Affinity DataKi: 1nMAssay Description:Aromatase inhibitor potency as iron-binding-related type II difference spectrumMore data for this Ligand-Target Pair
Affinity DataKi: 1.5nMAssay Description:Inhibition of human placental microsome cytochrome P450 19A1More data for this Ligand-Target Pair
Affinity DataKi: 26nMAssay Description:In vitro inhibition against neutral endopeptidase 24.11 (NEP) in rat kidney cortex membraneMore data for this Ligand-Target Pair
Affinity DataKi: 470nMAssay Description:Competitive inhibition of human placental Cytochrome P450 19A1More data for this Ligand-Target Pair
Affinity DataIC50: 0.0300nMAssay Description:Aromatase inhibitor potency as iron-binding-related type II difference spectrumMore data for this Ligand-Target Pair
Affinity DataIC50: 0.300nMAssay Description:Binding potency for human ER alphaMore data for this Ligand-Target Pair
Affinity DataIC50: 0.400nMAssay Description:Binding potency for human ER alphaMore data for this Ligand-Target Pair
Affinity DataIC50: 0.5nMAssay Description:Binding potency for human ER alphaMore data for this Ligand-Target Pair
Affinity DataIC50: 0.600nMAssay Description:Binding potency for human ER alphaMore data for this Ligand-Target Pair
Affinity DataIC50: 0.600nMAssay Description:Binding potency for human ER alphaMore data for this Ligand-Target Pair
Affinity DataIC50: 0.600nMAssay Description:Binding potency for human ER alphaMore data for this Ligand-Target Pair
Affinity DataIC50: 0.600nMAssay Description:Binding potency for human ER alphaMore data for this Ligand-Target Pair
Affinity DataIC50: 0.700nMAssay Description:Binding potency for human ER alphaMore data for this Ligand-Target Pair
Affinity DataIC50: 0.700nMAssay Description:Binding potency for human ER alphaMore data for this Ligand-Target Pair
Affinity DataIC50: 0.800nMAssay Description:Binding potency for human ER alphaMore data for this Ligand-Target Pair
Affinity DataIC50: 0.800nMAssay Description:Enzyme activities were measured in the presence of the test inhibitor in spectrophotometric assay.More data for this Ligand-Target Pair
Affinity DataIC50: 0.800nMAssay Description:Binding potency for human ER alphaMore data for this Ligand-Target Pair
Affinity DataIC50: 0.800nMAssay Description:Enzyme activities were measured in the presence of the test inhibitor in spectrophotometric assay.More data for this Ligand-Target Pair
Affinity DataIC50: 0.900nMAssay Description:Binding potency for human ER alphaMore data for this Ligand-Target Pair
Affinity DataIC50: 1nMAssay Description:In vitro inhibition of Thromboxane A2 synthaseMore data for this Ligand-Target Pair
Affinity DataIC50: 1nMAssay Description:In vitro inhibition of Thromboxane A2 synthaseMore data for this Ligand-Target Pair
Affinity DataIC50: 1nMAssay Description:In vitro inhibition of Thromboxane A2 synthaseMore data for this Ligand-Target Pair
Affinity DataIC50: 1nMAssay Description:Binding potency for human ER alphaMore data for this Ligand-Target Pair
Affinity DataIC50: 1.10nMAssay Description:Binding potency for human ER betaMore data for this Ligand-Target Pair
Affinity DataIC50: 1.10nMAssay Description:Enzyme activities were measured in the presence of the test inhibitor in spectrophotometric assay.More data for this Ligand-Target Pair
Affinity DataIC50: 1.20nMAssay Description:Binding affinity to human ERbetaMore data for this Ligand-Target Pair
Affinity DataIC50: 1.20nMAssay Description:In vitro inhibition against angiotensin converting enzyme (ACE)More data for this Ligand-Target Pair
Affinity DataIC50: 1.20nMAssay Description:Binding affinity to human recombinant ERbeta by scintillation proximity assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.20nMAssay Description:Enzyme activities were measured in the presence of the test inhibitor in spectrophotometric assay.More data for this Ligand-Target Pair
Affinity DataIC50: 1.20nMAssay Description:Binding affinity at human recombinant ERbetaMore data for this Ligand-Target Pair
Affinity DataIC50: 1.20nMAssay Description:Binding potency for human ER alphaMore data for this Ligand-Target Pair
Affinity DataIC50: 1.30nMAssay Description:Binding potency for human ER alphaMore data for this Ligand-Target Pair
Affinity DataIC50: 1.30nMAssay Description:Binding potency for human ER alphaMore data for this Ligand-Target Pair
Affinity DataIC50: 1.40nMAssay Description:Binding affinity at human recombinant ERalphaMore data for this Ligand-Target Pair
Affinity DataIC50: 1.40nMAssay Description:Binding affinity to human recombinant ERalpha by scintillation proximity assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.40nMAssay Description:Binding affinity to human ERalphaMore data for this Ligand-Target Pair
Affinity DataIC50: 1.5nMAssay Description:In vitro inhibition of Thromboxane A2 synthaseMore data for this Ligand-Target Pair
TargetAlpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase(Homo sapiens (Human))
Merck Sharp & Dohme
US Patent
Merck Sharp & Dohme
US Patent
Affinity DataIC50: 1.60nMT: 2°CAssay Description:A solution of 1 M LiHMDS in THF (51.7 ml, 51.7 mmol) was added dropwise to a mixture of Intermediate 3 (7.5 g, 17.2 mmol) and 5-(tert-butyl)-4-methyl...More data for this Ligand-Target Pair
Affinity DataIC50: 1.60nMAssay Description:Enzyme activities were measured in the presence of the test inhibitor in spectrophotometric assay.More data for this Ligand-Target Pair
Affinity DataIC50: 1.60nMAssay Description:Enzyme activities were measured in the presence of the test inhibitor in spectrophotometric assay.More data for this Ligand-Target Pair
Affinity DataIC50: 1.80nMAssay Description:Binding potency for human ER alphaMore data for this Ligand-Target Pair
Affinity DataIC50: 1.80nMAssay Description:Enzyme activities were measured in the presence of the test inhibitor in spectrophotometric assay.More data for this Ligand-Target Pair
Affinity DataIC50: 2nMAssay Description:In vitro inhibition of Thromboxane A2 synthaseMore data for this Ligand-Target Pair
Affinity DataIC50: 2nMAssay Description:In vitro inhibition of thromboxane synthasase in microsomal platelet preparationMore data for this Ligand-Target Pair
Affinity DataIC50: 2nMAssay Description:Enzyme activities were measured in the presence of the test inhibitor in spectrophotometric assay.More data for this Ligand-Target Pair
Affinity DataIC50: 2nMAssay Description:Enzyme activities were measured in the presence of the test inhibitor in spectrophotometric assay.More data for this Ligand-Target Pair
Affinity DataIC50: 2nMAssay Description:Enzyme activities were measured in the presence of the test inhibitor in spectrophotometric assay.More data for this Ligand-Target Pair
Affinity DataIC50: 2nMAssay Description:In vitro inhibition of cytochrome P450 19A1More data for this Ligand-Target Pair
Affinity DataIC50: 2nMAssay Description:The compound was tested in vitro for its inhibitory activity against thromboxane synthase A2 (TXA2)More data for this Ligand-Target Pair
Affinity DataIC50: 2nMAssay Description:In vitro inhibition of Thromboxane A2 synthaseMore data for this Ligand-Target Pair