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Found 502 with Last Name = 'frennesson' and Initial = 'd'
TargetInsulin-like growth factor 1 receptor(Rattus norvegicus)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50318112((S)-4-(2-(3-chlorophenyl)-2-hydroxyethylamino)-3-(...)
Affinity DataKi:  28nMAssay Description:Inhibition of rat IGF1RMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50252094((S)-4-(2-(3-chlorophenyl)-2-hydroxyethylamino)-3-(...)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50252295(3-(6-(4-((1R,4S)-5-oxa-2-aza-bicyclo[2.2.1]heptan-...)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50252237((S)-methyl 1-(2-(4-(2-(3-chlorophenyl)-2-hydroxyet...)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM27879(4-{[(2S)-2-(3-chlorophenyl)-2-hydroxyethyl]amino}-...)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50252193(4-((S)-2-(3-chlorophenyl)-2-hydroxyethylamino)-3-(...)
Affinity DataIC50:  0.700nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50252236((S)-N-(1-(2-(4-(2-(3-chlorophenyl)-2-hydroxyethyla...)
Affinity DataIC50:  0.700nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50252297((S)-3-(6-(4-(4-acetylpiperazin-1-yl)piperidin-1-yl...)
Affinity DataIC50:  0.800nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50252143((S)-4-(2-(3-chlorophenyl)-2-hydroxyethylamino)-3-(...)
Affinity DataIC50:  0.900nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50252142((S)-4-(2-(3-chlorophenyl)-2-hydroxyethylamino)-3-(...)
Affinity DataIC50:  1nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM107016(US8592579, 219)
Affinity DataIC50:  1nMpH: 7.4Assay Description:Kinase assay using IGF1-receptor.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Homo sapiens (Human))TBA
LigandPNGBDBM144614(US8969586, 1 | US9598436, 1)
Affinity DataIC50:  1nMAssay Description:Binding affinity against Melatonin receptor using ovine pars tuberalis membranes of the pituitary.More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM107013(US8592579, 211)
Affinity DataIC50:  1nMpH: 7.4Assay Description:Kinase assay using IGF1-receptor.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM107018(US8592579, 254)
Affinity DataIC50:  1nMpH: 7.4Assay Description:Kinase assay using IGF1-receptor.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM107023(US8592579, 288)
Affinity DataIC50:  1nMpH: 7.4Assay Description:Kinase assay using IGF1-receptor.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCytochrome P450 3A4(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50252238((S)-methyl 1-(2-(4-(2-(3-chlorophenyl)-2-hydroxyet...)
Affinity DataIC50:  1nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50252144((S)-4-(2-(3-chlorophenyl)-2-hydroxyethylamino)-3-(...)
Affinity DataIC50:  1.30nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50252300((S)-4-(2-(3-chlorophenyl)-2-hydroxyethylamino)-3-(...)
Affinity DataIC50:  1.70nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50252303((S)-2-hydroxyethyl 4-(1-(2-(4-(2-(3-chlorophenyl)-...)
Affinity DataIC50:  1.80nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM107003(CHEMBL575447 | US8592579, 110)
Affinity DataIC50:  2nMpH: 7.4Assay Description:Kinase assay using IGF1-receptor.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Macaca fascicularis)TBA
LigandPNGBDBM50405216(CHEMBL5290029)
Affinity DataIC50:  2nMAssay Description:Inhibitory activity against cell free dihydrofolate reductase (DHFR) from ratMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Macaca fascicularis)TBA
LigandPNGBDBM50405216(CHEMBL5290029)
Affinity DataIC50:  2nMAssay Description:Inhibitory activity against cell free dihydrofolate redutase (DHFR) from Mycobacterium lufuMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1/G1/S-specific cyclin-E2(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50299138((S)-1-(4-(5-cyclopropyl-1H-pyrazol-3-ylamino)pyrro...)
Affinity DataIC50:  2nMAssay Description:Inhibition of CDK2/Cyclin E after 60 mins by fluorescence electrophoresisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM50299148((S)-1-(4-(5-cyclopropyl-1H-pyrazol-3-ylamino)pyrro...)
Affinity DataIC50:  2nMAssay Description:Inhibition of IGF1R after 60 mins by fluorescence electrophoresisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM50299143((S)-1-(4-(5-cyclopropyl-1H-pyrazol-3-ylamino)pyrro...)
Affinity DataIC50:  2nMAssay Description:Inhibition of IGF1R after 60 mins by fluorescence electrophoresisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM107026(US8592579, 301)
Affinity DataIC50:  2nMpH: 7.4Assay Description:Kinase assay using IGF1-receptor.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM107024(US8592579, 293)
Affinity DataIC50:  2nMpH: 7.4Assay Description:Kinase assay using IGF1-receptor.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM107021(US8592579, 259)
Affinity DataIC50:  2nMpH: 7.4Assay Description:Kinase assay using IGF1-receptor.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM107020(US8592579, 256)
Affinity DataIC50:  2nMpH: 7.4Assay Description:Kinase assay using IGF1-receptor.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM107012(US8592579, 209)
Affinity DataIC50:  2nMpH: 7.4Assay Description:Kinase assay using IGF1-receptor.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Homo sapiens (Human))TBA
LigandPNGBDBM50404835(CHEMBL5284599)
Affinity DataIC50:  2nMAssay Description:Binding affinity against Melatonin receptor using ovine pars tuberalis membranes of the pituitary.More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM107000(US8592579, 104)
Affinity DataIC50:  2nMpH: 7.4Assay Description:Kinase assay using IGF1-receptor.More data for this Ligand-Target Pair
TargetCytochrome P450 3A4(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50252296((S)-4-(2-(3-chlorophenyl)-2-hydroxyethylamino)-3-(...)
Affinity DataIC50:  2.40nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50252302((S)-2-methoxyethyl 4-(1-(2-(4-(2-(3-chlorophenyl)-...)
Affinity DataIC50:  2.40nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50252194((S)-4-(2-(3-chlorophenyl)-2-hydroxyethylamino)-3-(...)
Affinity DataIC50:  2.60nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Homo sapiens (Human))TBA
LigandPNGBDBM50405184(CHEMBL5290743)
Affinity DataIC50:  3nMAssay Description:Binding affinity against Melatonin receptor using ovine pars tuberalis membranes of the pituitary.More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM107028(US8592579, 318)
Affinity DataIC50:  3nMpH: 7.4Assay Description:Kinase assay using IGF1-receptor.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCytochrome P450 3A4(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50252299((S)-4-(2-(3-chlorophenyl)-2-hydroxyethylamino)-3-(...)
Affinity DataIC50:  3nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM107022(US8592579, 287)
Affinity DataIC50:  3nMpH: 7.4Assay Description:Kinase assay using IGF1-receptor.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Homo sapiens (Human))TBA
LigandPNGBDBM50404839(CHEMBL5286021)
Affinity DataIC50:  3nMAssay Description:Binding affinity against Melatonin receptor using ovine pars tuberalis membranes of the pituitary.More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM107003(CHEMBL575447 | US8592579, 110)
Affinity DataIC50:  3nMAssay Description:Inhibition of IGF1R after 60 mins by fluorescence electrophoresisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50252294(4-((S)-2-(3-chlorophenyl)-2-hydroxyethylamino)-3-(...)
Affinity DataIC50:  3.10nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50252301((S)-methyl 4-(1-(2-(4-(2-(3-chlorophenyl)-2-hydrox...)
Affinity DataIC50:  3.5nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50252195((S)-4-(2-(3-chlorophenyl)-2-hydroxyethylamino)-3-(...)
Affinity DataIC50:  3.90nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Homo sapiens (Human))TBA
LigandPNGBDBM50405189(CHEMBL5284859)
Affinity DataIC50:  4nMAssay Description:Binding affinity by the displacement of [3H]NMS binding to muscarinic M1 receptor of rat brainMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Homo sapiens (Human))TBA
LigandPNGBDBM50405217(CHEMBL5265986)
Affinity DataIC50:  4nMAssay Description:Binding affinity by the displacement of [3H]NMS binding to muscarinic M1 receptor of rat brainMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM50299145((S)-1-(4-(5-cyclopropyl-1H-pyrazol-3-ylamino)pyrro...)
Affinity DataIC50:  4nMAssay Description:Inhibition of IGF1R after 60 mins by fluorescence electrophoresisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM107001(US8592579, 105)
Affinity DataIC50:  4nMpH: 7.4Assay Description:Kinase assay using IGF1-receptor.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCytochrome P450 3A4(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50252293((S)-4-(2-(3-chlorophenyl)-2-hydroxyethylamino)-3-(...)
Affinity DataIC50:  4.10nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50252235((S)-4-(2-(3-chlorophenyl)-2-hydroxyethylamino)-3-(...)
Affinity DataIC50:  4.5nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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