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Found 33 with Last Name = 'dassonville-klimpt' and Initial = 'a'
TargetAromatase(Homo sapiens (Human))
Universidade Federal Do Rio Grande Do Sul (Ufrgs)

Curated by ChEMBL
LigandPNGBDBM50240798((8R,9S,10R,13S,14S)-4-Hydroxy-10,13-dimethyl-1,6,7...)
Affinity DataIC50:  800nMAssay Description:Inhibition of aromatase in human placental microsomes assessed as tritiated water release after 15 mins using [1beta, 3H]androstenedione as substrate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50602549(CHEMBL5183354)
Affinity DataIC50:  2.30E+3nMAssay Description:Inhibition of CYP3A4 in human liver microsomes assessed as reduction in 6-beta-hydroxy-testosterone formation using testosterone as substrate preincu...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50602549(CHEMBL5183354)
Affinity DataIC50:  2.80E+3nMAssay Description:Inhibition of CYP3A4 in human liver microsomes assessed as reduction in 1'-hydroxy midazolam formation using midazolam as substrate preincubated for ...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50602549(CHEMBL5183354)
Affinity DataIC50:  2.90E+3nMAssay Description:Inhibition of CYP3A4 in human liver microsomes assessed as reduction in 6-beta-hydroxy-testosterone formation using testosterone as substrate preincu...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50602550(CHEMBL5177406)
Affinity DataIC50:  5.60E+3nMAssay Description:Inhibition of hERG channel expressed in CHO cells at holding potential of -80 mV by whole cell patch clamp methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50602549(CHEMBL5183354)
Affinity DataIC50:  5.90E+3nMAssay Description:Inhibition of CYP3A4 in human liver microsomes assessed as reduction in 1'-hydroxy midazolam formation using midazolam as substrate preincubated for ...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50602553(CHEMBL5204309)
Affinity DataIC50:  7.00E+3nMAssay Description:Inhibition of hERG channel expressed in CHO cells at holding potential of -80 mV by whole cell patch clamp methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50602551(CHEMBL5181317)
Affinity DataIC50:  8.80E+3nMAssay Description:Inhibition of hERG channel expressed in CHO cells at holding potential of -80 mV by whole cell patch clamp methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetAromatase(Homo sapiens (Human))
Universidade Federal Do Rio Grande Do Sul (Ufrgs)

Curated by ChEMBL
LigandPNGBDBM7458(5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one...)
Affinity DataIC50:  1.00E+4nMAssay Description:Inhibition of aromatase in human placental microsomes assessed as tritiated water release after 15 mins using [1beta, 3H]androstenedione as substrate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50377446((S,R)-MEFLOQUINE)
Affinity DataIC50:  1.20E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes assessed as reduction in 6-beta-hydroxy-testosterone formation using testosterone as substrate preincu...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50377446((S,R)-MEFLOQUINE)
Affinity DataIC50:  1.36E+4nMAssay Description:Inhibition of hERG channel expressed in CHO cells at holding potential of -80 mV by whole cell patch clamp methodMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50151865(CHEMBL172 | MEFLOQUINE)
Affinity DataIC50:  1.50E+4nMAssay Description:Inhibition of hERG channel expressed in CHO cells at holding potential of -80 mV by whole cell patch clamp methodMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50602549(CHEMBL5183354)
Affinity DataIC50:  1.73E+4nMAssay Description:Inhibition of hERG channel expressed in CHO cells at holding potential of -80 mV by whole cell patch clamp methodMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50151865(CHEMBL172 | MEFLOQUINE)
Affinity DataIC50:  1.80E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes assessed as reduction in 6-beta-hydroxy-testosterone formation using testosterone as substrate preincu...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50377446((S,R)-MEFLOQUINE)
Affinity DataIC50:  1.90E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes assessed as reduction in 6-beta-hydroxy-testosterone formation using testosterone as substrate preincu...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50151865(CHEMBL172 | MEFLOQUINE)
Affinity DataIC50:  1.90E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes assessed as reduction in 6-beta-hydroxy-testosterone formation using testosterone as substrate preincu...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50151865(CHEMBL172 | MEFLOQUINE)
Affinity DataIC50:  3.00E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes assessed as reduction in 1'-hydroxy midazolam formation using midazolam as substrate preincubated for ...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50602552(CHEMBL5191501)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of hERG channel expressed in CHO cells at holding potential of -80 mV by whole cell patch clamp methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetAromatase(Homo sapiens (Human))
Universidade Federal Do Rio Grande Do Sul (Ufrgs)

Curated by ChEMBL
LigandPNGBDBM50148911((3beta)-3-hydroxyurs-12-en-28-oic acid | 3beta-hyd...)
Affinity DataIC50:  3.20E+4nMAssay Description:Inhibition of aromatase in human placental microsomes assessed as tritiated water release after 15 mins using [1beta, 3H]androstenedione as substrate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50151865(CHEMBL172 | MEFLOQUINE)
Affinity DataIC50:  3.30E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes assessed as reduction in 1'-hydroxy midazolam formation using midazolam as substrate preincubated for ...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50377446((S,R)-MEFLOQUINE)
Affinity DataIC50:  4.30E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes assessed as reduction in 1'-hydroxy midazolam formation using midazolam as substrate preincubated for ...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50377446((S,R)-MEFLOQUINE)
Affinity DataIC50:  4.50E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes assessed as reduction in 1'-hydroxy midazolam formation using midazolam as substrate preincubated for ...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetAromatase(Homo sapiens (Human))
Universidade Federal Do Rio Grande Do Sul (Ufrgs)

Curated by ChEMBL
LigandPNGBDBM50245649(2-Cyano-2,3-seco-4-yliden-olean-12-enoic acid | CH...)
Affinity DataIC50: >5.00E+5nMAssay Description:Inhibition of aromatase in human placental microsomes assessed as tritiated water release after 15 mins using [1beta, 3H]androstenedione as substrate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
Universidade Federal Do Rio Grande Do Sul (Ufrgs)

Curated by ChEMBL
LigandPNGBDBM50245648((E )-3-Oximeurs-12-en-28-oic acid | CHEMBL487888)
Affinity DataIC50: >5.00E+5nMAssay Description:Inhibition of aromatase in human placental microsomes assessed as tritiated water release after 15 mins using [1beta, 3H]androstenedione as substrate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
Universidade Federal Do Rio Grande Do Sul (Ufrgs)

Curated by ChEMBL
LigandPNGBDBM50245704(4-aza-A-homo-3-oxo-ursolic acid | CHEMBL454421)
Affinity DataIC50: >5.00E+5nMAssay Description:Inhibition of aromatase in human placental microsomes assessed as tritiated water release after 15 mins using [1beta, 3H]androstenedione as substrate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
Universidade Federal Do Rio Grande Do Sul (Ufrgs)

Curated by ChEMBL
LigandPNGBDBM50245647((1S,2R,4aS,6aS,6bR,8aR,12aR,12bR,14bS)-1,2,6a,6b,9...)
Affinity DataIC50: >5.00E+5nMAssay Description:Inhibition of aromatase in human placental microsomes assessed as tritiated water release after 15 mins using [1beta, 3H]androstenedione as substrate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
Universidade Federal Do Rio Grande Do Sul (Ufrgs)

Curated by ChEMBL
LigandPNGBDBM50225913(CHEMBL264924 | N-{3-[4-(3-aminopropyl)piperazinyl]...)
Affinity DataIC50: >5.00E+5nMAssay Description:Inhibition of aromatase in human placental microsomes assessed as tritiated water release after 15 mins using [1beta, 3H]androstenedione as substrate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
Universidade Federal Do Rio Grande Do Sul (Ufrgs)

Curated by ChEMBL
LigandPNGBDBM50225900(CHEMBL270215 | N-{3-[4-(3-aminopropyl)piperazinyl]...)
Affinity DataIC50: >5.00E+5nMAssay Description:Inhibition of aromatase in human placental microsomes assessed as tritiated water release after 15 mins using [1beta, 3H]androstenedione as substrate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistidine-rich protein PFHRP-II(Plasmodium falciparum)
Universidade Federal Do Rio Grande Do Sul (Ufrgs)

Curated by ChEMBL
LigandPNGBDBM50411865(CHEMBL261832)
Affinity DataIC50:  5.25E+6nMAssay Description:Inhibition of beta-hematin formationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistidine-rich protein PFHRP-II(Plasmodium falciparum)
Universidade Federal Do Rio Grande Do Sul (Ufrgs)

Curated by ChEMBL
LigandPNGBDBM22985(Aralen | CHEMBL76 | CHLOROQUINE PHOSPHATE | Chloro...)
Affinity DataIC50:  5.90E+6nMAssay Description:Inhibition of beta-hematin formationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistidine-rich protein PFHRP-II(Plasmodium falciparum)
Universidade Federal Do Rio Grande Do Sul (Ufrgs)

Curated by ChEMBL
LigandPNGBDBM50225900(CHEMBL270215 | N-{3-[4-(3-aminopropyl)piperazinyl]...)
Affinity DataIC50: >2.00E+7nMAssay Description:Inhibition of beta-hematin formationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistidine-rich protein PFHRP-II(Plasmodium falciparum)
Universidade Federal Do Rio Grande Do Sul (Ufrgs)

Curated by ChEMBL
LigandPNGBDBM50411864(CHEMBL436662)
Affinity DataIC50: >2.00E+7nMAssay Description:Inhibition of beta-hematin formationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistidine-rich protein PFHRP-II(Plasmodium falciparum)
Universidade Federal Do Rio Grande Do Sul (Ufrgs)

Curated by ChEMBL
LigandPNGBDBM50148911((3beta)-3-hydroxyurs-12-en-28-oic acid | 3beta-hyd...)
Affinity DataIC50: >2.00E+7nMAssay Description:Inhibition of beta-hematin formationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed