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Found 345 with Last Name = 'dockendorff' and Initial = 'c'
TargetAlpha-1A adrenergic receptor(Homo sapiens (Human))
Marquette University

Curated by ChEMBL
LigandPNGBDBM50529214(CHEMBL343822)
Affinity DataKi:  1.10E+3nMAssay Description:Inhibition of alpha1A adrenergic receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Homo sapiens (Human))
Marquette University

Curated by ChEMBL
LigandPNGBDBM50529212(CHEMBL4471453)
Affinity DataKi:  1.80E+3nMAssay Description:Inhibition of alpha1 adrenergic receptor (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProtein polybromo-1(Homo sapiens (Human))
Marquette University

Curated by ChEMBL
LigandPNGBDBM50529212(CHEMBL4471453)
Affinity DataKi:  2.50E+3nMAssay Description:Inhibition of PBR receptor (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Homo sapiens (Human))
Marquette University

Curated by ChEMBL
LigandPNGBDBM50529214(CHEMBL343822)
Affinity DataKi:  3.90E+3nMAssay Description:Inhibition of alpha1 adrenergic receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Homo sapiens (Human))
Marquette University

Curated by ChEMBL
LigandPNGBDBM50529213(CHEMBL4465132)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of D3 receptor (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Homo sapiens (Human))
Marquette University

Curated by ChEMBL
LigandPNGBDBM50529213(CHEMBL4465132)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of alpha1 adrenergic receptor (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Marquette University

Curated by ChEMBL
LigandPNGBDBM50502780(CHEMBL4471584)
Affinity DataIC50:  0.708nMAssay Description:Agonist activity at Gi-coupled mu opioid receptor (unknown origin) expressed in HEK293T cells assessed as inhibition of cAMP production at pH 6.5 mea...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Marquette University

Curated by ChEMBL
LigandPNGBDBM50502783(CHEMBL4468844)
Affinity DataIC50:  0.708nMAssay Description:Agonist activity at Gi-coupled mu opioid receptor (unknown origin) expressed in HEK293T cells assessed as inhibition of cAMP production at pH 6.5 mea...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Marquette University

Curated by ChEMBL
LigandPNGBDBM50502780(CHEMBL4471584)
Affinity DataIC50:  0.710nMAssay Description:Agonist activity at Gi-coupled mu opioid receptor (unknown origin) expressed in HEK293T cells assessed as inhibition of cAMP production at pH 6.5 mea...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Marquette University

Curated by ChEMBL
LigandPNGBDBM50502783(CHEMBL4468844)
Affinity DataIC50:  0.710nMAssay Description:Agonist activity at Gi-coupled mu opioid receptor (unknown origin) expressed in HEK293T cells assessed as inhibition of cAMP production at pH 6.5 mea...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Marquette University

Curated by ChEMBL
LigandPNGBDBM21015((2S)-2-{2-[(2R)-2-[(2S)-2-amino-3-(4-hydroxyphenyl...)
Affinity DataIC50:  0.794nMAssay Description:Agonist activity at Gi-coupled mu opioid receptor (unknown origin) expressed in HEK293T cells assessed as inhibition of cAMP production at pH 7.4 mea...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Marquette University

Curated by ChEMBL
LigandPNGBDBM21015((2S)-2-{2-[(2R)-2-[(2S)-2-amino-3-(4-hydroxyphenyl...)
Affinity DataIC50:  1.90nMAssay Description:Agonist activity at Gi-coupled mu opioid receptor (unknown origin) expressed in HEK293T cells assessed as inhibition of cAMP production at pH 6.5 mea...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 2(Homo sapiens (Human))
Marquette University

Curated by ChEMBL
LigandPNGBDBM50503927(CHEMBL4470628)
Affinity DataIC50:  2nMAssay Description:Antagonist activity at PAR2 in human EAhy926 cells assessed as inhibition of trypsin-induced intracellular calcium mobilization preincubated for 15 m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetScavenger receptor class B member 1(Mus musculus)
Marquette University

Curated by ChEMBL
LigandPNGBDBM50069751(CHEMBL2356114)
Affinity DataIC50:  5nMAssay Description:Inhibition of mouse SR-BI isoform 1 expressed in CHO cells assessed as reduction in uptake of [3H]CE from [3H]CE-HDL by by liquid scintillation count...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 1(Homo sapiens (Human))
Marquette University

Curated by ChEMBL
LigandPNGBDBM50098215(4-Amino-N-benzyl-2-[2-{3-[1-(2,6-dichloro-benzyl)-...)
Affinity DataIC50:  5nMAssay Description:Antagonist activity at PAR1 in human MDA-MB-231 cells assessed as inhibition of TFLLRN-NH2-induced intracellular calcium mobilization preincubated fo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetScavenger receptor class B member 1(Mus musculus)
Marquette University

Curated by ChEMBL
LigandPNGBDBM50069751(CHEMBL2356114)
Affinity DataIC50:  5nMAssay Description:Inhibition of mouse SR-B1 overexpressed in CHO cells assessed as inhibition of [3H]cholesteryl ester uptake into cells after 2 to 3 hrs by liquid sci...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Marquette University

Curated by ChEMBL
LigandPNGBDBM50276409((1S,2S)-N-(2-methoxyethyl)-2-(thiophen-3-yl)-1,2,3...)
Affinity DataIC50:  5.30nMAssay Description:Displacement of [125I]FK33824 from human cloned mu opioid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Marquette University

Curated by ChEMBL
LigandPNGBDBM50008984(4-(4-Chloro-benzyl)-2-(1-methyl-azepan-4-yl)-2H-ph...)
Affinity DataIC50:  5.5nMAssay Description:Agonist activity at Gi-coupled mu opioid receptor (unknown origin) expressed in HEK293T cells assessed as inhibition of cAMP production at pH 6.5 mea...More data for this Ligand-Target Pair
TargetMu-type opioid receptor(Homo sapiens (Human))
Marquette University

Curated by ChEMBL
LigandPNGBDBM50502786(CHEMBL4441320)
Affinity DataIC50:  5.5nMAssay Description:Agonist activity at Gi-coupled mu opioid receptor (unknown origin) expressed in HEK293T cells assessed as inhibition of cAMP production at pH 6.5 mea...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Marquette University

Curated by ChEMBL
LigandPNGBDBM50502783(CHEMBL4468844)
Affinity DataIC50:  5.90nMAssay Description:Agonist activity at Gi-coupled mu opioid receptor (unknown origin) expressed in HEK293T cells assessed as inhibition of cAMP production at pH 7.4 mea...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Marquette University

Curated by ChEMBL
LigandPNGBDBM50502784(CHEMBL4458454)
Affinity DataIC50:  6.5nMAssay Description:Agonist activity at Gi-coupled mu opioid receptor (unknown origin) expressed in HEK293T cells assessed as inhibition of cAMP production at pH 6.5 mea...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Marquette University

Curated by ChEMBL
LigandPNGBDBM50502780(CHEMBL4471584)
Affinity DataIC50:  7.60nMAssay Description:Agonist activity at Gi-coupled mu opioid receptor (unknown origin) expressed in HEK293T cells assessed as inhibition of cAMP production at pH 7.4 mea...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 1(Homo sapiens (Human))
Marquette University

Curated by ChEMBL
LigandPNGBDBM50503928(CHEMBL4459024)
Affinity DataIC50:  10nMAssay Description:Antagonist activity at PAR1 in human MDA-MB-231 cells assessed as inhibition of TFLLRN-NH2-induced intracellular calcium mobilization preincubated fo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Marquette University

Curated by ChEMBL
LigandPNGBDBM50008984(4-(4-Chloro-benzyl)-2-(1-methyl-azepan-4-yl)-2H-ph...)
Affinity DataIC50:  11nMAssay Description:Agonist activity at Gi-coupled mu opioid receptor (unknown origin) expressed in HEK293T cells assessed as inhibition of cAMP production at pH 7.4 mea...More data for this Ligand-Target Pair
TargetMu-type opioid receptor(Homo sapiens (Human))
Marquette University

Curated by ChEMBL
LigandPNGBDBM50502785(CHEMBL4550454)
Affinity DataIC50:  12nMAssay Description:Agonist activity at Gi-coupled mu opioid receptor (unknown origin) expressed in HEK293T cells assessed as inhibition of cAMP production at pH 6.5 mea...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetScavenger receptor class B member 1(Mus musculus)
Marquette University

Curated by ChEMBL
LigandPNGBDBM50069751(CHEMBL2356114)
Affinity DataIC50:  17nMAssay Description:Inhibition of mouse SR-BI isoform 1 expressed in CHO cells assessed as reduction in transfer of fluorescent lipid DiI from human HDL particles into c...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 1(Homo sapiens (Human))
Marquette University

Curated by ChEMBL
LigandPNGBDBM50098215(4-Amino-N-benzyl-2-[2-{3-[1-(2,6-dichloro-benzyl)-...)
Affinity DataIC50:  20nMAssay Description:Antagonist activity at PAR1 in human EAhy926 cells assessed as inhibition of TFLLRN-NH2-induced intracellular calcium mobilization pretreated for 15 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 1(Homo sapiens (Human))
Marquette University

Curated by ChEMBL
LigandPNGBDBM50098215(4-Amino-N-benzyl-2-[2-{3-[1-(2,6-dichloro-benzyl)-...)
Affinity DataIC50:  20nMAssay Description:Antagonist activity at PAR1 in human EAhy926 cells assessed as inhibition of TFLLRN-NH2-induced intracellular calcium mobilization preincubated for 1...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 1(Homo sapiens (Human))
Marquette University

Curated by ChEMBL
LigandPNGBDBM50098215(4-Amino-N-benzyl-2-[2-{3-[1-(2,6-dichloro-benzyl)-...)
Affinity DataIC50:  20nMAssay Description:Antagonist activity at PAR1 in human EAhy926 cells assessed as inhibition of TFLLRN-NH2-induced intracellular calcium mobilization pretreated for 15 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetScavenger receptor class B member 1(Mus musculus)
Marquette University

Curated by ChEMBL
LigandPNGBDBM50088281(CHEMBL3427475)
Affinity DataIC50:  23nMAssay Description:Inhibition of mouse SR-BI isoform 1 expressed in CHO cells assessed as reduction in transfer of fluorescent lipid DiI from human HDL particles into c...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Marquette University

Curated by ChEMBL
LigandPNGBDBM50502782(CHEMBL4516683)
Affinity DataIC50:  25nMAssay Description:Agonist activity at Gi-coupled mu opioid receptor (unknown origin) expressed in HEK293T cells assessed as inhibition of cAMP production at pH 6.5 mea...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetScavenger receptor class B member 1(Mus musculus)
Marquette University

Curated by ChEMBL
LigandPNGBDBM50088195(CHEMBL3427497)
Affinity DataIC50:  26nMAssay Description:Inhibition of mouse SR-BI isoform 1 expressed in CHO cells assessed as reduction in transfer of fluorescent lipid DiI from human HDL particles into c...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetScavenger receptor class B member 1(Mus musculus)
Marquette University

Curated by ChEMBL
LigandPNGBDBM50088267(CHEMBL3427489)
Affinity DataIC50:  27nMAssay Description:Inhibition of mouse SR-BI isoform 1 expressed in CHO cells assessed as reduction in transfer of fluorescent lipid DiI from human HDL particles into c...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 1(Homo sapiens (Human))
Marquette University

Curated by ChEMBL
LigandPNGBDBM50503926(CHEMBL4472608)
Affinity DataIC50:  30nMAssay Description:Antagonist activity at PAR1 in human EAhy926 cells assessed as inhibition of TFLLRN-NH2-induced intracellular calcium mobilization preincubated for 1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 1(Homo sapiens (Human))
Marquette University

Curated by ChEMBL
LigandPNGBDBM50461680(CHEMBL4226439)
Affinity DataIC50:  32nMAssay Description:Antagonist activity at PAR1 in human EAhy926 cells assessed as inhibition of TFLLRN-NH2-induced intracellular calcium mobilization pretreated for 15 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 1(Homo sapiens (Human))
Marquette University

Curated by ChEMBL
LigandPNGBDBM50461681(Atopaxar | E-5555 | E5555 | ER-172594-00)
Affinity DataIC50:  32nMAssay Description:Antagonist activity at PAR1 in human EAhy926 cells assessed as inhibition of TFLLRN-NH2-induced intracellular calcium mobilization pretreated for 15 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 1(Homo sapiens (Human))
Marquette University

Curated by ChEMBL
LigandPNGBDBM50461680(CHEMBL4226439)
Affinity DataIC50:  32nMAssay Description:Antagonist activity at PAR1 in human EAhy926 cells assessed as inhibition of TFLLRN-NH2-induced intracellular calcium mobilization pretreated for 15 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 1(Homo sapiens (Human))
Marquette University

Curated by ChEMBL
LigandPNGBDBM50461681(Atopaxar | E-5555 | E5555 | ER-172594-00)
Affinity DataIC50:  33nMAssay Description:Antagonist activity at PAR1 in human EAhy926 cells assessed as inhibition of TFLLRN-NH2-induced intracellular calcium mobilization pretreated for 15 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 1(Homo sapiens (Human))
Marquette University

Curated by ChEMBL
LigandPNGBDBM50503924(CHEMBL4437508)
Affinity DataIC50:  40nMAssay Description:Antagonist activity at PAR1 in human EAhy926 cells assessed as inhibition of TFLLRN-NH2-induced intracellular calcium mobilization preincubated for 1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily KQT member 2(Homo sapiens (Human))
Marquette University

Curated by ChEMBL
LigandPNGBDBM50529214(CHEMBL343822)
Affinity DataIC50:  48nMAssay Description:Inhibition of Kv7.2 in human HEK293 cells incubated for 1 hr by thallium flux assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetScavenger receptor class B member 1(Mus musculus)
Marquette University

Curated by ChEMBL
LigandPNGBDBM50069719(CHEMBL2358771)
Affinity DataIC50:  54nMAssay Description:Inhibition of mouse SR-B1 overexpressed in CHO cells assessed as inhibition of transfer of the fluorescent lipid DiI from HDL particles to cells afte...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetScavenger receptor class B member 1(Mus musculus)
Marquette University

Curated by ChEMBL
LigandPNGBDBM50088283(CHEMBL1478888)
Affinity DataIC50:  55nMAssay Description:Inhibition of mouse SR-BI isoform 1 expressed in CHO cells assessed as reduction in transfer of fluorescent lipid DiI from human HDL particles into c...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily KQT member 2(Homo sapiens (Human))
Marquette University

Curated by ChEMBL
LigandPNGBDBM50529215(CHEBI:35046 | CHEMBL342375)
Affinity DataIC50:  55nMAssay Description:Inhibition of Kv7.2 in human HEK293 cells incubated for 1 hr by thallium flux assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Marquette University

Curated by ChEMBL
LigandPNGBDBM50276496(3-chloro-N-(2-methoxyethyl)-N-((1R,2R)-2-(4-phenyl...)
Affinity DataIC50:  58nMAssay Description:Displacement of [125I]FK33824 from human cloned mu opioid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetScavenger receptor class B member 1(Mus musculus)
Marquette University

Curated by ChEMBL
LigandPNGBDBM50069697(CHEMBL2356172)
Affinity DataIC50:  60nMAssay Description:Inhibition of mouse SR-B1 overexpressed in CHO cells assessed as inhibition of transfer of the fluorescent lipid DiI from HDL particles to cells afte...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Marquette University

Curated by ChEMBL
LigandPNGBDBM50276363((+/-)-N-(2-methoxyethyl)-2-(thiophen-3-yl)-1,2,3,4...)
Affinity DataIC50:  69nMAssay Description:Displacement of [125I]FK33824 from human cloned mu opioid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Marquette University

Curated by ChEMBL
LigandPNGBDBM50502784(CHEMBL4458454)
Affinity DataIC50:  78nMAssay Description:Agonist activity at Gi-coupled mu opioid receptor (unknown origin) expressed in HEK293T cells assessed as inhibition of cAMP production at pH 7.4 mea...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Marquette University

Curated by ChEMBL
LigandPNGBDBM50502785(CHEMBL4550454)
Affinity DataIC50:  89nMAssay Description:Agonist activity at Gi-coupled mu opioid receptor (unknown origin) expressed in HEK293T cells assessed as inhibition of cAMP production at pH 7.4 mea...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetScavenger receptor class B member 1(Mus musculus)
Marquette University

Curated by ChEMBL
LigandPNGBDBM50069714(CHEMBL2356554)
Affinity DataIC50:  92nMAssay Description:Inhibition of mouse SR-B1 overexpressed in CHO cells assessed as inhibition of transfer of the fluorescent lipid DiI from HDL particles to cells afte...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 1(Homo sapiens (Human))
Marquette University

Curated by ChEMBL
LigandPNGBDBM50503928(CHEMBL4459024)
Affinity DataIC50:  97nMAssay Description:Antagonist activity at PAR1 in human EAhy926 cells assessed as inhibition of TFLLRN-NH2-induced intracellular calcium mobilization preincubated for 1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
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