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Found 57 with Last Name = 'delaye' and Initial = 'po'
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))TBA
LigandPNGBDBM50609298(CHEMBL5268404)
Affinity DataKi:  0.0500nMAssay Description:Binding affinity to human recombinant JAK2 assessed as inhibition constant incubated for 30 mins by microtiter plate reader analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))TBA
LigandPNGBDBM50609298(CHEMBL5268404)
Affinity DataKi:  0.100nMAssay Description:Binding affinity to human recombinant JAK1 assessed as inhibition constant incubated for 30 mins by microtiter plate reader analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetCorticotropin-releasing factor receptor 1(Homo sapiens (Human))TBA
LigandPNGBDBM50272695(3-(4-chloro-2-morpholinothiazol-5-yl)-2,6-dimethyl...)
Affinity DataKi:  10nMAssay Description:Binding affinity to human recombinant CRF1 in HEK cell line assessed as inhibition constant incubated for 2 hrs by MicroBeta scintillation counter me...More data for this Ligand-Target Pair
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TargetAmyloid-beta precursor protein(Homo sapiens (Human))TBA
LigandPNGBDBM50122787(2-(4'-dimethylaminophenyl)-6-iodoimidazo[1,2-a]pyr...)
Affinity DataKi:  11nMAssay Description:Binding affinity to A beta-amyloid plaque (unknown origin)More data for this Ligand-Target Pair
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TargetCorticotropin-releasing factor receptor 2(Homo sapiens (Human))TBA
LigandPNGBDBM50272695(3-(4-chloro-2-morpholinothiazol-5-yl)-2,6-dimethyl...)
Affinity DataKi:  1.69E+4nMAssay Description:Binding affinity to human recombinant CRF2 in HEK cell line assessed as inhibition constant incubated for 4 to 5 hrs by Scintillation Proximity AssayMore data for this Ligand-Target Pair
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TargetGlycogen synthase kinase-3 alpha(Homo sapiens (Human))TBA
LigandPNGBDBM610463(BDBM610464 | BDBM610465 | N-(4-(2-Methylmorpholino...)
Affinity DataIC50:  0.0900nMAssay Description:Inhibition of GSK3alpha (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
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TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))TBA
LigandPNGBDBM610463(BDBM610464 | BDBM610465 | N-(4-(2-Methylmorpholino...)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of GSK3beta (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50609288(CHEMBL5268087)
Affinity DataIC50: <0.310nMAssay Description:Inhibition of TRKA (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
LigandPNGBDBM285634(3-(4-chloro-3,5-difluoro-phenyl)-N-cyclopropyl-imi...)
Affinity DataIC50: <0.488nMAssay Description:Inhibition of human recombinant PDE4A incubated for 30 mins by Scintillation Proximity AssayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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LigandPNGBDBM288405(US10087187, Compound 106)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of PI3Kbeta (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))TBA
LigandPNGBDBM50609297(CHEMBL5285673)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of human recombinant JAK3 incubated for 3 hrs by caliper analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetProteinase-activated receptor 2(Homo sapiens (Human))TBA
LigandPNGBDBM50609292(CHEMBL5273903)
Affinity DataIC50:  0.700nMAssay Description:Inhibition of PAR2 expressed in human HT-29 cells incubated for 30 mins by FLIPR Tetra system methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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LigandPNGBDBM193163(US9193736, 79)
Affinity DataIC50: <1nMAssay Description:Inhibition of human recombinant PDE10A expressed in Sf9 cells incubated for 60 mins by scintillation counter analysisMore data for this Ligand-Target Pair
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LigandPNGBDBM350389(4-amino-6-((1-(3-chloro-6-phenylimidazo[1,2-b]pyri...)
Affinity DataIC50:  1nMAssay Description:Inhibition of PI3Kbeta (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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LigandPNGBDBM50322535(3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N...)
Affinity DataIC50:  1.20nMAssay Description:Inhibition of BCR-ABL (unknown origin) expressed in mouse BaF3 cells assessed as cell growth inhibition incubated for 20 mins by TR-FRET assayMore data for this Ligand-Target Pair
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LigandPNGBDBM285634(3-(4-chloro-3,5-difluoro-phenyl)-N-cyclopropyl-imi...)
Affinity DataIC50:  1.60nMAssay Description:Inhibition of human recombinant PDE4B incubated for 30 mins by Scintillation Proximity AssayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))TBA
LigandPNGBDBM50609297(CHEMBL5285673)
Affinity DataIC50:  2.30nMAssay Description:Inhibition of GST-fused human JAK1 incubated for 3 hrs by caliper analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetHepatocyte growth factor receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50609287(CHEMBL5284720)
Affinity DataIC50: <3nMAssay Description:Inhibition of c-Met (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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LigandPNGBDBM285634(3-(4-chloro-3,5-difluoro-phenyl)-N-cyclopropyl-imi...)
Affinity DataIC50:  4.70nMAssay Description:Inhibition of human recombinant PDE4C incubated for 30 mins by Scintillation Proximity AssayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetNT-3 growth factor receptor(Homo sapiens (Human))TBA
LigandPNGBDBM136597(US10005783, 14 | US10047097, 14 | US10774085, Exam...)
Affinity DataIC50:  5nMAssay Description:Inhibition of TRKC (unknown origin)More data for this Ligand-Target Pair
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TargetBDNF/NT-3 growth factors receptor(Homo sapiens (Human))TBA
LigandPNGBDBM136597(US10005783, 14 | US10047097, 14 | US10774085, Exam...)
Affinity DataIC50:  5nMAssay Description:Inhibition of TRKB (unknown origin)More data for this Ligand-Target Pair
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TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))TBA
LigandPNGBDBM136597(US10005783, 14 | US10047097, 14 | US10774085, Exam...)
Affinity DataIC50:  5nMAssay Description:Inhibition of TRKA (unknown origin)More data for this Ligand-Target Pair
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TargetGlycogen synthase kinase-3 alpha(Homo sapiens (Human))TBA
LigandPNGBDBM610450(2-Phenyl-N-(pyridin-3-yl)imidazo[1,2-b]pyridazine-...)
Affinity DataIC50:  5.30nMAssay Description:Inhibition of GSK3alpha (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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LigandPNGBDBM50609289(CHEMBL5282271)
Affinity DataIC50:  6nMAssay Description:Inhibition of PI3Kalpha (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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LigandPNGBDBM50609291(CHEMBL5281874)
Affinity DataIC50:  6nMAssay Description:Inhibition of PI3Kalpha (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))TBA
LigandPNGBDBM50364776(CHEMBL1952141 | CHEMBL1952329)
Affinity DataIC50:  7nMAssay Description:Inhibition of PIM1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
LigandPNGBDBM50322535(3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N...)
Affinity DataIC50:  8.80nMAssay Description:Inhibition of Bcr-Abl T315I mutant (unknown origin) expressed in mouse BaF3 cells assessed as cell growth inhibition incubated for 20 mins by TR-FRET...More data for this Ligand-Target Pair
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TargetMicrotubule-associated protein tau(Homo sapiens (Human))TBA
LigandPNGBDBM610463(BDBM610464 | BDBM610465 | N-(4-(2-Methylmorpholino...)
Affinity DataIC50:  9.20nMAssay Description:Inhibition of Tau (unknown origin) phosphorylationMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails PubMed
TargetCalcium-dependent protein kinase 1(Plasmodium Falciparum)TBA
LigandPNGBDBM50609296(CHEMBL5282946)
Affinity DataIC50:  10nMAssay Description:Inhibition of Plasmodium falciparum CDPK1More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))TBA
LigandPNGBDBM11835(1-(3-{6-[(cyclopropylmethyl)amino]imidazo[1,2-a]py...)
Affinity DataIC50:  12nMAssay Description:Inhibition of PIM1 (unknown origin)More data for this Ligand-Target Pair
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TargetCorticotropin-releasing factor receptor 1(Homo sapiens (Human))TBA
LigandPNGBDBM50609295(CHEMBL5269179)
Affinity DataIC50:  16nMAssay Description:Inhibition of human recombinant CRF1 in HEK cell line incubated for 2 hrs by MicroBeta scintillation counter methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))TBA
LigandPNGBDBM610450(2-Phenyl-N-(pyridin-3-yl)imidazo[1,2-b]pyridazine-...)
Affinity DataIC50:  17nMAssay Description:Inhibition of GSK3beta (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
LigandPNGBDBM50609293(CHEMBL5279580)
Affinity DataIC50:  27nMAssay Description:Inhibition of PDE10A2 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetCasein kinase I isoform epsilon(Homo sapiens (Human))TBA
LigandPNGBDBM50609299(CHEMBL5279523)
Affinity DataIC50:  57nMAssay Description:Inhibition of human CK1 epsilon incubated for 2 hrs by scintillation counter analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))TBA
LigandPNGBDBM16673(4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamo...)
Affinity DataIC50:  57nMAssay Description:Inhibition of human VEGFR2 by TR-FRET assayMore data for this Ligand-Target Pair
LigandPNGBDBM50397991(CHEMBL2180408)
Affinity DataIC50:  58nMAssay Description:Inhibition of PDE10A2 (unknown origin)More data for this Ligand-Target Pair
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LigandPNGBDBM50609289(CHEMBL5282271)
Affinity DataIC50:  70nMAssay Description:Inhibition of PI3Kdelta (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
LigandPNGBDBM50609291(CHEMBL5281874)
Affinity DataIC50:  75nMAssay Description:Inhibition of Akt phosphorylation in human HCT-116 cellsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
LigandPNGBDBM350389(4-amino-6-((1-(3-chloro-6-phenylimidazo[1,2-b]pyri...)
Affinity DataIC50:  87nMAssay Description:Inhibition of PI3Kdelta (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))TBA
LigandPNGBDBM16673(4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamo...)
Affinity DataIC50:  90nMAssay Description:Inhibition of PDGFRbeta (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails PubMedDrugBank

TargetCorticotropin-releasing factor receptor 1(Homo sapiens (Human))TBA
LigandPNGBDBM50609294(CHEMBL5280146)
Affinity DataIC50:  120nMAssay Description:Inhibition of human recombinant CRF1 in HEK cell line incubated for 2 hrs by MicroBeta scintillation counter methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
LigandPNGBDBM285634(3-(4-chloro-3,5-difluoro-phenyl)-N-cyclopropyl-imi...)
Affinity DataIC50:  145nMAssay Description:Inhibition of human recombinant PDE4D incubated for 30 mins by Scintillation Proximity AssayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
LigandPNGBDBM50609289(CHEMBL5282271)
Affinity DataIC50:  150nMAssay Description:Inhibition of PI3Kbeta (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
LigandPNGBDBM50609289(CHEMBL5282271)
Affinity DataIC50:  157nMAssay Description:Inhibition of PI3Kgamma (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
LigandPNGBDBM350389(4-amino-6-((1-(3-chloro-6-phenylimidazo[1,2-b]pyri...)
Affinity DataIC50:  168nMAssay Description:Inhibition of PI3Kgamma (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
LigandPNGBDBM13530(4-[(4-methylpiperazin-1-yl)methyl]-N-[4-methyl-3-[...)
Affinity DataIC50:  260nMAssay Description:Inhibition of BCR-ABL (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSerine/threonine-protein kinase pim-2(Homo sapiens (Human))TBA
LigandPNGBDBM50364776(CHEMBL1952141 | CHEMBL1952329)
Affinity DataIC50:  363nMAssay Description:Inhibition of PIM2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
LigandPNGBDBM288405(US10087187, Compound 106)
Affinity DataIC50:  372nMAssay Description:Inhibition of PI3Kdelta (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetTumor necrosis factor(Homo sapiens (Human))TBA
LigandPNGBDBM14361((R,S)-Rolipram | 4-(3-cyclopentyloxy-4-methoxy-phe...)
Affinity DataIC50:  500nMAssay Description:Inhibition of TNFalpha in LPS-stimulated human mononuclear cell line by radioimmunoassayMore data for this Ligand-Target Pair
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TargetMicrotubule-associated protein tau(Homo sapiens (Human))TBA
LigandPNGBDBM610450(2-Phenyl-N-(pyridin-3-yl)imidazo[1,2-b]pyridazine-...)
Affinity DataIC50:  660nMAssay Description:Inhibition of Tau (unknown origin) phosphorylationMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
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