Compile Data Set for Download or QSAR
maximum 50k data
Found 45 with Last Name = 'friedman' and Initial = 'hs'
TargetDihydrofolate reductase(Candida albicans)
Wellcome Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50049912(7-(1,1-Dimethyl-propyl)-8-methyl-7H-pyrrolo[3,2-f]...)
Affinity DataKi:  0.00710nMAssay Description:Inhibition of Dihydrofolate reductase enzyme from Candida albicansMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
Wellcome Research Laboratories

Curated by ChEMBL
LigandPNGBDBM18224(6-[(2,5-dimethoxyphenyl)methyl]-5-methylpyrido[2,3...)
Affinity DataKi:  0.0250nMAssay Description:Inhibition of human recombinant Dihydrofolate reductase enzymeMore data for this Ligand-Target Pair
TargetDihydrofolate reductase(Candida albicans)
Wellcome Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50049905(7-(1-Ethyl-propyl)-8-methyl-7H-pyrrolo[3,2-f]quina...)
Affinity DataKi:  0.0300nMAssay Description:Inhibition of Dihydrofolate reductase enzyme from Candida albicansMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
Wellcome Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50049906(7-tert-Butyl-8-ethyl-7H-pyrrolo[3,2-f]quinazoline-...)
Affinity DataKi:  0.100nMAssay Description:Inhibition of human recombinant Dihydrofolate reductase enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
Wellcome Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50049901(7-sec-Butyl-8-ethyl-7H-pyrrolo[3,2-f]quinazoline-1...)
Affinity DataKi:  0.100nMAssay Description:Inhibition of human recombinant Dihydrofolate reductase enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
Wellcome Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50049907(7-(1-Ethyl-propyl)-8-isopropyl-7H-pyrrolo[3,2-f]qu...)
Affinity DataKi:  0.100nMAssay Description:Inhibition of human recombinant Dihydrofolate reductase enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Candida albicans)
Wellcome Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50049911(8-tert-Butyl-7H-pyrrolo[3,2-f]quinazoline-1,3-diam...)
Affinity DataKi:  0.120nMAssay Description:Inhibition of Dihydrofolate reductase enzyme from Candida albicansMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Candida albicans)
Wellcome Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50049898(8-Isopropyl-7H-pyrrolo[3,2-f]quinazoline-1,3-diami...)
Affinity DataKi:  0.160nMAssay Description:Inhibition of Dihydrofolate reductase enzyme from Candida albicansMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
Wellcome Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50049909(8-tert-Butyl-7-isopropyl-7H-pyrrolo[3,2-f]quinazol...)
Affinity DataKi:  0.200nMAssay Description:Inhibition of human recombinant Dihydrofolate reductase enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
Wellcome Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50049897(8-Ethyl-7-(1-ethyl-propyl)-7H-pyrrolo[3,2-f]quinaz...)
Affinity DataKi:  0.200nMAssay Description:Inhibition of human recombinant Dihydrofolate reductase enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Candida albicans)
Wellcome Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50049899(7-Isopropyl-8-methyl-7H-pyrrolo[3,2-f]quinazoline-...)
Affinity DataKi:  0.220nMAssay Description:Inhibition of Dihydrofolate reductase enzyme from Candida albicansMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Candida albicans)
Wellcome Research Laboratories

Curated by ChEMBL
LigandPNGBDBM18043(1,3-DIAMINO-7-(1-ETHYEPROPYE)-7H-PYRRALO-[3,2-F]QU...)
Affinity DataKi:  0.220nMAssay Description:Inhibition of Dihydrofolate reductase enzyme from Candida albicansMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedMMDB

TargetDihydrofolate reductase(Candida albicans)
Wellcome Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50049914(7-(3,4,5-Trimethoxy-benzyl)-7H-pyrrolo[3,2-f]quina...)
Affinity DataKi:  0.230nMAssay Description:Inhibition of Dihydrofolate reductase enzyme from Candida albicansMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
Wellcome Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50049905(7-(1-Ethyl-propyl)-8-methyl-7H-pyrrolo[3,2-f]quina...)
Affinity DataKi:  0.300nMAssay Description:Inhibition of human recombinant Dihydrofolate reductase enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Candida albicans)
Wellcome Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50049902(7,8-Diethyl-7H-pyrrolo[3,2-f]quinazoline-1,3-diami...)
Affinity DataKi:  0.330nMAssay Description:Inhibition of Dihydrofolate reductase enzyme from Candida albicansMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Candida albicans)
Wellcome Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50049913(7-Ethyl-8-isopropyl-7H-pyrrolo[3,2-f]quinazoline-1...)
Affinity DataKi:  0.330nMAssay Description:Inhibition of Dihydrofolate reductase enzyme from Candida albicansMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Candida albicans)
Wellcome Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50049896(8-Butyl-7-tert-butyl-7H-pyrrolo[3,2-f]quinazoline-...)
Affinity DataKi:  0.380nMAssay Description:Inhibition of Dihydrofolate reductase enzyme from Candida albicansMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
Wellcome Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50049912(7-(1,1-Dimethyl-propyl)-8-methyl-7H-pyrrolo[3,2-f]...)
Affinity DataKi:  0.400nMAssay Description:Inhibition of human recombinant Dihydrofolate reductase enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
Wellcome Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50049903(7-(1-Ethyl-propyl)-8-propyl-7H-pyrrolo[3,2-f]quina...)
Affinity DataKi:  0.400nMAssay Description:Inhibition of human recombinant Dihydrofolate reductase enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Candida albicans)
Wellcome Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50049910(7-Ethyl-8-propyl-7H-pyrrolo[3,2-f]quinazoline-1,3-...)
Affinity DataKi:  0.650nMAssay Description:Inhibition of Dihydrofolate reductase enzyme from Candida albicansMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Candida albicans)
Wellcome Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50049915(8-Ethyl-7-methyl-7H-pyrrolo[3,2-f]quinazoline-1,3-...)
Affinity DataKi:  1.30nMAssay Description:Inhibition of Dihydrofolate reductase enzyme from Candida albicansMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
Wellcome Research Laboratories

Curated by ChEMBL
LigandPNGBDBM18268(5-methyl-6-{[(3,4,5-trimethoxyphenyl)amino]methyl}...)
Affinity DataKi:  1.40nMAssay Description:Inhibition of human recombinant Dihydrofolate reductase enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetDihydrofolate reductase(Candida albicans)
Wellcome Research Laboratories

Curated by ChEMBL
LigandPNGBDBM18268(5-methyl-6-{[(3,4,5-trimethoxyphenyl)amino]methyl}...)
Affinity DataKi:  1.90nMAssay Description:Inhibition of Dihydrofolate reductase enzyme from Candida albicansMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Candida albicans)
Wellcome Research Laboratories

Curated by ChEMBL
LigandPNGBDBM18224(6-[(2,5-dimethoxyphenyl)methyl]-5-methylpyrido[2,3...)
Affinity DataKi:  1.90nMAssay Description:Inhibition of Dihydrofolate reductase enzyme from Candida albicansMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Candida albicans)
Wellcome Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50049908(7,8-Dimethyl-7H-pyrrolo[3,2-f]quinazoline-1,3-diam...)
Affinity DataKi:  2nMAssay Description:Inhibition of Dihydrofolate reductase enzyme from Candida albicansMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
Wellcome Research Laboratories

