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Found 172 with Last Name = 'gibbons' and Initial = 'cp'
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50314613((S)-N-(4-(4,4-dimethylcyclohexyloxy)-5-fluoro-2-me...)
Affinity DataKi:  0.900nMAssay Description:Binding affinity to 5HT2C receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50314616((S)-N-(4-(cyclohexylmethoxy)-5-fluoro-2-methoxyben...)
Affinity DataKi:  1.70nMAssay Description:Binding affinity to 5HT2C receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50314614((S)-N-(4-(4,4-dimethylcyclohexyloxy)-2,5-difluorob...)
Affinity DataKi:  1.80nMAssay Description:Binding affinity to 5HT2C receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50314618(CHEMBL1090397 | N-((4'-chloro-3-fluorobiphenyl-4-y...)
Affinity DataKi:  4nMAssay Description:Binding affinity to 5HT2C receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50314623((S)-N-(4-cyclohexylbenzyl)pyrrolidine-2-carboxamid...)
Affinity DataKi:  4.40nMAssay Description:Binding affinity to 5HT2C receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50314624((S)-N-((3',5'-dichlorobiphenyl-4-yl)methyl)pyrroli...)
Affinity DataKi:  8nMAssay Description:Binding affinity to 5HT2C receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50314613((S)-N-(4-(4,4-dimethylcyclohexyloxy)-5-fluoro-2-me...)
Affinity DataKi:  12.8nMAssay Description:Binding affinity to 5HT2A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50314614((S)-N-(4-(4,4-dimethylcyclohexyloxy)-2,5-difluorob...)
Affinity DataKi:  13.7nMAssay Description:Binding affinity to 5HT2A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50161646((1R)-8-chloro-2,3,4,5-tetrahydro-1-methyl-1H-3-ben...)
Affinity DataKi:  15nMAssay Description:Displacement of [125I]DOI from human recombinant 5HT2C receptor expressed in HEK293 cells by scintillation countingMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50314626((S)-N-(4-(benzyloxy)benzyl)pyrrolidine-2-carboxami...)
Affinity DataKi:  20nMAssay Description:Binding affinity to 5HT2C receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50314625((S)-N-(4-(3-fluorophenoxy)benzyl)pyrrolidine-2-car...)
Affinity DataKi:  23nMAssay Description:Binding affinity to 5HT2C receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50314615((S)-N-(3,5-difluoro-4-((1s,4s)-4-methylcyclohexylo...)
Affinity DataKi:  25nMAssay Description:Binding affinity to 5HT2C receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50314617((2S,6R)-4-((3,5-dimethylisoxazol-4-yl)methoxy)-2,6...)
Affinity DataKi:  43nMAssay Description:Binding affinity to 5HT2C receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50314619((2S,6R)-benzyl 2,6-dimethylpiperazine-1-carboxylat...)
Affinity DataKi:  83nMAssay Description:Binding affinity to 5HT2C receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50342539(2-(3-chlorobenzyl)-6,7,8,9-tetrahydro-5H-pyrimido[...)
Affinity DataKi:  84nMAssay Description:Displacement of [3H]meselurgine from human 5HT2C receptor expressed in Swiss mouse 3T3 cells by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50342538(2-benzyl-6,7,8,9-tetrahydro-5H-pyrimido[5,4-d]azep...)
Affinity DataKi:  160nMAssay Description:Displacement of [3H]meselurgine from human 5HT2C receptor expressed in Swiss mouse 3T3 cells by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50161646((1R)-8-chloro-2,3,4,5-tetrahydro-1-methyl-1H-3-ben...)
Affinity DataKi:  167nMAssay Description:Displacement of [3H]meselurgine from human 5HT2C receptor expressed in Swiss mouse 3T3 cells by scintillation proximity assayMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50342547(2-(3-methylbenzyl)-6,7,8,9-tetrahydro-5H-pyrimido[...)
Affinity DataKi:  244nMAssay Description:Displacement of [3H]meselurgine from human 5HT2C receptor expressed in Swiss mouse 3T3 cells by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50342548(2-(2-methylbenzyl)-6,7,8,9-tetrahydro-5H-pyrimido[...)
Affinity DataKi:  305nMAssay Description:Displacement of [3H]meselurgine from human 5HT2C receptor expressed in Swiss mouse 3T3 cells by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50342544(2-(3-(trifluoromethyl)benzyl)-6,7,8,9-tetrahydro-5...)
Affinity DataKi:  308nMAssay Description:Displacement of [3H]meselurgine from human 5HT2C receptor expressed in Swiss mouse 3T3 cells by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50314620((S)-N-(4-(trifluoromethoxy)benzyl)pyrrolidine-2-ca...)
Affinity DataKi:  324nMAssay Description:Binding affinity to 5HT2C receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50342549(2-(4-fluorobenzyl)-6,7,8,9-tetrahydro-5H-pyrimido[...)
Affinity DataKi:  470nMAssay Description:Displacement of [3H]meselurgine from human 5HT2C receptor expressed in Swiss mouse 3T3 cells by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50314622(3-(aminomethyl)-N-(4-(trifluoromethoxy)benzyl)benz...)
Affinity DataKi:  585nMAssay Description:Binding affinity to 5HT2C receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50314621(CHEMBL1090400 | N-(4-(trifluoromethoxy)benzyl)pyrr...)
Affinity DataKi:  643nMAssay Description:Binding affinity to 5HT2C receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2B(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50314614((S)-N-(4-(4,4-dimethylcyclohexyloxy)-2,5-difluorob...)
Affinity DataKi:  1.67E+3nMAssay Description:Binding affinity to 5HT2B receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2B(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50314626((S)-N-(4-(benzyloxy)benzyl)pyrrolidine-2-carboxami...)
Affinity DataKi:  1.72E+3nMAssay Description:Binding affinity to 5HT2B receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50342545(2-(2-chlorobenzyl)-6,7,8,9-tetrahydro-5H-pyrimido[...)
Affinity DataKi:  1.85E+3nMAssay Description:Displacement of [3H]meselurgine from human 5HT2C receptor expressed in Swiss mouse 3T3 cells by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2B(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50314625((S)-N-(4-(3-fluorophenoxy)benzyl)pyrrolidine-2-car...)
Affinity DataKi:  2.40E+3nMAssay Description:Binding affinity to 5HT2B receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2B(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50314618(CHEMBL1090397 | N-((4'-chloro-3-fluorobiphenyl-4-y...)
Affinity DataKi:  3.50E+3nMAssay Description:Binding affinity to 5HT2B receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2B(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50314613((S)-N-(4-(4,4-dimethylcyclohexyloxy)-5-fluoro-2-me...)
Affinity DataKi:  3.94E+3nMAssay Description:Binding affinity to 5HT2B receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2B(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50314623((S)-N-(4-cyclohexylbenzyl)pyrrolidine-2-carboxamid...)
Affinity DataKi:  4.12E+3nMAssay Description:Binding affinity to 5HT2B receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2B(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50314617((2S,6R)-4-((3,5-dimethylisoxazol-4-yl)methoxy)-2,6...)
Affinity DataKi: >1.00E+4nMAssay Description:Binding affinity to 5HT2B receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2B(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50314620((S)-N-(4-(trifluoromethoxy)benzyl)pyrrolidine-2-ca...)
Affinity DataKi: >1.00E+4nMAssay Description:Binding affinity to 5HT2B receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Pfizer

LigandPNGBDBM16384(4-(4-fluorophenyl)-5-[3-(2-methoxyphenyl)-[1,2,4]t...)
Affinity DataIC50:  0.400nMAssay Description:The IC50s were determined by incubating each test compound with activated p38-alpha in a 96-well plate that had been pre-treated with ATF-2-GST to al...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Pfizer

LigandPNGBDBM16385(5-[3-(2-ethoxyphenyl)-[1,2,4]triazolo[3,4-a]pyridi...)
Affinity DataIC50:  0.400nMAssay Description:The IC50s were determined by incubating each test compound with activated p38-alpha in a 96-well plate that had been pre-treated with ATF-2-GST to al...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Pfizer

LigandPNGBDBM16390(4-(2,4-difluorophenyl)-5-[3-(1-methylcyclopropyl)-...)
Affinity DataIC50:  0.700nMAssay Description:The IC50s were determined by incubating each test compound with activated p38-alpha in a 96-well plate that had been pre-treated with ATF-2-GST to al...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Pfizer

LigandPNGBDBM16392(4-(2,4-difluorophenyl)-5-[3-(1-methylcyclobutyl)-[...)
Affinity DataIC50:  1.10nMAssay Description:The IC50s were determined by incubating each test compound with activated p38-alpha in a 96-well plate that had been pre-treated with ATF-2-GST to al...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Pfizer

LigandPNGBDBM16393(5-{3-tert-butyl-[1,2,4]triazolo[3,4-a]pyridin-6-yl...)
Affinity DataIC50:  1.10nMAssay Description:The IC50s were determined by incubating each test compound with activated p38-alpha in a 96-well plate that had been pre-treated with ATF-2-GST to al...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Pfizer

LigandPNGBDBM16398(4-(2,5-difluorophenyl)-5-[3-(1-methylcyclobutyl)-[...)
Affinity DataIC50:  1.5nMAssay Description:The IC50s were determined by incubating each test compound with activated p38-alpha in a 96-well plate that had been pre-treated with ATF-2-GST to al...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Pfizer

LigandPNGBDBM16404(5-{3-tert-butyl-[1,2,4]triazolo[3,4-a]pyridin-6-yl...)
Affinity DataIC50:  1.80nMAssay Description:The IC50s were determined by incubating each test compound with activated p38-alpha in a 96-well plate that had been pre-treated with ATF-2-GST to al...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Pfizer

LigandPNGBDBM16346(4-(4-chloro-2-fluorophenyl)-5-[3-(propan-2-yl)-[1,...)
Affinity DataIC50:  2.20nMpH: 7.2 T: 2°CAssay Description:The IC50s were determined by incubating each test compound with activated p38-alpha in a 96-well plate that had been pre-treated with ATF-2-GST to al...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Pfizer

LigandPNGBDBM16401(5-[3-(1-methylcyclopropyl)-[1,2,4]triazolo[3,4-a]p...)
Affinity DataIC50:  2.30nMAssay Description:The IC50s were determined by incubating each test compound with activated p38-alpha in a 96-well plate that had been pre-treated with ATF-2-GST to al...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Pfizer

LigandPNGBDBM16348(4-(2-chloro-4-fluorophenyl)-5-[3-(propan-2-yl)-[1,...)
Affinity DataIC50:  2.5nMAssay Description:The IC50s were determined by incubating each test compound with activated p38-alpha in a 96-well plate that had been pre-treated with ATF-2-GST to al...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Pfizer

LigandPNGBDBM16403(5-[3-(1-methylcyclobutyl)-[1,2,4]triazolo[3,4-a]py...)
Affinity DataIC50:  2.5nMAssay Description:The IC50s were determined by incubating each test compound with activated p38-alpha in a 96-well plate that had been pre-treated with ATF-2-GST to al...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Pfizer

LigandPNGBDBM16405(3-(2,5-difluorophenyl)-4-[3-(propan-2-yl)-[1,2,4]t...)
Affinity DataIC50:  2.80nMAssay Description:The IC50s were determined by incubating each test compound with activated p38-alpha in a 96-well plate that had been pre-treated with ATF-2-GST to al...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Pfizer

LigandPNGBDBM16340(4-(2-chlorophenyl)-5-[3-(propan-2-yl)-[1,2,4]triaz...)
Affinity DataIC50:  3nMpH: 7.2 T: 2°CAssay Description:The IC50s were determined by incubating each test compound with activated p38-alpha in a 96-well plate that had been pre-treated with ATF-2-GST to al...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Pfizer

LigandPNGBDBM16396(4-(2,5-difluorophenyl)-5-[3-(1-methylcyclopropyl)-...)
Affinity DataIC50:  3nMAssay Description:The IC50s were determined by incubating each test compound with activated p38-alpha in a 96-well plate that had been pre-treated with ATF-2-GST to al...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Pfizer

LigandPNGBDBM16351(5-[3-(propan-2-yl)-[1,2,4]triazolo[3,4-a]pyridin-6...)
Affinity DataIC50:  3.20nMAssay Description:The IC50s were determined by incubating each test compound with activated p38-alpha in a 96-well plate that had been pre-treated with ATF-2-GST to al...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Pfizer

LigandPNGBDBM16386(5-{3-tert-butyl-[1,2,4]triazolo[3,4-a]pyridin-6-yl...)
Affinity DataIC50:  3.5nMAssay Description:The IC50s were determined by incubating each test compound with activated p38-alpha in a 96-well plate that had been pre-treated with ATF-2-GST to al...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Pfizer

LigandPNGBDBM16389(5-{3-cyclopropyl-[1,2,4]triazolo[3,4-a]pyridin-6-y...)
Affinity DataIC50:  3.5nMAssay Description:The IC50s were determined by incubating each test compound with activated p38-alpha in a 96-well plate that had been pre-treated with ATF-2-GST to al...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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