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Found 130 with Last Name = 'dorn' and Initial = 'cp'
TargetNeutrophil elastase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50016904(CHEMBL3273012)
Affinity DataKi:  2.20E+4nMAssay Description:Noncompetitive inhibition of human granulocyte elastase using Ac-Ala-Ala-Pro-Ala-p-nitroanilide as substrate by Dixon plot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50016905(CHEMBL3273010)
Affinity DataKi:  3.60E+4nMAssay Description:Noncompetitive inhibition of human granulocyte elastase using Ac-Ala-Ala-Pro-Ala-p-nitroanilide as substrate by Dixon plot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50016903(CHEMBL3273013)
Affinity DataKi:  3.80E+4nMAssay Description:Noncompetitive inhibition of human granulocyte elastase using Ac-Ala-Ala-Pro-Ala-p-nitroanilide as substrate by Dixon plot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50016930(CHEMBL3273008)
Affinity DataKi:  3.90E+4nMAssay Description:Noncompetitive inhibition of human granulocyte elastase using Ac-Ala-Ala-Pro-Ala-p-nitroanilide as substrate by Dixon plot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50016906(CHEMBL3273009)
Affinity DataKi:  3.90E+4nMAssay Description:Noncompetitive inhibition of human granulocyte elastase using Ac-Ala-Ala-Pro-Ala-p-nitroanilide as substrate by Dixon plot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50016929(CHEMBL3273011)
Affinity DataKi:  3.90E+4nMAssay Description:Noncompetitive inhibition of human granulocyte elastase using Ac-Ala-Ala-Pro-Ala-p-nitroanilide as substrate by Dixon plot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50220136(3-[2-{1-[3,5-di(trifluoromethyl)phenyl]ethoxy}-3-(...)
Affinity DataIC50:  0.0900nMAssay Description:compounds were evaluated for inhibitory activity against human Tachykinin receptor 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetSubstance-P receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50000040(((2S,3S)-2-Benzhydryl-1-aza-bicyclo[2.2.2]oct-3-yl...)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of [125I]-Substance P binding to human NK1 receptors in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50096519(Benzoic acid (S)-2-(3,4-dichloro-phenyl)-4-(spiro[...)
Affinity DataIC50:  4nMAssay Description:Binding affinity towards human CCR5 receptor in Chinese hamster ovary (CHO) cells using [125I]-MIP-1 alpha as radioligand at a concentration of 1000 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50096520(Benzyl (S)-2-(3,4-dichloro-phenyl)-4-(spiro[1-benz...)
Affinity DataIC50:  4nMAssay Description:Binding affinity towards human CCR5 receptor in Chinese hamster ovary (CHO) cells using [125I]-MIP-1 alpha as radioligand at a concentration of 1000 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50281196((S)-Piperazine-1,2,4-tricarboxylic acid 4-dipentyl...)
Affinity DataIC50:  9nMAssay Description:Inhibition of [125I]-Substance P binding to human NK1 receptors in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
TargetSubstance-P receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50281189((S)-Piperazine-1,2,4-tricarboxylic acid 4-dipentyl...)
Affinity DataIC50:  9nMAssay Description:Inhibition of [125I]-Substance P binding to human NK1 receptors in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
TargetSubstance-P receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50281194((S)-Piperazine-1,2,4-tricarboxylic acid 2-[(2-diet...)
Affinity DataIC50:  11nMAssay Description:Inhibition of [125I]-Substance P binding to human NK1 receptors in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
TargetSubstance-P receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50281198((S)-Piperazine-1,2,4-tricarboxylic acid 4-dipentyl...)
Affinity DataIC50:  17nMAssay Description:Inhibition of [125I]-Substance P binding to human NK1 receptors in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50096515((2S)-2-(3,4-dichlorophenyl)-1-[(N-methyl-N-phenyls...)
Affinity DataIC50:  35nMAssay Description:Binding affinity towards human CCR5 receptor in Chinese hamster ovary (CHO) cells using [125I]-MIP-1 alpha as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50096506(1'-[3-(3,4-dichlorophenyl)-4-methyl(4-phenylphenyl...)
Affinity DataIC50:  40nMAssay Description:Binding affinity towards human CCR5 receptor in Chinese hamster ovary (CHO) cells using [125I]-MIP-1 alpha as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50096535(1'-[4-[4-chlorophenyl(methyl)sulfonamido]-3-(3,4-d...)