Curated by ChEMBL
LigandPNGBDBM18043(1,3-DIAMINO-7-(1-ETHYEPROPYE)-7H-PYRRALO-[3,2-F]QU...)
Affinity DataKi:  4.5nMAssay Description:Inhibition of human recombinant Dihydrofolate reductase enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
Wellcome Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50049914(7-(3,4,5-Trimethoxy-benzyl)-7H-pyrrolo[3,2-f]quina...)
Affinity DataKi:  6nMAssay Description:Inhibition of human recombinant Dihydrofolate reductase enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
Wellcome Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50049899(7-Isopropyl-8-methyl-7H-pyrrolo[3,2-f]quinazoline-...)
Affinity DataKi:  6.40nMAssay Description:Inhibition of human recombinant Dihydrofolate reductase enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
Wellcome Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50049898(8-Isopropyl-7H-pyrrolo[3,2-f]quinazoline-1,3-diami...)
Affinity DataKi:  10nMAssay Description:Inhibition of human recombinant Dihydrofolate reductase enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
Wellcome Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50049902(7,8-Diethyl-7H-pyrrolo[3,2-f]quinazoline-1,3-diami...)
Affinity DataKi:  10nMAssay Description:Inhibition of human recombinant Dihydrofolate reductase enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Candida albicans)
Wellcome Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50049904(7H-Pyrrolo[3,2-f]quinazoline-1,3-diamine | CHEMBL3...)
Affinity DataKi:  23nMAssay Description:Inhibition of Dihydrofolate reductase enzyme from Candida albicansMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
Wellcome Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50049910(7-Ethyl-8-propyl-7H-pyrrolo[3,2-f]quinazoline-1,3-...)
Affinity DataKi:  24nMAssay Description:Inhibition of human recombinant Dihydrofolate reductase enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Candida albicans)
Wellcome Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50049900(7-Methyl-7H-pyrrolo[3,2-f]quinazoline-1,3-diamine ...)
Affinity DataKi:  25nMAssay Description:Inhibition of Dihydrofolate reductase enzyme from Candida albicansMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
Wellcome Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50049915(8-Ethyl-7-methyl-7H-pyrrolo[3,2-f]quinazoline-1,3-...)
Affinity DataKi:  29nMAssay Description:Inhibition of human recombinant Dihydrofolate reductase enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
Wellcome Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50049896(8-Butyl-7-tert-butyl-7H-pyrrolo[3,2-f]quinazoline-...)
Affinity DataKi:  30nMAssay Description:Inhibition of human recombinant Dihydrofolate reductase enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
Wellcome Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50049908(7,8-Dimethyl-7H-pyrrolo[3,2-f]quinazoline-1,3-diam...)
Affinity DataKi:  87nMAssay Description:Inhibition of human recombinant Dihydrofolate reductase enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
Wellcome Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50049900(7-Methyl-7H-pyrrolo[3,2-f]quinazoline-1,3-diamine ...)
Affinity DataKi:  230nMAssay Description:Inhibition of human recombinant Dihydrofolate reductase enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
Wellcome Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50049904(7H-Pyrrolo[3,2-f]quinazoline-1,3-diamine | CHEMBL3...)
Affinity DataKi:  1.00E+3nMAssay Description:Inhibition of human recombinant Dihydrofolate reductase enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranslocator protein(Rattus norvegicus (rat))
University Of Kansas

Curated by ChEMBL
LigandPNGBDBM50058155((R)-3-{4-[Bis-(2-chloro-ethyl)-amino]-phenyl}-2-[4...)
Affinity DataIC50:  3.27E+5nMAssay Description:The compound was tested for binding affinity against PBR(peripheral benzodiazepine receptor) in normal rat brain homogenateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranslocator protein(Rattus norvegicus (rat))
University Of Kansas

Curated by ChEMBL
LigandPNGBDBM50058155((R)-3-{4-[Bis-(2-chloro-ethyl)-amino]-phenyl}-2-[4...)
Affinity DataIC50:  3.27E+5nMAssay Description:The compound was tested for binding affinity against PBR(peripheral benzodiazepine receptor) in normal rat brain homogenateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranslocator protein(Rattus norvegicus (rat))
University Of Kansas

Curated by ChEMBL
LigandPNGBDBM50058155((R)-3-{4-[Bis-(2-chloro-ethyl)-amino]-phenyl}-2-[4...)
Affinity DataIC50:  3.90E+5nMAssay Description:Binding affinity for PBR (peripheral benzodiazepine receptor) in rat RG-2 glioma cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranslocator protein(Rattus norvegicus (rat))
University Of Kansas

Curated by ChEMBL
LigandPNGBDBM50027835(7-Chloro-5-phenyl-1,3-dihydro-benzo[e][1,4]diazepi...)
Affinity DataIC50:  5.20E+5nMAssay Description:The compound was tested for binding affinity against PBR(peripheral benzodiazepine receptor) in normal rat brain homogenateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranslocator protein(Rattus norvegicus (rat))
University Of Kansas

Curated by ChEMBL
LigandPNGBDBM22040(4 -chlorodiazepam | 4' Cl-diazepam | 7-chloro-...)
Affinity DataKd:  3.5nMAssay Description:Binding affinity constant for Benzodiazepine receptor in rat RG-2 glioma cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranslocator protein(Rattus norvegicus (rat))
University Of Kansas

Curated by ChEMBL
LigandPNGBDBM22040(4 -chlorodiazepam | 4' Cl-diazepam | 7-chloro-...)
Affinity DataKd:  1.30E+3nMAssay Description:Binding affinity constant for Benzodiazepine receptor in normal rat brain homogenateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranslocator protein(Rattus norvegicus (rat))
University Of Kansas

Curated by ChEMBL
LigandPNGBDBM22040(4 -chlorodiazepam | 4' Cl-diazepam | 7-chloro-...)
Affinity DataKd:  4.00E+3nMAssay Description:Binding affinity constant for Benzodiazepine receptor in rat C6 glioma cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed