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Found 194 with Last Name = 'eckman' and Initial = 'j'
TargetHistamine H1 receptor(Homo sapiens (Human))
Ucb Pharma

Curated by ChEMBL
LigandPNGBDBM50073179(8-Chloro-11-piperidin-4-ylidene-6,11-dihydro-5H-be...)
Affinity DataKi:  0.970nMAssay Description:Binding affinity towards human histamine H1 receptor expressed in CHO-K1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetHistamine H1 receptor(Homo sapiens (Human))
Ucb Pharma

Curated by ChEMBL
LigandPNGBDBM50155336(1-{4-[4-(4-{4-[bis(4-fluorophenyl)methyl]piperazin...)
Affinity DataKi:  3.63nMAssay Description:Binding affinity for recombinant human Histamine H1 receptor expressed in CHO K1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Homo sapiens (Human))
Ucb Pharma

Curated by ChEMBL
LigandPNGBDBM50144624((5-{4-[(R)-(4-Chloro-phenyl)-phenyl-methyl]-pipera...)
Affinity DataKi:  4nMAssay Description:In vitro binding affinity towards histamine H1 receptor expressed in CHO-K1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Homo sapiens (Human))
Ucb Pharma

Curated by ChEMBL
LigandPNGBDBM50160828(CHEMBL366925 | N-hydroxycarbamate derivative)
Affinity DataKi:  5.01nMAssay Description:Binding affinity for human Histamine H1 receptor in CHO K1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Homo sapiens (Human))
Ucb Pharma

Curated by ChEMBL
LigandPNGBDBM50160827(CHEMBL179590 | N-hydroxycarbamate derivative)
Affinity DataKi:  5.89nMAssay Description:Binding affinity for human Histamine H1 receptor in CHO K1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Homo sapiens (Human))
Ucb Pharma

Curated by ChEMBL
LigandPNGBDBM22890(2-(2-{4-[(4-chlorophenyl)(phenyl)methyl]piperazin-...)
Affinity DataKi:  5.89nMAssay Description:Binding affinity for human Histamine H1 receptor in CHO K1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetHistamine H1 receptor(Homo sapiens (Human))
Ucb Pharma

Curated by ChEMBL
LigandPNGBDBM50160831(CHEMBL181085 | N-hydroxycarbamate derivative)
Affinity DataKi:  7.59nMAssay Description:Binding affinity for human Histamine H1 receptor in CHO K1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Homo sapiens (Human))
Ucb Pharma

Curated by ChEMBL
LigandPNGBDBM50155335(1-{4-[4-(3-{4-[(R)-(4-chlorophenyl)(phenyl)methyl]...)
Affinity DataKi:  9nMAssay Description:Binding affinity towards human histamine H1 receptor expressed in CHO-K1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Homo sapiens (Human))
Ucb Pharma

Curated by ChEMBL
LigandPNGBDBM50160829(CHEMBL180233 | N-hydroxycarbamate derivative)
Affinity DataKi:  9.55nMAssay Description:Binding affinity for human Histamine H1 receptor in CHO K1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Homo sapiens (Human))
Ucb Pharma

Curated by ChEMBL
LigandPNGBDBM50155341(1-(4-{4-[3-(4-{13-chloro-4-azatricyclo[9.4.0.0^{3,...)
Affinity DataKi:  14nMAssay Description:Binding affinity towards human histamine H1 receptor expressed in CHO-K1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Homo sapiens (Human))
Ucb Pharma

Curated by ChEMBL
LigandPNGBDBM22890(2-(2-{4-[(4-chlorophenyl)(phenyl)methyl]piperazin-...)
Affinity DataKi:  14nMAssay Description:In vitro binding affinity towards histamine H1 receptor expressed in CHO-K1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetHistamine H1 receptor(Homo sapiens (Human))
Ucb Pharma

Curated by ChEMBL
LigandPNGBDBM22890(2-(2-{4-[(4-chlorophenyl)(phenyl)methyl]piperazin-...)
Affinity DataKi:  14nMAssay Description:Binding affinity towards human histamine H1 receptor expressed in CHO-K1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetHistamine H1 receptor(Homo sapiens (Human))
Ucb Pharma

Curated by ChEMBL
LigandPNGBDBM50160830(CHEMBL360666 | N-hydroxycarbamate derivative)
Affinity DataKi:  17.8nMAssay Description:Binding affinity for human Histamine H1 receptor in CHO K1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Homo sapiens (Human))
Ucb Pharma

Curated by ChEMBL
LigandPNGBDBM50155337(1-(4-{4-[2-(4-{13-chloro-4-azatricyclo[9.4.0.0^{3,...)
Affinity DataKi:  19nMAssay Description:Binding affinity towards human histamine H1 receptor expressed in CHO-K1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Homo sapiens (Human))
Ucb Pharma

Curated by ChEMBL
LigandPNGBDBM50155336(1-{4-[4-(4-{4-[bis(4-fluorophenyl)methyl]piperazin...)
Affinity DataKi:  26nMAssay Description:Binding affinity towards human histamine H1 receptor expressed in CHO-K1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Homo sapiens (Human))
Ucb Pharma

Curated by ChEMBL
LigandPNGBDBM50155338(1-{4-[4-(4-{4-[(R)-(4-chlorophenyl)(phenyl)methyl]...)
Affinity DataKi:  30nMAssay Description:Binding affinity towards human histamine H1 receptor expressed in CHO-K1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Homo sapiens (Human))
Ucb Pharma

Curated by ChEMBL
LigandPNGBDBM50155334(1-(4-{4-[4-(4-{13-chloro-4-azatricyclo[9.4.0.0^{3,...)
Affinity DataKi:  50nMAssay Description:Binding affinity towards human histamine H1 receptor expressed in CHO-K1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Homo sapiens (Human))
Ucb Pharma

Curated by ChEMBL
LigandPNGBDBM50144626(CHEMBL305662 | [4-((2S,5S)-5-{4-[(R)-(4-Chloro-phe...)
Affinity DataKi:  50nMAssay Description:In vitro binding affinity towards histamine H1 receptor expressed in CHO-K1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Homo sapiens (Human))
Ucb Pharma

Curated by ChEMBL
LigandPNGBDBM50155339(1-{4-[4-(3-{4-[bis(4-fluorophenyl)methyl]piperazin...)
Affinity DataKi:  109nMAssay Description:Binding affinity towards human histamine H1 receptor expressed in CHO-K1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Homo sapiens (Human))
Ucb Pharma

Curated by ChEMBL
LigandPNGBDBM50144625(1-[4-(5-{4-[(R)-(4-Chloro-phenyl)-phenyl-methyl]-p...)
Affinity DataKi:  150nMAssay Description:In vitro binding affinity towards histamine H1 receptor expressed in CHO-K1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Homo sapiens (Human))
Ucb Pharma

Curated by ChEMBL
LigandPNGBDBM50144627(CHEMBL74688 | [4-((2R,5R)-5-{4-[(R)-(4-Chloro-phen...)
Affinity DataKi:  180nMAssay Description:In vitro binding affinity towards histamine H1 receptor expressed in CHO-K1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Homo sapiens (Human))
Ucb Pharma

Curated by ChEMBL
LigandPNGBDBM50144622(CHEMBL312082 | [3-(5-{4-[(R)-(4-Chloro-phenyl)-phe...)
Affinity DataKi:  190nMAssay Description:In vitro binding affinity towards histamine H1 receptor expressed in CHO-K1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Homo sapiens (Human))
Ucb Pharma

Curated by ChEMBL
LigandPNGBDBM50155340(1-{4-[4-(2-{4-[bis(4-fluorophenyl)methyl]piperazin...)
Affinity DataKi:  295nMAssay Description:Binding affinity towards human histamine H1 receptor expressed in CHO-K1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Homo sapiens (Human))
Ucb Pharma

Curated by ChEMBL
LigandPNGBDBM50155333(1-{4-[4-(2-{4-[(R)-(4-chlorophenyl)(phenyl)methyl]...)
Affinity DataKi:  305nMAssay Description:Binding affinity towards human histamine H1 receptor expressed in CHO-K1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Homo sapiens (Human))
Ucb Pharma

Curated by ChEMBL
LigandPNGBDBM22876(CHEMBL998 | Claritin | Loratadine | Sch 29851 | US...)
Affinity DataKi:  414nMAssay Description:Binding affinity towards human histamine H1 receptor expressed in CHO-K1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetHistamine H1 receptor(Homo sapiens (Human))
Ucb Pharma

Curated by ChEMBL
LigandPNGBDBM50144620(CHEMBL73706 | [4-(5-{4-[Bis-(4-fluoro-phenyl)-meth...)
Affinity DataKi:  550nMAssay Description:In vitro binding affinity towards histamine H1 receptor expressed in CHO-K1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Homo sapiens (Human))
Ucb Pharma

Curated by ChEMBL
LigandPNGBDBM50144623(CHEMBL74779 | [4-((2S,5S)-5-{4-[Bis-(4-fluoro-phen...)
Affinity DataKi:  660nMAssay Description:In vitro binding affinity towards histamine H1 receptor expressed in CHO-K1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50350832(CHEMBL1819274)
Affinity DataIC50:  1nMAssay Description:Inhibition of HDAC1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50350831(CHEMBL1819273)
Affinity DataIC50:  1nMAssay Description:Inhibition of HDAC1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50350818(CHEMBL1819257)
Affinity DataIC50:  1.30nMAssay Description:Inhibition of HDAC1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50350827(CHEMBL1819267)
Affinity DataIC50:  1.5nMAssay Description:Inhibition of HDAC1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-activating factor receptor(Homo sapiens (Human))
University Of Virginia

Curated by ChEMBL
LigandPNGBDBM50408421(CHEMBL2113725)
Affinity DataIC50:  2nMAssay Description:Displacement of [3H]-PAF from PAF receptor of human platelet membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50350820(CHEMBL1819260)
Affinity DataIC50:  2nMAssay Description:Inhibition of HDAC1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50350835(CHEMBL1819272)
Affinity DataIC50:  2nMAssay Description:Inhibition of HDAC1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50350833(CHEMBL1819275)
Affinity DataIC50:  3nMAssay Description:Inhibition of HDAC1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50350830(CHEMBL1819270)
Affinity DataIC50:  3nMAssay Description:Inhibition of HDAC1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50350821(CHEMBL1819261)
Affinity DataIC50:  4nMAssay Description:Inhibition of HDAC1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50350826(CHEMBL1819266)
Affinity DataIC50:  5nMAssay Description:Inhibition of HDAC1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50350829(CHEMBL1819269)
Affinity DataIC50:  6nMAssay Description:Inhibition of HDAC1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50350838(CHEMBL1819271)
Affinity DataIC50:  6nMAssay Description:Inhibition of HDAC1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-activating factor receptor(Homo sapiens (Human))
University Of Virginia

Curated by ChEMBL
LigandPNGBDBM50002823(2-{3-Methoxy-2-propoxy-5-[(2S,5S)-5-(3,4,5-trimeth...)
Affinity DataIC50:  6nMAssay Description:Displacement of [3H]-PAF from PAF receptor of human platelet membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50350824(CHEMBL1819264)
Affinity DataIC50:  8nMAssay Description:Inhibition of HDAC1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-activating factor receptor(Homo sapiens (Human))
University Of Virginia

Curated by ChEMBL
LigandPNGBDBM50286666(CHEMBL347382 | N-hydroxy-N'-[3-methoxy-5-(5-(3,4,5...)
Affinity DataIC50:  8nMAssay Description:In vitro inhibition of 5-lipoxygenase in RBL-2H3 (Rat basophilic leukaemia) cells.More data for this Ligand-Target Pair
In DepthDetails Article
TargetPlatelet-activating factor receptor(Homo sapiens (Human))
University Of Virginia

Curated by ChEMBL
LigandPNGBDBM50286666(CHEMBL347382 | N-hydroxy-N'-[3-methoxy-5-(5-(3,4,5...)
Affinity DataIC50:  8nMAssay Description:In vitro affinity for human PAF receptor on platelet membranes using [3H]-PAF displacement.More data for this Ligand-Target Pair
In DepthDetails Article
TargetHistone deacetylase 1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50350828(CHEMBL1819268)
Affinity DataIC50:  10nMAssay Description:Inhibition of HDAC1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-activating factor receptor(Homo sapiens (Human))
University Of Virginia

Curated by ChEMBL
LigandPNGBDBM50408414(CHEMBL2113720)
Affinity DataIC50:  10nMAssay Description:Displacement of [3H]-PAF from PAF receptor of human platelet membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50350822(CHEMBL1819262)
Affinity DataIC50:  11nMAssay Description:Inhibition of HDAC1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50350817(CHEMBL1819256)
Affinity DataIC50:  12nMAssay Description:Inhibition of HDAC1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50350816(CHEMBL1819255)
Affinity DataIC50:  12nMAssay Description:Inhibition of HDAC1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50350813(CHEMBL1819141)
Affinity DataIC50:  12nMAssay Description:Inhibition of HDAC1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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