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Found 45 with Last Name = 'duhl' and Initial = 'd'
TargetKinesin-like protein KIF11(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM103307(US8546434, 4)
Affinity DataIC50:  0.600nMpH: 7.5 T: 2°CAssay Description:In vitro activity assay using KSP.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetKinesin-like protein KIF11(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM34539(US8546434, 13)
Affinity DataIC50:  0.690nMAssay Description:In vitro activity assay using KSP.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetKinesin-like protein KIF11(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM103306(US8546434, 3)
Affinity DataIC50:  0.740nMpH: 7.5 T: 2°CAssay Description:In vitro activity assay using KSP.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetKinesin-like protein KIF11(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM103305(US8546434, 2)
Affinity DataIC50:  0.830nMpH: 7.5 T: 2°CAssay Description:In vitro activity assay using KSP.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetKinesin-like protein KIF11(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM103309(US8546434, 6)
Affinity DataIC50:  0.830nMpH: 7.5 T: 2°CAssay Description:In vitro activity assay using KSP.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetKinesin-like protein KIF11(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM34538(US8546434, 12)
Affinity DataIC50:  0.870nMAssay Description:In vitro activity assay using KSP.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetKinesin-like protein KIF11(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM34536(US8546434, 10)
Affinity DataIC50:  0.900nMAssay Description:In vitro activity assay using KSP.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetKinesin-like protein KIF11(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM103304(US8546434, 1)
Affinity DataIC50:  0.960nMpH: 7.5 T: 2°CAssay Description:In vitro activity assay using KSP.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetKinesin-like protein KIF11(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM34532(US8546434, 7)
Affinity DataIC50:  1.23nMAssay Description:In vitro activity assay using KSP.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetKinesin-like protein KIF11(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM34537(US8546434, 11)
Affinity DataIC50:  1.40nMAssay Description:In vitro activity assay using KSP.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetKinesin-like protein KIF11(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM103308(US8546434, 5)
Affinity DataIC50:  1.46nMpH: 7.5 T: 2°CAssay Description:In vitro activity assay using KSP.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetKinesin-like protein KIF11(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM34534(US8546434, 8)
Affinity DataIC50:  1.49nMAssay Description:In vitro activity assay using KSP.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetKinesin-like protein KIF11(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM34540(US8546434, 14)
Affinity DataIC50:  2.34nMAssay Description:In vitro activity assay using KSP.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetKinesin-like protein KIF11(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM50305245((+/-)-3-amino-1-(6-ethyl-1-(3-hydroxyphenyl)-3,4-d...)
Affinity DataIC50:  11nMAssay Description:Inhibition of EG5 after 2 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKinesin-like protein KIF11(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM50305246((+/-)-3-amino-1-(1-(3-hydroxyphenyl)-6-methyl-3,4-...)
Affinity DataIC50:  20nMAssay Description:Inhibition of EG5 after 2 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKinesin-like protein KIF11(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM50305246((+/-)-3-amino-1-(1-(3-hydroxyphenyl)-6-methyl-3,4-...)
Affinity DataIC50:  20nMAssay Description:Inhibition of EG5 after 2 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKinesin-like protein KIF11(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM50305241((+/-)-3-amino-1-(6-bromo-1-(3-hydroxyphenyl)-3,4-d...)
Affinity DataIC50:  27nMAssay Description:Inhibition of EG5 after 2 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKinesin-like protein KIF11(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM50305242((+/-)-3-amino-1-(6-chloro-1-(3-hydroxyphenyl)-3,4-...)
Affinity DataIC50:  39nMAssay Description:Inhibition of EG5 after 2 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKinesin-like protein KIF11(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM50305237((+/-)-2-amino-1-(1-(3-hydroxyphenyl)-6-methyl-3,4-...)
Affinity DataIC50:  49nMAssay Description:Inhibition of EG5 after 2 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKinesin-like protein KIF11(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM34535(US8546434, 9)
Affinity DataIC50:  49.4nMAssay Description:In vitro activity assay using KSP.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetKinesin-like protein KIF11(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM50305236((+/-)-4-amino-1-(1-(3-hydroxyphenyl)-6-methyl-3,4-...)
Affinity DataIC50:  86nMAssay Description:Inhibition of EG5 after 2 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKinesin-like protein KIF11(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM50305234((+/-)-1-(1-(3-hydroxyphenyl)-6-methyl-3,4-dihydro-...)
Affinity DataIC50:  100nMAssay Description:Inhibition of EG5 after 2 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKinesin-like protein KIF11(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM50305222((+/-)-3-amino-1-(1-(3-fluorophenyl)-6-methyl-3,4-d...)
Affinity DataIC50:  100nMAssay Description:Inhibition of EG5 after 2 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKinesin-like protein KIF11(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM50305231((+/-)-N-(3-(6-chloro-1-(3-hydroxyphenyl)-3,4-dihyd...)
Affinity DataIC50:  155nMAssay Description:Inhibition of EG5 after 2 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKinesin-like protein KIF11(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM50305228((+/-)-3-amino-1-(6-methyl-1-phenyl-3,4-dihydro-1H-...)
Affinity DataIC50:  175nMAssay Description:Inhibition of EG5 after 2 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKinesin-like protein KIF11(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM50305235((+/-)-3-(2-(2-aminoethylsulfonyl)-6-chloro-2,3,4,9...)
Affinity DataIC50:  186nMAssay Description:Inhibition of EG5 after 2 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKinesin-like protein KIF11(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM50305248(1-(1-(3-hydroxyphenyl)-6-methyl-3,4-dihydro-1H-pyr...)
Affinity DataIC50:  200nMAssay Description:Inhibition of EG5 after 2 hrsMore data for this Ligand-Target Pair
TargetKinesin-like protein KIF11(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM50305239((+/-)-3-amino-1-(1-(3-hydroxyphenyl)-6-(trifluorom...)
Affinity DataIC50:  200nMAssay Description:Inhibition of EG5 after 2 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKinesin-like protein KIF11(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM50305221((+/-)-3-amino-1-(6-chloro-1-cyclohexyl-3,4-dihydro...)
Affinity DataIC50:  230nMAssay Description:Inhibition of EG5 after 2 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKinesin-like protein KIF11(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM50305238((+/-)-1-(1-(3-hydroxyphenyl)-6-methyl-3,4-dihydro-...)
Affinity DataIC50:  460nMAssay Description:Inhibition of EG5 after 2 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKinesin-like protein KIF11(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM50305219((+/-)-3-amino-1-(1-(3-hydroxyphenyl)-3,4-dihydro-1...)
Affinity DataIC50:  630nMAssay Description:Inhibition of EG5 after 2 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKinesin-like protein KIF11(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM50305247((+/-)-3-amino-1-(6-fluoro-1-(3-hydroxyphenyl)-3,4-...)
Affinity DataIC50:  760nMAssay Description:Inhibition of EG5 after 2 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKinesin-like protein KIF11(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM50305230((2S)-2-amino-1-(6-chloro-1-(3-hydroxyphenyl)-3,4-d...)
Affinity DataIC50:  760nMAssay Description:Inhibition of EG5 after 2 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKinesin-like protein KIF11(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM50305232((+/-)-1-(6-chloro-1-(3-hydroxyphenyl)-3,4-dihydro-...)
Affinity DataIC50:  860nMAssay Description:Inhibition of EG5 after 2 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKinesin-like protein KIF11(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM50305233((+/-)-(1-(3-hydroxyphenyl)-6-methyl-3,4-dihydro-1H...)
Affinity DataIC50:  900nMAssay Description:Inhibition of EG5 after 2 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKinesin-like protein KIF11(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM50305243((+/-)-3-amino-1-(1-(3-hydroxyphenyl)-6-phenyl-3,4-...)
Affinity DataIC50:  1.70E+3nMAssay Description:Inhibition of EG5 after 2 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKinesin-like protein KIF11(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM50305223(1-(1-(3-hydroxyphenyl)-3,4-dihydro-1H-pyrido[3,4-b...)
Affinity DataIC50:  2.50E+3nMAssay Description:Inhibition of EG5 after 2 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKinesin-like protein KIF11(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM50305240((+/-)-3-amino-1-(6-hydroxy-1-(3-hydroxyphenyl)-3,4...)
Affinity DataIC50:  4.50E+3nMAssay Description:Inhibition of EG5 after 2 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKinesin-like protein KIF11(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM50305220((+/-)-3-amino-1-(1-(2-aminopyridin-4-yl)-6-chloro-...)
Affinity DataIC50:  6.60E+3nMAssay Description:Inhibition of EG5 after 2 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKinesin-like protein KIF11(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM50305229((2R)-2-amino-1-(6-chloro-1-(3-hydroxyphenyl)-3,4-d...)
Affinity DataIC50:  8.10E+3nMAssay Description:Inhibition of EG5 after 2 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKinesin-like protein KIF11(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM50305227((+/-)-3-amino-1-(1-(3-methoxyphenyl)-6-methyl-3,4-...)
Affinity DataIC50:  1.10E+4nMAssay Description:Inhibition of EG5 after 2 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKinesin-like protein KIF11(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM50305224((+/-)-5-(2-(3-aminopropanoyl)-6-chloro-2,3,4,9-tet...)
Affinity DataIC50: >2.50E+4nMAssay Description:Inhibition of EG5 after 2 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKinesin-like protein KIF11(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM50305225((+/-)-5-(2-(3-aminopropanoyl)-6-methyl-2,3,4,9-tet...)
Affinity DataIC50: >2.50E+4nMAssay Description:Inhibition of EG5 after 2 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKinesin-like protein KIF11(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM50305226((+/-)-N-(3-(2-(3-aminopropanoyl)-6-methyl-2,3,4,9-...)
Affinity DataIC50: >2.50E+4nMAssay Description:Inhibition of EG5 after 2 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKinesin-like protein KIF11(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM50305244((+/-)-3-amino-1-(1-(3-hydroxyphenyl)-6-isopropyl-3...)
Affinity DataIC50: >2.50E+4nMAssay Description:Inhibition of EG5 after 2 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed