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Found 971 with Last Name = 'gray' and Initial = 'dl'
TargetOxytocin receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50044676(CHEMBL439044)
Affinity DataKi:  0.330nMAssay Description:Displacement of [3H]8-arginine-vasopressin from human oxytocin receptor expressed in CHO cell membrane incubated for 1 hr by liquid scintillation cou...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOxytocin receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50205990(CHEMBL395429 | OXYTOCIN)
Affinity DataKi:  0.440nMAssay Description:Displacement of [3H]8-arginine-vasopressin from human oxytocin receptor expressed in CHO cell membrane incubated for 1 hr by liquid scintillation cou...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(1A) dopamine receptor(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM160878(US10093655, Example 48 | US11014909, Example 48 | ...)
Affinity DataKi:  0.571nMAssay Description:The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Dif...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetD(1A) dopamine receptor(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM160878(US10093655, Example 48 | US11014909, Example 48 | ...)
Affinity DataKi:  0.571nMAssay Description:D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determin...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetD(1A) dopamine receptor(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM160878(US10093655, Example 48 | US11014909, Example 48 | ...)
Affinity DataKi:  0.571nMpH: 7.4Assay Description:The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., "Di...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetOxytocin receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50180014(CHEMBL3814744)
Affinity DataKi:  0.970nMAssay Description:Displacement of [3H]8-arginine-vasopressin from human oxytocin receptor expressed in CHO cell membrane incubated for 1 hr by liquid scintillation cou...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50333433(3-(2-(2-chloro-6-fluorophenoxy)-6-fluorophenoxy)az...)
Affinity DataKi:  1nMAssay Description:Displacement of [3H]8-OH-DPAT from human cloned 5HT1A receptor by liquid scintillation spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50333450((R)-3-(2-(2-chloro-6-fluorophenoxy)-6-fluorophenox...)
Affinity DataKi:  1nMAssay Description:Displacement of [3H]8-OH-DPAT from human cloned 5HT1A receptor by liquid scintillation spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50299799(4-(4,5-difluoro-2-(4-fluorophenoxy)phenyl)piperidi...)
Affinity DataKi:  1nMAssay Description:Displacement of [125I]RTI-55 from human DAT expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50299799(4-(4,5-difluoro-2-(4-fluorophenoxy)phenyl)piperidi...)
Affinity DataKi:  1nMAssay Description:Displacement of [125I]RTI-55 from human NET expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOxytocin receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50180155(CHEMBL3813894)
Affinity DataKi:  1.10nMAssay Description:Displacement of [3H]8-arginine-vasopressin from human oxytocin receptor expressed in CHO cell membrane incubated for 1 hr by liquid scintillation cou...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOxytocin receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50180132(CHEMBL3814633)
Affinity DataKi:  1.30nMAssay Description:Displacement of [3H]8-arginine-vasopressin from human oxytocin receptor expressed in CHO cell membrane incubated for 1 hr by liquid scintillation cou...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(1A) dopamine receptor(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM130462(US8822494, 8)
Affinity DataKi:  1.83nMAssay Description:The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Dif...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetD(1A) dopamine receptor(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM200951(6-[4-(isoquinolin-1-yloxy)-2-methylphenyl]-1,5-dim...)
Affinity DataKi:  1.90nMpH: 7.4Assay Description:The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Dif...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50309512(2-(2,3-dichlorophenoxy)-3-(piperidin-4-yl)pyridine...)
Affinity DataKi:  2nMAssay Description:Displacement of [3H]citalopram from human SERT expressed in HEK293 cells by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50299789(4-(5-fluoro-2-(4-fluorobenzyloxy)phenyl)piperidine...)
Affinity DataKi:  2nMAssay Description:Displacement of [125I]RTI-55 from human NET expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50299801(4-(2-(3-fluorophenoxy)-4-methylphenyl)piperidine |...)
Affinity DataKi:  2nMAssay Description:Displacement of [125I]RTI-55 from human SERT expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50299789(4-(5-fluoro-2-(4-fluorobenzyloxy)phenyl)piperidine...)
Affinity DataKi:  2nMAssay Description:Displacement of [125I]RTI-55 from human SERT expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50299800(4-(2-(3,4-dichlorobenzyloxy)-5-fluorophenyl)piperi...)
Affinity DataKi:  2nMAssay Description:Displacement of [125I]RTI-55 from human SERT expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50309515(2-(2,4-dichlorophenoxy)-3-(piperidin-4-yl)pyridine...)
Affinity DataKi:  2.70nMAssay Description:Displacement of [3H]citalopram from human SERT expressed in HEK293 cells by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50333434(3-(2-fluoro-6-(2-fluoro-6-methylphenoxy)phenoxy)az...)
Affinity DataKi:  3nMAssay Description:Displacement of [3H]8-OH-DPAT from human cloned 5HT1A receptor by liquid scintillation spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50299796(4-(2-(2-fluoro-5-methylphenoxy)phenyl)piperidine |...)
Affinity DataKi:  3nMAssay Description:Displacement of [125I]RTI-55 from human NET expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50333448(3-(2-(2-chloro-6-fluorophenoxy)-6-fluorophenoxy)py...)
Affinity DataKi:  3nMAssay Description:Displacement of [3H]8-OH-DPAT from human cloned 5HT1A receptor by liquid scintillation spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(1A) dopamine receptor(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM160912(US10093655, Example 2 | US11014909, Example 2 | US...)
Affinity DataKi:  3.11nMAssay Description:D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determin...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetD(1A) dopamine receptor(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM160912(US10093655, Example 2 | US11014909, Example 2 | US...)
Affinity DataKi:  3.11nMpH: 7.4Assay Description:The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., "Di...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetD(1A) dopamine receptor(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM160912(US10093655, Example 2 | US11014909, Example 2 | US...)
Affinity DataKi:  3.11nMAssay Description:The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Dif...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetD(1A) dopamine receptor(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM160861(US10093655, Example 31 | US11014909, Example 31 | ...)
Affinity DataKi:  3.61nMpH: 7.4Assay Description:The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., "Di...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetD(1A) dopamine receptor(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM160861(US10093655, Example 31 | US11014909, Example 31 | ...)
Affinity DataKi:  3.61nMAssay Description:D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determin...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetD(1A) dopamine receptor(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM160861(US10093655, Example 31 | US11014909, Example 31 | ...)
Affinity DataKi:  3.61nMAssay Description:The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Dif...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetOxytocin receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50180160(CHEMBL3815099)
Affinity DataKi:  3.70nMAssay Description:Displacement of [3H]8-arginine-vasopressin from human oxytocin receptor expressed in CHO cell membrane incubated for 1 hr by liquid scintillation cou...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50309523(1-(2-(2-chloro-6-fluorophenoxy)pyridin-3-yl)pipera...)
Affinity DataKi:  3.70nMAssay Description:Displacement of [3H]8-OH-DPAT from human cloned 5HT1A receptor by filtration techniquesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50333442(4-(2-fluoro-6-(2-fluoro-6-methylphenoxy)phenoxy)pi...)
Affinity DataKi:  4nMAssay Description:Displacement of [3H]8-OH-DPAT from human cloned 5HT1A receptor by liquid scintillation spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50299787(4-(2,4-difluorophenyl)-2-(2-(piperazin-1-yl)benzyl...)
Affinity DataKi:  4nMAssay Description:Displacement of [3H]8-OH-DPAT from human 5HT1A receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50333447(3-(2-fluoro-6-(2-fluoro-6-methylphenoxy)phenoxy)py...)
Affinity DataKi:  4nMAssay Description:Displacement of [3H]8-OH-DPAT from human cloned 5HT1A receptor by liquid scintillation spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(1A) dopamine receptor(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM130461(US8822494, 7)
Affinity DataKi:  4.12nMAssay Description:The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Dif...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetD(1A) dopamine receptor(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM160894(US10093655, Example 64 | US11014909, Example 64 | ...)
Affinity DataKi:  4.17nMAssay Description:D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determin...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetD(1A) dopamine receptor(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM160894(US10093655, Example 64 | US11014909, Example 64 | ...)
Affinity DataKi:  4.17nMpH: 7.4Assay Description:The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., "Di...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetD(1A) dopamine receptor(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM160894(US10093655, Example 64 | US11014909, Example 64 | ...)
Affinity DataKi:  4.17nMAssay Description:The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Dif...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetD(1A) dopamine receptor(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM364218(US9856263, 1 | US9856263, 2 | US9856263, 3)
Affinity DataKi:  4.5nMAssay Description:Frozen cells were quickly thawed, re-suspended in 50 mL warm media and allowed to sit for 5 min prior to centrifugation (1000 rpm) at room temperatur...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50309522(1-(2-(2-chlorophenoxy)pyridin-3-yl)piperazine | CH...)
Affinity DataKi:  4.5nMAssay Description:Displacement of [3H]8-OH-DPAT from human cloned 5HT1A receptor by filtration techniquesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(1A) dopamine receptor(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM130480(US8822494, 26 | US8822494, 27)
Affinity DataKi:  4.56nMAssay Description:The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Dif...More data for this Ligand-Target Pair
In DepthDetails US Patent
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50309505(4-(2-fluoro-6-(2-fluorophenoxy)phenyl)piperidine |...)
Affinity DataKi:  4.60nMAssay Description:Displacement of [3H]8-OH-DPAT from human cloned 5HT1A receptor by filtration techniquesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(1A) dopamine receptor(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM130451(US8822494, 44)
Affinity DataKi:  4.60nMAssay Description:The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Dif...More data for this Ligand-Target Pair
In DepthDetails US Patent
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50309505(4-(2-fluoro-6-(2-fluorophenoxy)phenyl)piperidine |...)
Affinity DataKi:  4.60nMAssay Description:Displacement of [3H]8-OH-DPAT from human cloned 5HT1A receptor by liquid scintillation spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(1A) dopamine receptor(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM337378(5-{4-[(3-Hydroxy-2,3-dihydrofuro[3,2-c]pyridin-4-y...)
Affinity DataKi:  4.80nMAssay Description:D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determin...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetD(1A) dopamine receptor(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM130463(US8822494, 10 | US8822494, 9)
Affinity DataKi:  4.87nMAssay Description:The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Dif...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50262626(CHEMBL515936 | Ethanesulfonic acid biphenyl-2-ylme...)
Affinity DataKi:  5nMAssay Description:Inhibition of [3H]nisoxetine reuptake at human NET expressed in HEK293 cells by SPAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50262625(CHEMBL476312 | N-Biphenyl-2-ylmethyl-N-(S)-pyrroli...)
Affinity DataKi:  5nMAssay Description:Inhibition of [3H]nisoxetine reuptake at human NET expressed in HEK293 cells by SPAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50299802(4-(3,4-dichlorophenyl)-2-(2-(piperazin-1-yl)benzyl...)
Affinity DataKi:  5nMAssay Description:Displacement of [125I]RTI-55 from human NET expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50299798(4-(2-(3-chlorophenoxy)phenyl)piperidine | CHEMBL57...)
Affinity DataKi:  5nMAssay Description:Displacement of [3H]8-OH-DPAT from human 5HT1A receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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