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Found 351 with Last Name = 'gao' and Initial = 'r'
TargetProthrombin(Homo sapiens (Human))
North China Pharmaceutical New Drug R&D

US Patent
LigandPNGBDBM294039(Process 1 | US10106557, Compound 1)
Affinity DataKi:  0.470nMpH: 7.4Assay Description:The activity of the compound to be tested against prothrombinase was determined by the production of thrombin. In summary, 12.5 μL human factor ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProthrombin(Homo sapiens (Human))
North China Pharmaceutical New Drug R&D

US Patent
LigandPNGBDBM294042(US10106557, Compound 8)
Affinity DataKi:  0.900nMpH: 7.4Assay Description:The activity of the compound to be tested against prothrombinase was determined by the production of thrombin. In summary, 12.5 μL human factor ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCoagulation factor X(Homo sapiens (Human))
North China Pharmaceutical New Drug R&D

US Patent
LigandPNGBDBM294039(Process 1 | US10106557, Compound 1)
Affinity DataKi:  1.01nMpH: 8.3Assay Description:The inhibitory activity on coagulation factor Xa activity in human was measured by using Tris-HCl buffer (50 mM, pH 8.3, 150 mM NaCl). A buffer of 50...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCoagulation factor X(Homo sapiens (Human))
North China Pharmaceutical New Drug R&D

US Patent
LigandPNGBDBM294042(US10106557, Compound 8)
Affinity DataKi:  1.92nMpH: 8.3Assay Description:The inhibitory activity on coagulation factor Xa activity in human was measured by using Tris-HCl buffer (50 mM, pH 8.3, 150 mM NaCl). A buffer of 50...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCoagulation factor X(Homo sapiens (Human))
North China Pharmaceutical New Drug R&D

US Patent
LigandPNGBDBM50024354(CHEMBL3330444 | US10106557, Compound 2)
Affinity DataKi:  1.93nMpH: 8.3Assay Description:The inhibitory activity on coagulation factor Xa activity in human was measured by using Tris-HCl buffer (50 mM, pH 8.3, 150 mM NaCl). A buffer of 50...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCoagulation factor X(Rattus norvegicus (rat))
North China Pharmaceutical New Drug R&D

US Patent
LigandPNGBDBM294039(Process 1 | US10106557, Compound 1)
Affinity DataKi:  2.87nMpH: 8.3Assay Description:The inhibitory activity on coagulation factor Xa activity in rats was measured by using Tris-HCl buffer (50 mM, pH 8.3, 150 mM NaCl). A buffer of 50 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCoagulation factor X(Rattus norvegicus (rat))
North China Pharmaceutical New Drug R&D

US Patent
LigandPNGBDBM294042(US10106557, Compound 8)
Affinity DataKi:  3.17nMpH: 8.3Assay Description:The inhibitory activity on coagulation factor Xa activity in rats was measured by using Tris-HCl buffer (50 mM, pH 8.3, 150 mM NaCl). A buffer of 50 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCoagulation factor X(Homo sapiens (Human))
North China Pharmaceutical New Drug R&D

US Patent
LigandPNGBDBM294041(US10106557, Compound 7)
Affinity DataKi:  4.13nMpH: 8.3Assay Description:The inhibitory activity on coagulation factor Xa activity in human was measured by using Tris-HCl buffer (50 mM, pH 8.3, 150 mM NaCl). A buffer of 50...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProthrombin(Homo sapiens (Human))
North China Pharmaceutical New Drug R&D

US Patent
LigandPNGBDBM50024354(CHEMBL3330444 | US10106557, Compound 2)
Affinity DataKi:  4.22nMpH: 7.4Assay Description:The activity of the compound to be tested against prothrombinase was determined by the production of thrombin. In summary, 12.5 μL human factor ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProthrombin(Homo sapiens (Human))
North China Pharmaceutical New Drug R&D

US Patent
LigandPNGBDBM294041(US10106557, Compound 7)
Affinity DataKi:  4.41nMpH: 7.4Assay Description:The activity of the compound to be tested against prothrombinase was determined by the production of thrombin. In summary, 12.5 μL human factor ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCoagulation factor X(Rattus norvegicus (rat))
North China Pharmaceutical New Drug R&D

US Patent
LigandPNGBDBM50024354(CHEMBL3330444 | US10106557, Compound 2)
Affinity DataKi:  4.45nMpH: 8.3Assay Description:The inhibitory activity on coagulation factor Xa activity in rats was measured by using Tris-HCl buffer (50 mM, pH 8.3, 150 mM NaCl). A buffer of 50 ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCoagulation factor X(Homo sapiens (Human))
North China Pharmaceutical New Drug R&D

US Patent
LigandPNGBDBM294043(US10106557, Compound 30)
Affinity DataKi:  9.71nMpH: 8.3Assay Description:The inhibitory activity on coagulation factor Xa activity in human was measured by using Tris-HCl buffer (50 mM, pH 8.3, 150 mM NaCl). A buffer of 50...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProthrombin(Homo sapiens (Human))
North China Pharmaceutical New Drug R&D

US Patent
LigandPNGBDBM294043(US10106557, Compound 30)
Affinity DataKi:  16.2nMpH: 7.4Assay Description:The activity of the compound to be tested against prothrombinase was determined by the production of thrombin. In summary, 12.5 μL human factor ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCoagulation factor X(Rattus norvegicus (rat))
North China Pharmaceutical New Drug R&D

US Patent
LigandPNGBDBM294041(US10106557, Compound 7)
Affinity DataKi:  16.5nMpH: 8.3Assay Description:The inhibitory activity on coagulation factor Xa activity in rats was measured by using Tris-HCl buffer (50 mM, pH 8.3, 150 mM NaCl). A buffer of 50 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCoagulation factor X(Rattus norvegicus (rat))
North China Pharmaceutical New Drug R&D

US Patent
LigandPNGBDBM294043(US10106557, Compound 30)
Affinity DataKi:  21.5nMpH: 8.3Assay Description:The inhibitory activity on coagulation factor Xa activity in rats was measured by using Tris-HCl buffer (50 mM, pH 8.3, 150 mM NaCl). A buffer of 50 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50445876(CHEMBL3105692)
Affinity DataKi:  25nMAssay Description:Displacement of 25-[26,27-3H]hydroxycholesterol from RORgammat receptor ligand binding domain (unknown origin) after 60 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50445875(CHEMBL3105671)
Affinity DataKi:  32nMAssay Description:Displacement of 25-[26,27-3H]hydroxycholesterol from RORgammat receptor ligand binding domain (unknown origin) after 60 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50445877(CHEMBL3105681)
Affinity DataKi:  40nMAssay Description:Displacement of 25-[26,27-3H]hydroxycholesterol from RORgammat receptor ligand binding domain (unknown origin) after 60 minsMore data for this Ligand-Target Pair
Target6-phosphogluconate dehydrogenase, decarboxylating(Rattus norvegicus)
Johns Hopkins University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50590158(CHEMBL5174714)
Affinity DataKi:  100nMAssay Description:Inhibition of rat 6PGD assessed as inhibition constant by spectrophotometric methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetCoagulation factor X(Homo sapiens (Human))
North China Pharmaceutical New Drug R&D

US Patent
LigandPNGBDBM294044(US10106557, Compound 34)
Affinity DataKi:  106nMpH: 8.3Assay Description:The inhibitory activity on coagulation factor Xa activity in human was measured by using Tris-HCl buffer (50 mM, pH 8.3, 150 mM NaCl). A buffer of 50...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50445878(CHEMBL3105815)
Affinity DataKi:  398nMAssay Description:Displacement of 25-[26,27-3H]hydroxycholesterol from RORgammat receptor ligand binding domain (unknown origin) after 60 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
North China Pharmaceutical New Drug R&D

US Patent
LigandPNGBDBM294042(US10106557, Compound 8)
Affinity DataKi: >1.00E+3nMpH: 7.4Assay Description:The inhibitory activity on human thrombin was determined by using a buffer (10 mM HEPES buffer, pH 7.4, 2 mM CaCl2). Appropriate wells in the Greiner...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProthrombin(Homo sapiens (Human))
North China Pharmaceutical New Drug R&D

US Patent
LigandPNGBDBM294041(US10106557, Compound 7)
Affinity DataKi: >1.00E+3nMpH: 7.4Assay Description:The inhibitory activity on human thrombin was determined by using a buffer (10 mM HEPES buffer, pH 7.4, 2 mM CaCl2). Appropriate wells in the Greiner...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProthrombin(Homo sapiens (Human))
North China Pharmaceutical New Drug R&D

US Patent
LigandPNGBDBM294039(Process 1 | US10106557, Compound 1)
Affinity DataKi: >1.00E+3nMpH: 7.4Assay Description:The inhibitory activity on human thrombin was determined by using a buffer (10 mM HEPES buffer, pH 7.4, 2 mM CaCl2). Appropriate wells in the Greiner...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProthrombin(Homo sapiens (Human))
North China Pharmaceutical New Drug R&D

US Patent
LigandPNGBDBM294043(US10106557, Compound 30)
Affinity DataKi: >1.00E+3nMpH: 7.4Assay Description:The inhibitory activity on human thrombin was determined by using a buffer (10 mM HEPES buffer, pH 7.4, 2 mM CaCl2). Appropriate wells in the Greiner...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProthrombin(Homo sapiens (Human))
North China Pharmaceutical New Drug R&D

US Patent
LigandPNGBDBM50024354(CHEMBL3330444 | US10106557, Compound 2)
Affinity DataKi: >1.00E+3nMpH: 7.4Assay Description:The inhibitory activity on human thrombin was determined by using a buffer (10 mM HEPES buffer, pH 7.4, 2 mM CaCl2). Appropriate wells in the Greiner...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSerine protease 1(Homo sapiens (Human))
North China Pharmaceutical New Drug R&D

US Patent
LigandPNGBDBM50024354(CHEMBL3330444 | US10106557, Compound 2)
Affinity DataKi: >2.00E+4nMpH: 8.2Assay Description:The inhibitory activity on human trypsin was determined by using buffer (50 mM Tris, pH 8.2, and 20 mM CaCl2). Appropriate wells in the Greiner 384 m...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSerine protease 1(Homo sapiens (Human))
North China Pharmaceutical New Drug R&D

US Patent
LigandPNGBDBM294041(US10106557, Compound 7)
Affinity DataKi: >2.00E+4nMpH: 8.2Assay Description:The inhibitory activity on human trypsin was determined by using buffer (50 mM Tris, pH 8.2, and 20 mM CaCl2). Appropriate wells in the Greiner 384 m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine protease 1(Homo sapiens (Human))
North China Pharmaceutical New Drug R&D

US Patent
LigandPNGBDBM294039(Process 1 | US10106557, Compound 1)
Affinity DataKi: >2.00E+4nMpH: 8.2Assay Description:The inhibitory activity on human trypsin was determined by using buffer (50 mM Tris, pH 8.2, and 20 mM CaCl2). Appropriate wells in the Greiner 384 m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine protease 1(Homo sapiens (Human))
North China Pharmaceutical New Drug R&D

US Patent
LigandPNGBDBM294043(US10106557, Compound 30)
Affinity DataKi: >2.00E+4nMpH: 8.2Assay Description:The inhibitory activity on human trypsin was determined by using buffer (50 mM Tris, pH 8.2, and 20 mM CaCl2). Appropriate wells in the Greiner 384 m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine protease 1(Homo sapiens (Human))
North China Pharmaceutical New Drug R&D

US Patent
LigandPNGBDBM294042(US10106557, Compound 8)
Affinity DataKi: >2.00E+4nMpH: 8.2Assay Description:The inhibitory activity on human trypsin was determined by using buffer (50 mM Tris, pH 8.2, and 20 mM CaCl2). Appropriate wells in the Greiner 384 m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCarbonic anhydrase 9(Homo sapiens (Human))
East China University Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM10881(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
Affinity DataIC50:  0.25nMAssay Description:Inhibition of recombinant human carbonic anhydrase 9 after 15 mins by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
East China University Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM10882(6-ethoxy-1,3-benzothiazole-2-sulfonamide | CHEMBL1...)
Affinity DataIC50:  0.300nMAssay Description:Inhibition of full length carbonic anhydrase-2 in human erythrocytesMore data for this Ligand-Target Pair
TargetCarbonic anhydrase 9(Homo sapiens (Human))
East China University Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM50430551(CHEMBL2336905)
Affinity DataIC50:  0.480nMAssay Description:Inhibition of recombinant human carbonic anhydrase 9 after 15 mins by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 9(Homo sapiens (Human))
East China University Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM10882(6-ethoxy-1,3-benzothiazole-2-sulfonamide | CHEMBL1...)
Affinity DataIC50:  0.990nMAssay Description:Inhibition of GST-tagged recombinant carbonic anhydrase-9 catalytic domain (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
Capital Normal University

Curated by ChEMBL
LigandPNGBDBM18050(2-[(4-{[(2,4-diaminopteridin-6-yl)methyl](methyl)a...)
Affinity DataIC50:  2.10nMAssay Description:Inhibition of human dihydrofolate reductase by spectrophotometric analysisMore data for this Ligand-Target Pair
TargetCarbonic anhydrase 1(Homo sapiens (Human))
East China University Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM50005000(CHEMBL2392425)
Affinity DataIC50:  2.10nMAssay Description:Inhibition of full length carbonic anhydrase-1 in human erythrocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 9(Homo sapiens (Human))
East China University Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM10880(AZA | AZA2 | AZM acetazolamide | Acerazolamide, AA...)
Affinity DataIC50:  2.60nMAssay Description:Inhibition of GST-tagged recombinant carbonic anhydrase-9 catalytic domain (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 9(Homo sapiens (Human))
East China University Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM50005003(CHEMBL2392423)
Affinity DataIC50:  2.90nMAssay Description:Inhibition of GST-tagged recombinant carbonic anhydrase-9 catalytic domain (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Nankai University

Curated by ChEMBL
LigandPNGBDBM50243953(CHEMBL4101340)
Affinity DataIC50:  3nMAssay Description:Inhibition of N-terminal FLAG-tagged recombinant human mTOR (1362 to end residues)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Nankai University

Curated by ChEMBL
LigandPNGBDBM50243924(CHEMBL4075931)
Affinity DataIC50:  3nMAssay Description:Inhibition of N-terminal FLAG-tagged recombinant human mTOR (1362 to end residues)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Nankai University

Curated by ChEMBL
LigandPNGBDBM50243948(CHEMBL4096248)
Affinity DataIC50:  3nMAssay Description:Inhibition of N-terminal FLAG-tagged recombinant human mTOR (1362 to end residues)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 1(Homo sapiens (Human))
East China University Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM50004961(CHEMBL2392428)
Affinity DataIC50:  3.10nMAssay Description:Inhibition of full length carbonic anhydrase-1 in human erythrocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 9(Homo sapiens (Human))
East China University Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM50005002(CHEMBL2392424)
Affinity DataIC50:  3.10nMAssay Description:Inhibition of GST-tagged recombinant carbonic anhydrase-9 catalytic domain (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 9(Homo sapiens (Human))
East China University Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM50430550(CHEMBL2336906)
Affinity DataIC50:  3.30nMAssay Description:Inhibition of recombinant human carbonic anhydrase 9 after 15 mins by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Nankai University

Curated by ChEMBL
LigandPNGBDBM50243960(CHEMBL4083691)
Affinity DataIC50:  4nMAssay Description:Inhibition of N-terminal FLAG-tagged recombinant human mTOR (1362 to end residues)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Nankai University

Curated by ChEMBL
LigandPNGBDBM50243973(CHEMBL4064699)
Affinity DataIC50:  4nMAssay Description:Inhibition of N-terminal FLAG-tagged recombinant human mTOR (1362 to end residues)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 9(Homo sapiens (Human))
East China University Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM50005000(CHEMBL2392425)
Affinity DataIC50:  4.5nMAssay Description:Inhibition of GST-tagged recombinant carbonic anhydrase-9 catalytic domain (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
East China University Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM10881(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
Affinity DataIC50:  4.80nMAssay Description:Inhibition of recombinant human carbonic anhydrase 2 after 15 mins by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Temple University

US Patent
LigandPNGBDBM352210(US10239868, Entry 14 | US10287274, Entry 14 | US10...)
Affinity DataIC50:  6nMAssay Description:A stock concentration of 5 nM [3H]LSD (lysergic acid diethyl amide) is prepared in 50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4 (Assay Buffer). Ali...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
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