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Found 823 with Last Name = 'ellis' and Initial = 'cd'
TargetCoagulation factor X(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50097626(1-(3-Carbamimidoyl-phenyl)-1H-tetrazole-5-carboxyl...)
Affinity DataKi:  0.0370nMAssay Description:Inhibition of human purified factor XaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50288406(1-(2-Acetylamino-3-phenyl-propionyl)-pyrrolidine-2...)
Affinity DataKi:  0.0400nMAssay Description:Inhibition of thrombinMore data for this Ligand-Target Pair
TargetCoagulation factor X(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50369433(CHEMBL1202108)
Affinity DataKi:  0.0400nMAssay Description:Binding affinity to purified human coagulation factor Xa (FXa)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50288406(1-(2-Acetylamino-3-phenyl-propionyl)-pyrrolidine-2...)
Affinity DataKi:  0.0450nMAssay Description:Inhibition of trypsinMore data for this Ligand-Target Pair
In DepthDetails Article
TargetProthrombin(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50369433(CHEMBL1202108)
Affinity DataKi:  0.0450nMAssay Description:The binding affinity towards thrombin obtained from human purified enzymes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM12659(1-(3-Aminobenzisoxazol-5-yl)-3-trifluoromethyl-5-[...)
Affinity DataKi:  0.0900nM ΔG°:  -56.8kJ/molepH: 7.0 T: 2°CAssay Description:Ki values were obtained from human purified enzyme. All assays were run in microtiter plates. Plates were read for 30 min at 405 nm. Rates were deter...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM12659(1-(3-Aminobenzisoxazol-5-yl)-3-trifluoromethyl-5-[...)
Affinity DataKi:  0.0900nMAssay Description:Inhibition of human factor 10aMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM12661(1-(3-Aminobenzisoxazol-5-yl)-3-trifluoromethyl-5-[...)
Affinity DataKi:  0.100nM ΔG°:  -56.5kJ/molepH: 7.0 T: 2°CAssay Description:Ki values were obtained from human purified enzyme. All assays were run in microtiter plates. Plates were read for 30 min at 405 nm. Rates were deter...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50079240(3-(3-Carbamimidoyl-phenyl)-5-tetrazol-1-ylmethyl-4...)
Affinity DataKi:  0.110nMAssay Description:Binding affinity towards human purified Coagulation factor Xa (FXa)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50289586(3-Methyl-2'-sulfamoyl-biphenyl-4-carboxylic acid [...)
Affinity DataKi:  0.110nMAssay Description:Inhibition of trypsinMore data for this Ligand-Target Pair
In DepthDetails Article
TargetCoagulation factor X(Oryctolagus cuniculus)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50079240(3-(3-Carbamimidoyl-phenyl)-5-tetrazol-1-ylmethyl-4...)
Affinity DataKi:  0.110nMAssay Description:Inhibitory activity against Rabbit factor Xa was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50079240(3-(3-Carbamimidoyl-phenyl)-5-tetrazol-1-ylmethyl-4...)
Affinity DataKi:  0.110nMAssay Description:Inhibitory activity against factor Xa using human purified enzyme.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50079257(3-(3-Carbamimidoyl-phenyl)-5-tetrazol-1-ylmethyl-4...)
Affinity DataKi:  0.150nMAssay Description:Binding affinity towards human purified Coagulation factor Xa (FXa)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM12657(1-[3-(Aminomethyl)phenyl]-N-[3-fluoro-2-(methylsul...)
Affinity DataKi:  0.150nM ΔG°:  -55.5kJ/molepH: 7.0 T: 2°CAssay Description:Ki values were obtained from human purified enzyme. All assays were run in microtiter plates. Plates were read for 30 min at 405 nm. Rates were deter...More data for this Ligand-Target Pair
TargetCoagulation factor X(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM12660(1-(3-Aminobenzisoxazol-5-yl)-3-trifluoromethyl-5-[...)
Affinity DataKi:  0.160nM ΔG°:  -55.3kJ/molepH: 7.0 T: 2°CAssay Description:Ki values were obtained from human purified enzyme. All assays were run in microtiter plates. Plates were read for 30 min at 405 nm. Rates were deter...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50079240(3-(3-Carbamimidoyl-phenyl)-5-tetrazol-1-ylmethyl-4...)
Affinity DataKi:  0.170nMAssay Description:Inhibitory activity against trypsin using human purified enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50079240(3-(3-Carbamimidoyl-phenyl)-5-tetrazol-1-ylmethyl-4...)
Affinity DataKi:  0.170nMAssay Description:Binding affinity towards human purified Coagulation factor Xa (FXa)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM12675(1-(3-amino-1,2-benzoxazol-5-yl)-N-(2-fluoro-4-{2-[...)
Affinity DataKi:  0.170nM ΔG°:  -55.2kJ/molepH: 7.0 T: 2°CAssay Description:Ki values were obtained from human purified enzyme. All assays were run in microtiter plates. Plates were read for 30 min at 405 nm. Rates were deter...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM12676(1-(3-Aminobenzisoxazol-5-yl)-3-trifluoromethyl-N-[...)
Affinity DataKi:  0.190nM ΔG°:  -54.9kJ/molepH: 7.0 T: 2°CAssay Description:Ki values were obtained from human purified enzyme. All assays were run in microtiter plates. Plates were read for 30 min at 405 nm. Rates were deter...More data for this Ligand-Target Pair
TargetCoagulation factor X(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50224712(1-(3-aminobenzo[d]isoxazol-5-yl)-5-(5-(2-oxopyridi...)
Affinity DataKi:  0.200nMAssay Description:Inhibition of human factor 10aMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50084682(1-[3-(4-Carbamimidoyl-phenyl)-2-(2-methyl-1,2,3,4-...)
Affinity DataKi:  0.210nMAssay Description:Inhibition of thrombinMore data for this Ligand-Target Pair
In DepthDetails Article
TargetCoagulation factor X(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50079253(3-(3-Carbamimidoyl-phenyl)-5-tetrazol-1-ylmethyl-4...)
Affinity DataKi:  0.320nMAssay Description:Binding affinity towards human purified Coagulation factor Xa (FXa)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50123033(1-(3-Amino-benzo[d]isoxazol-5-yl)-1H-tetrazole-5-c...)
Affinity DataKi:  0.350nMAssay Description:Inhibition of human purified factor XaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50289591(2'-Diethylsulfamoyl-3-methyl-biphenyl-4-carboxylic...)
Affinity DataKi:  0.360nMAssay Description:Inhibition of thrombinMore data for this Ligand-Target Pair
In DepthDetails Article
TargetCoagulation factor X(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM12677(1-(3-Aminobenzisoxazol-5-yl)-3-trifluoromethyl-N-[...)
Affinity DataKi:  0.370nM ΔG°:  -53.3kJ/molepH: 7.0 T: 2°CAssay Description:Ki values were obtained from human purified enzyme. All assays were run in microtiter plates. Plates were read for 30 min at 405 nm. Rates were deter...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50123037(1-(3-Amino-benzo[d]isoxazol-5-yl)-1H-tetrazole-5-c...)
Affinity DataKi:  0.390nMAssay Description:Inhibition of human purified factor XaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50289587(3-Methyl-biphenyl-4-carboxylic acid [(R)-4-guanidi...)
Affinity DataKi:  0.420nMAssay Description:Inhibition of thrombinMore data for this Ligand-Target Pair
In DepthDetails Article
TargetCoagulation factor X(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50079238(3-(3-Carbamimidoyl-phenyl)-5-tetrazol-1-ylmethyl-4...)
Affinity DataKi:  0.440nMAssay Description:Binding affinity towards human purified Coagulation factor Xa (FXa)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50289575(3-Methyl-2'-trifluoromethyl-biphenyl-4-carboxylic ...)
Affinity DataKi:  0.460nMAssay Description:Inhibition of thrombinMore data for this Ligand-Target Pair
In DepthDetails Article
TargetCoagulation factor X(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM12662(1-(3-Aminobenzisoxazol-5-yl)-3-trifluoromethyl-5-[...)
Affinity DataKi:  0.510nM ΔG°:  -52.5kJ/molepH: 7.0 T: 2°CAssay Description:Ki values were obtained from human purified enzyme. All assays were run in microtiter plates. Plates were read for 30 min at 405 nm. Rates were deter...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM12666(1-(3-Aminobenzisoxazol-5-yl)-3-trifluoromethyl-5-[...)
Affinity DataKi:  0.520nM ΔG°:  -52.5kJ/molepH: 7.0 T: 2°CAssay Description:Ki values were obtained from human purified enzyme. All assays were run in microtiter plates. Plates were read for 30 min at 405 nm. Rates were deter...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50079236(3-(3-Carbamimidoyl-phenyl)-5-tetrazol-1-ylmethyl-4...)
Affinity DataKi:  0.520nMAssay Description:Binding affinity towards human purified Coagulation factor Xa (FXa)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM12667(1-(3-Aminobenzisoxazol-5-yl)-3-trifluoromethyl-5-[...)
Affinity DataKi:  0.600nM ΔG°:  -52.1kJ/molepH: 7.0 T: 2°CAssay Description:Ki values were obtained from human purified enzyme. All assays were run in microtiter plates. Plates were read for 30 min at 405 nm. Rates were deter...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50289591(2'-Diethylsulfamoyl-3-methyl-biphenyl-4-carboxylic...)
Affinity DataKi:  0.620nMAssay Description:Inhibition of trypsinMore data for this Ligand-Target Pair
In DepthDetails Article
TargetCoagulation factor X(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50224704(1-(3-aminobenzo[d]isoxazol-5-yl)-5-(5-(2-(pyrrolid...)
Affinity DataKi:  0.630nMAssay Description:Inhibition of human factor 10aMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50289582(3-Methyl-2'-methylsulfonylcarbamate-biphenyl-4-car...)
Affinity DataKi:  0.640nMAssay Description:Inhibition of trypsinMore data for this Ligand-Target Pair
In DepthDetails Article
TargetSerine protease 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50084682(1-[3-(4-Carbamimidoyl-phenyl)-2-(2-methyl-1,2,3,4-...)
Affinity DataKi:  0.700nMAssay Description:Inhibition of trypsinMore data for this Ligand-Target Pair
In DepthDetails Article
TargetCoagulation factor X(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM12663(1-(3-Aminobenzisoxazol-5-yl)-3-trifluoromethyl-5-[...)
Affinity DataKi:  0.700nM ΔG°:  -51.7kJ/molepH: 7.0 T: 2°CAssay Description:Ki values were obtained from human purified enzyme. All assays were run in microtiter plates. Plates were read for 30 min at 405 nm. Rates were deter...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM12671(1-(3-Aminobenzisoxazol-5-yl)-3-trifluoromethyl-5-[...)
Affinity DataKi:  0.730nM ΔG°:  -51.6kJ/molepH: 7.0 T: 2°CAssay Description:Ki values were obtained from human purified enzyme. All assays were run in microtiter plates. Plates were read for 30 min at 405 nm. Rates were deter...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50079230(3-(3-Carbamimidoyl-phenyl)-5-ethoxymethyl-4,5-dihy...)
Affinity DataKi:  0.800nMAssay Description:Binding affinity towards human purified Coagulation factor Xa (FXa)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50224711(1-(3-aminobenzo[d]isoxazol-5-yl)-5-(5-(2-(methylsu...)
Affinity DataKi:  0.820nMAssay Description:Inhibition of human factor 10aMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50079211(CHEMBL327404 | {3-(3-Carbamimidoyl-phenyl)-5-[5-(2...)
Affinity DataKi:  0.830nMAssay Description:Binding affinity to purified human coagulation factor Xa (FXa)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50079211(CHEMBL327404 | {3-(3-Carbamimidoyl-phenyl)-5-[5-(2...)
Affinity DataKi:  0.830nMAssay Description:Binding affinity to purified human coagulation factor Xa (FXa)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50289586(3-Methyl-2'-sulfamoyl-biphenyl-4-carboxylic acid [...)
Affinity DataKi:  0.920nMAssay Description:Inhibition of thrombinMore data for this Ligand-Target Pair
In DepthDetails Article
TargetCoagulation factor X(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM12664(1-(3-Aminobenzisoxazol-5-yl)-3-trifluoromethyl-5-[...)
Affinity DataKi:  0.920nM ΔG°:  -51.1kJ/molepH: 7.0 T: 2°CAssay Description:Ki values were obtained from human purified enzyme. All assays were run in microtiter plates. Plates were read for 30 min at 405 nm. Rates were deter...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50079251(3-(3-Carbamimidoyl-phenyl)-5-tetrazol-1-ylmethyl-4...)
Affinity DataKi:  0.920nMAssay Description:Binding affinity towards human purified Coagulation factor Xa (FXa)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50289576(Biphenyl-4-carboxylic acid [(R)-4-guanidino-1-((2S...)
Affinity DataKi:  0.940nMAssay Description:Inhibition of thrombinMore data for this Ligand-Target Pair
In DepthDetails Article
TargetCoagulation factor X(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50123038(1-(3-Amino-benzo[d]isoxazol-5-yl)-1H-tetrazole-5-c...)
Affinity DataKi:  0.980nMAssay Description:Inhibition of human purified factor XaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50079250(3-(3-Carbamimidoyl-phenyl)-5-tetrazol-1-ylmethyl-4...)
Affinity DataKi:  1nMAssay Description:Binding affinity towards human purified Coagulation factor Xa (FXa)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM12673(1-(3-amino-1,2-benzoxazol-5-yl)-N-{2-fluoro-4-[2-(...)
Affinity DataKi:  1nM ΔG°:  -50.9kJ/molepH: 7.0 T: 2°CAssay Description:Ki values were obtained from human purified enzyme. All assays were run in microtiter plates. Plates were read for 30 min at 405 nm. Rates were deter...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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