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Found 404 with Last Name = 'ghai' and Initial = 'rd'
TargetNeprilysin(Rattus norvegicus (Rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50283607(7-(2-Mercaptomethyl-3-phenyl-propionylamino)-hepta...)
Affinity DataKi:  26nMAssay Description:In vitro inhibition against neutral endopeptidase 24.11 (NEP) in rat kidney cortex membraneMore data for this Ligand-Target Pair
In DepthDetails Article
TargetNeprilysin(Oryctolagus cuniculus (rabbit))
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50251742((3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyl-tetrahydro...)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of enkephalinase activity in membranes prepared from rabbitMore data for this Ligand-Target Pair
TargetNeprilysin(Rattus norvegicus (Rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50251742((3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyl-tetrahydro...)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of enkephalinase activity in synaptic membranes prepared from rat striatumMore data for this Ligand-Target Pair
TargetNeprilysin(Rattus norvegicus (Rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50034841((S)-5-Biphenyl-4-yl-4-(2-carboxy-ethylcarbamoyl)-p...)
Affinity DataIC50:  0.700nMAssay Description:The compound was tested in vitro for inhibition of Neutral endopeptidase by using Leu enkephalin as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Rattus norvegicus (Rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50034846((2R,4R)-5-Biphenyl-4-yl-4-(3-carboxy-propionylamin...)
Affinity DataIC50:  0.740nMAssay Description:The compound was tested in vitro for inhibition of Neutral endopeptidase by using Leu enkephalin as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Rattus norvegicus (Rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50042828(4-Hydroxy-1-(9-mercaptomethyl-10-oxo-azecane-2-car...)
Affinity DataIC50:  0.800nMAssay Description:Inhibition of NEP 24.11 from rat kidneyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Rattus norvegicus (Rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50034851(3-[(S)-3-Biphenyl-4-yl-2-(phosphonomethyl-amino)-p...)
Affinity DataIC50:  0.810nMAssay Description:The compound was tested in vitro for inhibition of Neutral endopeptidase by using Leu enkephalin as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Homo sapiens (Human))
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50056252((6S,9S)-6-Mercaptomethyl-7-oxo-6,7,8,9,10,11,12,13...)
Affinity DataIC50:  0.900nMAssay Description:Inhibitory concentration required to inhibit neutral endopeptidase (NEP)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Homo sapiens (Human))
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50056252((6S,9S)-6-Mercaptomethyl-7-oxo-6,7,8,9,10,11,12,13...)
Affinity DataIC50:  0.900nMAssay Description:Inhibition of neutral endopeptidaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Rattus norvegicus (Rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50064106(CGS-26303 | CHEMBL290698 | {[(R)-2-Biphenyl-4-yl-1...)
Affinity DataIC50:  0.930nMAssay Description:In vitro inhibitory activity against neutral endopeptidase (NEP)More data for this Ligand-Target Pair
In DepthDetails Article
TargetNeprilysin(Rattus norvegicus (Rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50048318((S)-2-{[1-((S)-2-Mercapto-3-methyl-butyrylamino)-c...)
Affinity DataIC50:  1.20nMAssay Description:Evaluation of in vitro inhibitory activity against Neutral endopeptidaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiotensin-converting enzyme 2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50017129((S)-1-((S)-2-((R)-1-ethoxy-1-oxo-4-phenylbutan-2-y...)
Affinity DataIC50:  1.20nMAssay Description:In vitro inhibition against angiotensin converting enzyme (ACE)More data for this Ligand-Target Pair
In DepthDetails Article
TargetNeprilysin(Rattus norvegicus (Rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50285328(CHEMBL285747 | {[(S)-2-Biphenyl-4-yl-1-(1H-tetrazo...)
Affinity DataIC50:  1.40nMAssay Description:In vitro inhibitory activity against neutral endopeptidase (NEP)More data for this Ligand-Target Pair
In DepthDetails Article
TargetNeprilysin(Oryctolagus cuniculus (rabbit))
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50017742(CHEMBL316180 | disodium 2-benzyl-4-(3-carboxylatop...)
Affinity DataIC50:  1.40nMAssay Description:Inhibition of enkephalinase activity in membranes prepared from rabbitMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Rattus norvegicus (Rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50048312((S)-3-(4-Hydroxy-phenyl)-2-{[1-((S)-2-mercapto-3-m...)
Affinity DataIC50:  1.5nMAssay Description:Evaluation of in vitro inhibitory activity against Neutral endopeptidaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Rattus norvegicus (Rat))
TBA

Curated by ChEMBL
LigandPNGBDBM21641(2-(2-benzyl-3-sulfanylpropanamido)acetic acid | CH...)
Affinity DataIC50:  1.5nMAssay Description:The compound was tested in vitro for inhibition of Neutral endopeptidase by using Leu enkephalin as substrateMore data for this Ligand-Target Pair
TargetNeprilysin(Rattus norvegicus (Rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50048320((S)-2-{[1-((S)-2-Mercapto-3-methyl-butyrylamino)-c...)
Affinity DataIC50:  1.5nMAssay Description:Evaluation of in vitro inhibitory activity against Neutral endopeptidaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Rattus norvegicus (Rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50285340(CHEMBL290285 | {[(S)-2-(2-Methoxy-biphenyl-4-yl)-1...)
Affinity DataIC50:  1.5nMAssay Description:In vitro inhibitory activity against neutral endopeptidase (NEP)More data for this Ligand-Target Pair
In DepthDetails Article
TargetNeprilysin(Rattus norvegicus (Rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50034851(3-[(S)-3-Biphenyl-4-yl-2-(phosphonomethyl-amino)-p...)
Affinity DataIC50:  1.60nMAssay Description:The compound was tested for inhibition of Neutral endopeptidase by using GAAP as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Rattus norvegicus (Rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50048304((S)-3-(4-Fluoro-phenyl)-2-{[1-((S)-2-mercapto-3-me...)
Affinity DataIC50:  1.80nMAssay Description:Evaluation of in vitro inhibitory activity against Neutral endopeptidaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Rattus norvegicus (Rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50034851(3-[(S)-3-Biphenyl-4-yl-2-(phosphonomethyl-amino)-p...)
Affinity DataIC50:  1.90nMAssay Description:In vitro inhibition of Neutral endopeptidase (NEP) enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiotensin-converting enzyme(Oryctolagus cuniculus)
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50021127(2-(1-Carboxymethyl-2-oxo-2,3,4,5-tetrahydro-1H-ben...)
Affinity DataIC50:  2nMAssay Description:Tested in vitro for the inhibition against neutral endopeptidase (NEP) from rat kidneyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Rattus norvegicus (Rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50048303((S)-3-(5-Hydroxy-1H-indol-3-yl)-2-{[1-((S)-2-merca...)
Affinity DataIC50:  2nMAssay Description:Evaluation of in vitro inhibitory activity against Neutral endopeptidaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Oryctolagus cuniculus (rabbit))
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50017736(2-Benzyl-4-(3-carboxy-propionylamino)-5-phenyl-pen...)
Affinity DataIC50:  2nMAssay Description:Inhibition of enkephalinase activity in membranes prepared from rabbitMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Rattus norvegicus (Rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50034851(3-[(S)-3-Biphenyl-4-yl-2-(phosphonomethyl-amino)-p...)
Affinity DataIC50:  2nMAssay Description:The compound was tested in vitro for inhibition of Neutral endopeptidase by using ANF(atrial natriuretic factor) as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Rattus norvegicus (Rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50042835(1-(9-Mercaptomethyl-10-oxo-azecane-2-carbonyl)-pyr...)
Affinity DataIC50:  2nMAssay Description:Inhibition of NEP 24.11 from rat kidneyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Homo sapiens (Human))
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50283642((S)-3-Biphenyl-4-yl-2-{(S)-3-methyl-2-[((R)-phosph...)
Affinity DataIC50:  2nMAssay Description:In vitro inhibitory concentration against neutral endopeptidaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetNeprilysin(Rattus norvegicus (Rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50040401((S)-[3-Biphenyl-4-yl-2-(phosphonomethyl-amino)-pro...)
Affinity DataIC50:  2nMAssay Description:In vitro inhibition of Neutral endopeptidase (NEP) enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Rattus norvegicus (Rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50048314((S)-3-(1H-Indol-3-yl)-2-{[1-((S)-2-mercapto-3-meth...)
Affinity DataIC50:  2.10nMAssay Description:Evaluation of in vitro inhibitory activity against Neutral endopeptidaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Rattus norvegicus (Rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50048315((S)-2-{[1-((S)-2-Mercapto-3-methyl-butyrylamino)-c...)
Affinity DataIC50:  2.20nMAssay Description:Evaluation of in vitro inhibitory activity against Neutral endopeptidaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Rattus norvegicus (Rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50048305((S)-2-{[1-((S)-2-Mercapto-3-methyl-butyrylamino)-c...)
Affinity DataIC50:  2.60nMAssay Description:Evaluation of in vitro inhibitory activity against Neutral endopeptidaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Homo sapiens (Human))
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50056249((6S,9S)-6-Mercaptomethyl-7-oxo-5,6,7,8,9,10,11,12,...)
Affinity DataIC50:  3nMAssay Description:Inhibition of neutral endopeptidaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Rattus norvegicus (Rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50042827(9-Mercaptomethyl-10-oxo-azecane-2-carboxylic acid ...)
