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Found 64 with Last Name = 'fobare' and Initial = 'w'
TargetBeta-secretase 1(Homo sapiens (Human))
Wyeth

Curated by ChEMBL
LigandPNGBDBM50314994(2-(2-amino-6-((2-(2-chlorophenyl)-5-(4-(pyrimidin-...)
Affinity DataIC50:  40nMAssay Description:Inhibition of human recombinant BACE1 expressed CHO cells by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Wyeth

Curated by ChEMBL
LigandPNGBDBM50314993(2-(2-amino-6-((2-(2-chlorophenyl)-5-(4-(pyrimidin-...)
Affinity DataIC50:  70nMAssay Description:Inhibition of human recombinant BACE1 expressed CHO cells by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Wyeth

Curated by ChEMBL
LigandPNGBDBM50315000(6-((2-(2-chlorophenyl)-5-(4-(pyrimidin-5-yloxy)phe...)
Affinity DataIC50:  100nMAssay Description:Inhibition of human recombinant BACE1 expressed CHO cells by FRET assayMore data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
Wyeth

Curated by ChEMBL
LigandPNGBDBM50314996(2-(2-amino-6-((2-(2-chlorophenyl)-5-(4-(pentyloxy)...)
Affinity DataIC50:  110nMAssay Description:Inhibition of human recombinant BACE1 expressed CHO cells by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Wyeth

Curated by ChEMBL
LigandPNGBDBM50220305(4-(3-(2-(amino(3-hydroxypropylamino)methyleneamino...)
Affinity DataIC50:  140nMAssay Description:Inhibition of BACE1 by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Wyeth

Curated by ChEMBL
LigandPNGBDBM50220314(CHEMBL237063 | N-(amino(3-hydroxypropylamino)methy...)
Affinity DataIC50:  150nMAssay Description:Inhibition of BACE1 by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Wyeth

Curated by ChEMBL
LigandPNGBDBM50314995(2-(2-amino-6-((2-(2-chlorophenyl)-5-(4-(pentyloxy)...)
Affinity DataIC50:  170nMAssay Description:Inhibition of human recombinant BACE1 expressed CHO cells by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Wyeth

Curated by ChEMBL
LigandPNGBDBM50220306(-4-(3-(2-(amino(3-hydroxypropylamino)methyleneamin...)
Affinity DataIC50:  200nMAssay Description:Inhibition of BACE1 by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Wyeth

Curated by ChEMBL
LigandPNGBDBM50315008(3-(2-amino-6-((2-(2-chlorophenyl)-5-(4-(pentyloxy)...)
Affinity DataIC50:  220nMAssay Description:Inhibition of human recombinant BACE1 expressed CHO cells by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Wyeth

Curated by ChEMBL
LigandPNGBDBM50220313(4-(3-(2-(amino(3-hydroxypropylamino)methyleneamino...)
Affinity DataIC50:  260nMAssay Description:Inhibition of BACE1 by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Wyeth

Curated by ChEMBL
LigandPNGBDBM50220309(4-(3-(2-(amino(3-hydroxypropylamino)methyleneamino...)
Affinity DataIC50:  280nMAssay Description:Inhibition of BACE1 by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Wyeth

Curated by ChEMBL
LigandPNGBDBM50314998(6-((2-(2-chlorophenyl)-5-(4-(thiophen-2-yloxy)phen...)
Affinity DataIC50:  290nMAssay Description:Inhibition of human recombinant BACE1 expressed CHO cells by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Wyeth

Curated by ChEMBL
LigandPNGBDBM50315012(6-((2-(2-chlorophenyl)-5-(4-(pyridin-3-yloxy)pheny...)
Affinity DataIC50:  410nMAssay Description:Inhibition of human recombinant BACE1 expressed CHO cells by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Wyeth

Curated by ChEMBL
LigandPNGBDBM50315010(6-((2-(2-chlorophenyl)-5-(4-(pyridazin-3-yloxy)phe...)
Affinity DataIC50:  410nMAssay Description:Inhibition of human recombinant BACE1 expressed CHO cells by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Wyeth

Curated by ChEMBL
LigandPNGBDBM50315004(4-(4-(1-((6-aminopyridin-2-yl)methyl)-5-(2-chlorop...)
Affinity DataIC50:  420nMAssay Description:Inhibition of human recombinant BACE1 expressed CHO cells by FRET assayMore data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
Wyeth

Curated by ChEMBL
LigandPNGBDBM50314999(6-((2-(2-chlorophenyl)-5-(4-(pyrazin-2-yloxy)pheny...)
Affinity DataIC50:  460nMAssay Description:Inhibition of human recombinant BACE1 expressed CHO cells by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Wyeth

