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Found 127 with Last Name = 'gregor' and Initial = 've'
TargetProto-oncogene tyrosine-protein kinase ROS(Homo sapiens (Human))
Chembridge

US Patent
LigandPNGBDBM130912(US8822500, [1])
Affinity DataIC50:  0.205nMpH: 7.5Assay Description:Compounds to be tested were dissolved in 100% DMSO in a range of concentrations from 10-8 to 10-3 M including negative control (DMSO), then diluted w...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProto-oncogene tyrosine-protein kinase ROS(Homo sapiens (Human))
Chembridge

US Patent
LigandPNGBDBM130909(US10683289, Example Staurosporine | US10927120, Co...)
Affinity DataIC50:  0.248nMpH: 7.5Assay Description:Compounds to be tested were dissolved in 100% DMSO in a range of concentrations from 10-8 to 10-3 M including negative control (DMSO), then diluted w...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProto-oncogene tyrosine-protein kinase ROS(Homo sapiens (Human))
Chembridge

US Patent
LigandPNGBDBM130910(US8822500, [4])
Affinity DataIC50:  0.300nMpH: 7.5Assay Description:Compounds to be tested were dissolved in 100% DMSO in a range of concentrations from 10-8 to 10-3 M including negative control (DMSO), then diluted w...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProto-oncogene tyrosine-protein kinase ROS(Homo sapiens (Human))
Chembridge

US Patent
LigandPNGBDBM130911(US8822500, [2])
Affinity DataIC50:  0.436nMpH: 7.5Assay Description:Compounds to be tested were dissolved in 100% DMSO in a range of concentrations from 10-8 to 10-3 M including negative control (DMSO), then diluted w...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetNT-3 growth factor receptor(Homo sapiens (Human))
Chembridge

US Patent
LigandPNGBDBM130909(US10683289, Example Staurosporine | US10927120, Co...)
Affinity DataIC50:  0.525nMpH: 7.5Assay Description:Compounds to be tested were dissolved in 100% DMSO in a range of concentrations from 10-8 to 10-3 M including negative control (DMSO), then diluted w...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProto-oncogene tyrosine-protein kinase ROS(Homo sapiens (Human))
Chembridge

US Patent
LigandPNGBDBM130919(US8822500, [18])
Affinity DataIC50:  0.688nMpH: 7.5Assay Description:Compounds to be tested were dissolved in 100% DMSO in a range of concentrations from 10-8 to 10-3 M including negative control (DMSO), then diluted w...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCarboxylic ester hydrolase(Equus caballus (Horse))
TBA

Curated by ChEMBL
LigandPNGBDBM8986(7-chloro-1,2,3,4-tetrahydroacridin-9-amine | Tacri...)
Affinity DataIC50:  0.700nMAssay Description:Inhibition of (BChE) Butyrylcholinesterase of horse serumMore data for this Ligand-Target Pair
In DepthDetails Article
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Chembridge

US Patent
LigandPNGBDBM130912(US8822500, [1])
Affinity DataIC50:  1.14nMpH: 7.5Assay Description:Compounds to be tested were dissolved in 100% DMSO in a range of concentrations from 10-8 to 10-3 M including negative control (DMSO), then diluted w...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBDNF/NT-3 growth factors receptor(Homo sapiens (Human))
Chembridge

US Patent
LigandPNGBDBM130909(US10683289, Example Staurosporine | US10927120, Co...)
Affinity DataIC50:  1.18nMpH: 7.5Assay Description:Compounds to be tested were dissolved in 100% DMSO in a range of concentrations from 10-8 to 10-3 M including negative control (DMSO), then diluted w...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCarboxylic ester hydrolase(Equus caballus (Horse))
TBA

Curated by ChEMBL
LigandPNGBDBM50060470(10-azatetracyclo[10.2.1.02,11.04,9]pentadeca-2,4,6...)
Affinity DataIC50:  1.30nMAssay Description:Inhibition of (BChE) Butyrylcholinesterase of horse serumMore data for this Ligand-Target Pair
In DepthDetails Article
TargetSerine/threonine-protein kinase receptor R3(Homo sapiens (Human))
Chembridge

US Patent
LigandPNGBDBM130909(US10683289, Example Staurosporine | US10927120, Co...)
Affinity DataIC50:  1.36nMpH: 7.5Assay Description:Compounds to be tested were dissolved in 100% DMSO in a range of concentrations from 10-8 to 10-3 M including negative control (DMSO), then diluted w...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Chembridge

US Patent
LigandPNGBDBM130909(US10683289, Example Staurosporine | US10927120, Co...)
Affinity DataIC50:  1.41nMpH: 7.5Assay Description:Compounds to be tested were dissolved in 100% DMSO in a range of concentrations from 10-8 to 10-3 M including negative control (DMSO), then diluted w...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetNT-3 growth factor receptor(Homo sapiens (Human))
Chembridge

US Patent
LigandPNGBDBM130912(US8822500, [1])
Affinity DataIC50:  1.58nMpH: 7.5Assay Description:Compounds to be tested were dissolved in 100% DMSO in a range of concentrations from 10-8 to 10-3 M including negative control (DMSO), then diluted w...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAcetylcholinesterase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM8987(6-chloro-1,2,3,4-tetrahydroacridin-9-amine | 6-chl...)
Affinity DataIC50:  1.80nMAssay Description:Inhibition of acetylcholinesterase (AChE) of human red blood cell (type XIII) by modified radiometric AChE assayMore data for this Ligand-Target Pair
In DepthDetails Article
TargetBDNF/NT-3 growth factors receptor(Homo sapiens (Human))
Chembridge

US Patent
LigandPNGBDBM130912(US8822500, [1])
Affinity DataIC50:  2.06nMpH: 7.5Assay Description:Compounds to be tested were dissolved in 100% DMSO in a range of concentrations from 10-8 to 10-3 M including negative control (DMSO), then diluted w...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
Chembridge

US Patent
LigandPNGBDBM130909(US10683289, Example Staurosporine | US10927120, Co...)
Affinity DataIC50:  2.19nMpH: 7.5Assay Description:Compounds to be tested were dissolved in 100% DMSO in a range of concentrations from 10-8 to 10-3 M including negative control (DMSO), then diluted w...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAcetylcholinesterase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM8960((+/-)-2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimet...)
Affinity DataIC50:  2.30nMAssay Description:Inhibition of acetylcholinesterase (AChE) of human red blood cell (type XIII) by modified radiometric AChE assayMore data for this Ligand-Target Pair
TargetAcetylcholinesterase(Electrophorus electricus (Electric eel))
TBA

Curated by ChEMBL
LigandPNGBDBM50280625(7-chloro-10-azatetracyclo[10.2.1.02,11.04,9]pentad...)
Affinity DataIC50:  2.30nMAssay Description:Inhibition of acetylcholinesterase (AChE) in electric eel (type V-S) by modified radiometric assayMore data for this Ligand-Target Pair
In DepthDetails Article
TargetProto-oncogene tyrosine-protein kinase ROS(Homo sapiens (Human))
Chembridge

US Patent
LigandPNGBDBM130921(US8822500, [24A])
Affinity DataIC50:  2.37nMpH: 7.5Assay Description:Compounds to be tested were dissolved in 100% DMSO in a range of concentrations from 10-8 to 10-3 M including negative control (DMSO), then diluted w...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetNT-3 growth factor receptor(Homo sapiens (Human))
Chembridge

US Patent
LigandPNGBDBM130910(US8822500, [4])
Affinity DataIC50:  2.60nMpH: 7.5Assay Description:Compounds to be tested were dissolved in 100% DMSO in a range of concentrations from 10-8 to 10-3 M including negative control (DMSO), then diluted w...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAcetylcholinesterase(Electrophorus electricus (Electric eel))
TBA

Curated by ChEMBL
LigandPNGBDBM8987(6-chloro-1,2,3,4-tetrahydroacridin-9-amine | 6-chl...)
Affinity DataIC50:  2.90nMAssay Description:Inhibition of acetylcholinesterase (AChE) in electric eel (type V-S) by modified radiometric assayMore data for this Ligand-Target Pair
In DepthDetails Article
TargetBDNF/NT-3 growth factors receptor(Homo sapiens (Human))
Chembridge

US Patent
LigandPNGBDBM130910(US8822500, [4])
Affinity DataIC50:  3.48nMpH: 7.5Assay Description:Compounds to be tested were dissolved in 100% DMSO in a range of concentrations from 10-8 to 10-3 M including negative control (DMSO), then diluted w...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
Chembridge

US Patent
LigandPNGBDBM130912(US8822500, [1])
Affinity DataIC50:  3.53nMpH: 7.5Assay Description:Compounds to be tested were dissolved in 100% DMSO in a range of concentrations from 10-8 to 10-3 M including negative control (DMSO), then diluted w...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Chembridge

US Patent
LigandPNGBDBM130919(US8822500, [18])
Affinity DataIC50:  4.33nMpH: 7.5Assay Description:Compounds to be tested were dissolved in 100% DMSO in a range of concentrations from 10-8 to 10-3 M including negative control (DMSO), then diluted w...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAcetylcholinesterase(Electrophorus electricus (Electric eel))
TBA

Curated by ChEMBL
LigandPNGBDBM50279984(8-Chloro-1,2,3,4-tetrahydro-acridin-9-ylamine | 9-...)
Affinity DataIC50:  4.40nMAssay Description:Inhibition of acetylcholinesterase (AChE) in electric eel (type V-S) by modified radiometric assayMore data for this Ligand-Target Pair
In DepthDetails Article
TargetAcetylcholinesterase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50280625(7-chloro-10-azatetracyclo[10.2.1.02,11.04,9]pentad...)
Affinity DataIC50:  4.5nMAssay Description:Inhibition of acetylcholinesterase (AChE) of human red blood cell (type XIII) by modified radiometric AChE assayMore data for this Ligand-Target Pair
In DepthDetails Article
TargetSerine/threonine-protein kinase receptor R3(Homo sapiens (Human))
Chembridge

US Patent
LigandPNGBDBM130912(US8822500, [1])
Affinity DataIC50:  4.70nMpH: 7.5Assay Description:Compounds to be tested were dissolved in 100% DMSO in a range of concentrations from 10-8 to 10-3 M including negative control (DMSO), then diluted w...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Chembridge

US Patent
LigandPNGBDBM130910(US8822500, [4])
Affinity DataIC50:  5.00nMpH: 7.5Assay Description:Compounds to be tested were dissolved in 100% DMSO in a range of concentrations from 10-8 to 10-3 M including negative control (DMSO), then diluted w...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCarboxylic ester hydrolase(Equus caballus (Horse))
TBA

Curated by ChEMBL
LigandPNGBDBM8961(1,2,3,4-tetrahydro-9-acridinamine | 1,2,3,4-tetrah...)
Affinity DataIC50:  5.20nMAssay Description:Inhibition of (BChE) Butyrylcholinesterase of horse serumMore data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
Chembridge

US Patent
LigandPNGBDBM130910(US8822500, [4])
Affinity DataIC50:  5.98nMpH: 7.5Assay Description:Compounds to be tested were dissolved in 100% DMSO in a range of concentrations from 10-8 to 10-3 M including negative control (DMSO), then diluted w...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Chembridge

US Patent
LigandPNGBDBM130921(US8822500, [24A])
Affinity DataIC50:  5.99nMpH: 7.5Assay Description:Compounds to be tested were dissolved in 100% DMSO in a range of concentrations from 10-8 to 10-3 M including negative control (DMSO), then diluted w...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Chembridge

US Patent
LigandPNGBDBM130913(US8822500, [28])
Affinity DataIC50:  6.35nMpH: 7.5Assay Description:Compounds to be tested were dissolved in 100% DMSO in a range of concentrations from 10-8 to 10-3 M including negative control (DMSO), then diluted w...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Chembridge

US Patent
LigandPNGBDBM130915(US8822500, [13])
Affinity DataIC50:  6.36nMpH: 7.5Assay Description:Compounds to be tested were dissolved in 100% DMSO in a range of concentrations from 10-8 to 10-3 M including negative control (DMSO), then diluted w...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAcetylcholinesterase(Electrophorus electricus (Electric eel))
TBA

Curated by ChEMBL
LigandPNGBDBM50280627(5-chloro-10-azatetracyclo[10.2.1.02,11.04,9]pentad...)
Affinity DataIC50:  6.5nMAssay Description:Inhibition of acetylcholinesterase (AChE) in electric eel (type V-S) by modified radiometric assayMore data for this Ligand-Target Pair
In DepthDetails Article
TargetCarboxylic ester hydrolase(Equus caballus (Horse))
TBA

Curated by ChEMBL
LigandPNGBDBM8987(6-chloro-1,2,3,4-tetrahydroacridin-9-amine | 6-chl...)
Affinity DataIC50:  7.90nMAssay Description:Inhibition of (BChE) Butyrylcholinesterase of horse serumMore data for this Ligand-Target Pair
In DepthDetails Article
TargetSerine/threonine-protein kinase receptor R3(Homo sapiens (Human))
Chembridge

US Patent
LigandPNGBDBM130919(US8822500, [18])
Affinity DataIC50:  9.16nMpH: 7.5Assay Description:Compounds to be tested were dissolved in 100% DMSO in a range of concentrations from 10-8 to 10-3 M including negative control (DMSO), then diluted w...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAcetylcholinesterase(Electrophorus electricus (Electric eel))
TBA

Curated by ChEMBL
LigandPNGBDBM8960((+/-)-2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimet...)
Affinity DataIC50:  9.20nMAssay Description:Inhibition of acetylcholinesterase (AChE) in electric eel (type V-S) by modified radiometric assayMore data for this Ligand-Target Pair
In DepthDetails Article
TargetAcetylcholinesterase(Electrophorus electricus (Electric eel))
TBA

Curated by ChEMBL
LigandPNGBDBM8961(1,2,3,4-tetrahydro-9-acridinamine | 1,2,3,4-tetrah...)
Affinity DataIC50:  9.30nMAssay Description:Inhibition of acetylcholinesterase (AChE) in electric eel (type V-S) by modified radiometric assayMore data for this Ligand-Target Pair
In DepthDetails Article
TargetAcetylcholinesterase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50279984(8-Chloro-1,2,3,4-tetrahydro-acridin-9-ylamine | 9-...)
Affinity DataIC50:  9.40nMAssay Description:Inhibition of acetylcholinesterase (AChE) of human red blood cell (type XIII) by modified radiometric AChE assayMore data for this Ligand-Target Pair
In DepthDetails Article
TargetSerine/threonine-protein kinase receptor R3(Homo sapiens (Human))
Chembridge

US Patent
LigandPNGBDBM130910(US8822500, [4])
Affinity DataIC50:  9.81nMpH: 7.5Assay Description:Compounds to be tested were dissolved in 100% DMSO in a range of concentrations from 10-8 to 10-3 M including negative control (DMSO), then diluted w...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Chembridge

US Patent
LigandPNGBDBM130920(US8822500, [24])
Affinity DataIC50:  10.4nMpH: 7.5Assay Description:Compounds to be tested were dissolved in 100% DMSO in a range of concentrations from 10-8 to 10-3 M including negative control (DMSO), then diluted w...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
Chembridge

US Patent
LigandPNGBDBM130921(US8822500, [24A])
Affinity DataIC50:  11.2nMpH: 7.5Assay Description:Compounds to be tested were dissolved in 100% DMSO in a range of concentrations from 10-8 to 10-3 M including negative control (DMSO), then diluted w...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAcetylcholinesterase(Electrophorus electricus (Electric eel))
TBA

Curated by ChEMBL
LigandPNGBDBM50060470(10-azatetracyclo[10.2.1.02,11.04,9]pentadeca-2,4,6...)
Affinity DataIC50:  12nMAssay Description:Inhibition of acetylcholinesterase (AChE) in electric eel (type V-S) by modified radiometric assayMore data for this Ligand-Target Pair
In DepthDetails Article
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Chembridge

US Patent
LigandPNGBDBM130911(US8822500, [2])
Affinity DataIC50:  12.2nMpH: 7.5Assay Description:Compounds to be tested were dissolved in 100% DMSO in a range of concentrations from 10-8 to 10-3 M including negative control (DMSO), then diluted w...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCarboxylic ester hydrolase(Equus caballus (Horse))
TBA

Curated by ChEMBL
LigandPNGBDBM50279984(8-Chloro-1,2,3,4-tetrahydro-acridin-9-ylamine | 9-...)
Affinity DataIC50:  13nMAssay Description:Inhibition of (BChE) Butyrylcholinesterase of horse serumMore data for this Ligand-Target Pair
In DepthDetails Article
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
Chembridge

US Patent
LigandPNGBDBM130919(US8822500, [18])
Affinity DataIC50:  13.1nMpH: 7.5Assay Description:Compounds to be tested were dissolved in 100% DMSO in a range of concentrations from 10-8 to 10-3 M including negative control (DMSO), then diluted w...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Chembridge

US Patent
LigandPNGBDBM130911(US8822500, [2])
Affinity DataIC50:  14.0nMpH: 7.5Assay Description:Compounds to be tested were dissolved in 100% DMSO in a range of concentrations from 10-8 to 10-3 M including negative control (DMSO), then diluted w...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSerine/threonine-protein kinase receptor R3(Homo sapiens (Human))
Chembridge

US Patent
LigandPNGBDBM130911(US8822500, [2])
Affinity DataIC50:  14.0nMpH: 7.5Assay Description:Compounds to be tested were dissolved in 100% DMSO in a range of concentrations from 10-8 to 10-3 M including negative control (DMSO), then diluted w...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSerine/threonine-protein kinase receptor R3(Homo sapiens (Human))
Chembridge

US Patent
LigandPNGBDBM130921(US8822500, [24A])
Affinity DataIC50:  14.6nMpH: 7.5Assay Description:Compounds to be tested were dissolved in 100% DMSO in a range of concentrations from 10-8 to 10-3 M including negative control (DMSO), then diluted w...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCarboxylic ester hydrolase(Equus caballus (Horse))
TBA

Curated by ChEMBL
LigandPNGBDBM50280627(5-chloro-10-azatetracyclo[10.2.1.02,11.04,9]pentad...)
Affinity DataIC50:  15nMAssay Description:Inhibition of (BChE) Butyrylcholinesterase of horse serumMore data for this Ligand-Target Pair
In DepthDetails Article
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