Affinity DataIC50:  3nMAssay Description:Inhibition of NEP 24.11 from rat kidneyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Rattus norvegicus (Rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50042827(9-Mercaptomethyl-10-oxo-azecane-2-carboxylic acid ...)
Affinity DataIC50:  3nMAssay Description:Inhibition of NEP 24.11 from rat kidneyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Rattus norvegicus (Rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50040409((S)-2-[3-Biphenyl-4-yl-2-(phosphonomethyl-amino)-p...)
Affinity DataIC50:  3nMAssay Description:In vitro inhibition of Neutral endopeptidase (NEP) enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Rattus norvegicus (Rat))
TBA

Curated by ChEMBL
LigandPNGBDBM21641(2-(2-benzyl-3-sulfanylpropanamido)acetic acid | CH...)
Affinity DataIC50:  3nMAssay Description:Inhibition of enkephalinase activity in synaptic membranes prepared from rat striatumMore data for this Ligand-Target Pair
TargetNeprilysin(Rattus norvegicus (Rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50048317((S)-3-(4-Hydroxy-phenyl)-2-{[1-((S)-2-mercapto-3-p...)
Affinity DataIC50:  3nMAssay Description:Evaluation of in vitro inhibitory activity against Neutral endopeptidaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Rattus norvegicus (Rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50048310((S)-2-{[1-((S)-2-Mercapto-3-methyl-butyrylamino)-c...)
Affinity DataIC50:  3nMAssay Description:Evaluation of in vitro inhibitory activity against Neutral endopeptidaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Homo sapiens (Human))
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50056249((6S,9S)-6-Mercaptomethyl-7-oxo-5,6,7,8,9,10,11,12,...)
Affinity DataIC50:  3nMAssay Description:Inhibitory concentration required to inhibit neutral endopeptidase (NEP)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Homo sapiens (Human))
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50085459((S)-3-Biphenyl-4-yl-2-[(S)-3-methyl-2-(phosphonome...)
Affinity DataIC50:  3nMAssay Description:In vitro inhibitory concentration against neutral endopeptidaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetNeprilysin(Rattus norvegicus (Rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50048316((S)-2-{[1-((S)-2-Mercapto-3-methyl-butyrylamino)-c...)
Affinity DataIC50:  3.10nMAssay Description:Evaluation of in vitro inhibitory activity against Neutral endopeptidaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Homo sapiens (Human))
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50056251((6R,9S)-6-Mercaptomethyl-7-oxo-5,6,7,8,9,10,11,12,...)
Affinity DataIC50:  4nMAssay Description:Inhibition of neutral endopeptidaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiotensin-converting enzyme(Homo sapiens (Human))
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50056262((3S,6S)-3-Mercaptomethyl-4-oxo-5-aza-bicyclo[10.3....)
Affinity DataIC50:  4nMAssay Description:Inhibitory concentration required to inhibit Angiotensin I converting enzyme (ACE)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Rattus norvegicus (Rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50040405(3-[3-Biphenyl-4-yl-2-(phosphonomethyl-amino)-propi...)
Affinity DataIC50:  4nMAssay Description:In vitro inhibition of Neutral endopeptidase (NEP) enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Rattus norvegicus (Rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50017755(2-Benzyl-4-(carboxymethyl-carbamoyl)-5-phenyl-pent...)
Affinity DataIC50:  4nMAssay Description:Inhibition of enkephalinase activity in synaptic membranes prepared from rat striatumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Homo sapiens (Human))
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50056259((3S,6S)-3-Mercaptomethyl-4-oxo-5-aza-bicyclo[11.3....)
Affinity DataIC50:  4nMAssay Description:Inhibitory concentration required to inhibit neutral endopeptidase (NEP)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Homo sapiens (Human))
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50056251((6R,9S)-6-Mercaptomethyl-7-oxo-5,6,7,8,9,10,11,12,...)
Affinity DataIC50:  4nMAssay Description:Inhibitory concentration required to inhibit neutral endopeptidase (NEP)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Homo sapiens (Human))
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50283637(2-{(S)-3-Biphenyl-4-yl-2-[(S)-3-methyl-1-oxo-2-(ph...)
Affinity DataIC50:  4nMAssay Description:In vitro inhibitory concentration against neutral endopeptidaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetNeprilysin(Rattus norvegicus (Rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50017734(2-Benzyl-4-(2-benzylsulfanyl-1-carboxy-ethylcarbam...)
Affinity DataIC50:  4nMAssay Description:Inhibition of enkephalinase activity in synaptic membranes prepared from rat striatumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Homo sapiens (Human))
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM21641(2-(2-benzyl-3-sulfanylpropanamido)acetic acid | CH...)
Affinity DataIC50:  4.30nMAssay Description:Inhibition of neutral endopeptidaseMore data for this Ligand-Target Pair
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