAssay Description:Binding inhibition towards human dopamine transporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50173715((+)3-((1S,2S)-2-Dimethylaminomethyl-cyclopropyl)-1...)
Affinity DataKi:  2.10E+3nMAssay Description:Binding inhibition towards human dopamine transporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50544002(CHEMBL4633717)
Affinity DataKi:  2.50E+3nMAssay Description:Displacement of [3H]-nisoxetine from human NET stably expressed in HEK cell membranes incubated for 90 mins under dark condition by scintillation cou...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEukaryotic initiation factor 4A-I(Homo sapiens (Human))TBA
LigandPNGBDBM50610969(CHEMBL5278302)
Affinity DataKi:  4.27E+3nMAssay Description:Competitive inhibition of human recombinant N-terminal His6-tagged eIF4A expressed in Escherichia coli BL21 CodonPlus cells using 250 uM ATP and vary...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50173715((+)3-((1S,2S)-2-Dimethylaminomethyl-cyclopropyl)-1...)
Affinity DataKi:  4.60E+3nMAssay Description:In vitro binding affinity towards human norepinephrine transporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50503222(CHEMBL4454100)
Affinity DataKi:  4.70E+3nMAssay Description:Displacement of [3H]-N-methylspiperone from recombinant human D3R expressed in HEK cell membranes after 90 mins by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEukaryotic initiation factor 4A-I(Homo sapiens (Human))TBA
LigandPNGBDBM50610969(CHEMBL5278302)
Affinity DataKi:  4.79E+3nMAssay Description:Uncompetitive inhibition of human recombinant N-terminal His6-tagged eIF4A expressed in Escherichia coli BL21 CodonPlus cells using varying concentra...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetEukaryotic initiation factor 4A-I(Homo sapiens (Human))TBA
LigandPNGBDBM50610942(CHEMBL5267864)
Affinity DataKi:  9.59E+3nMAssay Description:Competitive inhibition of human recombinant N-terminal His6-tagged eIF4A expressed in Escherichia coli BL21 CodonPlus cells using 250 uM ATP and vary...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50554937(CHEMBL4780654 | US20240059655, Compound PW0787)
Affinity DataKi: >1.00E+4nMAssay Description:Binding affinity to 5-HT2C (unknown origin) assessed as inhibition of ligand bindingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEukaryotic initiation factor 4A-I(Homo sapiens (Human))TBA
LigandPNGBDBM50610942(CHEMBL5267864)
Affinity DataKi:  1.03E+4nMAssay Description:Uncompetitive inhibition of human recombinant N-terminal His6-tagged eIF4A expressed in Escherichia coli BL21 CodonPlus cells using varying concentra...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetSubstance-P receptor(Rattus norvegicus (rat))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50108639(CHEMBL3596448)
Affinity DataIC50:  0.0300nMAssay Description:Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Rattus norvegicus (rat))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50108638(CHEMBL3596447)
Affinity DataIC50:  0.0500nMAssay Description:Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Rattus norvegicus (rat))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50108631(CHEMBL3596446)
Affinity DataIC50:  0.0500nMAssay Description:Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Rattus norvegicus (rat))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50220136(3-[2-{1-[3,5-di(trifluoromethyl)phenyl]ethoxy}-3-(...)
Affinity DataIC50:  0.0900nMAssay Description:Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50503347(CHEMBL4442431)
Affinity DataIC50:  0.100nMAssay Description:Inhibition of CXCR1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50503347(CHEMBL4442431)
Affinity DataIC50:  0.100nMAssay Description:Inhibition of CXCR2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIleal sodium/bile acid cotransporter(Rattus norvegicus)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50434850(CHEMBL2387397)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of rat ASBT expressed in HEK293 cells assessed as inhibition of [3H]-taurocholate uptake after 90 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50106365(CHEMBL3596492)
Affinity DataIC50:  0.200nMAssay Description:Binding affinity to human NK1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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