Affinity DataIC50:  40nMAssay Description:Binding affinity towards human CCR5 receptor in Chinese hamster ovary (CHO) cells using [125I]-MIP-1 alpha as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50015885(3-Acetoxymethyl-7-chloro-5,5,8-trioxo-5lambda*6*-t...)
Affinity DataIC50:  40nMAssay Description:Inhibitory concentration which is required to cause 50% inhibition of human leukocyte elastase (HLE) enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50096539(1'-[3-(3,4-dichlorophenyl)-4-[4-methoxyphenyl(meth...)
Affinity DataIC50:  40nMAssay Description:Binding affinity towards human CCR5 receptor in Chinese hamster ovary (CHO) cells using [125I]-MIP-1 alpha as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50281187((S)-Piperazine-1,2,4-tricarboxylic acid 2-[(3-diet...)
Affinity DataIC50:  41nMAssay Description:Inhibition of [125I]-Substance P binding to human NK1 receptors in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
TargetSubstance-P receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50281200((S)-Piperazine-1,2,4-tricarboxylic acid 2-[(2-dime...)
Affinity DataIC50:  55nMAssay Description:Inhibition of [125I]-Substance P binding to human NK1 receptors in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
TargetSubstance-P receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50281201((S)-Piperazine-1,2,4-tricarboxylic acid 2-[(2-amin...)
Affinity DataIC50:  57nMAssay Description:Inhibition of [125I]-Substance P binding to human NK1 receptors in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50096509(1'-[3-(3,4-dichlorophenyl)-4-methyl(2-naphthyl)sul...)
Affinity DataIC50:  60nMAssay Description:Binding affinity towards human CCR5 receptor in Chinese hamster ovary (CHO) cells using [125I]-MIP-1 alpha as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50015871(3-Acetoxymethyl-7-fluoro-5,5,8-trioxo-5lambda*6*-t...)
Affinity DataIC50:  60nMAssay Description:Inhibitory concentration which is required to cause 50% inhibition of human leukocyte elastase (HLE) enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50096529(1'-[3-(3,4-dichlorophenyl)-4-methyl(4-nitrophenyl)...)
Affinity DataIC50:  60nMAssay Description:Binding affinity towards human CCR5 receptor in Chinese hamster ovary (CHO) cells using [125I]-MIP-1 alpha as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50096536(1'-[3-(3,4-dichlorophenyl)-4-methyl(2-thienyl)sulf...)
Affinity DataIC50:  60nMAssay Description:Binding affinity towards human CCR5 receptor in Chinese hamster ovary (CHO) cells using [125I]-MIP-1 alpha as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50096534(1'-[3-(3,4-dichlorophenyl)-4-[1H-5-indolyl(methyl)...)
Affinity DataIC50:  70nMAssay Description:Binding affinity towards human CCR5 receptor in Chinese hamster ovary (CHO) cells using [125I]-MIP-1 alpha as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50096537(1'-[4-[3-chlorophenyl(methyl)sulfonamido]-3-(3,4-d...)
Affinity DataIC50:  70nMAssay Description:Binding affinity towards human CCR5 receptor in Chinese hamster ovary (CHO) cells using [125I]-MIP-1 alpha as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50096530(1'-[4-[2-chlorophenyl(methyl)sulfonamido]-3-(3,4-d...)
Affinity DataIC50:  80nMAssay Description:Binding affinity towards human CCR5 receptor in Chinese hamster ovary (CHO) cells using [125I]-MIP-1 alpha as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50096516(1'-[3-(3,4-dichlorophenyl)-4-methyl(8-quinolyl)sul...)
Affinity DataIC50:  90nMAssay Description:Binding affinity towards human CCR5 receptor in Chinese hamster ovary (CHO) cells using [125I]-MIP-1 alpha as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1/2(Ovis aries (Sheep))
TBA

Curated by ChEMBL
LigandPNGBDBM50226339(CHEMBL33378)
Affinity DataIC50:  100nMAssay Description:Inhibition of Prostaglandin G/H synthase of ram seminal vesicle microsomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50096512(1'-[3-(3,4-dichlorophenyl)-4-methyl(phenyl)sulfona...)
Affinity DataIC50:  100nMAssay Description:Binding affinity towards human CCR5 receptor in Chinese hamster ovary (CHO) cells using [125I]-MIP-1 alpha as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1/2(Ovis aries (Sheep))
TBA

Curated by ChEMBL
LigandPNGBDBM50226348(CHEMBL284705)
Affinity DataIC50:  100nMAssay Description:Inhibition of Prostaglandin G/H synthase of ram seminal vesicle microsomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50096508(1'-[3-(3,4-dichlorophenyl)-4-methyl(3-pyridyl)sulf...)
