Affinity DataKi: 0.501nMAssay Description:Binding affinity to dopamine D2 receptorMore data for this Ligand-Target Pair
Affinity DataKi: 1.26nMAssay Description:Binding affinity to dopamine D3 receptorMore data for this Ligand-Target Pair
Affinity DataKi: 3.16nMAssay Description:Binding affinity to 5HT2A receptorMore data for this Ligand-Target Pair
Affinity DataKi: >501nMAssay Description:Binding affinity to dopamine D3 receptorMore data for this Ligand-Target Pair
Affinity DataKi: >1.26E+3nMAssay Description:Binding affinity to dopamine D2 receptorMore data for this Ligand-Target Pair
Affinity DataKi: >2.51E+3nMAssay Description:Binding affinity to 5HT2A receptorMore data for this Ligand-Target Pair
Affinity DataIC50: 2nMAssay Description:Inhibition of human muscarinic M3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Medicines Research Centre
Curated by ChEMBL
Medicines Research Centre
Curated by ChEMBL
Affinity DataIC50: 7.90nMAssay Description:Antagonist activity at human mGluR5 expressed in CHO cells assessed as doxycycline induced calcium mobilizationMore data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Medicines Research Centre
Curated by ChEMBL
Medicines Research Centre
Curated by ChEMBL
Affinity DataIC50: 10nMAssay Description:Antagonist activity at human mGluR5 expressed in CHO cells assessed as doxycycline induced calcium mobilizationMore data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Medicines Research Centre
Curated by ChEMBL
Medicines Research Centre
Curated by ChEMBL
Affinity DataIC50: 10nMAssay Description:Antagonist activity at human mGluR5 expressed in CHO cells assessed as doxycycline induced calcium mobilizationMore data for this Ligand-Target Pair
Affinity DataIC50: 12.6nMAssay Description:Inhibition of human muscarinic M3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Medicines Research Centre
Curated by ChEMBL
Medicines Research Centre
Curated by ChEMBL
Affinity DataIC50: 13nMAssay Description:Antagonist activity at human mGluR5 expressed in CHO cells assessed as doxycycline induced calcium mobilizationMore data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Medicines Research Centre
Curated by ChEMBL
Medicines Research Centre
Curated by ChEMBL
Affinity DataIC50: 13nMAssay Description:Antagonist activity at human mGluR5 expressed in CHO cells assessed as doxycycline induced calcium mobilizationMore data for this Ligand-Target Pair
Affinity DataIC50: 19.9nMAssay Description:Inhibition of human muscarinic M3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 32nMAssay Description:Antagonist activity at mGluR5 in mouse astrocytes assessed as inhibition of L-quisqualate induced calcium release by FLIPR assayMore data for this Ligand-Target Pair
Affinity DataIC50: 32nMAssay Description:Antagonist activity at mGluR5 in mouse astrocytes assessed as inhibition of L-quisqualate induced calcium release by FLIPR assayMore data for this Ligand-Target Pair
Affinity DataIC50: 39.8nMAssay Description:Inhibition of human muscarinic M3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Medicines Research Centre
Curated by ChEMBL
Medicines Research Centre
Curated by ChEMBL
Affinity DataIC50: 40nMAssay Description:Antagonist activity at human mGluR5 expressed in CHO cells assessed as doxycycline induced calcium mobilizationMore data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Medicines Research Centre
Curated by ChEMBL
Medicines Research Centre
Curated by ChEMBL
Affinity DataIC50: 40nMAssay Description:Antagonist activity at human mGluR5 expressed in CHO cells assessed as doxycycline induced calcium mobilizationMore data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Medicines Research Centre
Curated by ChEMBL
Medicines Research Centre
Curated by ChEMBL
Affinity DataIC50: 40nMAssay Description:Antagonist activity at human mGluR5 expressed in CHO cells assessed as doxycycline induced calcium mobilizationMore data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Medicines Research Centre
Curated by ChEMBL
Medicines Research Centre
Curated by ChEMBL
Affinity DataIC50: 40nMAssay Description:Antagonist activity at human mGluR5 expressed in CHO cells assessed as doxycycline induced calcium mobilizationMore data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Medicines Research Centre
Curated by ChEMBL
Medicines Research Centre
Curated by ChEMBL
Affinity DataIC50: 40nMAssay Description:Antagonist activity at human mGluR5 expressed in CHO cells assessed as doxycycline induced calcium mobilizationMore data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Medicines Research Centre
Curated by ChEMBL
Medicines Research Centre
Curated by ChEMBL
Affinity DataIC50: 50nMAssay Description:Antagonist activity at human mGluR5 expressed in CHO cells assessed as doxycycline induced calcium mobilizationMore data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Medicines Research Centre
Curated by ChEMBL
Medicines Research Centre
Curated by ChEMBL
Affinity DataIC50: 63nMAssay Description:Antagonist activity at human mGluR5 expressed in CHO cells assessed as doxycycline induced calcium mobilizationMore data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Medicines Research Centre
Curated by ChEMBL
Medicines Research Centre
Curated by ChEMBL
Affinity DataIC50: 63nMAssay Description:Antagonist activity at human mGluR5 expressed in CHO cells assessed as doxycycline induced calcium mobilizationMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
TBA
Curated by ChEMBL
TBA
Curated by ChEMBL
Affinity DataIC50: 79.4nMAssay Description:Binding affinity to human ERGMore data for this Ligand-Target Pair
Affinity DataIC50: 126nMAssay Description:Inhibition of human muscarinic M3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Medicines Research Centre
Curated by ChEMBL
Medicines Research Centre
Curated by ChEMBL
Affinity DataIC50: 126nMAssay Description:Antagonist activity at human mGluR5 expressed in CHO cells assessed as doxycycline induced calcium mobilizationMore data for this Ligand-Target Pair
Affinity DataIC50: 158nMAssay Description:Inhibition of human muscarinic M4 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 200nMAssay Description:Inhibition of human muscarinic M2 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 251nMAssay Description:Inhibition of human muscarinic M3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Medicines Research Centre
Curated by ChEMBL
Medicines Research Centre
Curated by ChEMBL
Affinity DataIC50: 316nMAssay Description:Antagonist activity at human mGluR5 expressed in CHO cells assessed as doxycycline induced calcium mobilizationMore data for this Ligand-Target Pair
Affinity DataIC50: 398nMAssay Description:Inhibition of human muscarinic M4 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 398nMAssay Description:Inhibition of human muscarinic M2 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 500nMAssay Description:Inhibition of CYP2C19More data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Medicines Research Centre
Curated by ChEMBL
Medicines Research Centre
Curated by ChEMBL
Affinity DataIC50: 501nMAssay Description:Antagonist activity at human mGluR5 expressed in CHO cells assessed as doxycycline induced calcium mobilizationMore data for this Ligand-Target Pair
Affinity DataIC50: 501nMAssay Description:Inhibition of human muscarinic M5 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 794nMAssay Description:Inhibition of human muscarinic M5 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human muscarinic M3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 1.26E+3nMAssay Description:Inhibition of human muscarinic M3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 1.26E+3nMAssay Description:Inhibition of human muscarinic M3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 1.26E+3nMAssay Description:Inhibition of human muscarinic M2 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 1.26E+3nMAssay Description:Inhibition of human muscarinic M3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 1.50E+3nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
Affinity DataIC50: 1.58E+3nMAssay Description:Inhibition of human muscarinic M5 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 1.58E+3nMAssay Description:Inhibition of human muscarinic M4 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 1.60E+3nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of human muscarinic M3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of human muscarinic M2 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 2.51E+3nMAssay Description:Inhibition of human muscarinic M3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair