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Found 176 with Last Name = 'dotson' and Initial = 'r'
TargetThromboxane-A synthase(Homo sapiens (Human))
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50003780(4-(3-Pyridin-3-yl-propyl)-8-(toluene-4-sulfonylami...)
Affinity DataIC50:  1nMAssay Description:In vitro inhibition of Thromboxane A2 synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThromboxane-A synthase(Homo sapiens (Human))
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50003792(8-(4-Fluoro-benzenesulfonylamino)-4-(3-pyridin-3-y...)
Affinity DataIC50:  1nMAssay Description:In vitro inhibition of Thromboxane A2 synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThromboxane-A synthase(Homo sapiens (Human))
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50003784(8-(4-Chloro-benzenesulfonylamino)-4-[3-(4-methyl-p...)
Affinity DataIC50:  1nMAssay Description:In vitro inhibition of Thromboxane A2 synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Rattus norvegicus (rat))
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM25400((2R,3R,4S,5R)-2-[6-(cyclopentylamino)-9H-purin-9-y...)
Affinity DataIC50:  1nMAssay Description:Concentration required for 50% inhibition of [3H]-CHA binding on rat brain adenosine A1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThromboxane-A synthase(Homo sapiens (Human))
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50003803(8-(Naphthalene-2-sulfonylamino)-4-(3-pyridin-3-yl-...)
Affinity DataIC50:  1.5nMAssay Description:In vitro inhibition of Thromboxane A2 synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThromboxane-A synthase(Homo sapiens (Human))
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50003801(4-(3-Pyridin-3-yl-propyl)-8-(4-trifluoromethyl-ben...)
Affinity DataIC50:  2nMAssay Description:In vitro inhibition of Thromboxane A2 synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThromboxane-A synthase(Homo sapiens (Human))
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50003781(CHEMBL341686 | [5-(4-Chloro-benzenesulfonylamino)-...)
Affinity DataIC50:  2nMAssay Description:In vitro inhibition of Thromboxane A2 synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThromboxane-A synthase(Homo sapiens (Human))
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50003776(8-(4-Chloro-benzenesulfonylamino)-4-(3-pyridin-3-y...)
Affinity DataIC50:  2nMAssay Description:In vitro inhibition of thromboxane synthasase in microsomal platelet preparationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThromboxane-A synthase(Homo sapiens (Human))
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50003776(8-(4-Chloro-benzenesulfonylamino)-4-(3-pyridin-3-y...)
Affinity DataIC50:  2nMAssay Description:In vitro inhibition of thromboxane synthaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetThromboxane-A synthase(Homo sapiens (Human))
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50003776(8-(4-Chloro-benzenesulfonylamino)-4-(3-pyridin-3-y...)
Affinity DataIC50:  2nMAssay Description:In vitro inhibition of the compound against thromboxane synthaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetThromboxane-A synthase(Homo sapiens (Human))
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50003797(8-(4-Chloro-benzenesulfonylamino)-4-[2-(pyridin-3-...)
Affinity DataIC50:  2.60nMAssay Description:In vitro inhibition of thromboxane synthasase in microsomal platelet preparationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThromboxane-A synthase(Homo sapiens (Human))
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50003795(5-[1-Pyridin-3-yl-1-(3-trifluoromethyl-phenyl)-met...)
Affinity DataIC50:  3nMAssay Description:In vitro inhibition of Thromboxane A2 synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetThromboxane-A synthase(Homo sapiens (Human))
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50003798(8-(4-Chloro-benzenesulfonylamino)-4-(3-imidazol-1-...)
Affinity DataIC50:  3nMAssay Description:In vitro inhibition of Thromboxane A2 synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThromboxane-A synthase(Homo sapiens (Human))
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50003799(8-(4-Chloro-benzenesulfonylamino)-2-methyl-4-(3-py...)
Affinity DataIC50:  3nMAssay Description:In vitro inhibition of Thromboxane A2 synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThromboxane-A synthase(Homo sapiens (Human))
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50003800(8-(4-Methoxy-benzenesulfonylamino)-4-(3-pyridin-3-...)
Affinity DataIC50:  3nMAssay Description:In vitro inhibition of Thromboxane A2 synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThromboxane-A synthase(Homo sapiens (Human))
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50003796(8-(4-Chloro-benzenesulfonylamino)-4-[3-(1-oxy-pyri...)
Affinity DataIC50:  3nMAssay Description:In vitro inhibition of Thromboxane A2 synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThromboxane-A synthase(Homo sapiens (Human))
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50003797(8-(4-Chloro-benzenesulfonylamino)-4-[2-(pyridin-3-...)
Affinity DataIC50:  3nMAssay Description:In vitro inhibition of Thromboxane A2 synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThromboxane-A synthase(Homo sapiens (Human))
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50025953(6-Imidazo[1,5-a]pyridin-5-yl-hexanoic acid | CGS-1...)
Affinity DataIC50:  3nMAssay Description:In vitro inhibition of thromboxane synthaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetThromboxane-A synthase(Homo sapiens (Human))
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50003795(5-[1-Pyridin-3-yl-1-(3-trifluoromethyl-phenyl)-met...)
Affinity DataIC50:  3nMAssay Description:In vitro inhibition of the compound against thromboxane synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticleDrugBank

TargetThromboxane-A synthase(Homo sapiens (Human))
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50046312(8-(4-Chloro-benzenesulfonylamino)-4-[2-(pyridin-3-...)
Affinity DataIC50:  3.5nMAssay Description:In vitro inhibition of thromboxane synthasase in microsomal platelet preparationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThromboxane-A synthase(Homo sapiens (Human))
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50003789(8-(4-Methanesulfonyl-benzenesulfonylamino)-4-(3-py...)
Affinity DataIC50:  4nMAssay Description:In vitro inhibition of Thromboxane A2 synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThromboxane-A synthase(Homo sapiens (Human))
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50003794(8-(4-Azido-benzenesulfonylamino)-4-(3-pyridin-3-yl...)
Affinity DataIC50:  4nMAssay Description:In vitro inhibition of Thromboxane A2 synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThromboxane-A synthase(Homo sapiens (Human))
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50283051((Z)-7-[(2S,3R,4R)-4-(Biphenyl-4-ylmethoxy)-2-pyrid...)
Affinity DataIC50:  4.30nMAssay Description:In vitro inhibition of the compound against thromboxane synthaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetThromboxane-A synthase(Homo sapiens (Human))
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50283051((Z)-7-[(2S,3R,4R)-4-(Biphenyl-4-ylmethoxy)-2-pyrid...)
Affinity DataIC50:  4.30nMAssay Description:In vitro inhibition against thromboxane synthaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetThromboxane-A synthase(Homo sapiens (Human))
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50046311(8-(4-Chloro-benzenesulfonylamino)-4-(3-pyridin-3-y...)
Affinity DataIC50:  4.5nMAssay Description:In vitro inhibition of thromboxane synthasase in microsomal platelet preparationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThromboxane-A synthase(Homo sapiens (Human))
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50003787(4-Chloro-N-{8-pyridin-3-yl-5-[2-(5H-tetrazol-5-yl)...)
Affinity DataIC50:  5nMAssay Description:In vitro inhibition of Thromboxane A2 synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThromboxane-A synthase(Homo sapiens (Human))
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50046309(8-(4-Chloro-benzenesulfonylamino)-4-(3-pyridin-3-y...)
Affinity DataIC50:  5nMAssay Description:In vitro inhibition of thromboxane synthasase in microsomal platelet preparationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Rattus norvegicus (rat))
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50009552(2-[6-Amino-2-(2-morpholin-4-yl-ethylamino)-purin-9...)
Affinity DataIC50:  5nMAssay Description:Concentration required for 50% inhibition of [3H]-CHA binding on rat brain adenosine A1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Rattus norvegicus (rat))
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50118810((2R,3S,4R,5R)-2-(hydroxymethyl)-5-(6-((R)-1-phenyl...)
Affinity DataIC50:  5nMAssay Description:Concentration required for 50% inhibition of [3H]-CHA binding on rat brain adenosine A1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThromboxane-A synthase(Homo sapiens (Human))
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50003790(CHEMBL136880 | Potassium; 8-(4-chloro-benzenesulfo...)
Affinity DataIC50:  7nMAssay Description:In vitro inhibition of Thromboxane A2 synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThromboxane-A synthase(Homo sapiens (Human))
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50003804(7-(4-Chloro-benzenesulfonylamino)-3-(3-pyridin-3-y...)
Affinity DataIC50:  7nMAssay Description:In vitro inhibition of Thromboxane A2 synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThromboxane-A synthase(Homo sapiens (Human))
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50280267(CHEMBL295121 | [3-[3-(4-Chloro-benzenesulfonylamin...)
Affinity DataIC50:  7nMAssay Description:Inhibitory concentration of the compound against thromboxane synthase enzyme from human microsomal platelet preparationMore data for this Ligand-Target Pair
In DepthDetails Article
TargetThromboxane-A synthase(Homo sapiens (Human))
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50280268(3-[3-[2-(4-Chloro-benzenesulfonylamino)-ethyl]-5-(...)
Affinity DataIC50:  9nMAssay Description:Inhibitory concentration of the compound against thromboxane synthase enzyme from human microsomal platelet preparationMore data for this Ligand-Target Pair
In DepthDetails Article
TargetThromboxane-A synthase(Homo sapiens (Human))
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50003793(8-(4-Chloro-benzenesulfonylamino)-4-(3-pyridin-3-y...)
Affinity DataIC50:  10nMAssay Description:In vitro inhibition of Thromboxane A2 synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThromboxane-A synthase(Homo sapiens (Human))
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50283046((Z)-7-[(2S,3S,4S)-4-(Biphenyl-4-ylmethoxy)-2-pyrid...)
Affinity DataIC50:  10nMAssay Description:In vitro thromboxane receptor antagonist activity was determined by inhibition of U-46619 induced aggregation of washed human plateletsMore data for this Ligand-Target Pair
In DepthDetails Article
TargetThromboxane-A synthase(Homo sapiens (Human))
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50283042((Z)-7-[(2S,3S,4R)-4-(Biphenyl-4-ylmethoxy)-2-pyrid...)
Affinity DataIC50:  11nMAssay Description:In vitro inhibition of thromboxane synthaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetThromboxane A2 receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50283049((Z)-7-[(1R,2R,3S,5S)-5-(Biphenyl-4-ylmethoxy)-3-hy...)
Affinity DataIC50:  12nMAssay Description:In vitro thromboxane receptor antagonist activity was determined by inhibition of U-46619 induced aggregation of washed human plateletsMore data for this Ligand-Target Pair
In DepthDetails Article
TargetThromboxane-A synthase(Homo sapiens (Human))
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50283046((Z)-7-[(2S,3S,4S)-4-(Biphenyl-4-ylmethoxy)-2-pyrid...)
Affinity DataIC50:  13nMAssay Description:In vitro inhibition of thromboxane synthaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetThromboxane-A synthase(Homo sapiens (Human))
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50046310(8-(4-Chloro-benzenesulfonylamino)-4-[2-(pyridin-3-...)
Affinity DataIC50:  13nMAssay Description:In vitro inhibition of thromboxane synthasase in microsomal platelet preparationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThromboxane-A synthase(Homo sapiens (Human))
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50283046((Z)-7-[(2S,3S,4S)-4-(Biphenyl-4-ylmethoxy)-2-pyrid...)
Affinity DataIC50:  13nMAssay Description:In vitro inhibition of thromboxane synthaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetAdenosine receptor A2a/A2b(Rattus norvegicus)
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50009535((CGS 22,989) 2-[6-Amino-2-(2-cyclohex-1-enyl-ethyl...)
Affinity DataIC50:  13nMAssay Description:Concentration required for 50% inhibition of [3H]NECA binding on rat brain adenosine A2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThromboxane-A synthase(Homo sapiens (Human))
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50280260(7-{4-[3-(4-Chloro-benzenesulfonylamino)-propyl]-py...)
Affinity DataIC50:  15nMAssay Description:Inhibitory concentration of the compound against thromboxane synthase enzymeMore data for this Ligand-Target Pair
In DepthDetails Article
TargetThromboxane-A synthase(Homo sapiens (Human))
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50280264(3-[5-[2-(4-Chloro-benzenesulfonylamino)-ethyl]-2-(...)
Affinity DataIC50:  15nMAssay Description:Inhibitory concentration of the compound against thromboxane synthase enzyme from human microsomal platelet preparationMore data for this Ligand-Target Pair
In DepthDetails Article
TargetAdenosine receptor A2a/A2b(Rattus norvegicus)
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM21220((2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-N-ethyl-3,...)
Affinity DataIC50:  15nMAssay Description:Concentration required for 50% inhibition of [3H]NECA binding on rat brain adenosine A2 receptorMore data for this Ligand-Target Pair
TargetAdenosine receptor A1(Rattus norvegicus (rat))
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM21220((2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-N-ethyl-3,...)
Affinity DataIC50:  16nMAssay Description:Concentration required for 50% inhibition of [3H]-CHA binding on rat brain adenosine A1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThromboxane-A synthase(Homo sapiens (Human))
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50283051((Z)-7-[(2S,3R,4R)-4-(Biphenyl-4-ylmethoxy)-2-pyrid...)
Affinity DataIC50:  17nMAssay Description:In vitro inhibition of the compound against thromboxane synthaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetAdenosine receptor A2a/A2b(Rattus norvegicus)
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50009543(2-{6-Amino-2-[2-(5,6,7,8-tetrahydro-naphthalen-2-y...)
Affinity DataIC50:  17nMAssay Description:Concentration required for 50% inhibition of [3H]NECA binding on rat brain adenosine A2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThromboxane-A synthase(Homo sapiens (Human))
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50003791(CHEMBL343535 | [5-(4-Chloro-benzenesulfonylamino)-...)
Affinity DataIC50:  18nMAssay Description:In vitro inhibition of Thromboxane A2 synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThromboxane A2 receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50283047((Z)-7-[(2S,3S,4S)-4-(Biphenyl-4-ylmethoxy)-1,1-dio...)
Affinity DataIC50:  18nMAssay Description:In vitro thromboxane receptor antagonist activity was determined by inhibition of U-46619 induced aggregation of washed human plateletsMore data for this Ligand-Target Pair
In DepthDetails Article
TargetThromboxane A2 receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50003776(8-(4-Chloro-benzenesulfonylamino)-4-(3-pyridin-3-y...)
Affinity DataIC50:  18nMAssay Description:In vitro thromboxane receptor antagonist activity was determined by inhibition of U-46619 induced aggregation of washed human plateletsMore data for this Ligand-Target Pair
In DepthDetails Article
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