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Found 897 with Last Name = 'dhar' and Initial = 'a'
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Merck Research Laboratories

Curated by PDSP Ki Database
LigandPNGBDBM50084137(2-Methyl-6-(phenylethynyl)pyridine | 2-Methyl-6-ph...)
Affinity DataKi:  0.300nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase B(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50315769(3-(4-(4-(2-(3-((dimethylamino)methyl)phenyl)-1H-py...)
Affinity DataKi:  0.380nMAssay Description:Competitive inhibition of Aurora B ATP binding siteMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase B(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50315769(3-(4-(4-(2-(3-((dimethylamino)methyl)phenyl)-1H-py...)
Affinity DataKi:  0.380nMAssay Description:Competitive inhibition of human Aurora B ATP binding site by rapid dilution methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM13534(CHEMBL572878 | N-[4-({4-[(3-methyl-1H-pyrazol-5-yl...)
Affinity DataKi:  0.600nMAssay Description:Inhibition of Aurora AMore data for this Ligand-Target Pair
Target4,4'-diapophytoene synthase(Staphylococcus aureus)
Case Western Reserve University

Curated by ChEMBL
LigandPNGBDBM50049236((+/-)-1-Phosphono-4-(3-phenoxyphenyl)butylsulfonic...)
Affinity DataKi:  1.5nMAssay Description:Inhibition of Staphylococcus aureus ATCC 27659 histidine-tagged full length CrtM expressed in Escherichia coli BL21(DE3) cells assessed as decrease i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase C(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50315769(3-(4-(4-(2-(3-((dimethylamino)methyl)phenyl)-1H-py...)
Affinity DataKi:  1.5nMAssay Description:Competitive inhibition of human Aurora C ATP binding siteMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKinesin-like protein KIF11(Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM36350(6-[4-(Trifluoromethyl)phenyl]-3,4-dihydro-2(1H)-qu...)
Affinity DataKi:  1.70nMpH: 6.8Assay Description:Cell proliferation assay for wild-type cellsMore data for this Ligand-Target Pair
TargetAurora kinase B(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM13534(CHEMBL572878 | N-[4-({4-[(3-methyl-1H-pyrazol-5-yl...)
Affinity DataKi:  1.80nMAssay Description:Competitive inhibition of Aurora B ATP binding siteMore data for this Ligand-Target Pair
TargetCarbonic anhydrase 9(Homo sapiens (Human))
Manipal College Of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50492667(CHEMBL2407709)
Affinity DataKi:  2.20nMAssay Description:Inhibition of carbonic anhydrase 9 (unknown origin) preincubated for 15 mins by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 9(Homo sapiens (Human))
Norgine

US Patent
LigandPNGBDBM393561(US9969687, Compound 232)
Affinity DataKi:  3nMAssay Description:A calcium flux assay was used to determine the ability of the compounds to interfere with the binding between CCR9 and its chemokine ligand (TECK) in...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetC-C chemokine receptor type 9(Homo sapiens (Human))
Norgine

US Patent
LigandPNGBDBM393572(US9969687, Compound 244)
Affinity DataKi:  3nMAssay Description:A calcium flux assay was used to determine the ability of the compounds to interfere with the binding between CCR9 and its chemokine ligand (TECK) in...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetC-C chemokine receptor type 9(Homo sapiens (Human))
Norgine

US Patent
LigandPNGBDBM393520(US9969687, Compound 183)
Affinity DataKi:  3nMAssay Description:A calcium flux assay was used to determine the ability of the compounds to interfere with the binding between CCR9 and its chemokine ligand (TECK) in...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetKinesin-like protein KIF11(Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM50220180(CHEMBL243669 | N-[3-fluoro-4'-(trifluoromethyl)-4-...)
Affinity DataKi:  3.5nMAssay Description:Inhibition of human KSP motor domain by ATPase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 9(Homo sapiens (Human))
Norgine

US Patent
LigandPNGBDBM393600(US9969687, Compound 281)
Affinity DataKi:  4nMAssay Description:A calcium flux assay was used to determine the ability of the compounds to interfere with the binding between CCR9 and its chemokine ligand (TECK) in...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAurora kinase C(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM13534(CHEMBL572878 | N-[4-({4-[(3-methyl-1H-pyrazol-5-yl...)
Affinity DataKi:  4.60nMAssay Description:Competitive inhibition of Aurora C ATP binding siteMore data for this Ligand-Target Pair
TargetCarbonic anhydrase 9(Homo sapiens (Human))
Manipal College Of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50492669(CHEMBL2407710)
Affinity DataKi:  4.70nMAssay Description:Inhibition of carbonic anhydrase 9 (unknown origin) preincubated for 15 mins by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 9(Homo sapiens (Human))
Norgine

US Patent
LigandPNGBDBM393530(US9969687, Compound 194)
Affinity DataKi:  6nMAssay Description:A calcium flux assay was used to determine the ability of the compounds to interfere with the binding between CCR9 and its chemokine ligand (TECK) in...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetC-C chemokine receptor type 9(Homo sapiens (Human))
Norgine

US Patent
LigandPNGBDBM393559(US9969687, Compound 230)
Affinity DataKi:  6nMAssay Description:A calcium flux assay was used to determine the ability of the compounds to interfere with the binding between CCR9 and its chemokine ligand (TECK) in...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetC-C chemokine receptor type 9(Homo sapiens (Human))
Norgine

US Patent
LigandPNGBDBM393557(US9969687, Compound 228)
Affinity DataKi:  6nMAssay Description:A calcium flux assay was used to determine the ability of the compounds to interfere with the binding between CCR9 and its chemokine ligand (TECK) in...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetC-C chemokine receptor type 9(Homo sapiens (Human))
Norgine

US Patent
LigandPNGBDBM393553(US9969687, Compound 224)
Affinity DataKi:  6nMAssay Description:A calcium flux assay was used to determine the ability of the compounds to interfere with the binding between CCR9 and its chemokine ligand (TECK) in...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetKinesin-like protein KIF11(Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM50220182(CHEMBL390629 | N-[4'-(trifluoromethyl)-4-biphenyly...)
Affinity DataKi:  6.20nMAssay Description:Inhibition of human KSP motor domain by ATPase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 9(Homo sapiens (Human))
Norgine

US Patent
LigandPNGBDBM393569(US9969687, Compound 241)
Affinity DataKi:  7nMAssay Description:A calcium flux assay was used to determine the ability of the compounds to interfere with the binding between CCR9 and its chemokine ligand (TECK) in...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCarbonic anhydrase 9(Homo sapiens (Human))
Manipal College Of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50492665(CHEMBL2407708)
Affinity DataKi:  7.70nMAssay Description:Inhibition of carbonic anhydrase 9 (unknown origin) preincubated for 15 mins by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 9(Homo sapiens (Human))
Norgine

US Patent
LigandPNGBDBM393566(US9969687, Compound 237)
Affinity DataKi:  9nMAssay Description:A calcium flux assay was used to determine the ability of the compounds to interfere with the binding between CCR9 and its chemokine ligand (TECK) in...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGTPase KRas(Homo sapiens (Human))
Dana Farber Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50501345(CHEMBL3958857)
Affinity DataKi:  9nMAssay Description:Binding affinity to GMP-stabilized FLAG-tagged KRAS G12C mutant (unknown origin) using desthiobiotin-GTP probe by alphascreen assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 9(Homo sapiens (Human))
Manipal College Of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50492664(CHEMBL2407711)
Affinity DataKi:  9.20nMAssay Description:Inhibition of carbonic anhydrase 9 (unknown origin) preincubated for 15 mins by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 9(Homo sapiens (Human))
Norgine

US Patent
LigandPNGBDBM393606(US9969687, Compound 287)
Affinity DataKi:  10nMAssay Description:A calcium flux assay was used to determine the ability of the compounds to interfere with the binding between CCR9 and its chemokine ligand (TECK) in...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetC-C chemokine receptor type 9(Homo sapiens (Human))
Norgine

US Patent
LigandPNGBDBM393534(US9969687, Compound 199)
Affinity DataKi:  10nMAssay Description:A calcium flux assay was used to determine the ability of the compounds to interfere with the binding between CCR9 and its chemokine ligand (TECK) in...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetC-C chemokine receptor type 9(Homo sapiens (Human))
Norgine

US Patent
LigandPNGBDBM393585(US9969687, Compound 261)
Affinity DataKi:  11nMAssay Description:A calcium flux assay was used to determine the ability of the compounds to interfere with the binding between CCR9 and its chemokine ligand (TECK) in...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetC-C chemokine receptor type 9(Homo sapiens (Human))
Norgine

US Patent
LigandPNGBDBM393528(US9969687, Compound 192)
Affinity DataKi:  12nMAssay Description:A calcium flux assay was used to determine the ability of the compounds to interfere with the binding between CCR9 and its chemokine ligand (TECK) in...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetC-C chemokine receptor type 9(Homo sapiens (Human))
Norgine

US Patent
LigandPNGBDBM393552(US9969687, Compound 222)
Affinity DataKi:  12nMAssay Description:A calcium flux assay was used to determine the ability of the compounds to interfere with the binding between CCR9 and its chemokine ligand (TECK) in...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetC-C chemokine receptor type 9(Homo sapiens (Human))
Norgine

US Patent
LigandPNGBDBM393603(US9969687, Compound 284)
Affinity DataKi:  12nMAssay Description:A calcium flux assay was used to determine the ability of the compounds to interfere with the binding between CCR9 and its chemokine ligand (TECK) in...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetC-C chemokine receptor type 9(Homo sapiens (Human))
Norgine

US Patent
LigandPNGBDBM393516(US9969687, Compound 175)
Affinity DataKi:  12nMAssay Description:A calcium flux assay was used to determine the ability of the compounds to interfere with the binding between CCR9 and its chemokine ligand (TECK) in...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetC-C chemokine receptor type 9(Homo sapiens (Human))
Norgine

US Patent
LigandPNGBDBM393567(US9969687, Compound 238)
Affinity DataKi:  13nMAssay Description:A calcium flux assay was used to determine the ability of the compounds to interfere with the binding between CCR9 and its chemokine ligand (TECK) in...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetC-C chemokine receptor type 9(Homo sapiens (Human))
Norgine

US Patent
LigandPNGBDBM393517(US9969687, Compound 176)
Affinity DataKi:  13nMAssay Description:A calcium flux assay was used to determine the ability of the compounds to interfere with the binding between CCR9 and its chemokine ligand (TECK) in...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Manipal College Of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM10880(AZA | AZA2 | AZM acetazolamide | Acerazolamide, AA...)
Affinity DataKi:  13nMAssay Description:Inhibition of cytosolic carbonic anhydrase 2 (unknown origin) preincubated for 15 mins by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
TargetC-C chemokine receptor type 9(Homo sapiens (Human))
Norgine

US Patent
LigandPNGBDBM393605(US9969687, Compound 286)
Affinity DataKi:  14nMAssay Description:A calcium flux assay was used to determine the ability of the compounds to interfere with the binding between CCR9 and its chemokine ligand (TECK) in...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetC-C chemokine receptor type 9(Homo sapiens (Human))
Norgine

US Patent
LigandPNGBDBM393609(US9969687, Compound 290)
Affinity DataKi:  14nMAssay Description:A calcium flux assay was used to determine the ability of the compounds to interfere with the binding between CCR9 and its chemokine ligand (TECK) in...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCarbonic anhydrase 9(Homo sapiens (Human))
Manipal College Of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50492671(CHEMBL2407713)
Affinity DataKi:  14nMAssay Description:Inhibition of carbonic anhydrase 9 (unknown origin) preincubated for 15 mins by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 9(Homo sapiens (Human))
Norgine

US Patent
LigandPNGBDBM393610(US9969687, Compound 291)
Affinity DataKi:  15nMAssay Description:A calcium flux assay was used to determine the ability of the compounds to interfere with the binding between CCR9 and its chemokine ligand (TECK) in...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetC-C chemokine receptor type 9(Homo sapiens (Human))
Norgine

US Patent
LigandPNGBDBM393611(US9969687, Compound 292)
Affinity DataKi:  16nMAssay Description:A calcium flux assay was used to determine the ability of the compounds to interfere with the binding between CCR9 and its chemokine ligand (TECK) in...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetC-C chemokine receptor type 9(Homo sapiens (Human))
Norgine

US Patent
LigandPNGBDBM393541(US9969687, Compound 208)
Affinity DataKi:  16nMAssay Description:A calcium flux assay was used to determine the ability of the compounds to interfere with the binding between CCR9 and its chemokine ligand (TECK) in...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Homo sapiens (Human))
University Of California Riverside

Curated by ChEMBL
LigandPNGBDBM50587038(CHEMBL5090086)
Affinity DataKi:  17nMAssay Description:Inhibition of human Mcl-1 assessed as inhibition constant by DELFIA displacement assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 9(Homo sapiens (Human))
Norgine

US Patent
LigandPNGBDBM393536(US9969687, Compound 201)
Affinity DataKi:  17nMAssay Description:A calcium flux assay was used to determine the ability of the compounds to interfere with the binding between CCR9 and its chemokine ligand (TECK) in...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetC-C chemokine receptor type 9(Homo sapiens (Human))
Norgine

US Patent
LigandPNGBDBM393597(US9969687, Compound 278)
Affinity DataKi:  17nMAssay Description:A calcium flux assay was used to determine the ability of the compounds to interfere with the binding between CCR9 and its chemokine ligand (TECK) in...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetC-C chemokine receptor type 9(Homo sapiens (Human))
Norgine

US Patent
LigandPNGBDBM393598(US9969687, Compound 279)
Affinity DataKi:  17nMAssay Description:A calcium flux assay was used to determine the ability of the compounds to interfere with the binding between CCR9 and its chemokine ligand (TECK) in...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetC-C chemokine receptor type 9(Homo sapiens (Human))
Norgine

US Patent
LigandPNGBDBM393580(US9969687, Compound 256)
Affinity DataKi:  18nMAssay Description:A calcium flux assay was used to determine the ability of the compounds to interfere with the binding between CCR9 and its chemokine ligand (TECK) in...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetC-C chemokine receptor type 9(Homo sapiens (Human))
Norgine

US Patent
LigandPNGBDBM393588(US9969687, Compound 264)
Affinity DataKi:  18nMAssay Description:A calcium flux assay was used to determine the ability of the compounds to interfere with the binding between CCR9 and its chemokine ligand (TECK) in...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCarbonic anhydrase 9(Homo sapiens (Human))
Manipal College Of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50492672(CHEMBL2407712)
Affinity DataKi:  19nMAssay Description:Inhibition of carbonic anhydrase 9 (unknown origin) preincubated for 15 mins by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 9(Homo sapiens (Human))
Norgine

US Patent
LigandPNGBDBM393602(US9969687, Compound 283)
Affinity DataKi:  20nMAssay Description:A calcium flux assay was used to determine the ability of the compounds to interfere with the binding between CCR9 and its chemokine ligand (TECK) in...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
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