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Found 516 with Last Name = 'danley' and Initial = 'de'
TargetThyroid hormone receptor beta(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50123058(2-(3,5-dichloro-4-(4-hydroxy-3-(piperidin-1-ylsulf...)
Affinity DataKi:  0.0200nMAssay Description:Inhibitory activity against [125I]-T3 binding to human TRbeta1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThyroid hormone receptor beta(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50123046(2-[4-(4-Hydroxy-3-isopropyl-phenoxy)-3,5-dimethyl-...)
Affinity DataKi:  0.0300nMAssay Description:Inhibitory activity against [125I]-T3 binding to human TRbeta1 receptorMore data for this Ligand-Target Pair
TargetThyroid hormone receptor beta(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50123044(5-(2,6-dichloro-4-(3,5-dioxo-4,5-dihydro-1,2,4-tri...)
Affinity DataKi:  0.0400nMAssay Description:Inhibitory activity against [125I]-T3 binding to human TRbeta1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThyroid hormone receptor beta(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50123044(5-(2,6-dichloro-4-(3,5-dioxo-4,5-dihydro-1,2,4-tri...)
Affinity DataKi:  0.0400nMAssay Description:Inhibitory activity against [125I]-T3 binding to human TRbeta1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThyroid hormone receptor beta(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50123045(CHEMBL413699 | N-Cyclohexyl-5-[2,6-dichloro-4-(3,5...)
Affinity DataKi:  0.0700nMAssay Description:Inhibitory activity against [125I]-T3 binding to human TRbeta1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThyroid hormone receptor beta(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM18860((2R)-2-amino-3-[4-(4-hydroxy-3-iodophenoxy)-3,5-di...)
Affinity DataKi:  0.0800nMAssay Description:Inhibitory activity against [125I]-T3 binding to human TRbeta1 receptorMore data for this Ligand-Target Pair
TargetThyroid hormone receptor beta(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50123054(5-(2,6-dichloro-4-(3,5-dioxo-4,5-dihydro-1,2,4-tri...)
Affinity DataKi:  0.100nMAssay Description:Inhibitory activity against [125I]-T3 binding to human TRbeta1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThyroid hormone receptor beta(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50123064(2-(3-chloro-4-(4-hydroxy-3-(piperidin-1-ylsulfonyl...)
Affinity DataKi:  0.130nMAssay Description:Inhibitory activity against [125I]-T3 binding to human TRbeta1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThyroid hormone receptor beta(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50123063(2-{3,5-Dichloro-4-[4-hydroxy-3-(indole-1-sulfonyl)...)
Affinity DataKi:  0.230nMAssay Description:Inhibitory activity against [125I]-T3 binding to human TRbeta1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThyroid hormone receptor beta(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50123052(2-[4-(3-{8-azaspiro[bicyclo[3.2.1]octane-3,2'-oxol...)
Affinity DataKi:  0.280nMAssay Description:Inhibitory activity against [125I]T3 binding to human TRbeta1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThyroid hormone receptor beta(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50123061(2-[4-(3-{8-azaspiro[bicyclo[3.2.1]octane-3,2'-[1,3...)
Affinity DataKi:  0.310nMAssay Description:Inhibitory activity against [125I]-T3 binding to human TRbeta1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThyroid hormone receptor beta(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50123059(2-{4-[3-(2-Aza-bicyclo[2.2.1]heptane-2-carbonyl)-4...)
Affinity DataKi:  0.370nMAssay Description:Inhibitory activity against [125I]-T3 binding to human TRbeta1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThyroid hormone receptor beta(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50123059(2-{4-[3-(2-Aza-bicyclo[2.2.1]heptane-2-carbonyl)-4...)
Affinity DataKi:  0.370nMAssay Description:Inhibitory activity against [125I]-T3 binding to human TRbeta1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThyroid hormone receptor beta(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50123057(CHEMBL124039 | N-Cyclobutyl-5-[2,6-dichloro-4-(3,5...)
Affinity DataKi:  0.400nMAssay Description:Inhibitory activity against [125I]-T3 binding to human TRbeta1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThyroid hormone receptor beta(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50123062(CHEMBL340158 | N-Cyclohexyl-5-[2,6-dichloro-4-(3,5...)
Affinity DataKi:  0.460nMAssay Description:Inhibitory activity against [125I]-T3 binding to human TRbeta1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThyroid hormone receptor beta(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50123056(2-(4-(4-hydroxy-3-(piperidin-1-ylsulfonyl)phenoxy)...)
Affinity DataKi:  0.460nMAssay Description:Inhibitory activity against [125I]-T3 binding to human TRbeta1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThyroid hormone receptor beta(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50123059(2-{4-[3-(2-Aza-bicyclo[2.2.1]heptane-2-carbonyl)-4...)
Affinity DataKi:  0.590nMAssay Description:Inhibitory activity against [125I]-T3 binding to human TRbeta1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThyroid hormone receptor beta(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50123049(2-(3,5-dichloro-4-(4-hydroxy-3-(piperidine-1-carbo...)
Affinity DataKi:  0.630nMAssay Description:Inhibitory activity against [125I]-T3 binding to human TRbeta1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThyroid hormone receptor beta(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50123050(CHEMBL124318 | N-Cyclobutyl-5-[2,6-dichloro-4-(3,5...)
Affinity DataKi:  0.640nMAssay Description:Inhibitory activity against [125I]-T3 binding to human TRbeta1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThyroid hormone receptor beta(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50123055(2-(3,5-dichloro-4-(4-hydroxy-3-(morpholine-4-carbo...)
Affinity DataKi:  0.720nMAssay Description:Inhibitory activity against [125I]-T3 binding to human TRbeta1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50073839(CHEMBL283066 | [4-(1,3-Dioxo-1,3-dihydro-isoindol-...)
Affinity DataKi:  1.40nMAssay Description:Inhibition of recombinant matrix metalloprotease-3 (MMP-3)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThyroid hormone receptor beta(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50123060(2-{3-Chloro-4-[4-hydroxy-3-(piperidine-1-carbonyl)...)
Affinity DataKi:  1.90nMAssay Description:Inhibitory activity against [125I]-T3 binding to human TRbeta1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThyroid hormone receptor beta(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50123053(2-[3,5-Dimethyl-4-(3-methyl-4-methylsulfanyl-pheno...)
Affinity DataKi:  2nMAssay Description:Inhibitory activity against [125I]-T3 binding to human TRbeta1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50073823(CHEMBL24871 | {4-[((S)-1-Acetyl-pyrrolidine-2-carb...)
Affinity DataKi:  6.10nMAssay Description:Inhibition of recombinant matrix metalloprotease-2 (MMP-2)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThyroid hormone receptor beta(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50123047(2-{3-Chloro-4-[4-hydroxy-3-(4-methyl-piperazine-1-...)
Affinity DataKi:  13nMAssay Description:Inhibitory activity against [125I]-T3 binding to human TRbeta1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50073839(CHEMBL283066 | [4-(1,3-Dioxo-1,3-dihydro-isoindol-...)
Affinity DataKi:  20nMAssay Description:Inhibition of recombinant matrix metalloprotease-2 (MMP-2)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThyroid hormone receptor beta(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50123048(2-(3-chloro-4-(4-hydroxy-3-(morpholinosulfonyl)phe...)
Affinity DataKi:  27nMAssay Description:Inhibitory activity against [125I]-T3 binding to human TRbeta1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50073823(CHEMBL24871 | {4-[((S)-1-Acetyl-pyrrolidine-2-carb...)
Affinity DataKi:  62nMAssay Description:Inhibition of recombinant matrix metalloprotease-3 (MMP-3)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThyroid hormone receptor beta(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50123051(1-[4-(4-Hydroxy-3-isopropyl-phenoxy)-3,5-dimethyl-...)
Affinity DataKi:  1.00E+4nMAssay Description:Inhibitory activity against [125I]-T3 binding to human TRbeta1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50224846(4-(2-{4-[5-(6,8,10-trioxo-1,7,9-triaza-spiro[4.5]d...)
Affinity DataIC50:  0.0500nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50224838(1-{6-[4-(6-fluoro-1H-benzoimidazol-2-yl)-phenoxy]-...)
Affinity DataIC50:  0.0800nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50224842(1-(6-{4-[4-(3-fluoro-phenyl)-oxazol-2-yl]-phenoxy}...)
Affinity DataIC50:  0.0900nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50224852(1-{6-[4-(6-chloro-1H-benzoimidazol-2-yl)-phenoxy]-...)
Affinity DataIC50:  0.100nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50224856(1-{6-[4-(1H-benzoimidazol-2-yl)-phenoxy]-pyridin-3...)
Affinity DataIC50:  0.110nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50224847(3-(2-{4-[5-(6,8,10-trioxo-1,7,9-triaza-spiro[4.5]d...)
Affinity DataIC50:  0.110nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50224837(1-(6-{4-[4-(4-fluoro-phenyl)-oxazol-2-yl]-phenoxy}...)
Affinity DataIC50:  0.120nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50224857(1-(6-{4-[4-(2-fluoro-phenyl)-oxazol-2-yl]-phenoxy}...)
Affinity DataIC50:  0.160nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50285792(4-Oxo-piperidine-1-carboxylic acid {(S)-1-[(R)-1-(...)
Affinity DataIC50:  0.300nMAssay Description:Inhibition against recombinant human renin (rHR)More data for this Ligand-Target Pair
In DepthDetails Article
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50194306(5-(2-ethoxyethyl)-5-(4-(4-(4-(3-fluorophenyl)oxazo...)
Affinity DataIC50:  0.350nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50224845(5-(2-ethoxyethyl)-5-(4-(4-(6-fluoro-1H-benzo[d]imi...)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50194301(4-(2-(4-(4-(5-(2-ethoxyethyl)-2,4,6-trioxo-hexahyd...)
Affinity DataIC50:  0.430nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50224853(5-(4-(4-(1H-benzo[d]imidazol-2-yl)phenoxy)phenoxy)...)
Affinity DataIC50:  0.490nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50194304(3-(2-(4-(4-(5-(2-ethoxyethyl)-2,4,6-trioxo-hexahyd...)
Affinity DataIC50:  0.520nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50163809(5-Amino-3-(2-ethoxy-ethyl)-3-[4-(4-oxazol-5-yl-phe...)
Affinity DataIC50:  0.540nMAssay Description:Inhibitory concentration against matrix metalloprotease 13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50224849(1-[6-(4-bromo-phenoxy)-pyridin-3-yl]-1,7,9-triaza-...)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50224854(5-(2-ethoxyethyl)-5-[4-(4-fluorophenoxy)phenoxy]ba...)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50163808(5-Amino-3-(2-ethoxy-ethyl)-3-{4-[4-(1H-pyrazol-4-y...)
Affinity DataIC50:  0.610nMAssay Description:Inhibitory concentration against matrix metalloprotease 13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50194289(5-(2-ethoxy-ethyl)-5-(4-{4-[4-(4-fluoro-phenyl)-ox...)
Affinity DataIC50:  0.680nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50163812(5-Amino-3-(2-ethoxy-ethyl)-3-[4-(4-fluoro-phenoxy)...)
Affinity DataIC50:  0.870nMAssay Description:Inhibitory concentration against matrix metalloprotease 13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50163807(5-Amino-3-[4-(4-bromo-phenoxy)-phenoxy]-3-(2-ethox...)
Affinity DataIC50:  0.870nMAssay Description:Inhibitory concentration against matrix metalloprotease 13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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