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Found 492 with Last Name = 'goodman' and Initial = 'c'
TargetD(2) dopamine receptor(Homo sapiens (Human))
Florida A&M University

Curated by ChEMBL
LigandPNGBDBM50185473(4-(3-(4-chlorophenyl)-3-hydroxy-8-aza-bicyclo[3.2....)
Affinity DataKi:  1.60nMAssay Description:Binding affinity to human cloned dopamine D2 receptor by radioligand binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(4) dopamine receptor(Homo sapiens (Human))
Florida A&M University

Curated by ChEMBL
LigandPNGBDBM50185474((+)-4-(3-(4-chlorophenyl)-3-hydroxypyrrolidin-1-yl...)
Affinity DataKi:  3.60nMAssay Description:Binding affinity to human cloned dopamine D4.4 receptor by radioligand binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(4) dopamine receptor(Homo sapiens (Human))
Florida A&M University

Curated by ChEMBL
LigandPNGBDBM50185474((+)-4-(3-(4-chlorophenyl)-3-hydroxypyrrolidin-1-yl...)
Affinity DataKi:  3.60nMAssay Description:Binding affinity to human cloned dopamine D4.4 receptor by radioligand binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Homo sapiens (Human))
Florida A&M University

Curated by ChEMBL
LigandPNGBDBM50185473(4-(3-(4-chlorophenyl)-3-hydroxy-8-aza-bicyclo[3.2....)
Affinity DataKi:  5.10nMAssay Description:Binding affinity to human cloned dopamine D3 receptor by radioligand binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(4) dopamine receptor(Homo sapiens (Human))
Florida A&M University

Curated by ChEMBL
LigandPNGBDBM50185473(4-(3-(4-chlorophenyl)-3-hydroxy-8-aza-bicyclo[3.2....)
Affinity DataKi:  5.30nMAssay Description:Binding affinity to human cloned dopamine D4.4 receptor by radioligand binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Florida A&M University

Curated by ChEMBL
LigandPNGBDBM50185473(4-(3-(4-chlorophenyl)-3-hydroxy-8-aza-bicyclo[3.2....)
Affinity DataKi:  28nMAssay Description:Binding affinity to human cloned 5HT1A receptor by radioligand binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Florida A&M University

Curated by ChEMBL
LigandPNGBDBM50185473(4-(3-(4-chlorophenyl)-3-hydroxy-8-aza-bicyclo[3.2....)
Affinity DataKi:  31nMAssay Description:Binding affinity to human cloned 5HT2A receptor by radioligand binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A adrenergic receptor(Homo sapiens (Human))
Florida A&M University

Curated by ChEMBL
LigandPNGBDBM50185473(4-(3-(4-chlorophenyl)-3-hydroxy-8-aza-bicyclo[3.2....)
Affinity DataKi:  39nMAssay Description:Binding affinity to human cloned adrenergic alpha-1A receptor by radioligand binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1B adrenergic receptor(Homo sapiens (Human))
Florida A&M University

Curated by ChEMBL
LigandPNGBDBM50185473(4-(3-(4-chlorophenyl)-3-hydroxy-8-aza-bicyclo[3.2....)
Affinity DataKi:  43nMAssay Description:Binding affinity to human cloned adrenergic alpha-1B receptor by radioligand binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Florida A&M University

Curated by ChEMBL
LigandPNGBDBM50185474((+)-4-(3-(4-chlorophenyl)-3-hydroxypyrrolidin-1-yl...)
Affinity DataKi:  51nMAssay Description:Binding affinity to human cloned dopamine D2 receptor by radioligand binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Florida A&M University

Curated by ChEMBL
LigandPNGBDBM50185474((+)-4-(3-(4-chlorophenyl)-3-hydroxypyrrolidin-1-yl...)
Affinity DataKi:  51nMAssay Description:Binding affinity to human cloned dopamine D2 receptor by radioligand binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Florida A&M University

Curated by ChEMBL
LigandPNGBDBM50185474((+)-4-(3-(4-chlorophenyl)-3-hydroxypyrrolidin-1-yl...)
Affinity DataKi:  76nMAssay Description:Binding affinity to human cloned 5HT2A receptor by radioligand binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Florida A&M University

Curated by ChEMBL
LigandPNGBDBM50185474((+)-4-(3-(4-chlorophenyl)-3-hydroxypyrrolidin-1-yl...)
Affinity DataKi:  76nMAssay Description:Binding affinity to human cloned 5HT2A receptor by radioligand binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2C adrenergic receptor(Homo sapiens (Human))
Florida A&M University

Curated by ChEMBL
LigandPNGBDBM50185474((+)-4-(3-(4-chlorophenyl)-3-hydroxypyrrolidin-1-yl...)
Affinity DataKi:  94nMAssay Description:Binding affinity to human cloned adrenergic alpha-2C receptor by radioligand binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2C adrenergic receptor(Homo sapiens (Human))
Florida A&M University

Curated by ChEMBL
LigandPNGBDBM50185474((+)-4-(3-(4-chlorophenyl)-3-hydroxypyrrolidin-1-yl...)
Affinity DataKi:  94nMAssay Description:Binding affinity to human cloned adrenergic alpha-2C receptor by radioligand binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1B adrenergic receptor(Homo sapiens (Human))
Florida A&M University

Curated by ChEMBL
LigandPNGBDBM50185474((+)-4-(3-(4-chlorophenyl)-3-hydroxypyrrolidin-1-yl...)
Affinity DataKi:  102nMAssay Description:Binding affinity to human cloned adrenergic alpha-1B receptor by radioligand binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1B adrenergic receptor(Homo sapiens (Human))
Florida A&M University

Curated by ChEMBL
LigandPNGBDBM50185474((+)-4-(3-(4-chlorophenyl)-3-hydroxypyrrolidin-1-yl...)
Affinity DataKi:  102nMAssay Description:Binding affinity to human cloned adrenergic alpha-1B receptor by radioligand binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A adrenergic receptor(Homo sapiens (Human))
Florida A&M University

Curated by ChEMBL
LigandPNGBDBM50185474((+)-4-(3-(4-chlorophenyl)-3-hydroxypyrrolidin-1-yl...)
Affinity DataKi:  114nMAssay Description:Binding affinity to human cloned adrenergic alpha-1A receptor by radioligand binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A adrenergic receptor(Homo sapiens (Human))
Florida A&M University

Curated by ChEMBL
LigandPNGBDBM50185474((+)-4-(3-(4-chlorophenyl)-3-hydroxypyrrolidin-1-yl...)
Affinity DataKi:  114nMAssay Description:Binding affinity to human cloned adrenergic alpha-1A receptor by radioligand binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2C adrenergic receptor(Homo sapiens (Human))
Florida A&M University

Curated by ChEMBL
LigandPNGBDBM50185473(4-(3-(4-chlorophenyl)-3-hydroxy-8-aza-bicyclo[3.2....)
Affinity DataKi:  143nMAssay Description:Binding affinity to human cloned adrenergic alpha-2C receptor by radioligand binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2B adrenergic receptor(Homo sapiens (Human))
Florida A&M University

Curated by ChEMBL
LigandPNGBDBM50185473(4-(3-(4-chlorophenyl)-3-hydroxy-8-aza-bicyclo[3.2....)
Affinity DataKi:  516nMAssay Description:Binding affinity to human cloned adrenergic alpha-2B receptor by radioligand binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Florida A&M University

Curated by ChEMBL
LigandPNGBDBM50185474((+)-4-(3-(4-chlorophenyl)-3-hydroxypyrrolidin-1-yl...)
Affinity DataKi:  722nMAssay Description:Binding affinity to human cloned 5HT1A receptor by radioligand binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Florida A&M University

Curated by ChEMBL
LigandPNGBDBM50185474((+)-4-(3-(4-chlorophenyl)-3-hydroxypyrrolidin-1-yl...)
Affinity DataKi:  722nMAssay Description:Binding affinity to human cloned 5HT1A receptor by radioligand binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
Florida A&M University

Curated by ChEMBL
LigandPNGBDBM50185473(4-(3-(4-chlorophenyl)-3-hydroxy-8-aza-bicyclo[3.2....)
Affinity DataKi:  872nMAssay Description:Binding affinity to human cloned 5HT2C receptor by radioligand binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Homo sapiens (Human))
Florida A&M University

Curated by ChEMBL
LigandPNGBDBM50185474((+)-4-(3-(4-chlorophenyl)-3-hydroxypyrrolidin-1-yl...)
Affinity DataKi:  1.07E+3nMAssay Description:Binding affinity to human cloned dopamine D3 receptor by radioligand binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Homo sapiens (Human))
Florida A&M University

Curated by ChEMBL
LigandPNGBDBM50185474((+)-4-(3-(4-chlorophenyl)-3-hydroxypyrrolidin-1-yl...)
Affinity DataKi:  1.07E+3nMAssay Description:Binding affinity to human cloned dopamine D3 receptor by radioligand binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Homo sapiens (Human))
Florida A&M University

Curated by ChEMBL
LigandPNGBDBM50185474((+)-4-(3-(4-chlorophenyl)-3-hydroxypyrrolidin-1-yl...)
Affinity DataKi:  1.47E+3nMAssay Description:Binding affinity to human cloned histamine H1 receptor by radioligand binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Homo sapiens (Human))
Florida A&M University

Curated by ChEMBL
LigandPNGBDBM50185474((+)-4-(3-(4-chlorophenyl)-3-hydroxypyrrolidin-1-yl...)
Affinity DataKi:  1.47E+3nMAssay Description:Binding affinity to human cloned histamine H1 receptor by radioligand binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2A adrenergic receptor(Homo sapiens (Human))
Florida A&M University

Curated by ChEMBL
LigandPNGBDBM50185474((+)-4-(3-(4-chlorophenyl)-3-hydroxypyrrolidin-1-yl...)
Affinity DataKi:  2.24E+3nMAssay Description:Binding affinity to human cloned adrenergic alpha-2A receptor by radioligand binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2A adrenergic receptor(Homo sapiens (Human))
Florida A&M University

Curated by ChEMBL
LigandPNGBDBM50185474((+)-4-(3-(4-chlorophenyl)-3-hydroxypyrrolidin-1-yl...)
Affinity DataKi:  2.24E+3nMAssay Description:Binding affinity to human cloned adrenergic alpha-2A receptor by radioligand binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2A adrenergic receptor(Homo sapiens (Human))
Florida A&M University

Curated by ChEMBL
LigandPNGBDBM50185473(4-(3-(4-chlorophenyl)-3-hydroxy-8-aza-bicyclo[3.2....)
Affinity DataKi:  2.84E+3nMAssay Description:Binding affinity to human cloned adrenergic alpha-2A receptor by radioligand binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
Florida A&M University

Curated by ChEMBL
LigandPNGBDBM50185474((+)-4-(3-(4-chlorophenyl)-3-hydroxypyrrolidin-1-yl...)
Affinity DataKi:  3.60E+3nMAssay Description:Binding affinity to human cloned 5HT2C receptor by radioligand binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
Florida A&M University

Curated by ChEMBL
LigandPNGBDBM50185474((+)-4-(3-(4-chlorophenyl)-3-hydroxypyrrolidin-1-yl...)
Affinity DataKi:  3.60E+3nMAssay Description:Binding affinity to human cloned 5HT2C receptor by radioligand binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2B adrenergic receptor(Homo sapiens (Human))
Florida A&M University

Curated by ChEMBL
LigandPNGBDBM50185474((+)-4-(3-(4-chlorophenyl)-3-hydroxypyrrolidin-1-yl...)
Affinity DataKi:  4.55E+3nMAssay Description:Binding affinity to human cloned adrenergic alpha-2B receptor by radioligand binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Homo sapiens (Human))
Florida A&M University

Curated by ChEMBL
LigandPNGBDBM50185473(4-(3-(4-chlorophenyl)-3-hydroxy-8-aza-bicyclo[3.2....)
Affinity DataKi:  8.78E+3nMAssay Description:Binding affinity to human cloned histamine H1 receptor by radioligand binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGTPase KRas [1-169,G12C,C118A](Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM544213(6-Chloro-1-(4- cyclopropyl-6- isopropyl-pyrimidin-...)
Affinity DataIC50:  6nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGTPase KRas [1-169,G12C,C118A](Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM544157(6-Chloro-1-(4,6- diisopropylpyrimidin- 5-yl)-4-[(2...)
Affinity DataIC50:  6nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGTPase KRas [1-169,G12C,C118A](Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM544213(6-Chloro-1-(4- cyclopropyl-6- isopropyl-pyrimidin-...)
Affinity DataIC50:  8nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGTPase KRas [1-169,G12C,C118A](Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM544283((M)-N-[2-[6- Chloro-4- [(2S,5R)-2,5- dimethyl-4- p...)
Affinity DataIC50:  8nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGTPase KRas [1-169,G12C,C118A](Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM544106((M)-6-Chloro- 7-(2,4- difluorophenyl)- 4-[(2S,5R)-...)
Affinity DataIC50:  8nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGTPase KRas [1-169,G12C,C118A](Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM544212(US11285156, Ex.# 108-1)
Affinity DataIC50:  9nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGTPase KRas [1-169,G12C,C118A](Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM544107((M)-6-Chloro- 4-[(2S,5R)-2,5- dimethyl-4- prop-2-e...)
Affinity DataIC50:  10nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGTPase KRas [1-169,G12C,C118A](Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM544382(4-((2S,5R)-4-Acryloyl-2,5-dimethylpiperazin-1-yl)-...)
Affinity DataIC50:  10nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGTPase KRas [1-169,G12D]()
Amgen

US Patent
LigandPNGBDBM550333(4-((2S,5R,M)-4-Acryloyl-2,5-dimethylpiperazin-1-yl...)
Affinity DataIC50:  13nMAssay Description:The following assay conditions were employed: Coupled Nucleotide Exchange Assay: Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGTPase KRas [1-169,G12C,C118A](Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM544076((M)-7-(2- Amino-4,5- difluoro- phenyl)-6- chloro-4...)
Affinity DataIC50:  14nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGTPase KRas [1-169,G12D]()
Amgen

US Patent
LigandPNGBDBM550345((M)-4-(4-Acryloyl-cis-3,5-dimethylpiperazin-1-yl)-...)
Affinity DataIC50:  14nMAssay Description:The following assay conditions were employed: Coupled Nucleotide Exchange Assay: Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGTPase KRas [1-169,G12C,C118A](Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM544428(US11285156, Ex.# 222-2)
Affinity DataIC50:  14nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGTPase KRas [1-169,G12C,C118A](Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM544046(US11285156, Ex.# 92-1)
Affinity DataIC50:  16nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGTPase KRas [1-169,G12D]()
Amgen

US Patent
LigandPNGBDBM550344((M)-4-(4-Acryloyl-cis-3,5-dimethylpiperazin-1-yl)-...)
Affinity DataIC50:  16nMAssay Description:The following assay conditions were employed: Coupled Nucleotide Exchange Assay: Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGTPase KRas [1-169,G12C,C118A](Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM544057((M)-7-(2- Aminophenyl)- 6-chloro-4- [(2S,5R)-2,5- ...)
Affinity DataIC50:  19nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
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