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Found 268 with Last Name = 'finzel' and Initial = 'bc'
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Pharmacia & Upjohn

Curated by ChEMBL
LigandPNGBDBM50054629(3-(Cyclopropyl-phenyl-methyl)-4-hydroxy-6,6-diprop...)
Affinity DataKi:  15nMAssay Description:HIV Protease inhibitory activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Upjohn

LigandPNGBDBM771(3-[cyclopropyl(phenyl)methyl]-4-hydroxy-2H,5H,6H,7...)
Affinity DataKi:  15nM ΔG°:  -44.2kJ/molepH: 5.0 T: 2°CAssay Description:HIV-1 protease was purified and refolded from E. coli inclusion bodies. The substrate used spans the p17-p24 processing site (R-V-S-Q-N-Y-P-I-V-Q-N-K...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Pharmacia & Upjohn

Curated by ChEMBL
LigandPNGBDBM50054610(4-Hydroxy-6-phenethyl-3-(1-phenyl-allyl)-6-propyl-...)
Affinity DataKi:  16nMAssay Description:HIV Protease inhibitory activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Upjohn

LigandPNGBDBM784(4-hydroxy-3-(2-methyl-1-phenylpropyl)-2H,5H,6H,7H,...)
Affinity DataKi:  22nM ΔG°:  -43.3kJ/molepH: 5.0 T: 2°CAssay Description:HIV-1 protease was purified and refolded from E. coli inclusion bodies. The substrate used spans the p17-p24 processing site (R-V-S-Q-N-Y-P-I-V-Q-N-K...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Pharmacia & Upjohn

Curated by ChEMBL
LigandPNGBDBM50054615(4-Hydroxy-3-(1-phenyl-propyl)-6,6-dipropyl-5,6-dih...)
Affinity DataKi:  22nMAssay Description:HIV Protease inhibitory activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Upjohn

LigandPNGBDBM783(4-hydroxy-3-(1-phenylbutyl)-2H,5H,6H,7H,8H,9H,10H-...)
Affinity DataKi:  29nM ΔG°:  -42.6kJ/molepH: 5.0 T: 2°CAssay Description:HIV-1 protease was purified and refolded from E. coli inclusion bodies. The substrate used spans the p17-p24 processing site (R-V-S-Q-N-Y-P-I-V-Q-N-K...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Pharmacia & Upjohn

Curated by ChEMBL
LigandPNGBDBM50054616(3-(1,3-Diphenyl-propyl)-4-hydroxy-6-phenethyl-6-pr...)
Affinity DataKi:  33nMAssay Description:HIV Protease inhibitory activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Pharmacia & Upjohn

Curated by ChEMBL
LigandPNGBDBM50054619(4-Hydroxy-6-phenethyl-3-(1-phenyl-propyl)-6-propyl...)
Affinity DataKi:  35nMAssay Description:HIV Protease inhibitory activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Pharmacia & Upjohn

Curated by ChEMBL
LigandPNGBDBM50054630(3-(Cyclopentyl-phenyl-methyl)-4-hydroxy-6,6-diprop...)
Affinity DataKi:  39nMAssay Description:HIV Protease inhibitory activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Pharmacia & Upjohn

Curated by ChEMBL
LigandPNGBDBM50054614(3-((E)-1,3-Diphenyl-allyl)-4-hydroxy-6-phenethyl-6...)
Affinity DataKi:  50nMAssay Description:HIV Protease inhibitory activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Upjohn

LigandPNGBDBM789(3-(Dicyclopropylmethy1)-5,6,7,8,9,l0-hexahydro-4-d...)
Affinity DataKi:  57nM ΔG°:  -40.9kJ/molepH: 5.0 T: 2°CAssay Description:HIV-1 protease was purified and refolded from E. coli inclusion bodies. The substrate used spans the p17-p24 processing site (R-V-S-Q-N-Y-P-I-V-Q-N-K...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Pharmacia & Upjohn

Curated by ChEMBL
LigandPNGBDBM50054618(3-(Cyclopentyl-phenyl-methyl)-4-hydroxy-6-phenethy...)
Affinity DataKi:  59nMAssay Description:HIV Protease inhibitory activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Upjohn

LigandPNGBDBM786(4-hydroxy-3-(1-phenylpentyl)-2H,5H,6H,7H,8H,9H,10H...)
Affinity DataKi:  62nM ΔG°:  -40.7kJ/molepH: 5.0 T: 2°CAssay Description:HIV-1 protease was purified and refolded from E. coli inclusion bodies. The substrate used spans the p17-p24 processing site (R-V-S-Q-N-Y-P-I-V-Q-N-K...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Pharmacia & Upjohn

Curated by ChEMBL
LigandPNGBDBM50054628(3-(Cyclopropyl-phenyl-methyl)-4-hydroxy-6-phenethy...)
Affinity DataKi:  64nMAssay Description:HIV Protease inhibitory activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Upjohn

LigandPNGBDBM782(4-hydroxy-3-(1-phenylpropyl)-2H,5H,6H,7H,8H,9H,10H...)
Affinity DataKi:  75nM ΔG°:  -40.3kJ/molepH: 5.0 T: 2°CAssay Description:HIV-1 protease was purified and refolded from E. coli inclusion bodies. The substrate used spans the p17-p24 processing site (R-V-S-Q-N-Y-P-I-V-Q-N-K...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Upjohn

LigandPNGBDBM787(4-hydroxy-3-(3-methyl-1-phenylbutyl)-2H,5H,6H,7H,8...)
Affinity DataKi:  90nM ΔG°:  -39.8kJ/molepH: 5.0 T: 2°CAssay Description:HIV-1 protease was purified and refolded from E. coli inclusion bodies. The substrate used spans the p17-p24 processing site (R-V-S-Q-N-Y-P-I-V-Q-N-K...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Pharmacia & Upjohn

Curated by ChEMBL
LigandPNGBDBM50054608(4-Hydroxy-6-phenyl-3-(1-phenyl-propyl)-6-propyl-5,...)
Affinity DataKi:  95nMAssay Description:HIV Protease inhibitory activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Pharmacia & Upjohn

Curated by ChEMBL
LigandPNGBDBM50054609(6-Ethyl-4-hydroxy-6-phenyl-3-(1-phenyl-propyl)-5,6...)
Affinity DataKi:  160nMAssay Description:HIV Protease inhibitory activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Upjohn

LigandPNGBDBM788(3-(Diphenylmethyl)-5,6,7,8,9,1O-hexahydro-4-hydrox...)
Affinity DataKi:  180nM ΔG°:  -38.1kJ/molepH: 5.0 T: 2°CAssay Description:HIV-1 protease was purified and refolded from E. coli inclusion bodies. The substrate used spans the p17-p24 processing site (R-V-S-Q-N-Y-P-I-V-Q-N-K...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Pharmacia & Upjohn

Curated by ChEMBL
LigandPNGBDBM50054624(6-Cyclohexyl-4-hydroxy-3-[1-(3-hydroxy-phenyl)-pro...)
Affinity DataKi:  610nMAssay Description:HIV Protease inhibitory activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50382322(CHEMBL2024689)
Affinity DataIC50:  1nMAssay Description:Inhibition of ALK5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50382321(CHEMBL2024688)
Affinity DataIC50:  1nMAssay Description:Inhibition of ALK5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50382324(CHEMBL2024691)
Affinity DataIC50:  2nMAssay Description:Inhibition of ALK5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50382320(CHEMBL2024687)
Affinity DataIC50:  3nMAssay Description:Inhibition of ALK5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50382319(CHEMBL2024686)
Affinity DataIC50:  4nMAssay Description:Inhibition of ALK5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50382318(CHEMBL2024685)
Affinity DataIC50:  4nMAssay Description:Inhibition of ALK5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50382325(CHEMBL2024693)
Affinity DataIC50:  5nMAssay Description:Inhibition of ALK5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50382323(CHEMBL2024690)
Affinity DataIC50:  6nMAssay Description:Inhibition of ALK5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50382317(CHEMBL2024684)
Affinity DataIC50:  13nMAssay Description:Inhibition of ALK5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50166407((Z)-2-Benzoylamino-3-[4-(2-bromo-6-fluoro-phenoxy)...)
Affinity DataIC50:  30nMAssay Description:Inhibitory concentration against RNA dependent RNA polymerase Nonstructural protein 5B (HCV NS5B polymerase) in Hepatitis C virusMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50166407((Z)-2-Benzoylamino-3-[4-(2-bromo-6-fluoro-phenoxy)...)
Affinity DataIC50:  30nMAssay Description:Inhibitory concentration against Hepatitis C virus NS5B polymeraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50166360((Z)-2-Benzoylamino-3-[4-(2-iodo-phenoxy)-phenyl]-a...)
Affinity DataIC50:  40nMAssay Description:Inhibitory concentration against Hepatitis C virus NS5B polymeraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTGF-beta receptor type-1(Mus musculus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50382318(CHEMBL2024685)
Affinity DataIC50:  44nMAssay Description:Inhibition of ALK5 in mouse NIH/3T3 cells by smad binding element reporter based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTGF-beta receptor type-1(Mus musculus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50382325(CHEMBL2024693)
Affinity DataIC50:  46nMAssay Description:Inhibition of ALK5 in mouse NIH/3T3 cells by smad binding element reporter based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTGF-beta receptor type-1(Mus musculus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50382324(CHEMBL2024691)
Affinity DataIC50:  47nMAssay Description:Inhibition of ALK5 in mouse NIH/3T3 cells by smad binding element reporter based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50167658((Z)-3-[4-(2-Bromo-phenoxy)-phenyl]-2-(2-ethyl-benz...)
Affinity DataIC50:  50nMAssay Description:Inhibitory concentration against RNA dependent RNA polymerase Nonstructural protein 5B (HCV NS5B polymerase) in Hepatitis C virusMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetActivin receptor type-1B(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50382317(CHEMBL2024684)
Affinity DataIC50:  59nMAssay Description:Inhibition of ALK4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50167655(CHEMBL371345 | {(Z)-2-Benzoylamino-3-[4-(2-bromo-p...)
Affinity DataIC50:  60nMAssay Description:Inhibitory concentration against RNA dependent RNA polymerase Nonstructural protein 5B (HCV NS5B polymerase) in Hepatitis C virusMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTGF-beta receptor type-1(Mus musculus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50382321(CHEMBL2024688)
Affinity DataIC50:  61nMAssay Description:Inhibition of ALK5 in mouse NIH/3T3 cells by smad binding element reporter based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50382326(CHEMBL2024692)
Affinity DataIC50:  69nMAssay Description:Inhibition of ALK5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50166374((Z)-2-Benzoylamino-3-[4-(2-chloro-6-fluoro-phenoxy...)
Affinity DataIC50:  70nMAssay Description:Inhibitory concentration against Hepatitis C virus NS5B polymeraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50167633((Z)-2-[(Adamantane-1-carbonyl)-amino]-3-[4-(2-brom...)
Affinity DataIC50:  70nMAssay Description:Inhibitory concentration against RNA dependent RNA polymerase Nonstructural protein 5B (HCV NS5B polymerase) in Hepatitis C virusMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTGF-beta receptor type-1(Mus musculus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50382323(CHEMBL2024690)
Affinity DataIC50:  73nMAssay Description:Inhibition of ALK5 in mouse NIH/3T3 cells by smad binding element reporter based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50167652((Z)-3-[4-(2-Bromo-phenoxy)-phenyl]-2-(2-hydroxy-be...)
Affinity DataIC50:  80nMAssay Description:Inhibitory concentration against RNA dependent RNA polymerase Nonstructural protein 5B (HCV NS5B polymerase) in Hepatitis C virusMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50167672((Z)-3-[4-(2-Bromo-phenoxy)-phenyl]-2-(3-fluoro-ben...)
Affinity DataIC50:  90nMAssay Description:Inhibitory concentration against RNA dependent RNA polymerase Nonstructural protein 5B (HCV NS5B polymerase) in Hepatitis C virusMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50166405((Z)-2-Benzoylamino-3-[4-(2-bromo-phenoxy)-phenyl]-...)
Affinity DataIC50:  100nMAssay Description:Inhibitory concentration against Hepatitis C virus NS5B polymeraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50166405((Z)-2-Benzoylamino-3-[4-(2-bromo-phenoxy)-phenyl]-...)
Affinity DataIC50:  100nMAssay Description:Inhibitory concentration against RNA dependent RNA polymerase Nonstructural protein 5B (HCV NS5B polymerase) in Hepatitis C virusMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50167626((Z)-2-[(Bicyclo[2.2.1]heptane-2-carbonyl)-amino]-3...)
Affinity DataIC50:  100nMAssay Description:Inhibitory concentration against RNA dependent RNA polymerase Nonstructural protein 5B (HCV NS5B polymerase) in Hepatitis C virusMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50167628((Z)-3-[4-(2-Bromo-phenoxy)-phenyl]-2-(4-chloro-ben...)
Affinity DataIC50:  110nMAssay Description:Inhibitory concentration against RNA dependent RNA polymerase Nonstructural protein 5B (HCV NS5B polymerase) in Hepatitis C virusMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50167642((Z)-2-(4-Bromo-benzoylamino)-3-[4-(2-bromo-phenoxy...)
Affinity DataIC50:  120nMAssay Description:Inhibitory concentration against RNA dependent RNA polymerase Nonstructural protein 5B (HCV NS5B polymerase) in Hepatitis C virusMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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