Curated by ChEMBL
LigandPNGBDBM50315008(3-(2-amino-6-((2-(2-chlorophenyl)-5-(4-(pentyloxy)...)
Affinity DataIC50:  470nMAssay Description:Inhibition of cathepsin D by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 2(Homo sapiens (Human))
Wyeth

Curated by ChEMBL
LigandPNGBDBM50315008(3-(2-amino-6-((2-(2-chlorophenyl)-5-(4-(pentyloxy)...)
Affinity DataIC50:  470nMAssay Description:Inhibition of BACE2 by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Wyeth

Curated by ChEMBL
LigandPNGBDBM50315005(6-((2-(2-chlorophenyl)-5-(4-(pentyloxy)phenyl)-1H-...)
Affinity DataIC50:  550nMAssay Description:Inhibition of human recombinant BACE1 expressed CHO cells by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Wyeth

Curated by ChEMBL
LigandPNGBDBM50220319(2-(2-(2-chlorophenyl)-4-(4-propoxyphenyl)thiophen-...)
Affinity DataIC50:  590nMAssay Description:Inhibition of BACE1 by FRET assayMore data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
Wyeth

Curated by ChEMBL
LigandPNGBDBM50315003(CHEMBL1092227 | N-allyl-4-(1-((6-aminopyridin-2-yl...)
Affinity DataIC50:  590nMAssay Description:Inhibition of human recombinant BACE1 expressed CHO cells by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Wyeth

Curated by ChEMBL
LigandPNGBDBM50315001(6-((2-(2-chlorophenyl)-5-(4-(pyridin-4-yloxy)pheny...)
Affinity DataIC50:  590nMAssay Description:Inhibition of human recombinant BACE1 expressed CHO cells by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Wyeth

Curated by ChEMBL
LigandPNGBDBM50220312(2-(4-(2-chlorophenyl)-2-(4-propoxyphenyl)thiophen-...)
Affinity DataIC50:  630nMAssay Description:Inhibition of BACE1 by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Wyeth

Curated by ChEMBL
LigandPNGBDBM50220315(CHEMBL236852 | N-(diaminomethylene)-2-(4-phenyl-2-...)
Affinity DataIC50:  680nMAssay Description:Inhibition of BACE1 by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Wyeth

Curated by ChEMBL
LigandPNGBDBM50220318(2-(2-(4-(4-acetylphenoxy)phenyl)-4-(2-chlorophenyl...)
Affinity DataIC50:  750nMAssay Description:Inhibition of BACE1 by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Wyeth

Curated by ChEMBL
LigandPNGBDBM50315011(6-((2-(2-chlorophenyl)-5-(4-(pyridin-2-yloxy)pheny...)
Affinity DataIC50:  810nMAssay Description:Inhibition of human recombinant BACE1 expressed CHO cells by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Wyeth

Curated by ChEMBL
LigandPNGBDBM50315002(6-((2-(2-chlorophenyl)-5-(4-phenoxyphenyl)-1H-pyrr...)
Affinity DataIC50:  850nMAssay Description:Inhibition of human recombinant BACE1 expressed CHO cells by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Wyeth

Curated by ChEMBL
LigandPNGBDBM50220310(4-(3-(2-(amino(3-hydroxypropylamino)methyleneamino...)
Affinity DataIC50:  930nMAssay Description:Inhibition of BACE1 by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Wyeth

Curated by ChEMBL
LigandPNGBDBM50314997(CHEMBL1093806 | N-(4-(1-((6-aminopyridin-2-yl)meth...)
Affinity DataIC50:  980nMAssay Description:Inhibition of human recombinant BACE1 expressed CHO cells by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 2(Homo sapiens (Human))
Wyeth

Curated by ChEMBL
LigandPNGBDBM50314995(2-(2-amino-6-((2-(2-chlorophenyl)-5-(4-(pentyloxy)...)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of BACE2 by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Wyeth

Curated by ChEMBL
LigandPNGBDBM50315019(6-((2-(2-chlorophenyl)-5-(4-propoxyphenyl)-1H-pyrr...)
Affinity DataIC50:  1.15E+3nMAssay Description:Inhibition of human recombinant BACE1 expressed CHO cells by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Wyeth

Curated by ChEMBL
LigandPNGBDBM50315014(4-(1-((6-aminopyridin-2-yl)methyl)-5-phenyl-1H-pyr...)
Affinity DataIC50:  1.20E+3nMAssay Description:Inhibition of human recombinant BACE1 expressed CHO cells by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Wyeth

Curated by ChEMBL
LigandPNGBDBM50220308(CHEMBL237282 | N-(amino(3-hydroxypropylamino)methy...)
Affinity DataIC50:  1.54E+3nMAssay Description:Inhibition of BACE1 by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Wyeth

Curated by ChEMBL
LigandPNGBDBM50220311(CHEMBL391108 | N-(amino(3-hydroxypropylamino)methy...)
Affinity DataIC50:  1.55E+3nMAssay Description:Inhibition of BACE1 by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Wyeth

Curated by ChEMBL
LigandPNGBDBM50315018(6-((2-(4-butoxyphenyl)-5-(2-chlorophenyl)-1H-pyrro...)
Affinity DataIC50:  1.65E+3nMAssay Description:Inhibition of human recombinant BACE1 expressed CHO cells by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Wyeth

Curated by ChEMBL
LigandPNGBDBM50315015(4-(1-((6-aminopyridin-2-yl)methyl)-5-phenyl-1H-pyr...)
Affinity DataIC50:  1.78E+3nMAssay Description:Inhibition of human recombinant BACE1 expressed CHO cells by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Wyeth

Curated by ChEMBL
LigandPNGBDBM50220307(CHEMBL237061 | N-(diaminomethylene)-2-(2-phenyl-4-...)
Affinity DataIC50:  1.89E+3nMAssay Description:Inhibition of BACE1 by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Wyeth

Curated by ChEMBL
LigandPNGBDBM50315017(4-(1-((6-aminopyridin-2-yl)methyl)-5-phenyl-1H-pyr...)
Affinity DataIC50:  2.25E+3nMAssay Description:Inhibition of human recombinant BACE1 expressed CHO cells by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Wyeth

Curated by ChEMBL
LigandPNGBDBM50315006(6-((2-(2-chlorophenyl)-5-(4-methoxyphenyl)-1H-pyrr...)
Affinity DataIC50:  2.45E+3nMAssay Description:Inhibition of human recombinant BACE1 expressed CHO cells by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Wyeth

Curated by ChEMBL
LigandPNGBDBM50315009(4-(1-((6-aminopyridin-2-yl)methyl)-5-phenyl-1H-pyr...)
Affinity DataIC50:  3.00E+3nMAssay Description:Inhibition of human recombinant BACE1 expressed CHO cells by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Wyeth

Curated by ChEMBL
LigandPNGBDBM50315016(4-(1-((6-aminopyridin-2-yl)methyl)-5-phenyl-1H-pyr...)
Affinity DataIC50:  3.00E+3nMAssay Description:Inhibition of human recombinant BACE1 expressed CHO cells by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Wyeth

Curated by ChEMBL
LigandPNGBDBM50315013(4-(1-((6-aminopyridin-2-yl)methyl)-5-phenyl-1H-pyr...)
Affinity DataIC50:  3.40E+3nMAssay Description:Inhibition of human recombinant BACE1 expressed CHO cells by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Wyeth

Curated by ChEMBL
LigandPNGBDBM16751((N-(diaminomethylene)-2,4-diphenyl-1H-pyrrole-1-ac...)
Affinity DataIC50:  3.70E+3nMAssay Description:Inhibition of BACE1 by FRET assayMore data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
Wyeth

Curated by ChEMBL
LigandPNGBDBM50315007(6-((2,5-diphenyl-1H-pyrrol-1-yl)methyl)pyridin-2-a...)
Affinity DataIC50:  5.20E+3nMAssay Description:Inhibition of human recombinant BACE1 expressed CHO cells by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Wyeth

Curated by ChEMBL
LigandPNGBDBM50220316(2-(2-(4-(2-(1H-pyrazol-4-yl)ethoxy)phenyl)-4-(2-ch...)
Affinity DataIC50:  6.90E+3nMAssay Description:Inhibition of BACE1 by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 2(Homo sapiens (Human))
Wyeth

Curated by ChEMBL
LigandPNGBDBM50315004(4-(4-(1-((6-aminopyridin-2-yl)methyl)-5-(2-chlorop...)
Affinity DataIC50:  7.10E+3nMAssay Description:Inhibition of BACE2 by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Wyeth

Curated by ChEMBL
LigandPNGBDBM50220317(CHEMBL236850 | N-(diaminomethylene)-2-(2,4-dipheny...)
Affinity DataIC50:  8.30E+3nMAssay Description:Inhibition of BACE1 by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Wyeth

Curated by ChEMBL
LigandPNGBDBM50315003(CHEMBL1092227 | N-allyl-4-(1-((6-aminopyridin-2-yl...)
Affinity DataIC50:  4.36E+4nMAssay Description:Inhibition of cathepsin D by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Wyeth

Curated by ChEMBL
LigandPNGBDBM50315009(4-(1-((6-aminopyridin-2-yl)methyl)-5-phenyl-1H-pyr...)
Affinity DataIC50:  4.43E+4nMAssay Description:Inhibition of cathepsin D by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
Wyeth

Curated by ChEMBL
LigandPNGBDBM50314999(6-((2-(2-chlorophenyl)-5-(4-(pyrazin-2-yloxy)pheny...)
Affinity DataEC50:  1.33E+4nMAssay Description:Inhibition of human recombinant APP in CHO cells assessed as decrease in beta amyloid protein level by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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