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Found 982 with Last Name = 'earp' and Initial = 'hs'
TargetTyrosine-protein kinase Mer(Homo sapiens (Human))
University Of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM497267((2,6-dimethylpyridin-4- yl)(4-(7-((1R,4S)-4- hydro...)
Affinity DataKi:  0.190nMAssay Description:ATP competitive inhibition of MERTK (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Mer(Homo sapiens (Human))
University Of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50055499(CHEMBL3326002)
Affinity DataKi:  0.330nMAssay Description:Inhibition of Mer (unknown origin) by Off-chip Mobility Shift AssayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Mer(Homo sapiens (Human))
University Of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50469353(CHEMBL4283353)
Affinity DataKi:  0.430nMAssay Description:Inhibition of MERTK (unknown origin) using 5'-FAM-EFPIYDFLPAKKK-CONH2 as substrate after 180 mins by MCE assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Mer(Homo sapiens (Human))
University Of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50384584(CHEMBL2036807 | US9744172, Compound UNC607A)
Affinity DataKi:  0.560nMAssay Description:Inhibition of Mer using EFPIYDFLPAKKK-CONH2 as substrate by Michaelis-Menton equationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Mer(Homo sapiens (Human))
University Of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50384583(CHEMBL2036806)
Affinity DataKi:  0.730nMAssay Description:Inhibition of Mer using EFPIYDFLPAKKK-CONH2 as substrate by Michaelis-Menton equationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Mer(Homo sapiens (Human))
University Of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50384582(CHEMBL2036805)
Affinity DataKi:  1.40nMAssay Description:Inhibition of Mer using EFPIYDFLPAKKK-CONH2 as substrate by Michaelis-Menton equationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Mer(Homo sapiens (Human))
University Of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50384585(CHEMBL2036809)
Affinity DataKi:  2nMAssay Description:Inhibition of Mer using EFPIYDFLPAKKK-CONH2 as substrate by Michaelis-Menton equationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Mer(Homo sapiens (Human))
University Of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50384581(CHEMBL2036804)
Affinity DataKi:  2.70nMAssay Description:Inhibition of Mer using EFPIYDFLPAKKK-CONH2 as substrate by Michaelis-Menton equationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-G-associated kinase(Homo sapiens (Human))
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50524284(CHEMBL4443342)
Affinity DataKi:  3.10nMAssay Description:Binding affinity to C-terminal AVI-tagged GAK (unknown origin) (12 to 347 residues) expressed in Escherichia coli after 1.5 hrs by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-G-associated kinase(Homo sapiens (Human))
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50537138(CHEMBL4531690)
Affinity DataKi:  3.80nMAssay Description:Binding affinity to C-terminal AVI-tagged GAK (unknown origin) (12 to 347 residues) expressed in Escherichia coli after 1.5 hrs by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase receptor TYRO3(Homo sapiens (Human))
Unc Eshelman School Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50469353(CHEMBL4283353)
Affinity DataKi:  3.90nMAssay Description:Inhibition of TYRO3 (unknown origin) using 5'-FAM-EFPIYDFLPAKKK-CONH2 as substrate after 180 mins by MCE assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Mer(Homo sapiens (Human))
University Of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50384576(CHEMBL2036808)
Affinity DataKi:  4.30nMAssay Description:Inhibition of Mer using EFPIYDFLPAKKK-CONH2 as substrate by Michaelis-Menton equationMore data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Unc Eshelman School Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50469353(CHEMBL4283353)
Affinity DataKi:  16nMAssay Description:Inhibition of FLT3 (unknown origin) using 5'-FAM-KKKKEEIYFFF-CONH2 as substrate after 180 mins by MCE assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase receptor TYRO3(Homo sapiens (Human))
Unc Eshelman School Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM497267((2,6-dimethylpyridin-4- yl)(4-(7-((1R,4S)-4- hydro...)
Affinity DataKi:  19nMAssay Description:ATP competitive inhibition of TYRO3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase receptor UFO(Homo sapiens (Human))
Unc Eshelman School Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50469353(CHEMBL4283353)
Affinity DataKi:  40nMAssay Description:Inhibition of AXL (unknown origin) using 5'-FAM-KKKKEEIYFFF-CONH2 as substrate after 180 mins by MCE assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Unc Eshelman School Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM497267((2,6-dimethylpyridin-4- yl)(4-(7-((1R,4S)-4- hydro...)
Affinity DataKi:  42nMAssay Description:ATP competitive inhibition of FLT3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-G-associated kinase(Homo sapiens (Human))
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50537139(CHEMBL4535001)
Affinity DataKi:  49nMAssay Description:Binding affinity to C-terminal AVI-tagged GAK (unknown origin) (12 to 347 residues) expressed in Escherichia coli after 1.5 hrs by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase receptor UFO(Homo sapiens (Human))
Unc Eshelman School Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM497267((2,6-dimethylpyridin-4- yl)(4-(7-((1R,4S)-4- hydro...)
Affinity DataKi:  98nMAssay Description:ATP competitive inhibition of AXL (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-G-associated kinase(Homo sapiens (Human))
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50184765(CHEMBL3823499)
Affinity DataKi:  220nMAssay Description:Binding affinity to C-terminal AVI-tagged GAK (unknown origin) (12 to 347 residues) expressed in Escherichia coli after 1.5 hrs by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-G-associated kinase(Homo sapiens (Human))
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50524287(CHEMBL4462395)
Affinity DataKi:  2.50E+3nMAssay Description:Binding affinity to C-terminal AVI-tagged GAK (unknown origin) (12 to 347 residues) expressed in Escherichia coli after 1.5 hrs by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-G-associated kinase(Homo sapiens (Human))
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50516677(CHEMBL4514780)
Affinity DataKi:  8.20E+3nMAssay Description:Binding affinity to C-terminal AVI-tagged GAK (unknown origin) (12 to 347 residues) expressed in Escherichia coli after 1.5 hrs by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase 16(Homo sapiens (Human))
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50524287(CHEMBL4462395)
Affinity DataKi:  1.50E+4nMAssay Description:Binding affinity to C-terminal AVI-tagged STK16 (unknown origin) (13 to 305 residues) expressed in Escherichia coli after 1.5 hrs by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-G-associated kinase(Homo sapiens (Human))
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50524288(CHEMBL4518437)
Affinity DataKi:  1.90E+4nMAssay Description:Binding affinity to C-terminal AVI-tagged GAK (unknown origin) (12 to 347 residues) expressed in Escherichia coli after 1.5 hrs by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase 16(Homo sapiens (Human))
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50524284(CHEMBL4443342)
Affinity DataKi:  5.10E+4nMAssay Description:Binding affinity to C-terminal AVI-tagged STK16 (unknown origin) (13 to 305 residues) expressed in Escherichia coli after 1.5 hrs by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAP2-associated protein kinase 1(Homo sapiens (Human))
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50524284(CHEMBL4443342)
Affinity DataKi:  5.30E+4nMAssay Description:Binding affinity to C-terminal AVI-tagged AAK1 (unknown origin) (31 to 396 residues) expressed in Escherichia coli after 1.5 hrs by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAP2-associated protein kinase 1(Homo sapiens (Human))
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50524287(CHEMBL4462395)
Affinity DataKi:  7.80E+4nMAssay Description:Binding affinity to C-terminal AVI-tagged AAK1 (unknown origin) (31 to 396 residues) expressed in Escherichia coli after 1.5 hrs by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBMP-2-inducible protein kinase(Homo sapiens (Human))
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50524287(CHEMBL4462395)
Affinity DataKi:  9.50E+4nMAssay Description:Binding affinity to C-terminal AVI-tagged BMP2K (unknown origin) (38 to 345 residues) expressed in Escherichia coli after 1.5 hrs by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBMP-2-inducible protein kinase(Homo sapiens (Human))
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50524288(CHEMBL4518437)
Affinity DataKi: >1.00E+5nMAssay Description:Binding affinity to C-terminal AVI-tagged BMP2K (unknown origin) (38 to 345 residues) expressed in Escherichia coli after 1.5 hrs by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBMP-2-inducible protein kinase(Homo sapiens (Human))
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50524284(CHEMBL4443342)
Affinity DataKi: >1.00E+5nMAssay Description:Binding affinity to C-terminal AVI-tagged BMP2K (unknown origin) (38 to 345 residues) expressed in Escherichia coli after 1.5 hrs by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase 16(Homo sapiens (Human))
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50524288(CHEMBL4518437)
Affinity DataKi: >1.00E+5nMAssay Description:Binding affinity to C-terminal AVI-tagged STK16 (unknown origin) (13 to 305 residues) expressed in Escherichia coli after 1.5 hrs by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAP2-associated protein kinase 1(Homo sapiens (Human))
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50524288(CHEMBL4518437)
Affinity DataKi: >1.00E+5nMAssay Description:Binding affinity to C-terminal AVI-tagged AAK1 (unknown origin) (31 to 396 residues) expressed in Escherichia coli after 1.5 hrs by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetReceptor-interacting serine/threonine-protein kinase 2(Homo sapiens (Human))
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50537138(CHEMBL4531690)
Affinity DataIC50:  0.0110nMAssay Description:Displacement of fluorescent tracer from N-terminus of human RIPK2 expressed in HEK293T cells after 2 hrs by NanoBRET target engagement assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-G-associated kinase(Homo sapiens (Human))
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50537138(CHEMBL4531690)
Affinity DataIC50:  0.0600nMAssay Description:Displacement of fluorescent tracer from N-terminus of human GAK expressed in HEK293T cells after 2 hrs by NanoBRET target engagement assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Mer(Homo sapiens (Human))
University Of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50384584(CHEMBL2036807 | US9744172, Compound UNC607A)
Affinity DataIC50:  0.150nMAssay Description:Inhibition of Mer expressed in Escherichia coli BL21 (DE3) cells using EFPIYDFLPAKKK-CONH2 as substrate after 180 mins by microfluid capillary electr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Mer(Homo sapiens (Human))
University Of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50384583(CHEMBL2036806)
Affinity DataIC50:  0.25nMAssay Description:Inhibition of Mer expressed in Escherichia coli BL21 (DE3) cells using EFPIYDFLPAKKK-CONH2 as substrate after 180 mins by microfluid capillary electr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Unc Eshelman School Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50055496(CHEMBL3326006)
Affinity DataIC50:  0.350nMAssay Description:Inhibition of N-terminal GST-tagged human FLT3 cytoplasmic domain (564 to 993 end residues) expressed in baculovirus expression system using fluorece...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Mer(Homo sapiens (Human))
University Of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50055496(CHEMBL3326006)
Affinity DataIC50:  0.460nMAssay Description:Inhibition of N-terminal GST-tagged human MERTK cytoplasmic domain (528 to 999 end residues) expressed in baculovirus expression system using fluorec...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase Mer(Homo sapiens (Human))
University Of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50055498(CHEMBL3326004 | US10004755, Compound UNC1669A | US...)
Affinity DataIC50:  0.570nMAssay Description:Inhibition of Mer (unknown origin) by Off-chip Mobility Shift AssayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Mer(Homo sapiens (Human))
University Of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50469353(CHEMBL4283353)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of N-terminal GST-tagged human MERTK cytoplasmic domain (528 to 999 end residues) expressed in baculovirus expression system using fluorec...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Mer(Homo sapiens (Human))
University Of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50469353(CHEMBL4283353)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of N-terminal GST-tagged MERTK (528 to 999 residues) (unknown origin) cytoplasmic domain expressed in Sf21 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Mer(Homo sapiens (Human))
University Of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50444072(CHEMBL3092793)
Affinity DataIC50:  0.690nMAssay Description:Inhibition of Mer kinase (unknown origin) using 5-FAM-EFPIYDFLPAKKK-CONH2 as substrate after 180 mins by microfluidic capillary electrophoresis assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Mer(Homo sapiens (Human))
University Of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50444070(CHEMBL3092795)
Affinity DataIC50:  0.690nMAssay Description:Inhibition of Mer kinase (unknown origin) using 5-FAM-EFPIYDFLPAKKK-CONH2 as substrate after 180 mins by microfluidic capillary electrophoresis assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Mer(Homo sapiens (Human))
University Of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50444073(CHEMBL3092792)
Affinity DataIC50:  0.700nMAssay Description:Inhibition of Mer kinase (unknown origin) using 5-FAM-EFPIYDFLPAKKK-CONH2 as substrate after 180 mins by microfluidic capillary electrophoresis assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Mer(Homo sapiens (Human))
University Of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50055496(CHEMBL3326006)
Affinity DataIC50:  0.740nMAssay Description:Inhibition of Mer (unknown origin) by Off-chip Mobility Shift AssayMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase Mer(Homo sapiens (Human))
University Of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50384582(CHEMBL2036805)
Affinity DataIC50:  0.760nMAssay Description:Inhibition of Mer expressed in Escherichia coli BL21 (DE3) cells using EFPIYDFLPAKKK-CONH2 as substrate after 180 mins by microfluid capillary electr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Mer(Homo sapiens (Human))
University Of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM497267((2,6-dimethylpyridin-4- yl)(4-(7-((1R,4S)-4- hydro...)
Affinity DataIC50:  0.770nMAssay Description:Inhibition of N-terminal GST-tagged MERTK (528 to 999 residues) (unknown origin) cytoplasmic domain expressed in Sf21 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Unc Eshelman School Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50055496(CHEMBL3326006)
Affinity DataIC50:  0.800nMAssay Description:Inhibition of Flt3 (unknown origin) by Off-chip Mobility Shift AssayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Mer(Homo sapiens (Human))
University Of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50201078(CHEMBL3964573)
Affinity DataIC50:  0.800nMAssay Description:Inhibition of MerTK (unknown origin) by microfluidic capillary electrophoresis assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Mer(Homo sapiens (Human))
University Of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50444068(CHEMBL3092797)
Affinity DataIC50:  0.810nMAssay Description:Inhibition of Mer kinase (unknown origin) using 5-FAM-EFPIYDFLPAKKK-CONH2 as substrate after 180 mins by microfluidic capillary electrophoresis assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Mer(Homo sapiens (Human))
University Of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM497276((2,6-dimethylpyridin-4- yl)(4-(2-(((1S,2S)-2- ethy...)
Affinity DataIC50:  0.900nMAssay Description:Inhibition of MERTK (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
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