Affinity DataIC50:  100nMAssay Description:Binding affinity towards human CCR5 receptor in Chinese hamster ovary (CHO) cells using [125I]-MIP-1 alpha as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50096514(1N-[2-(3,4-dichlorophenyl)-4-spiro[2,3-dihydrobenz...)
Affinity DataIC50:  100nMAssay Description:Binding affinity towards human CCR5 receptor in Chinese hamster ovary (CHO) cells using [125I]-MIP-1 alpha as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50096528(1'-[4-cyclohexyl(methyl)sulfonamido-3-(3,4-dichlor...)
Affinity DataIC50:  100nMAssay Description:Binding affinity towards human CCR5 receptor in Chinese hamster ovary (CHO) cells using [125I]-MIP-1 alpha as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50096511(1'-[3-(3,4-dichlorophenyl)-4-methyl(2-thienyl)sulf...)
Affinity DataIC50:  120nMAssay Description:Binding affinity towards human CCR5 receptor in Chinese hamster ovary (CHO) cells using [125I]-MIP-1 alpha as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50096532(1'-[3-(3,4-dichlorophenyl)-4-methyl(3-quinolyl)sul...)
Affinity DataIC50:  120nMAssay Description:Binding affinity towards human CCR5 receptor in Chinese hamster ovary (CHO) cells using [125I]-MIP-1 alpha as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50096523(1'-[3-(3,4-dichlorophenyl)-4-ethyl(phenyl)sulfonam...)
Affinity DataIC50:  130nMAssay Description:Binding affinity towards human CCR5 receptor in Chinese hamster ovary (CHO) cells using [125I]-MIP-1 alpha as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50280912((S)-4-Dipentylcarbamoyl-1-diphenylcarbamoyl-pipera...)
Affinity DataIC50:  130nMAssay Description:Inhibition of [125I]-Substance P binding to human NK1 receptors in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
TargetSubstance-P receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50281192((S)-Piperazine-1,2,4-tricarboxylic acid 2-[(2-acet...)
Affinity DataIC50:  140nMAssay Description:Inhibition of [125I]-Substance P binding to human NK1 receptors in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50096538(1'-[3-(3,4-dichlorophenyl)-4-methyl(3-nitrophenyl)...)
Affinity DataIC50:  150nMAssay Description:Binding affinity towards human CCR5 receptor in Chinese hamster ovary (CHO) cells using [125I]-MIP-1 alpha as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50096527(1'-[3-(3,4-dichlorophenyl)-4-ethyl(phenyl)sulfonam...)
Affinity DataIC50:  160nMAssay Description:Binding affinity towards human CCR5 receptor in Chinese hamster ovary (CHO) cells using [125I]-MIP-1 alpha as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50281193((S)-Piperazine-1,2,4-tricarboxylic acid 2-({2-[(3,...)
Affinity DataIC50:  200nMAssay Description:Inhibition of [125I]-Substance P binding to human NK1 receptors in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
TargetSubstance-P receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50281191((S)-Piperazine-1,2,4-tricarboxylic acid 2-[(2-diis...)
Affinity DataIC50:  217nMAssay Description:Inhibition of [125I]-Substance P binding to human NK1 receptors in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50096505(1'-[3-(3,4-dichlorophenyl)-4-phenylsulfonamido-(3S...)
Affinity DataIC50:  230nMAssay Description:Binding affinity towards human CCR5 receptor in Chinese hamster ovary (CHO) cells using [125I]-MIP-1 alpha as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50281188((S)-Piperazine-1,2,4-tricarboxylic acid 4-dipentyl...)
Affinity DataIC50:  267nMAssay Description:Inhibition of [125I]-Substance P binding to human NK1 receptors in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
TargetSubstance-P receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50280905((S)-2-Hydroxymethyl-piperazine-1,4-dicarboxylic ac...)
Affinity DataIC50:  280nMAssay Description:Inhibition of [125I]-Substance P binding to human NK1 receptors in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
TargetSubstance-P receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50281199((S)-Piperazine-1,2,4-tricarboxylic acid 2-{[2-(ben...)
Affinity DataIC50:  290nMAssay Description:Inhibition of [125I]-Substance P binding to human NK1 receptors in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
TargetNeutrophil elastase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50015856(3-Acetoxymethyl-7-formyloxy-5,5,8-trioxo-5lambda*6...)
Affinity DataIC50:  300nMAssay Description:Inhibitory concentration which is required to cause 50% inhibition of human leukocyte elastase (HLE) enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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