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Found 549 with Last Name = 'evdokimov' and Initial = 'a'
TargetTyrosine-protein phosphatase non-receptor type 1 [1-298](Homo sapiens (Human))
Procter & Gamble Pharmaceuticals

LigandPNGBDBM13433(N-[(3S)-2-[(tert-butoxy)carbonyl]-3-(methylcarbamo...)
Affinity DataKi:  2.40E+4nM ΔG°:  -26.1kJ/molepH: 7.0 T: 2°CAssay Description:The activity of PTP1B enzyme was assayed with DiFMUP as substrate. Hydrolysis of substrate was monitored on a Victor V plate reader (Wallac). Kinetic...More data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1 [1-298](Homo sapiens (Human))
Procter & Gamble Pharmaceuticals

LigandPNGBDBM13529(N-(1-methyl-3-phenyl-1H-pyrazol-5-yl)sulfamic acid...)
Affinity DataKi: >5.00E+5nMAssay Description:The activity of PTP1B enzyme was assayed with DiFMUP as substrate. Hydrolysis of substrate was monitored on a Victor V plate reader (Wallac). Kinetic...More data for this Ligand-Target Pair
TargetCyclin-C/Cyclin-dependent kinase 8(Homo sapiens (Human))
Joint Stock Company “Biocad”

US Patent
LigandPNGBDBM640341(8-Amino-N-(cyclopropylmethyl)-5-(4- (1-(2-(dimethy...)
Affinity DataIC50:  0.880nMAssay Description:Capability of compounds of the present invention to bind to CDK8 protein was detected using LanthaScreen (ThermoFisher) assay. We detected FRET signa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclin-C/Cyclin-dependent kinase 8(Homo sapiens (Human))
Joint Stock Company “Biocad”

US Patent
LigandPNGBDBM640350(2-(4-(4-(8-amino-3-(azetidine-1- carbonyl)-1,7-nap...)
Affinity DataIC50:  0.960nMAssay Description:Capability of compounds of the present invention to bind to CDK8 protein was detected using LanthaScreen (ThermoFisher) assay. We detected FRET signa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Procter And Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50193734(2-{[3-(4-methoxy-phenyl)-1-(3-trifluoromethyl-benz...)
Affinity DataIC50:  1nMAssay Description:Displacement of Fluormone from PPAR gammaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-C/Cyclin-dependent kinase 8(Homo sapiens (Human))
Joint Stock Company “Biocad”

US Patent
LigandPNGBDBM640351(2-(4-(4-(8-amino-3-(azetidine-1- carbonyl)-1,7-nap...)
Affinity DataIC50:  1.01nMAssay Description:Capability of compounds of the present invention to bind to CDK8 protein was detected using LanthaScreen (ThermoFisher) assay. We detected FRET signa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclin-C/Cyclin-dependent kinase 8(Homo sapiens (Human))
Joint Stock Company “Biocad”

US Patent
LigandPNGBDBM640354(8-amino-N-(2-methoxyethyl)-N- methyl-5-(4-(1-(2-(4...)
Affinity DataIC50:  1.07nMAssay Description:Capability of compounds of the present invention to bind to CDK8 protein was detected using LanthaScreen (ThermoFisher) assay. We detected FRET signa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclin-C/Cyclin-dependent kinase 8(Homo sapiens (Human))
Joint Stock Company “Biocad”

US Patent
LigandPNGBDBM640346(8-amino-N-cyclopropyl-5-(4-(1-(2-(2- methoxyethyl)...)
Affinity DataIC50:  1.10nMAssay Description:Capability of compounds of the present invention to bind to CDK8 protein was detected using LanthaScreen (ThermoFisher) assay. We detected FRET signa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclin-C/Cyclin-dependent kinase 8(Homo sapiens (Human))
Joint Stock Company “Biocad”

US Patent
LigandPNGBDBM640345(8-amino-N-cyclopropyl-5-(4-(1-(2-(4- methylpiperaz...)
Affinity DataIC50:  1.10nMAssay Description:Capability of compounds of the present invention to bind to CDK8 protein was detected using LanthaScreen (ThermoFisher) assay. We detected FRET signa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclin-C/Cyclin-dependent kinase 8(Homo sapiens (Human))
Joint Stock Company “Biocad”

US Patent
LigandPNGBDBM640344(8-amino-N-cyclopropyl-5-(4-(1-(2- (dimethylamino)-...)
Affinity DataIC50:  1.11nMAssay Description:Capability of compounds of the present invention to bind to CDK8 protein was detected using LanthaScreen (ThermoFisher) assay. We detected FRET signa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclin-C/Cyclin-dependent kinase 8(Homo sapiens (Human))
Joint Stock Company “Biocad”

US Patent
LigandPNGBDBM640353(8-amino-5-(4-(1-(2-(dimethylamino)- 2-oxoethyl)-1H...)
Affinity DataIC50:  1.24nMAssay Description:Capability of compounds of the present invention to bind to CDK8 protein was detected using LanthaScreen (ThermoFisher) assay. We detected FRET signa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclin-C/Cyclin-dependent kinase 8(Homo sapiens (Human))
Joint Stock Company “Biocad”

US Patent
LigandPNGBDBM640352((8-amino-5-(4-(1-(2-methoxyethyl)- 1H-pyrazole-4-y...)
Affinity DataIC50:  1.27nMAssay Description:Capability of compounds of the present invention to bind to CDK8 protein was detected using LanthaScreen (ThermoFisher) assay. We detected FRET signa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclin-C/Cyclin-dependent kinase 8(Homo sapiens (Human))
Joint Stock Company “Biocad”

US Patent
LigandPNGBDBM640342(8-amino-N-(cyclopropylmethyl)-5-(4- (1-(2-(4-methy...)
Affinity DataIC50:  1.40nMAssay Description:Capability of compounds of the present invention to bind to CDK8 protein was detected using LanthaScreen (ThermoFisher) assay. We detected FRET signa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclin-C/Cyclin-dependent kinase 8(Homo sapiens (Human))
Joint Stock Company “Biocad”

US Patent
LigandPNGBDBM640349((8-amino-5-(4-(1-(2-methoxyethyl)- 1H-pyrazole-4-y...)
Affinity DataIC50:  1.44nMAssay Description:Capability of compounds of the present invention to bind to CDK8 protein was detected using LanthaScreen (ThermoFisher) assay. We detected FRET signa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclin-C/Cyclin-dependent kinase 8(Homo sapiens (Human))
Joint Stock Company “Biocad”

US Patent
LigandPNGBDBM640343(8-amino-N-(cyclopropylmethyl)-5-(4- (1-(2-methoxye...)
Affinity DataIC50:  1.63nMAssay Description:Capability of compounds of the present invention to bind to CDK8 protein was detected using LanthaScreen (ThermoFisher) assay. We detected FRET signa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclin-C/Cyclin-dependent kinase 8(Homo sapiens (Human))
Joint Stock Company “Biocad”

US Patent
LigandPNGBDBM640347(2-(4-(4-(8-amino-3-(4- methylpiperazine-1-carbonyl...)
Affinity DataIC50:  1.85nMAssay Description:Capability of compounds of the present invention to bind to CDK8 protein was detected using LanthaScreen (ThermoFisher) assay. We detected FRET signa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Procter And Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50193736(1-(3-(trifluoromethyl)benzyl)-3-(4-methoxyphenyl)-...)
Affinity DataIC50:  2nMAssay Description:Displacement of Fluormone from PPAR gammaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-C/Cyclin-dependent kinase 8(Homo sapiens (Human))
Joint Stock Company “Biocad”

US Patent
LigandPNGBDBM640348(2-(4-(4-(8-amino-3-(4- methylpiperazine-1-carbonyl...)
Affinity DataIC50:  2.03nMAssay Description:Capability of compounds of the present invention to bind to CDK8 protein was detected using LanthaScreen (ThermoFisher) assay. We detected FRET signa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclin-C/Cyclin-dependent kinase 8(Homo sapiens (Human))
Joint Stock Company “Biocad”

US Patent
LigandPNGBDBM640355(8-amino-N-(2-methoxyethyl)-5-(4-(1- (2-methoxyethy...)
Affinity DataIC50:  2.27nMAssay Description:Capability of compounds of the present invention to bind to CDK8 protein was detected using LanthaScreen (ThermoFisher) assay. We detected FRET signa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Procter And Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50193748(1-(3-(trifluoromethyl)benzyl)-3-(4-methoxyphenyl)-...)
Affinity DataIC50:  3nMAssay Description:Displacement of Fluormone from PPAR gammaMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Procter And Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50195351(1-(3-(2,5-dimethylbenzyl)-5-(3-cyclohexylpropyl)ph...)
Affinity DataIC50:  3nMAssay Description:Inhibition of human recombinant Lck by ProFlour assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Procter And Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50195345(3-(2-(1H-benzo[d]imidazol-1-yl)-6-(4-methylpiperaz...)
Affinity DataIC50:  3nMAssay Description:Inhibition of human recombinant Lck by ProFlour assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Procter And Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50195334(3-(2-(1H-benzo[d]imidazol-1-yl)-6-(2-(diethylamino...)
Affinity DataIC50:  3nMAssay Description:Inhibition of human recombinant Lck by ProFlour assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Procter And Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50195340(3-(4-(benzo[d]isoxazol-3-yl)pyrimidin-2-ylamino)-4...)
Affinity DataIC50:  4.20nMAssay Description:Inhibition of human recombinant Lck by ProFlour assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFarnesyl pyrophosphate synthase(Homo sapiens (Human))
University Of Southern California

Curated by ChEMBL
LigandPNGBDBM12576(Bisphosphonate 1 | CHEMBL923 | JMC515594 Compound ...)
Affinity DataIC50:  5.70nMAssay Description:Inhibition of human FPPSMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Procter And Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50195354(CHEMBL220924 | N1-(4-(benzo[d]isoxazol-3-yl)pyrimi...)
Affinity DataIC50:  6.80nMAssay Description:Inhibition of human recombinant Lck by ProFlour assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Procter And Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50193751(1-(3-(trifluoromethyl)benzyl)-3-(4-methoxyphenyl)-...)
Affinity DataIC50:  7nMAssay Description:Displacement of Fluormone from PPAR gammaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Procter And Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50193744(1-(3-(trifluoromethyl)benzyl)-N-(4-fluorophenylsul...)
Affinity DataIC50:  7nMAssay Description:Displacement of Fluormone from PPAR gammaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Procter And Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50195338(3-(2-(1H-benzo[d]imidazol-1-yl)-6-(2-morpholinoeth...)
Affinity DataIC50:  17nMAssay Description:Inhibition of human recombinant Lck by ProFlour assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50386310(CHEMBL2049092)
Affinity DataIC50:  22nMAssay Description:Inhibition of human recombinant KAT2 assessed as conversion of L-kynurenine into kynurenic acid after 15 to 20 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50386292(CHEMBL2047851)
Affinity DataIC50:  23nMAssay Description:Inhibition of human recombinant KAT2 assessed as conversion of L-kynurenine into kynurenic acid after 15 to 20 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Procter And Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50195329(3-(2-(1H-benzo[d]imidazol-1-yl)pyrimidin-4-ylamino...)
Affinity DataIC50:  24nMAssay Description:Inhibition of human recombinant Lck by ProFlour assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50386308(CHEMBL2047861)
Affinity DataIC50:  29nMAssay Description:Inhibition of human recombinant KAT2 assessed as conversion of L-kynurenine into kynurenic acid after 15 to 20 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50386294(CHEMBL2049095)
Affinity DataIC50:  29nMAssay Description:Inhibition of human recombinant KAT2 assessed as conversion of L-kynurenine into kynurenic acid after 15 to 20 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50386312(CHEMBL2049094)
Affinity DataIC50:  30nMAssay Description:Inhibition of human recombinant KAT2 assessed as conversion of L-kynurenine into kynurenic acid after 15 to 20 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50386311(CHEMBL2049093)
Affinity DataIC50:  36nMAssay Description:Inhibition of human recombinant KAT2 assessed as conversion of L-kynurenine into kynurenic acid after 15 to 20 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50386309(CHEMBL2047862)
Affinity DataIC50:  37nMAssay Description:Inhibition of human recombinant KAT2 assessed as conversion of L-kynurenine into kynurenic acid after 15 to 20 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50386303(CHEMBL2047856)
Affinity DataIC50:  40nMAssay Description:Inhibition of human recombinant KAT2 assessed as conversion of L-kynurenine into kynurenic acid after 15 to 20 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Procter And Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50195342(3-(2-(1H-benzo[d]imidazol-1-yl)-6-((1-methylpiperi...)
Affinity DataIC50:  43nMAssay Description:Inhibition of human recombinant Lck by ProFlour assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Procter And Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50195331(3-(2-(1H-benzo[d]imidazol-1-yl)-6-(3-(dimethylamin...)
Affinity DataIC50:  44nMAssay Description:Inhibition of human recombinant Lck by ProFlour assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Procter And Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50195352(3-(2-(1H-benzo[d]imidazol-1-yl)-6-(2-(4-methylpipe...)
Affinity DataIC50:  45nMAssay Description:Inhibition of human recombinant Lck by ProFlour assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50386295(CHEMBL2049096)
Affinity DataIC50:  45nMAssay Description:Inhibition of human recombinant KAT2 assessed as conversion of L-kynurenine into kynurenic acid after 15 to 20 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase HCK(Homo sapiens (Human))
Procter And Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50195334(3-(2-(1H-benzo[d]imidazol-1-yl)-6-(2-(diethylamino...)
Affinity DataIC50:  46nMAssay Description:Inhibition of human recombinant Hck by ProFlour assayMore data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Procter And Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50193733(1-(3-(benzyloxy)benzyl)-N-(3-(trifluoromethyl)phen...)
Affinity DataIC50:  50nMAssay Description:Displacement of Fluormone from PPAR gammaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein phosphatase beta(Homo sapiens (Human))
Procter & Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50188792(CHEMBL213750 | ammonium N-{4-[3-methoxy-2-(methoxy...)
Affinity DataIC50:  60nMAssay Description:Inhibition of HPTPbetaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Procter And Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50193729(1-(3-(trifluoromethyl)benzyl)-3-(4-methoxyphenyl)-...)
Affinity DataIC50:  60nMAssay Description:Displacement of Fluormone from PPAR gammaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Procter And Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50195343(3-(2-(1H-benzo[d]imidazol-1-yl)-6-(2-(4-methylpipe...)
Affinity DataIC50:  65nMAssay Description:Inhibition of human recombinant Lck by ProFlour assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein phosphatase beta(Homo sapiens (Human))
Procter & Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50188795(CHEMBL386550 | ammonium N-{4-[2,2-bis(3-methyl-1,2...)
Affinity DataIC50:  70nMAssay Description:Inhibition of HPTPbetaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Procter And Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50195344(3-(2-(1H-benzo[d]imidazol-1-yl)-6-methoxypyrimidin...)
Affinity DataIC50:  71nMAssay Description:Inhibition of human recombinant Lck by ProFlour assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Procter And Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50195346(3-(2-(1H-benzo[d]imidazol-1-yl)-6-(methylamino)pyr...)
Affinity DataIC50:  79nMAssay Description:Inhibition of human recombinant Lck by ProFlour assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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