Compile Data Set for Download or QSAR
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Found 895 with Last Name = 'dehmlow' and Initial = 'h'
TargetOxysterols receptor LXR-alpha(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50192109(2-(4-(benzyl(2,2,2-trifluoroethyl)amino)-3-chlorop...)
Affinity DataIC50:  1nMAssay Description:Binding affinity to LXRalpha by radioligand displacement assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLanosterol synthase(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50130785(CHEMBL542453 | CHEMBL609978 | {4-[6-(Allyl-methyl-...)
Affinity DataIC50:  1.90nMAssay Description:In vitro inhibition of human 2,3-oxidosqualene cyclase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOxysterols receptor LXR-alpha(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50192137(2-(3-chloro-4-(((2-(3-chlorophenyl)-5-methyloxazol...)
Affinity DataIC50:  2nMAssay Description:Binding affinity to LXRalpha by radioligand displacement assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOxysterols receptor LXR-beta(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50192148(2-(3-chloro-4-(ethyl(thiazol-4-ylmethyl)amino)phen...)
Affinity DataIC50:  2nMAssay Description:Binding affinity to LXRbeta by radioligand displacement assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLanosterol synthase(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50128063(Allyl-{6-[3-(4-bromo-phenyl)-benzo[d]isothiazol-6-...)
Affinity DataIC50:  2.90nMAssay Description:Inhibition of human liver microsome 2,3-OSC after 1 hr by Silica gel plate phosphor imagingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLanosterol synthase(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50128063(Allyl-{6-[3-(4-bromo-phenyl)-benzo[d]isothiazol-6-...)
Affinity DataIC50:  2.90nMAssay Description:Inhibitory activity against Oxidosqualene-lanosterol cyclase from human liver microsomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLanosterol synthase(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50128063(Allyl-{6-[3-(4-bromo-phenyl)-benzo[d]isothiazol-6-...)
Affinity DataIC50:  2.90nMAssay Description:In vitro inhibition of human 2,3-oxidosqualene cyclase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOxysterols receptor LXR-alpha(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50192134(2-(4-(benzyl(ethyl)amino)-3-chlorophenyl)-1,1,1,3,...)
Affinity DataIC50:  3nMAssay Description:Binding affinity to LXRalpha by radioligand displacement assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLanosterol synthase(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50128060(CHEMBL63524 | N-allyl-4-(4-(4-bromobenzoyl)phenoxy...)
Affinity DataIC50:  3nMAssay Description:Inhibitory activity against Oxidosqualene-lanosterol cyclase from human liver microsomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOxysterols receptor LXR-beta(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50192136(2-(4-(ethyl((5-methyl-2-(3-(trifluoromethyl)phenyl...)
Affinity DataIC50:  3nMAssay Description:Binding affinity to LXRbeta by radioligand displacement assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOxysterols receptor LXR-beta(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50192144(2-(3-chloro-4-(ethyl(phenethyl)amino)phenyl)-1,1,1...)
Affinity DataIC50:  3nMAssay Description:Binding affinity to LXRbeta by radioligand displacement assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOxysterols receptor LXR-beta(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50192134(2-(4-(benzyl(ethyl)amino)-3-chlorophenyl)-1,1,1,3,...)
Affinity DataIC50:  3nMAssay Description:Binding affinity to LXRbeta by radioligand displacement assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOxysterols receptor LXR-beta(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50192109(2-(4-(benzyl(2,2,2-trifluoroethyl)amino)-3-chlorop...)
Affinity DataIC50:  3nMAssay Description:Binding affinity to LXRbeta by radioligand displacement assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLanosterol synthase(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50128054(Allyl-{6-[1-(4-bromo-phenyl)-isoquinolin-6-yloxy]-...)
Affinity DataIC50:  3.5nMAssay Description:Inhibitory activity against Oxidosqualene-lanosterol cyclase from human liver microsomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLanosterol synthase(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50128054(Allyl-{6-[1-(4-bromo-phenyl)-isoquinolin-6-yloxy]-...)
Affinity DataIC50:  3.5nMAssay Description:In vitro inhibition of human 2,3-oxidosqualene cyclase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOxysterols receptor LXR-beta(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50192137(2-(3-chloro-4-(((2-(3-chlorophenyl)-5-methyloxazol...)
Affinity DataIC50:  4nMAssay Description:Binding affinity to LXRbeta by radioligand displacement assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLanosterol synthase(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50128055(Allyl-{6-[4-(4-bromo-phenyl)-1H-benzo[d][1,2]oxazi...)
Affinity DataIC50:  4.10nMAssay Description:In vitro inhibition of human 2,3-oxidosqualene cyclase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLanosterol synthase(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50128055(Allyl-{6-[4-(4-bromo-phenyl)-1H-benzo[d][1,2]oxazi...)
Affinity DataIC50:  4.10nMAssay Description:Inhibitory activity against Oxidosqualene-lanosterol cyclase from human liver microsomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLanosterol synthase(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50130788(CHEMBL116705 | CHEMBL611484 | {4-[6-(Allyl-methyl-...)
Affinity DataIC50:  4.10nMAssay Description:In vitro inhibition of human 2,3-oxidosqualene cyclase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLanosterol synthase(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50130783(CHEMBL115020 | CHEMBL611485 | {4-[6-(Allyl-methyl-...)
Affinity DataIC50:  4.60nMAssay Description:In vitro inhibition of human 2,3-oxidosqualene cyclase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLanosterol synthase(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50255431(4-(trifluoromethyl)phenyl 4-(5-(allyl(methyl)amino...)
Affinity DataIC50:  5nMAssay Description:Inhibition of human liver microsome 2,3-OSC after 1 hr by Silica gel plate phosphor imagingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOxysterols receptor LXR-alpha(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50192117(2-(4-(((2-(3-chlorophenyl)-5-methyloxazol-4-yl)met...)
Affinity DataIC50:  5nMAssay Description:Binding affinity to LXRalpha by radioligand displacement assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOxysterols receptor LXR-beta(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50192117(2-(4-(((2-(3-chlorophenyl)-5-methyloxazol-4-yl)met...)
Affinity DataIC50:  5nMAssay Description:Binding affinity to LXRbeta by radioligand displacement assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLanosterol synthase(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50128050(CHEMBL114259 | CHEMBL416694 | N-allyl-6-(4-(4-brom...)
Affinity DataIC50:  5.40nMAssay Description:In vitro inhibition of human 2,3-oxidosqualene cyclase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLanosterol synthase(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50128050(CHEMBL114259 | CHEMBL416694 | N-allyl-6-(4-(4-brom...)
Affinity DataIC50:  5.40nMAssay Description:Inhibitory activity against Oxidosqualene-lanosterol cyclase from human liver microsomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLanosterol synthase(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50130789(Allyl-{6-[3-(4-bromo-phenyl)-benzo[b]thiophen-6-yl...)
Affinity DataIC50:  5.60nMAssay Description:In vitro inhibition of human 2,3-oxidosqualene cyclase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLanosterol synthase(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50128065(CHEMBL304858 | CHEMBL324162 | N-allyl-6-(4-(4-brom...)
Affinity DataIC50:  5.70nMAssay Description:Inhibition of human liver microsome 2,3-OSC after 1 hr by Silica gel plate phosphor imagingMore data for this Ligand-Target Pair
TargetOxysterols receptor LXR-alpha(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50192113(2-(3-chloro-4-(ethyl((5-methyl-2-(3-(trifluorometh...)
Affinity DataIC50:  6nMAssay Description:Binding affinity to LXRalpha by radioligand displacement assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOxysterols receptor LXR-alpha(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50192136(2-(4-(ethyl((5-methyl-2-(3-(trifluoromethyl)phenyl...)
Affinity DataIC50:  6nMAssay Description:Binding affinity to LXRalpha by radioligand displacement assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOxysterols receptor LXR-alpha(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50192144(2-(3-chloro-4-(ethyl(phenethyl)amino)phenyl)-1,1,1...)
Affinity DataIC50:  6nMAssay Description:Binding affinity to LXRalpha by radioligand displacement assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLanosterol synthase(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50130786(CHEMBL115923 | CHEMBL611486 | {4-[6-(Allyl-methyl-...)
Affinity DataIC50:  6.20nMAssay Description:In vitro inhibition of human 2,3-oxidosqualene cyclase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLanosterol synthase(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50130774(CHEMBL115375 | CHEMBL611757 | {4-[6-(Allyl-methyl-...)
Affinity DataIC50:  6.30nMAssay Description:In vitro inhibition of human 2,3-oxidosqualene cyclase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLanosterol synthase(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50128065(CHEMBL304858 | CHEMBL324162 | N-allyl-6-(4-(4-brom...)
Affinity DataIC50:  6.5nMAssay Description:Inhibitory activity against Oxidosqualene-lanosterol cyclase from human liver microsomesMore data for this Ligand-Target Pair
TargetLanosterol synthase(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50128065(CHEMBL304858 | CHEMBL324162 | N-allyl-6-(4-(4-brom...)
Affinity DataIC50:  6.5nMAssay Description:In vitro inhibition of human 2,3-oxidosqualene cyclase.More data for this Ligand-Target Pair
TargetLanosterol synthase(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50130775(CHEMBL554209 | CHEMBL611758 | {4-[6-(Allyl-methyl-...)
Affinity DataIC50:  6.70nMAssay Description:In vitro inhibition of human 2,3-oxidosqualene cyclase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-converting enzyme 1(Homo sapiens (Human))
University Institute Of Pathology

Curated by ChEMBL
LigandPNGBDBM50159366((2S,4R)-4-Acetylsulfanyl-2-(2,4,5-trifluoro-benzyl...)
Affinity DataIC50:  6.90nMAssay Description:Inhibitory concentration against human ECE-1 by RIAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOxysterols receptor LXR-beta(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50192113(2-(3-chloro-4-(ethyl((5-methyl-2-(3-(trifluorometh...)
Affinity DataIC50:  7nMAssay Description:Binding affinity to LXRbeta by radioligand displacement assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOxysterols receptor LXR-beta(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50192115(3-(4-(2-((2-chloro-4-(1,1,1,3,3,3-hexafluoro-2-hyd...)
Affinity DataIC50:  7nMAssay Description:Binding affinity to LXRbeta by radioligand displacement assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLanosterol synthase(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50394835(CHEMBL2164235)
Affinity DataIC50:  7.80nMAssay Description:Inhibition of human liver microsome 2,3-OSC after 1 hr by Silica gel plate phosphor imagingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLanosterol synthase(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50130772(Allyl-{6-[3-(4-bromo-phenyl)-1,1-dioxo-1H-1lambda*...)
Affinity DataIC50:  7.80nMAssay Description:In vitro inhibition of human 2,3-oxidosqualene cyclase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLanosterol synthase(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50130784(Allyl-{6-[1-(4-bromo-phenyl)-3,4-dihydro-isoquinol...)
Affinity DataIC50:  7.90nMAssay Description:In vitro inhibition of human 2,3-oxidosqualene cyclase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLanosterol synthase(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50128070((4''-{[ALLYL(METHYL)AMINO]METHYL}-1,1''-BIPHENYL-4...)
Affinity DataIC50:  8nMAssay Description:Inhibition of human liver microsome 2,3-OSC after 1 hr by Silica gel plate phosphor imagingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOxysterols receptor LXR-beta(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50192138(CHEMBL215904 | methyl 2-(ethyl(4-(1,1,1,3,3,3-hexa...)
Affinity DataIC50:  8nMAssay Description:Binding affinity to LXRbeta by radioligand displacement assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLanosterol synthase(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50130787(CHEMBL114266 | CHEMBL612025 | {6-[6-(Allyl-methyl-...)
Affinity DataIC50:  8.70nMAssay Description:In vitro inhibition of human 2,3-oxidosqualene cyclase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLanosterol synthase(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50394836(CHEMBL2164234)
Affinity DataIC50:  10nMAssay Description:Inhibition of human liver microsome 2,3-OSC after 1 hr by Silica gel plate phosphor imagingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-converting enzyme 1(Homo sapiens (Human))
University Institute Of Pathology

Curated by ChEMBL
LigandPNGBDBM50159365((3R,5S)-5-{[(2,5-difluorobenzyl)amino]methyl}-1-(5...)
Affinity DataIC50:  10.4nMAssay Description:Inhibitory concentration against human ECE-1 by RIAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLanosterol synthase(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50394833(CHEMBL2164237)
Affinity DataIC50:  11.2nMAssay Description:Inhibition of human liver microsome 2,3-OSC after 1 hr by Silica gel plate phosphor imagingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLanosterol synthase(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50128066(CHEMBL66412 | METHYL-[4-(4-PIPERIDINE-1-YLMETHYL-P...)
Affinity DataIC50:  11.3nMAssay Description:Inhibitory activity against Oxidosqualene-lanosterol cyclase from human liver microsomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLanosterol synthase(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50130776(Allyl-{6-[4-(4-bromo-phenyl)-2H-chromen-7-yloxy]-h...)
Affinity DataIC50:  11.4nMAssay Description:In vitro inhibition of human 2,3-oxidosqualene cyclase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-converting enzyme 1(Homo sapiens (Human))
University Institute Of Pathology

Curated by ChEMBL
LigandPNGBDBM50098118((2S,4R)-4-Mercapto-2-(2,4,5-trifluoro-benzyloxymet...)
Affinity DataIC50:  12nMAssay Description:Inhibitory concentration against human ECE-1 by RIAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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