Found 29 with Last Name = 'd''amore' and Initial = 'c' TargetNuclear receptor subfamily 1 group I member 2(Homo sapiens (Human))
University Of Ljubljana
Curated by ChEMBL
University Of Ljubljana
Curated by ChEMBL
Affinity DataIC50: 850nMAssay Description:Antagonist activity at PXR (unknown origin) transfected in human HepG2 cells assessed as inhibition of rifampicin-induced reporter gene transcriptionMore data for this Ligand-Target Pair
TargetNuclear receptor subfamily 1 group I member 2(Homo sapiens (Human))
University Of Ljubljana
Curated by ChEMBL
University Of Ljubljana
Curated by ChEMBL
Affinity DataIC50: 850nMAssay Description:Antagonist activity at PXR (unknown origin)More data for this Ligand-Target Pair
TargetNuclear receptor subfamily 1 group I member 2(Homo sapiens (Human))
University Of Ljubljana
Curated by ChEMBL
University Of Ljubljana
Curated by ChEMBL
Affinity DataIC50: 1.10E+4nMAssay Description:Antagonist activity at human PXR transfected in human HepG2 cells co-transfected with pSG5-RXR/pCMV-beta-galactosidase/p(CYP3A4)-TK-Luc assessed as i...More data for this Ligand-Target Pair
TargetNuclear receptor subfamily 1 group I member 2(Homo sapiens (Human))
University Of Ljubljana
Curated by ChEMBL
University Of Ljubljana
Curated by ChEMBL
Affinity DataIC50: 1.20E+4nMAssay Description:Antagonist activity at human PXR transfected in African green monkey CV1 cells assessed as inhibition of SR12813-induced transactivation after 24 hrs...More data for this Ligand-Target Pair
TargetNuclear receptor subfamily 1 group I member 2(Homo sapiens (Human))
University Of Ljubljana
Curated by ChEMBL
University Of Ljubljana
Curated by ChEMBL
Affinity DataIC50: 1.40E+4nMAssay Description:Antagonist activity at human PXR transfected in human HepG2 cells co-transfected with pSG5-RXR/pCMV-beta-galactosidase/p(CYP3A4)-TK-Luc assessed as i...More data for this Ligand-Target Pair
TargetNuclear receptor subfamily 1 group I member 2(Homo sapiens (Human))
University Of Ljubljana
Curated by ChEMBL
University Of Ljubljana
Curated by ChEMBL
Affinity DataIC50: 1.46E+4nMAssay Description:Antagonist activity at full length human PXR transfected in human HepG2 cells assessed as reduction in rifaximin-induced receptor transactivation aft...More data for this Ligand-Target Pair
TargetNuclear receptor subfamily 1 group I member 2(Homo sapiens (Human))
University Of Ljubljana
Curated by ChEMBL
University Of Ljubljana
Curated by ChEMBL
Affinity DataIC50: 2.74E+4nMAssay Description:Antagonist activity at full length human PXR transfected in human HepG2 cells assessed as reduction in rifaximin-induced receptor transactivation aft...More data for this Ligand-Target Pair
TargetG-protein coupled bile acid receptor 1(Homo sapiens (Human))
University Of Naples&Quot;Federico Ii&Quot
Curated by ChEMBL
University Of Naples&Quot;Federico Ii&Quot
Curated by ChEMBL
Affinity DataEC50: 1.72E+4nMAssay Description:Agonist activity at human GPBAR1 expressed in HEK293T cells assessed as stimulation of cAMP response element-mediated receptor transactivation by luc...More data for this Ligand-Target Pair
TargetNuclear receptor subfamily 1 group I member 2(Homo sapiens (Human))
University Of Ljubljana
Curated by ChEMBL
University Of Ljubljana
Curated by ChEMBL
Affinity DataEC50: 1.05E+4nMAssay Description:Transactivation of full length human PXR transfected in human HepG2 cells after 18 hrs by luciferase reporter assay relative to rifaximinMore data for this Ligand-Target Pair
TargetNuclear receptor subfamily 1 group I member 2(Homo sapiens (Human))
University Of Ljubljana
Curated by ChEMBL
University Of Ljubljana
Curated by ChEMBL
Affinity DataEC50: 1.12E+4nMAssay Description:Transactivation of full length human PXR transfected in human HepG2 cells after 18 hrs by luciferase reporter assay relative to rifaximinMore data for this Ligand-Target Pair
TargetNuclear receptor subfamily 1 group I member 2(Homo sapiens (Human))
University Of Ljubljana
Curated by ChEMBL
University Of Ljubljana
Curated by ChEMBL
Affinity DataEC50: 5.20E+3nMAssay Description:Transactivation of human PXR expressed in HepG2 cells after 18 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
TargetNuclear receptor subfamily 1 group I member 2(Homo sapiens (Human))
University Of Ljubljana
Curated by ChEMBL
University Of Ljubljana
Curated by ChEMBL
Affinity DataEC50: 2.20E+3nMAssay Description:Transactivation of human PXR expressed in HepG2 cells after 18 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Universit£
Curated by ChEMBL
Universit£
Curated by ChEMBL
Affinity DataEC50: 100nMAssay Description:Transactivation of GAL4-fused PPARgamma ligand binding domain transfected in human HepG2 cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
3D Structure (crystal)TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Universit£
Curated by ChEMBL
Universit£
Curated by ChEMBL
Affinity DataEC50: 1.00E+4nMAssay Description:Transactivation of GAL4-fused PPARgamma ligand binding domain transfected in human HepG2 cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Universit£
Curated by ChEMBL
Universit£
Curated by ChEMBL
Affinity DataEC50: 2.00E+3nMAssay Description:Transactivation of GAL4-fused PPARgamma ligand binding domain transfected in human HepG2 cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Universit£
Curated by ChEMBL
Universit£
Curated by ChEMBL
Affinity DataEC50: 5.00E+3nMAssay Description:Transactivation of GAL4-fused PPARgamma ligand binding domain transfected in human HepG2 cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
TargetNuclear receptor subfamily 1 group I member 2(Homo sapiens (Human))
University Of Ljubljana
Curated by ChEMBL
University Of Ljubljana
Curated by ChEMBL
Affinity DataEC50: 2.10E+4nMAssay Description:Agonist activity at human full-length PXR transfected in human HepG2 cells co-transfected with pSG5-RXR assessed as induction of transactivation by d...More data for this Ligand-Target Pair
TargetNuclear receptor subfamily 1 group I member 2(Homo sapiens (Human))
University Of Ljubljana
Curated by ChEMBL
University Of Ljubljana
Curated by ChEMBL
Affinity DataEC50: 4.00E+3nMAssay Description:Agonist activity at human full-length PXR transfected in human HepG2 cells co-transfected with pSG5-RXR assessed as induction of transactivation by d...More data for this Ligand-Target Pair
TargetNuclear receptor subfamily 1 group I member 2(Homo sapiens (Human))
University Of Ljubljana
Curated by ChEMBL
University Of Ljubljana
Curated by ChEMBL
Affinity DataEC50: 1.80E+4nMAssay Description:Agonist activity at human full-length PXR transfected in human HepG2 cells co-transfected with pSG5-RXR assessed as induction of transactivation by d...More data for this Ligand-Target Pair
Affinity DataEC50: 3.00E+4nMAssay Description:Transactivation of FXR (unknown origin) expressed in human HepG2 cells co-expressing RXR assessed as beta-galactosidase activity after 18 hrs by luci...More data for this Ligand-Target Pair
Affinity DataEC50: 2.50E+4nMAssay Description:Antagonist activity at FXR (unknown origin) expressed in human HepG2 cells co-expressing RXR assessed as inhibition of CDCA-induced transactivation a...More data for this Ligand-Target Pair
TargetG-protein coupled bile acid receptor 1(Homo sapiens (Human))
University Of Naples&Quot;Federico Ii&Quot
Curated by ChEMBL
University Of Naples&Quot;Federico Ii&Quot
Curated by ChEMBL
Affinity DataEC50: 2.44E+4nMAssay Description:Agonist activity at human GPBAR1 expressed in HEK293T cells assessed as stimulation of cAMP response element-mediated receptor transactivation by luc...More data for this Ligand-Target Pair
TargetG-protein coupled bile acid receptor 1(Homo sapiens (Human))
University Of Naples&Quot;Federico Ii&Quot
Curated by ChEMBL
University Of Naples&Quot;Federico Ii&Quot
Curated by ChEMBL
Affinity DataEC50: 400nMAssay Description:Agonist activity at GP-BAR1 (unknown origin) in human HEK293 cells assessed as receptor transactivation at 100 nM to 50 uM incubated for 16 hrs by CR...More data for this Ligand-Target Pair
TargetG-protein coupled bile acid receptor 1(Homo sapiens (Human))
University Of Naples&Quot;Federico Ii&Quot
Curated by ChEMBL
University Of Naples&Quot;Federico Ii&Quot
Curated by ChEMBL
Affinity DataEC50: 1.03E+3nMAssay Description:Agonist activity at GP-BAR1 (unknown origin) in human HEK293 cells assessed as receptor transactivation at 100 nM to 50 uM incubated for 16 hrs by CR...More data for this Ligand-Target Pair
Affinity DataEC50: 2.00E+3nMAssay Description:Agonist activity at FXR (unknown origin) expressed in human HepG2 cells assessed as receptor transactivation at 100 nM to 50 uM incubated for 16 hrs ...More data for this Ligand-Target Pair
Affinity DataEC50: 9.00E+3nMAssay Description:Agonist activity at FXR (unknown origin) expressed in human HepG2 cells assessed as receptor transactivation at 100 nM to 50 uM incubated for 16 hrs ...More data for this Ligand-Target Pair
Affinity DataEC50: 2.40E+4nMAssay Description:Antagonist activity at FXR (unknown origin) expressed in human HepG2 cells co-expressing RXR assessed as inhibition of CDCA-induced transactivation a...More data for this Ligand-Target Pair
Affinity DataEC50: 1.00E+3nMAssay Description:Transactivation of human FXR transfected in human HepG2 cells by beta-galactosidase reporter gene assayMore data for this Ligand-Target Pair
TargetG-protein coupled bile acid receptor 1(Homo sapiens (Human))
University Of Naples&Quot;Federico Ii&Quot
Curated by ChEMBL
University Of Naples&Quot;Federico Ii&Quot
Curated by ChEMBL
Affinity DataEC50: 200nMAssay Description:Transactivation of human GP-BAR1 transfected in HEK293T cells assessed as induction of intracellular cAMP production after 18 hrs by cAMP responsive ...More data for this Ligand-Target Pair
