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Found 65 with Last Name = 'dassonville' and Initial = 'a'
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50062351((R)-N*4*-Hydroxy-N*1*-[(S)-2-(1H-indol-3-yl)-1-met...)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of MMP9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50062351((R)-N*4*-Hydroxy-N*1*-[(S)-2-(1H-indol-3-yl)-1-met...)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of MMP2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50062351((R)-N*4*-Hydroxy-N*1*-[(S)-2-(1H-indol-3-yl)-1-met...)
Affinity DataIC50:  1.5nMAssay Description:Inhibition of MMP1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50062351((R)-N*4*-Hydroxy-N*1*-[(S)-2-(1H-indol-3-yl)-1-met...)
Affinity DataIC50:  1.90nMAssay Description:Inhibition of MMP3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50135601((S,E)-N1-(3-(1H-indol-3-yl)-1-(methylamino)-1-oxop...)
Affinity DataIC50:  9.20nMAssay Description:Inhibition of MMP2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-14(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50135601((S,E)-N1-(3-(1H-indol-3-yl)-1-(methylamino)-1-oxop...)
Affinity DataIC50:  10nMAssay Description:Inhibition of MMP14More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-14(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50062351((R)-N*4*-Hydroxy-N*1*-[(S)-2-(1H-indol-3-yl)-1-met...)
Affinity DataIC50:  13nMAssay Description:Inhibition of MMP14More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50135601((S,E)-N1-(3-(1H-indol-3-yl)-1-(methylamino)-1-oxop...)
Affinity DataIC50:  17nMAssay Description:Inhibition of MMP9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50135601((S,E)-N1-(3-(1H-indol-3-yl)-1-(methylamino)-1-oxop...)
Affinity DataIC50:  18nMAssay Description:Inhibition of MMP1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50213416((2E)-3-(N-hydroxycarbamoyl)-2-[(2E)-3-phenylprop-2...)
Affinity DataIC50:  38nMAssay Description:Inhibition of MMP9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50213419((2E)-3-(N-hydroxycarbamoyl)-2-(3-phenylpropylidene...)
Affinity DataIC50:  45nMAssay Description:Inhibition of MMP9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil collagenase(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50213418((2E)-3-(N-hydroxycarbamoyl)-2-heptylidenepropionyl...)
Affinity DataIC50:  101nMAssay Description:Inhibition of MMP8More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50213416((2E)-3-(N-hydroxycarbamoyl)-2-[(2E)-3-phenylprop-2...)
Affinity DataIC50:  120nMAssay Description:Inhibition of MMP2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50213418((2E)-3-(N-hydroxycarbamoyl)-2-heptylidenepropionyl...)
Affinity DataIC50:  122nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50213418((2E)-3-(N-hydroxycarbamoyl)-2-heptylidenepropionyl...)
Affinity DataIC50:  123nMAssay Description:Inhibition of MMP2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50135601((S,E)-N1-(3-(1H-indol-3-yl)-1-(methylamino)-1-oxop...)
Affinity DataIC50:  179nMAssay Description:Inhibition of MMP3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50213419((2E)-3-(N-hydroxycarbamoyl)-2-(3-phenylpropylidene...)
Affinity DataIC50:  280nMAssay Description:Inhibition of MMP2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
Universidade Federal Do Rio Grande Do Sul (Ufrgs)

Curated by ChEMBL
LigandPNGBDBM50240798((8R,9S,10R,13S,14S)-4-Hydroxy-10,13-dimethyl-1,6,7...)
Affinity DataIC50:  800nMAssay Description:Inhibition of aromatase in human placental microsomes assessed as tritiated water release after 15 mins using [1beta, 3H]androstenedione as substrate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-14(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50213417((2E)-3-(N-hydroxycarbamoyl)-2-[(2E)-but-2-en-1-yli...)
Affinity DataIC50:  913nMAssay Description:Inhibition of MMP14More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50213417((2E)-3-(N-hydroxycarbamoyl)-2-[(2E)-but-2-en-1-yli...)
Affinity DataIC50:  974nMAssay Description:Inhibition of MMP9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50213417((2E)-3-(N-hydroxycarbamoyl)-2-[(2E)-but-2-en-1-yli...)
Affinity DataIC50:  984nMAssay Description:Inhibition of MMP1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50213416((2E)-3-(N-hydroxycarbamoyl)-2-[(2E)-3-phenylprop-2...)
Affinity DataIC50:  1.24E+3nMAssay Description:Inhibition of MMP1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50213419((2E)-3-(N-hydroxycarbamoyl)-2-(3-phenylpropylidene...)
Affinity DataIC50:  1.92E+3nMAssay Description:Inhibition of MMP3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50602549(CHEMBL5183354)
Affinity DataIC50:  2.30E+3nMAssay Description:Inhibition of CYP3A4 in human liver microsomes assessed as reduction in 6-beta-hydroxy-testosterone formation using testosterone as substrate preincu...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetMatrix metalloproteinase-14(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50213416((2E)-3-(N-hydroxycarbamoyl)-2-[(2E)-3-phenylprop-2...)
Affinity DataIC50:  2.49E+3nMAssay Description:Inhibition of MMP14More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-14(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50213418((2E)-3-(N-hydroxycarbamoyl)-2-heptylidenepropionyl...)
Affinity DataIC50:  2.66E+3nMAssay Description:Inhibition of MMP14More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50602549(CHEMBL5183354)
Affinity DataIC50:  2.80E+3nMAssay Description:Inhibition of CYP3A4 in human liver microsomes assessed as reduction in 1'-hydroxy midazolam formation using midazolam as substrate preincubated for ...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50602549(CHEMBL5183354)
Affinity DataIC50:  2.90E+3nMAssay Description:Inhibition of CYP3A4 in human liver microsomes assessed as reduction in 6-beta-hydroxy-testosterone formation using testosterone as substrate preincu...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50602550(CHEMBL5177406)
Affinity DataIC50:  5.60E+3nMAssay Description:Inhibition of hERG channel expressed in CHO cells at holding potential of -80 mV by whole cell patch clamp methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50602549(CHEMBL5183354)
Affinity DataIC50:  5.90E+3nMAssay Description:Inhibition of CYP3A4 in human liver microsomes assessed as reduction in 1'-hydroxy midazolam formation using midazolam as substrate preincubated for ...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50602553(CHEMBL5204309)
Affinity DataIC50:  7.00E+3nMAssay Description:Inhibition of hERG channel expressed in CHO cells at holding potential of -80 mV by whole cell patch clamp methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetStromelysin-1(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50213417((2E)-3-(N-hydroxycarbamoyl)-2-[(2E)-but-2-en-1-yli...)
Affinity DataIC50:  8.61E+3nMAssay Description:Inhibition of MMP3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50602551(CHEMBL5181317)
Affinity DataIC50:  8.80E+3nMAssay Description:Inhibition of hERG channel expressed in CHO cells at holding potential of -80 mV by whole cell patch clamp methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50213419((2E)-3-(N-hydroxycarbamoyl)-2-(3-phenylpropylidene...)
Affinity DataIC50:  9.13E+3nMAssay Description:Inhibition of MMP1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
Universidade Federal Do Rio Grande Do Sul (Ufrgs)

Curated by ChEMBL
LigandPNGBDBM7458(5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one...)
Affinity DataIC50:  1.00E+4nMAssay Description:Inhibition of aromatase in human placental microsomes assessed as tritiated water release after 15 mins using [1beta, 3H]androstenedione as substrate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50377446((S,R)-MEFLOQUINE)
Affinity DataIC50:  1.20E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes assessed as reduction in 6-beta-hydroxy-testosterone formation using testosterone as substrate preincu...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50377446((S,R)-MEFLOQUINE)
Affinity DataIC50:  1.36E+4nMAssay Description:Inhibition of hERG channel expressed in CHO cells at holding potential of -80 mV by whole cell patch clamp methodMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50151865(CHEMBL172 | MEFLOQUINE)
Affinity DataIC50:  1.50E+4nMAssay Description:Inhibition of hERG channel expressed in CHO cells at holding potential of -80 mV by whole cell patch clamp methodMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50602549(CHEMBL5183354)
Affinity DataIC50:  1.73E+4nMAssay Description:Inhibition of hERG channel expressed in CHO cells at holding potential of -80 mV by whole cell patch clamp methodMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50151865(CHEMBL172 | MEFLOQUINE)
Affinity DataIC50:  1.80E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes assessed as reduction in 6-beta-hydroxy-testosterone formation using testosterone as substrate preincu...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50151865(CHEMBL172 | MEFLOQUINE)
Affinity DataIC50:  1.90E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes assessed as reduction in 6-beta-hydroxy-testosterone formation using testosterone as substrate preincu...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50377446((S,R)-MEFLOQUINE)
Affinity DataIC50:  1.90E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes assessed as reduction in 6-beta-hydroxy-testosterone formation using testosterone as substrate preincu...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetStromelysin-1(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50213416((2E)-3-(N-hydroxycarbamoyl)-2-[(2E)-3-phenylprop-2...)
Affinity DataIC50:  2.10E+4nMAssay Description:Inhibition of MMP3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50151865(CHEMBL172 | MEFLOQUINE)
Affinity DataIC50:  3.00E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes assessed as reduction in 1'-hydroxy midazolam formation using midazolam as substrate preincubated for ...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50602552(CHEMBL5191501)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of hERG channel expressed in CHO cells at holding potential of -80 mV by whole cell patch clamp methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50213418((2E)-3-(N-hydroxycarbamoyl)-2-heptylidenepropionyl...)
Affinity DataIC50:  3.20E+4nMAssay Description:Inhibition of MMP1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
Universidade Federal Do Rio Grande Do Sul (Ufrgs)

Curated by ChEMBL
LigandPNGBDBM50148911((3beta)-3-hydroxyurs-12-en-28-oic acid | 3beta-hyd...)
Affinity DataIC50:  3.20E+4nMAssay Description:Inhibition of aromatase in human placental microsomes assessed as tritiated water release after 15 mins using [1beta, 3H]androstenedione as substrate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50151865(CHEMBL172 | MEFLOQUINE)
Affinity DataIC50:  3.30E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes assessed as reduction in 1'-hydroxy midazolam formation using midazolam as substrate preincubated for ...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50377446((S,R)-MEFLOQUINE)
Affinity DataIC50:  4.30E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes assessed as reduction in 1'-hydroxy midazolam formation using midazolam as substrate preincubated for ...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50377446((S,R)-MEFLOQUINE)
Affinity DataIC50:  4.50E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes assessed as reduction in 1'-hydroxy midazolam formation using midazolam as substrate preincubated for ...More data for this Ligand-Target Pair
In DepthDetails PubMed
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