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Found 68 with Last Name = 'gerchak' and Initial = 'c'
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50224496((S,E)-2-(4-(1H-indol-3-yl)piperidin-1-yl)-2-(1-(3-...)
Affinity DataIC50:  2nMAssay Description:Antagonist activity at CCR2 expressed in THP1 cells assessed as MCP1-induced calcium fluxMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50224501((E)-2-(4-(7-methoxy-1H-indol-3-yl)piperidin-1-yl)-...)
Affinity DataIC50:  2.5nMAssay Description:Inhibition of human CCR2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50224500((E)-2-(4-(5-amino-1H-indol-3-yl)piperidin-1-yl)-2-...)
Affinity DataIC50:  4nMAssay Description:Inhibition of human CCR2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50224523((E)-2-(4-(1H-indol-3-yl)piperidin-1-yl)-2-(1-(3-(3...)
Affinity DataIC50:  4nMAssay Description:Inhibition of human CCR2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50224502((E)-2-(4-(2-methyl-1H-indol-3-yl)piperidin-1-yl)-2...)
Affinity DataIC50:  4nMAssay Description:Inhibition of human CCR2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50224496((S,E)-2-(4-(1H-indol-3-yl)piperidin-1-yl)-2-(1-(3-...)
Affinity DataIC50:  4nMAssay Description:Inhibition of human CCR2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50224511((E)-2-(4-(1H-indol-3-yl)piperidin-1-yl)-2-(1-(3-(3...)
Affinity DataIC50:  5nMAssay Description:Inhibition of human CCR2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50224524((E)-2-(4-(5-(methylsulfonamido)-1H-indol-3-yl)pipe...)
Affinity DataIC50:  6.30nMAssay Description:Inhibition of human CCR2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50224519((E)-2-(4-(6-chloro-1H-indol-3-yl)piperidin-1-yl)-2...)
Affinity DataIC50:  7.70nMAssay Description:Inhibition of human CCR2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50224512(2-(1-((4-(trifluoromethoxy)phenyl)carbamoyl)piperi...)
Affinity DataIC50:  10nMAssay Description:Inhibition of human CCR2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50216434(CHEMBL245686 | dimethyl-(tetrahydro-pyran-4-yl)-{4...)
Affinity DataIC50:  10nMAssay Description:Displacement of [125I]MCP1 from CCR2 receptor expressed in THP1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50216453(CHEMBL247537 | dimethyl-{4-[(E)-3-(4'-methyl-biphe...)
Affinity DataIC50:  10nMAssay Description:Displacement of [125I]MCP1 from CCR2 receptor expressed in THP1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50224508((E)-2-(4-(5-hydroxy-1H-indol-3-yl)piperidin-1-yl)-...)
Affinity DataIC50:  15nMAssay Description:Inhibition of human CCR2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50224510((E)-2-(4-(1H-indol-3-yl)piperidin-1-yl)-2-(1-(3-(4...)
Affinity DataIC50:  15nMAssay Description:Inhibition of human CCR2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50224521((E)-2-(4-(5-methoxy-1H-indol-3-yl)piperidin-1-yl)-...)
Affinity DataIC50:  16.7nMAssay Description:Inhibition of human CCR2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50216435(CHEMBL397647 | N-(4-(3,4-dichlorobenzamido)benzyl)...)
Affinity DataIC50:  20nMAssay Description:Displacement of [125I]MCP1 from CCR2 receptor expressed in THP1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50224499((E)-2-(4-(1H-indol-3-yl)piperidin-1-yl)-2-(1-(3-(3...)
Affinity DataIC50:  20nMAssay Description:Inhibition of human CCR2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50224506((E)-2-(4-(6-fluoro-1H-indol-3-yl)piperidin-1-yl)-2...)
Affinity DataIC50:  20nMAssay Description:Inhibition of human CCR2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50224516(2-(1-((3,4-dichlorophenyl)carbamoyl)piperidin-4-yl...)
Affinity DataIC50:  25nMAssay Description:Inhibition of human CCR2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50216442(CHEMBL393631 | N-(4-(3,4-dichlorobenzamido)benzyl)...)
Affinity DataIC50:  30nMAssay Description:Displacement of [125I]MCP1 from CCR2 receptor expressed in THP1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50216445(CHEMBL246520 | N-(4-(3,4-dichlorobenzamido)benzyl)...)
Affinity DataIC50:  40nMAssay Description:Displacement of [125I]MCP1 from CCR2 receptor expressed in THP1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50224498((E)-2-(4-(5-fluoro-1H-indol-3-yl)piperidin-1-yl)-2...)
Affinity DataIC50:  50nMAssay Description:Inhibition of human CCR2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50224515((E)-2-(4-(1H-indol-3-yl)piperidin-1-yl)-2-(1-cinna...)
Affinity DataIC50:  80nMAssay Description:Inhibition of human CCR2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50216431(CHEMBL246728 | N-(4-(3,4-dichlorobenzamido)benzyl)...)
Affinity DataIC50:  90nMAssay Description:Displacement of [125I]MCP1 from CCR2 receptor expressed in THP1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50216435(CHEMBL397647 | N-(4-(3,4-dichlorobenzamido)benzyl)...)
Affinity DataIC50:  100nMAssay Description:Antagonist activity at CCR2 receptor in PBMC assessed as inhibition of MCP1-induced calcium mobilizationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50216435(CHEMBL397647 | N-(4-(3,4-dichlorobenzamido)benzyl)...)
Affinity DataIC50:  100nMAssay Description:Antagonist activity at CCR2 receptor in THP1 cells assessed as inhibition of MCP1-induced calcium mobilizationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50224505((E)-2-(4-(1H-indol-3-yl)piperidin-1-yl)-2-(1-(3-p-...)
Affinity DataIC50:  115nMAssay Description:Inhibition of human CCR2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50216432(CHEMBL394897 | N-(4-(7-chloro-2H-chromene-3-carbox...)
Affinity DataIC50:  120nMAssay Description:Displacement of [125I]MCP1 from CCR2 receptor expressed in THP1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50224517(2-(1-((4-(trifluoromethyl)phenyl)carbamoyl)piperid...)
Affinity DataIC50:  120nMAssay Description:Inhibition of human CCR2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50216447(CHEMBL246933 | N-(4-(7-methyl-2H-chromene-3-carbox...)
Affinity DataIC50:  170nMAssay Description:Displacement of [125I]MCP1 from CCR2 receptor expressed in THP1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50216446(CHEMBL264108 | N-(4-(7-bromo-2H-chromene-3-carboxa...)
Affinity DataIC50:  180nMAssay Description:Displacement of [125I]MCP1 from CCR2 receptor expressed in THP1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50216444(CHEMBL246313 | N-(4-(3,4-dichlorobenzamido)benzyl)...)
Affinity DataIC50:  200nMAssay Description:Displacement of [125I]MCP1 from CCR2 receptor expressed in THP1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50224514((R,E)-2-(4-(1H-indol-3-yl)piperidin-1-yl)-2-(1-(3-...)
Affinity DataIC50:  210nMAssay Description:Inhibition of human CCR2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50224507((E)-2-(4-(1H-indol-3-yl)piperidin-1-yl)-2-(1-(3-(4...)
Affinity DataIC50:  210nMAssay Description:Inhibition of human CCR2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50216455(CHEMBL248153 | N-(4-(3-chlorobenzamido)benzyl)-N,N...)
Affinity DataIC50:  230nMAssay Description:Displacement of [125I]MCP1 from CCR2 receptor expressed in THP1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50216448(CHEMBL248151 | N-(4-(3-bromobenzamido)benzyl)-N,N-...)
Affinity DataIC50:  250nMAssay Description:Displacement of [125I]MCP1 from CCR2 receptor expressed in THP1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50216454(CHEMBL246522 | N-(4-(3,4-dichlorobenzamido)benzyl)...)
Affinity DataIC50:  290nMAssay Description:Displacement of [125I]MCP1 from CCR2 receptor expressed in THP1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50224503(2-(4-(1H-indol-3-yl)piperidin-1-yl)-2-(1-(3-(3,4-d...)
Affinity DataIC50:  320nMAssay Description:Inhibition of human CCR2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50216452(CHEMBL245896 | N-(4-(3-chloro-4-fluorobenzamido)be...)
Affinity DataIC50:  390nMAssay Description:Displacement of [125I]MCP1 from CCR2 receptor expressed in THP1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50224520((E)-1-(4-((4-(1H-indol-3-yl)piperidin-1-yl)methyl)...)
Affinity DataIC50:  470nMAssay Description:Inhibition of human CCR2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50224513((E)-2-(4-(1H-indol-3-yl)piperidin-1-yl)-2-(1-(3-(4...)
Affinity DataIC50:  660nMAssay Description:Inhibition of human CCR2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50216438(CHEMBL245696 | N-(4-(3,5-dichlorobenzamido)benzyl)...)
Affinity DataIC50:  710nMAssay Description:Displacement of [125I]MCP1 from CCR2 receptor expressed in THP1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50224495(2-(1-((3,5-dichlorophenyl)carbamoyl)piperidin-4-yl...)
Affinity DataIC50:  720nMAssay Description:Inhibition of human CCR2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50216435(CHEMBL397647 | N-(4-(3,4-dichlorobenzamido)benzyl)...)
Affinity DataIC50:  1.00E+3nMAssay Description:Displacement of MIP1alpha from CCR5 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50216428(CHEMBL393632 | N-(4-(3,4-dichlorobenzamido)benzyl)...)
Affinity DataIC50:  1.02E+3nMAssay Description:Displacement of [125I]MCP1 from CCR2 receptor expressed in THP1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50224522(2-(4-(1H-indol-3-yl)piperidin-1-yl)-2-(1-(phenylca...)
Affinity DataIC50:  1.10E+3nMAssay Description:Inhibition of human CCR2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50224504((E)-2-(4-(1H-indol-3-yl)piperidin-1-yl)-2-(1-(3-(3...)
Affinity DataIC50:  1.80E+3nMAssay Description:Inhibition of human CCR2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50216449(CHEMBL396571 | N-(4-(3-(3-fluorophenyl)acrylamido)...)
Affinity DataIC50:  1.81E+3nMAssay Description:Displacement of [125I]MCP1 from CCR2 receptor expressed in THP1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50216429(CHEMBL245497 | N-(4-(4-chlorobenzamido)benzyl)-N,N...)
Affinity DataIC50:  2.00E+3nMAssay Description:Displacement of [125I]MCP1 from CCR2 receptor expressed in THP1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Mus musculus)
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50224496((S,E)-2-(4-(1H-indol-3-yl)piperidin-1-yl)-2-(1-(3-...)
Affinity DataIC50:  2.00E+3nMAssay Description:Displacement of [125I]-mouse MCP1 from CCR2 in mouse peripheral blood monocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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