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Found 36 with Last Name = 'dreier' and Initial = 'j'
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Homo sapiens (Human))
Basilea Pharmaceutica

US Patent
LigandPNGBDBM336125(US9738676, Comparative Compound A)
Affinity DataIC50:  0.100nMAssay Description:PDEs specifically hydrolyze cAMP and/or cGMP and release the product AMP and/or GMP. The potency of PDE inhibition by test compounds is determined wi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Homo sapiens (Human))
Basilea Pharmaceutica

US Patent
LigandPNGBDBM136701(US8865662, 4)
Affinity DataIC50:  30nMpH: 7.2Assay Description:PDE4 specifically hydrolyzes cAMP and releases the product AMP. The potency of PDE inhibition by said agents is determined in an in vitro enzymatic a...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Homo sapiens (Human))
Basilea Pharmaceutica

US Patent
LigandPNGBDBM336122(US9738676, WS2009/106419, Expl. 10)
Affinity DataIC50:  31nMAssay Description:PDEs specifically hydrolyze cAMP and/or cGMP and release the product AMP and/or GMP. The potency of PDE inhibition by test compounds is determined wi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Homo sapiens (Human))
Basilea Pharmaceutica

US Patent
LigandPNGBDBM336127(US9738676, Compound of Formula (I-A) according to ...)
Affinity DataIC50:  35nMAssay Description:PDEs specifically hydrolyze cAMP and/or cGMP and release the product AMP and/or GMP. The potency of PDE inhibition by test compounds is determined wi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Homo sapiens (Human))
Basilea Pharmaceutica

US Patent
LigandPNGBDBM336126(US9738676, Comparative Compound B)
Affinity DataIC50:  43nMAssay Description:PDEs specifically hydrolyze cAMP and/or cGMP and release the product AMP and/or GMP. The potency of PDE inhibition by test compounds is determined wi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Homo sapiens (Human))
Basilea Pharmaceutica

US Patent
LigandPNGBDBM336123(US9738676, WS2009/106419, Expl. 15)
Affinity DataIC50:  71nMAssay Description:PDEs specifically hydrolyze cAMP and/or cGMP and release the product AMP and/or GMP. The potency of PDE inhibition by test compounds is determined wi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Homo sapiens (Human))
Basilea Pharmaceutica

US Patent
LigandPNGBDBM136700(US8865662, 5)
Affinity DataIC50:  200nMpH: 7.2Assay Description:PDE4 specifically hydrolyzes cAMP and releases the product AMP. The potency of PDE inhibition by said agents is determined in an in vitro enzymatic a...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Homo sapiens (Human))
Basilea Pharmaceutica

US Patent
LigandPNGBDBM136697(US8865662, 1)
Affinity DataIC50:  230nMpH: 7.2Assay Description:PDE4 specifically hydrolyzes cAMP and releases the product AMP. The potency of PDE inhibition by said agents is determined in an in vitro enzymatic a...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Homo sapiens (Human))
Basilea Pharmaceutica

US Patent
LigandPNGBDBM336121(US9738676, WS2009/106419, Expl. 9)
Affinity DataIC50:  300nMAssay Description:PDEs specifically hydrolyze cAMP and/or cGMP and release the product AMP and/or GMP. The potency of PDE inhibition by test compounds is determined wi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Homo sapiens (Human))
Basilea Pharmaceutica

US Patent
LigandPNGBDBM136699(US8865662, 3 | US9738676, WS2011/018510, Expl. 2)
Affinity DataIC50:  630nMpH: 7.2Assay Description:PDE4 specifically hydrolyzes cAMP and releases the product AMP. The potency of PDE inhibition by said agents is determined in an in vitro enzymatic a...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Homo sapiens (Human))
Basilea Pharmaceutica

US Patent
LigandPNGBDBM136699(US8865662, 3 | US9738676, WS2011/018510, Expl. 2)
Affinity DataIC50:  876nMAssay Description:PDEs specifically hydrolyze cAMP and/or cGMP and release the product AMP and/or GMP. The potency of PDE inhibition by test compounds is determined wi...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Homo sapiens (Human))
Basilea Pharmaceutica

US Patent
LigandPNGBDBM136698(US8865662, 2)
Affinity DataIC50:  880nMpH: 7.2Assay Description:PDE4 specifically hydrolyzes cAMP and releases the product AMP. The potency of PDE inhibition by said agents is determined in an in vitro enzymatic a...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetDihydrofolate reductase(Homo sapiens (Human))
Oklahoma State University

Curated by ChEMBL
LigandPNGBDBM50294207(3-(5-((2,4-diaminopyrimidin-5-yl)methyl)-2,3-dimet...)
Affinity DataIC50: >1.60E+4nMAssay Description:Inhibition of human recombinant DHFRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
Oklahoma State University

Curated by ChEMBL
LigandPNGBDBM50294204(3-(5-((2,4-diaminopyrimidin-5-yl)methyl)-2,3-dimet...)
Affinity DataIC50: >1.90E+4nMAssay Description:Inhibition of human recombinant DHFRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
Oklahoma State University

Curated by ChEMBL
LigandPNGBDBM50294205(1-(1-cyclohexylphthalazin-2(1H)-yl)-3-(5-((2,4-dia...)
Affinity DataIC50: >1.90E+4nMAssay Description:Inhibition of human recombinant DHFRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
Oklahoma State University

Curated by ChEMBL
LigandPNGBDBM50294210(1-(1-butylphthalazin-2(1H)-yl)-3-(5-((2,4-diaminop...)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of human recombinant DHFRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
Oklahoma State University

Curated by ChEMBL
LigandPNGBDBM50294212(3-(5-((2,4-diaminopyrimidin-5-yl)methyl)-3-methoxy...)
Affinity DataIC50: >2.10E+4nMAssay Description:Inhibition of human recombinant DHFRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
Oklahoma State University

Curated by ChEMBL
LigandPNGBDBM50294215(3-(5-((2,4-diaminopyrimidin-5-yl)methyl)-2,3-dimet...)
Affinity DataIC50: >2.20E+4nMAssay Description:Inhibition of human recombinant DHFRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
Oklahoma State University

Curated by ChEMBL
LigandPNGBDBM50294206(1-(1-cyclopentylphthalazin-2(1H)-yl)-3-(5-((2,4-di...)
Affinity DataIC50: >2.20E+4nMAssay Description:Inhibition of human recombinant DHFRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
Oklahoma State University

Curated by ChEMBL
LigandPNGBDBM50294216(3-(5-((2,4-diaminopyrimidin-5-yl)methyl)-2,3-dimet...)
Affinity DataIC50: >2.30E+4nMAssay Description:Inhibition of human recombinant DHFRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
Oklahoma State University

Curated by ChEMBL
LigandPNGBDBM50294213(3-(5-((2,4-diaminopyrimidin-5-yl)methyl)-2-hydroxy...)
Affinity DataIC50: >2.40E+4nMAssay Description:Inhibition of human recombinant DHFRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Rattus norvegicus (rat))
Oklahoma State University

Curated by ChEMBL
LigandPNGBDBM50294209(3-(5-((2,4-diaminopyrimidin-5-yl)methyl)-2,3-dimet...)
Affinity DataIC50:  2.50E+4nMAssay Description:Inhibition of rat DHFRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Rattus norvegicus (rat))
Oklahoma State University

Curated by ChEMBL
LigandPNGBDBM50294210(1-(1-butylphthalazin-2(1H)-yl)-3-(5-((2,4-diaminop...)
Affinity DataIC50:  2.50E+4nMAssay Description:Inhibition of rat DHFRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Rattus norvegicus (rat))
Oklahoma State University

Curated by ChEMBL
LigandPNGBDBM50294211(3-(5-((2,4-diaminopyrimidin-5-yl)methyl)-3-hydroxy...)
Affinity DataIC50:  2.50E+4nMAssay Description:Inhibition of rat DHFRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Rattus norvegicus (rat))
Oklahoma State University

Curated by ChEMBL
LigandPNGBDBM50294203(3-(5-((2,4-diaminopyrimidin-5-yl)methyl)-2,3-dimet...)
Affinity DataIC50:  2.50E+4nMAssay Description:Inhibition of rat DHFRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Rattus norvegicus (rat))
Oklahoma State University

Curated by ChEMBL
LigandPNGBDBM50294204(3-(5-((2,4-diaminopyrimidin-5-yl)methyl)-2,3-dimet...)
Affinity DataIC50:  2.50E+4nMAssay Description:Inhibition of rat DHFRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Rattus norvegicus (rat))
Oklahoma State University

Curated by ChEMBL
LigandPNGBDBM50294205(1-(1-cyclohexylphthalazin-2(1H)-yl)-3-(5-((2,4-dia...)
Affinity DataIC50:  2.50E+4nMAssay Description:Inhibition of rat DHFRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Rattus norvegicus (rat))
Oklahoma State University

Curated by ChEMBL
LigandPNGBDBM50294206(1-(1-cyclopentylphthalazin-2(1H)-yl)-3-(5-((2,4-di...)
Affinity DataIC50:  2.50E+4nMAssay Description:Inhibition of rat DHFRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
Oklahoma State University

Curated by ChEMBL
LigandPNGBDBM50294209(3-(5-((2,4-diaminopyrimidin-5-yl)methyl)-2,3-dimet...)
Affinity DataIC50: >2.50E+4nMAssay Description:Inhibition of human recombinant DHFRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Rattus norvegicus (rat))
Oklahoma State University

Curated by ChEMBL
LigandPNGBDBM50294208(CHEMBL565059 | methyl 2-(2-(3-(5-((2,4-diaminopyri...)
Affinity DataIC50:  2.50E+4nMAssay Description:Inhibition of rat DHFRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Rattus norvegicus (rat))
Oklahoma State University

Curated by ChEMBL
LigandPNGBDBM50294207(3-(5-((2,4-diaminopyrimidin-5-yl)methyl)-2,3-dimet...)
Affinity DataIC50:  2.50E+4nMAssay Description:Inhibition of rat DHFRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
Oklahoma State University

Curated by ChEMBL
LigandPNGBDBM50294203(3-(5-((2,4-diaminopyrimidin-5-yl)methyl)-2,3-dimet...)
Affinity DataIC50: >2.70E+4nMAssay Description:Inhibition of human recombinant DHFRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
Oklahoma State University

Curated by ChEMBL
LigandPNGBDBM50294217(3-(5-((2,4-diaminopyrimidin-5-yl)methyl)-2,3-dimet...)
Affinity DataIC50: >2.80E+4nMAssay Description:Inhibition of human recombinant DHFRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
Oklahoma State University

Curated by ChEMBL
LigandPNGBDBM50294214(3-(5-((2,4-diaminopyrimidin-5-yl)methyl)-2,3-dimet...)
Affinity DataIC50: >4.20E+4nMAssay Description:Inhibition of human recombinant DHFRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
Oklahoma State University

Curated by ChEMBL
LigandPNGBDBM50294211(3-(5-((2,4-diaminopyrimidin-5-yl)methyl)-3-hydroxy...)
Affinity DataIC50:  1.10E+5nMAssay Description:Inhibition of human recombinant DHFRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
Oklahoma State University

Curated by ChEMBL
LigandPNGBDBM50294208(CHEMBL565059 | methyl 2-(2-(3-(5-((2,4-diaminopyri...)
Affinity DataIC50:  8.13E+5nMAssay Description:Inhibition of human recombinant DHFRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed