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Found 33 with Last Name = 'giraud' and Initial = 'e'
TargetDimer of Protein farnesyltransferase subunit beta(Homo sapiens (Human))
RhôNe-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50088001((+/-)-11-[2-(2-methoxyphenyl)acryloyl]-1-phenyl-(1...)
Affinity DataKi:  25nMAssay Description:Inhibition of farnesyltransferase by Ras/SPA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Protein farnesyltransferase subunit beta(Homo sapiens (Human))
RhôNe-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50088009((+/-)-11-[2-(2-methoxyphenyl)acetyl]-1-phenyl-(1R,...)
Affinity DataKi:  140nMAssay Description:Inhibition of farnesyltransferase by Ras/SPA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Protein farnesyltransferase subunit beta(Homo sapiens (Human))
RhôNe-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50088004(8-hydroxy-11-[2-(2-methoxyphenyl)acetyl]-1-phenyl-...)
Affinity DataKi:  250nMAssay Description:Inhibition of farnesyltransferase by Ras/SPA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Protein farnesyltransferase subunit beta(Homo sapiens (Human))
RhôNe-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50088008(11-[2-(2-methoxyphenyl)acetyl]-1-phenyl-(1R,8R,9S,...)
Affinity DataKi:  420nMAssay Description:Inhibition of farnesyltransferase by Ras/SPA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Protein farnesyltransferase subunit beta(Homo sapiens (Human))
RhôNe-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50088014(1-(2,3-dihydrobenzo[b]furan-5-yl)-11-[2-(2-methoxy...)
Affinity DataKi:  420nMAssay Description:Inhibition of farnesyltransferase by Ras/SPA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Protein farnesyltransferase subunit beta(Homo sapiens (Human))
RhôNe-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50088013(2-[11-[2-(2-methoxyphenyl)acetyl]-1-phenyl-(1R,8R,...)
Affinity DataKi:  738nMAssay Description:Inhibition of farnesyltransferase by Ras/SPA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Protein farnesyltransferase subunit beta(Homo sapiens (Human))
RhôNe-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50088002(1-(4-carboxymethoxyphenyl)-11-[2-(2-methoxyphenyl)...)
Affinity DataKi:  2.55E+4nMAssay Description:Inhibition of farnesyltransferase by Ras/SPA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Protein farnesyltransferase subunit beta(Homo sapiens (Human))
RhôNe-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50088003(11-[2-(2-benzyloxyphenyl)acetyl]-1-phenyl-(1R,8R,9...)
Affinity DataKi:  3.20E+4nMAssay Description:Inhibition of farnesyltransferase by Ras/SPA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Protein farnesyltransferase subunit beta(Homo sapiens (Human))
RhôNe-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50088005(2-(2-methoxyphenyl)-1-[1-phenyl-(1R,8S,9R,13R)-11-...)
Affinity DataKi:  4.00E+4nMAssay Description:Inhibition of farnesyltransferase by Ras/SPA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Protein farnesyltransferase subunit beta(Homo sapiens (Human))
RhôNe-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50088006(6-hydroxy-11-[2-(2-methoxyphenyl)acetyl]-1-phenyl-...)
Affinity DataKi:  5.00E+4nMAssay Description:Inhibition of farnesyltransferase by Ras/SPA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
University Of Turin

Curated by ChEMBL
LigandPNGBDBM50281169(CHEMBL4173846 | US20240034730, Compound 1)
Affinity DataIC50:  1.20nMAssay Description:Inhibition of human recombinant N-terminal GST-tagged DHODH expressed in Escherichia coli BL21(DE3) using dihydroorotate substrate preincubated for 5...More data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
University Of Turin

Curated by ChEMBL
LigandPNGBDBM50586377(CHEMBL5086254 | US20240034730, Compound 7)
Affinity DataIC50:  1.40nMAssay Description:Inhibition of human recombinant N-terminal GST-tagged DHODH expressed in Escherichia coli BL21(DE3) using dihydroorotate substrate preincubated for 5...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
University Of Turin

Curated by ChEMBL
LigandPNGBDBM15339(6-fluoro-2-[4-(2-fluorophenyl)phenyl]-3-methyl-qui...)
Affinity DataIC50:  1.80nMAssay Description:Inhibition of human recombinant N-terminal GST-tagged DHODH expressed in Escherichia coli BL21(DE3) using dihydroorotate substrate preincubated for 5...More data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
University Of Turin

Curated by ChEMBL
LigandPNGBDBM50586381(CHEMBL5092556 | US20240034730, Compound 11)
Affinity DataIC50:  2nMAssay Description:Inhibition of human recombinant N-terminal GST-tagged DHODH expressed in Escherichia coli BL21(DE3) using dihydroorotate substrate preincubated for 5...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
University Of Turin

Curated by ChEMBL
LigandPNGBDBM50586385(CHEMBL5090431 | US20240034730, Compound 15)
Affinity DataIC50:  2.30nMAssay Description:Inhibition of human recombinant N-terminal GST-tagged DHODH expressed in Escherichia coli BL21(DE3) using dihydroorotate substrate preincubated for 5...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
University Of Turin

Curated by ChEMBL
LigandPNGBDBM50586386(CHEMBL5084878 | US20240034730, Compound 16)
Affinity DataIC50:  2.80nMAssay Description:Inhibition of human recombinant N-terminal GST-tagged DHODH expressed in Escherichia coli BL21(DE3) using dihydroorotate substrate preincubated for 5...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
University Of Turin

Curated by ChEMBL
LigandPNGBDBM50586384(CHEMBL5088148 | US20240034730, Compound 14)
Affinity DataIC50:  2.80nMAssay Description:Inhibition of human recombinant N-terminal GST-tagged DHODH expressed in Escherichia coli BL21(DE3) using dihydroorotate substrate preincubated for 5...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
University Of Turin

Curated by ChEMBL
LigandPNGBDBM50586374(CHEMBL5075870 | US20240034730, Compound 4)
Affinity DataIC50:  3.40nMAssay Description:Inhibition of human recombinant N-terminal GST-tagged DHODH expressed in Escherichia coli BL21(DE3) using dihydroorotate substrate preincubated for 5...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
University Of Turin

Curated by ChEMBL
LigandPNGBDBM50586387(CHEMBL5090281 | US20240034730, Compound 17)
Affinity DataIC50:  4.10nMAssay Description:Inhibition of human recombinant N-terminal GST-tagged DHODH expressed in Escherichia coli BL21(DE3) using dihydroorotate substrate preincubated for 5...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
University Of Turin

Curated by ChEMBL
LigandPNGBDBM50281170(CHEMBL4165923 | US20240034730, Compound 2)
Affinity DataIC50:  4.30nMAssay Description:Inhibition of human recombinant N-terminal GST-tagged DHODH expressed in Escherichia coli BL21(DE3) using dihydroorotate substrate preincubated for 5...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
University Of Turin

Curated by ChEMBL
LigandPNGBDBM50586375(CHEMBL5087682 | US20240034730, Compound 5)
Affinity DataIC50:  5.80nMAssay Description:Inhibition of human recombinant N-terminal GST-tagged DHODH expressed in Escherichia coli BL21(DE3) using dihydroorotate substrate preincubated for 5...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
University Of Turin

Curated by ChEMBL
LigandPNGBDBM470454(N-(2-chloro-6-fluorophenyl)-4-[4-ethyl-3-(hydroxym...)
Affinity DataIC50:  6nMAssay Description:Inhibition of human recombinant N-terminal GST-tagged DHODH expressed in Escherichia coli BL21(DE3) using dihydroorotate substrate preincubated for 5...More data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
University Of Turin

Curated by ChEMBL
LigandPNGBDBM50586378(CHEMBL5079607 | US20240034730, Compound 8)
Affinity DataIC50:  6.20nMAssay Description:Inhibition of human recombinant N-terminal GST-tagged DHODH expressed in Escherichia coli BL21(DE3) using dihydroorotate substrate preincubated for 5...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
University Of Turin

Curated by ChEMBL
LigandPNGBDBM50586383(CHEMBL5078949 | US20240034730, Compound 13)
Affinity DataIC50:  6.30nMAssay Description:Inhibition of human recombinant N-terminal GST-tagged DHODH expressed in Escherichia coli BL21(DE3) using dihydroorotate substrate preincubated for 5...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDimer of Protein farnesyltransferase subunit beta(Homo sapiens (Human))
RhôNe-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50088000((+/-)-11-[2-(2-methoxyphenyl)acryloyl]-1-(4-methyl...)
Affinity DataIC50:  8nMAssay Description:Inhibition of FarnesyltransferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
University Of Turin

Curated by ChEMBL
LigandPNGBDBM50586380(CHEMBL5071607 | US20240034730, Compound 10)
Affinity DataIC50:  18nMAssay Description:Inhibition of human recombinant N-terminal GST-tagged DHODH expressed in Escherichia coli BL21(DE3) using dihydroorotate substrate preincubated for 5...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
University Of Turin

Curated by ChEMBL
LigandPNGBDBM119812(US20240034730, Compound ASLAN003 | US8691852, 20)
Affinity DataIC50:  35nMAssay Description:Inhibition of human recombinant N-terminal GST-tagged DHODH expressed in Escherichia coli BL21(DE3) using dihydroorotate substrate preincubated for 5...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
University Of Turin

Curated by ChEMBL
LigandPNGBDBM50281171(CHEMBL4177202 | US20240034730, Compound 3)
Affinity DataIC50:  35nMAssay Description:Inhibition of human recombinant N-terminal GST-tagged DHODH expressed in Escherichia coli BL21(DE3) using dihydroorotate substrate preincubated for 5...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Protein farnesyltransferase subunit beta(Homo sapiens (Human))
RhôNe-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50088001((+/-)-11-[2-(2-methoxyphenyl)acryloyl]-1-phenyl-(1...)
Affinity DataIC50:  50nMAssay Description:Inhibition of FarnesyltransferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
University Of Turin

Curated by ChEMBL
LigandPNGBDBM50586382(CHEMBL5079952 | US20240034730, Compound 12)
Affinity DataIC50:  72nMAssay Description:Inhibition of human recombinant N-terminal GST-tagged DHODH expressed in Escherichia coli BL21(DE3) using dihydroorotate substrate preincubated for 5...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
University Of Turin

Curated by ChEMBL
LigandPNGBDBM50586376(CHEMBL5090397 | US20240034730, Compound 6)
Affinity DataIC50:  91nMAssay Description:Inhibition of human recombinant N-terminal GST-tagged DHODH expressed in Escherichia coli BL21(DE3) using dihydroorotate substrate preincubated for 5...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
University Of Turin

Curated by ChEMBL
LigandPNGBDBM50586379(CHEMBL5080170 | US20240034730, Compound 9)
Affinity DataIC50:  150nMAssay Description:Inhibition of human recombinant N-terminal GST-tagged DHODH expressed in Escherichia coli BL21(DE3) using dihydroorotate substrate preincubated for 5...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDimer of Protein farnesyltransferase subunit beta(Homo sapiens (Human))
RhôNe-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50088009((+/-)-11-[2-(2-methoxyphenyl)acetyl]-1-phenyl-(1R,...)
Affinity DataIC50:  200nMAssay Description:Inhibition of FarnesyltransferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed