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Found 162 with Last Name = 'guedes' and Initial = 'rc'
TargetNeutrophil elastase(Homo sapiens (Human))
University Of Lisbon

Curated by ChEMBL
LigandPNGBDBM50303364(1-(4-((Benzo[d]oxazol-2-ylthio)methyl)phenyl)-3,3-...)
Affinity DataKi:  0.340nMAssay Description:Inhibition of human leukocyte elastase after 20 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
University Of Lisbon

Curated by ChEMBL
LigandPNGBDBM50303371(1-(6-((Benzo[d]thiazol-2-ylthio)methyl)pyridin-3-y...)
Affinity DataKi:  0.5nMAssay Description:Inhibition of human leukocyte elastase after 20 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
University Of Lisbon

Curated by ChEMBL
LigandPNGBDBM50235615(3,3-diethyl-1-(4-methoxyphenyl)azetidine-2,4-dione...)
Affinity DataKi:  0.710nMAssay Description:Inhibition of human leukocyte elastase after 20 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
University Of Lisbon

Curated by ChEMBL
LigandPNGBDBM50303369(1-(4-((Benzo[d]thiazol-2-ylthio)methyl)phenyl)-3,3...)
Affinity DataKi:  0.820nMAssay Description:Inhibition of human leukocyte elastase after 20 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
University Of Lisbon

Curated by ChEMBL
LigandPNGBDBM50303373(3-butyl-3-ethyl-1-phenylazetidine-2,4-dione | CHEM...)
Affinity DataKi:  0.850nMAssay Description:Inhibition of human leukocyte elastase after 20 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
University Of Lisbon

Curated by ChEMBL
LigandPNGBDBM50303363(2-(4-(3,3-Diethyl-2,4-dioxoazetidin-1-yl)benzylthi...)
Affinity DataKi:  1nMAssay Description:Inhibition of human leukocyte elastase after 20 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
University Of Lisbon

Curated by ChEMBL
LigandPNGBDBM50303370(1-(4-((5-Phenyl-1,3,4-oxadiazol-2-ylthio)methyl)ph...)
Affinity DataKi:  1.10nMAssay Description:Inhibition of human leukocyte elastase after 20 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
University Of Lisbon

Curated by ChEMBL
LigandPNGBDBM50235613(3,3-diethyl-1-phenylazetidine-2,4-dione | CHEMBL27...)
Affinity DataKi:  1.21nMAssay Description:Inhibition of human leukocyte elastase after 20 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
University Of Lisbon

Curated by ChEMBL
LigandPNGBDBM50303357(3,3-Diethyl-1-(6-methylpyridin-3-yl)azetidine-2,4-...)
Affinity DataKi:  1.30nMAssay Description:Inhibition of human leukocyte elastase after 20 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
University Of Lisbon

Curated by ChEMBL
LigandPNGBDBM50303372(3,3-Diethyl-1-(4-((phenylthio)methyl)phenyl)azetid...)
Affinity DataKi:  1.80nMAssay Description:Inhibition of human leukocyte elastase after 20 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
University Of Lisbon

Curated by ChEMBL
LigandPNGBDBM50303356(3,3-Diethyl-1-(pyridin-3-yl)azetidine-2,4-dione | ...)
Affinity DataKi:  2.20nMAssay Description:Inhibition of human leukocyte elastase after 20 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
University Of Lisbon

Curated by ChEMBL
LigandPNGBDBM50303361(3-Ethyl-3-isobutyl-1-phenylazetidine-2,4-dione | C...)
Affinity DataKi:  3.90nMAssay Description:Inhibition of human leukocyte elastase after 20 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
University Of Lisbon

Curated by ChEMBL
LigandPNGBDBM50303365(1-(2-((Benzo[d]oxazol-2-ylthio)methyl)phenyl)-3,3-...)
Affinity DataKi:  7.60nMAssay Description:Inhibition of human leukocyte elastase after 20 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
University Of Lisbon

Curated by ChEMBL
LigandPNGBDBM50235616(1-(4-chlorophenyl)-3,3-dimethylazetidine-2,4-dione...)
Affinity DataKi:  23.8nMAssay Description:Inhibition of human leukocyte elastase after 20 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
University Of Lisbon

Curated by ChEMBL
LigandPNGBDBM50303358(3,3-Diethyl-1-(naphthalen-1-yl)azetidine-2,4-dione...)
Affinity DataKi:  33.9nMAssay Description:Inhibition of human leukocyte elastase after 20 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
University Of Lisbon

Curated by ChEMBL
LigandPNGBDBM50235610(1-benzyl-3,3-dimethylazetidine-2,4-dione | CHEMBL5...)
Affinity DataKi:  34.4nMAssay Description:Inhibition of human leukocyte elastase after 20 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
University Of Lisbon

Curated by ChEMBL
LigandPNGBDBM50235611(4-(3,3-diethyl-2,4-dioxoazetidin-1-yl)benzonitrile...)
Affinity DataKi:  63.5nMAssay Description:Inhibition of human leukocyte elastase after 20 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
University Of Lisbon

Curated by ChEMBL
LigandPNGBDBM50303362(1-(2-((Benzo[d]thiazol-2-ylthio)methyl)phenyl)-3,3...)
Affinity DataKi:  99.3nMAssay Description:Inhibition of human leukocyte elastase after 20 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
University Of Lisbon

Curated by ChEMBL
LigandPNGBDBM50303359(1-benzyl-3,3-diethylazetidine-2,4-dione | CHEMBL27...)
Affinity DataKi:  114nMAssay Description:Inhibition of human leukocyte elastase after 20 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
University Of Lisbon

Curated by ChEMBL
LigandPNGBDBM50303374(3-Benzyl-3-ethyl-1-phenylazetidine-2,4-dione | CHE...)
Affinity DataKi:  127nMAssay Description:Inhibition of human leukocyte elastase after 20 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
University Of Lisbon

Curated by ChEMBL
LigandPNGBDBM50303368(1-(2-((1-Methyl-1H-imidazol-2-ylthio)methyl)phenyl...)
Affinity DataKi:  203nMAssay Description:Inhibition of human leukocyte elastase after 20 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
University Of Lisbon

Curated by ChEMBL
LigandPNGBDBM50303360(CHEMBL271820 | ethyl 2-(3,3-Diethyl-2,4-dioxoazeti...)
Affinity DataKi:  219nMAssay Description:Inhibition of human leukocyte elastase after 20 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
University Of Lisbon

Curated by ChEMBL
LigandPNGBDBM50303355(3,3-Diethyl-1-o-tolylazetidine-2,4-dione | CHEMBL5...)
Affinity DataKi:  233nMAssay Description:Inhibition of human leukocyte elastase after 20 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
University Of Lisbon

Curated by ChEMBL
LigandPNGBDBM50303366(3-Benzyl-3-methyl-1-phenylazetidine-2,4-dione | CH...)
Affinity DataKi:  4.45E+3nMAssay Description:Inhibition of human leukocyte elastase after 20 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholinesterase(Equus caballus (Horse))
Universidade De £Vora

Curated by ChEMBL
LigandPNGBDBM50503819(CHEMBL4565335)
Affinity DataKi:  4.10E+4nMAssay Description:Reversible competitive inhibition of equine BuChE by Lineweaver-burk plot analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
University Of Lisbon

Curated by ChEMBL
LigandPNGBDBM50235611(4-(3,3-diethyl-2,4-dioxoazetidin-1-yl)benzonitrile...)
Affinity DataKi:  6.35E+4nMAssay Description:Inhibition of human leukocyte elastaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Homo sapiens (Human))
University Of Lisbon

Curated by ChEMBL
LigandPNGBDBM10246((4S)-4-{[(1S)-1-{[(2S)-1-carboxy-3-oxopropan-2-yl]...)
Affinity DataIC50:  1.60nMAssay Description:Inhibition of human recombinant caspase 3 assessed as fluorescent 7-amido-4-methylcoumarin releaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgrammed cell death 1 ligand 1(Homo sapiens (Human))
Universidade De Lisboa

Curated by ChEMBL
LigandPNGBDBM50466080(CHEMBL4288470)
Affinity DataIC50:  5.20nMAssay Description:Inhibition of PD-L1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
University Of Lisbon

Curated by ChEMBL
LigandPNGBDBM50084637(2,2-Dimethyl-propionic acid 4-[2-(carboxymethyl-ca...)
Affinity DataIC50:  10nMAssay Description:Inhibition of human neutrophil elastase using MeO-Suc-Ala-Ala-Pro-Val-AMC as substrate incubated for 30 mins prior to substrate addition measured for...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgrammed cell death 1 ligand 1(Homo sapiens (Human))
Universidade De Lisboa

Curated by ChEMBL
LigandPNGBDBM50239947(CHEMBL4089730 | US20230303494, Compound BMS202 | U...)
Affinity DataIC50:  18nMAssay Description:Inhibition of PD-L1 (unknown origin)More data for this Ligand-Target Pair
TargetCaspase-7(Homo sapiens (Human))
University Of Lisbon

Curated by ChEMBL
LigandPNGBDBM10246((4S)-4-{[(1S)-1-{[(2S)-1-carboxy-3-oxopropan-2-yl]...)
Affinity DataIC50:  59.1nMAssay Description:Inhibition of human recombinant caspase 7 assessed as fluorescent 7-amido-4-methylcoumarin releaseMore data for this Ligand-Target Pair
TargetNeutrophil elastase(Homo sapiens (Human))
University Of Lisbon

Curated by ChEMBL
LigandPNGBDBM50444295(CHEMBL3093806)
Affinity DataIC50:  80nMAssay Description:Inhibition of human neutrophil elastase using MeO-Suc-Ala-Ala-Pro-Val-AMC as substrate incubated for 30 mins prior to substrate addition measured for...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgrammed cell death 1 ligand 1(Homo sapiens (Human))
Universidade De Lisboa

Curated by ChEMBL
LigandPNGBDBM50239945(CHEMBL4062686 | US9872852, Example 200)
Affinity DataIC50:  80nMAssay Description:Inhibition of PD-L1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
University Of Lisbon

Curated by ChEMBL
LigandPNGBDBM50444297(CHEMBL3093815)
Affinity DataIC50:  110nMAssay Description:Inhibition of human neutrophil elastase using MeO-Suc-Ala-Ala-Pro-Val-AMC as substrate incubated for 30 mins prior to substrate addition measured for...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFalcipain-2(Plasmodium falciparum)
University Of Lisbon

Curated by ChEMBL
LigandPNGBDBM50157741(CHEMBL374508 | E-64 | E64)
Affinity DataIC50:  112nMAssay Description:Inhibition of Plasmodium falciparum falcipain 2 incubated with compound for 10 mins before addition of 25 uM Z-Leu-Arg-AMC substrate by fluorescence ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgrammed cell death 1 ligand 1(Homo sapiens (Human))
Universidade De Lisboa

Curated by ChEMBL
LigandPNGBDBM50239943(CHEMBL4099869 | US9872852, Example 8)
Affinity DataIC50:  146nMAssay Description:Inhibition of PD-L1 (unknown origin)More data for this Ligand-Target Pair
TargetNeutrophil elastase(Homo sapiens (Human))
University Of Lisbon

Curated by ChEMBL
LigandPNGBDBM50444296(CHEMBL3093814)
Affinity DataIC50:  180nMAssay Description:Inhibition of human neutrophil elastase using MeO-Suc-Ala-Ala-Pro-Val-AMC as substrate incubated for 30 mins prior to substrate addition measured for...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA-(apurinic or apyrimidinic site) endonuclease(Homo sapiens (Human))
Universidade De Lisboa

LigandPNGBDBM203861((5-(acetylamino)-2-[2-(4-isothiocyanato-3-sulfophe...)
Affinity DataIC50:  250nMpH: 7.5Assay Description:In this assay, the complementary single-stranded oligonucleotides at 100 μm were mixed at a 1:1 ratio and annealed in assay buffer (50 mm Tris pH ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
University Of Lisbon

Curated by ChEMBL
LigandPNGBDBM50444300(CHEMBL3093808)
Affinity DataIC50:  280nMAssay Description:Inhibition of human neutrophil elastase using MeO-Suc-Ala-Ala-Pro-Val-AMC as substrate incubated for 30 mins prior to substrate addition measured for...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
University Of Lisbon

Curated by ChEMBL
LigandPNGBDBM50444301(CHEMBL3093809)
Affinity DataIC50:  300nMAssay Description:Inhibition of human neutrophil elastase using MeO-Suc-Ala-Ala-Pro-Val-AMC as substrate incubated for 30 mins prior to substrate addition measured for...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
University Of Lisbon

Curated by ChEMBL
LigandPNGBDBM50444312(CHEMBL3093821)
Affinity DataIC50:  450nMAssay Description:Inhibition of human neutrophil elastase using MeO-Suc-Ala-Ala-Pro-Val-AMC as substrate incubated for 30 mins prior to substrate addition measured for...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCysteine proteinase falcipain 3(Plasmodium falciparum)
University Of Lisbon

Curated by ChEMBL
LigandPNGBDBM50157741(CHEMBL374508 | E-64 | E64)
Affinity DataIC50:  482nMAssay Description:Inhibition of Plasmodium falciparum falcipain 3 incubated with compound for 10 mins before addition of 25 uM Z-Leu-Arg-AMC substrate by fluorescence ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
University Of Lisbon

Curated by ChEMBL
LigandPNGBDBM50444307(CHEMBL3093816)
Affinity DataIC50:  670nMAssay Description:Inhibition of human neutrophil elastase using MeO-Suc-Ala-Ala-Pro-Val-AMC as substrate incubated for 30 mins prior to substrate addition measured for...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
University Of Lisbon

Curated by ChEMBL
LigandPNGBDBM50444302(CHEMBL3093810)
Affinity DataIC50:  960nMAssay Description:Inhibition of human neutrophil elastase using MeO-Suc-Ala-Ala-Pro-Val-AMC as substrate incubated for 30 mins prior to substrate addition measured for...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholinesterase(Equus caballus (Horse))
Universidade De £Vora

Curated by ChEMBL
LigandPNGBDBM50344826(1-(4-chlorobenzyl)-3-hydroxy-3-phenylindolin-2-one...)
Affinity DataIC50:  1.02E+3nMAssay Description:Inhibition of equine serum BuChEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Mus musculus (mouse))
Universidade De £Vora

Curated by ChEMBL
LigandPNGBDBM8960((+/-)-2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimet...)
Affinity DataIC50:  1.06E+3nMAssay Description:Inhibition of AChE in Swiss mouse brain homogenate using acetylthiocholine iodide as substrate by Ellman's assayMore data for this Ligand-Target Pair
TargetNeutrophil elastase(Homo sapiens (Human))
University Of Lisbon

Curated by ChEMBL
LigandPNGBDBM50444306(CHEMBL3091487)
Affinity DataIC50:  1.19E+3nMAssay Description:Inhibition of human neutrophil elastase using MeO-Suc-Ala-Ala-Pro-Val-AMC as substrate incubated for 30 mins prior to substrate addition measured for...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
University Of Lisbon

Curated by ChEMBL
LigandPNGBDBM50444305(CHEMBL3093812)
Affinity DataIC50:  1.20E+3nMAssay Description:Inhibition of human neutrophil elastase using MeO-Suc-Ala-Ala-Pro-Val-AMC as substrate incubated for 30 mins prior to substrate addition measured for...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMyeloblastin(Homo sapiens (Human))
University Of Lisbon

Curated by ChEMBL
LigandPNGBDBM50384111(CHEMBL2029556)
Affinity DataIC50:  1.40E+3nMAssay Description:Inhibition of proteinase 3 using N-MeOSuc-Ala-Ala-Pro-Val-p-nitroanilide as substrate after 60 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKallikrein-1(Homo sapiens (Human))
Universidade De Lisboa

Curated by ChEMBL
LigandPNGBDBM50084637(2,2-Dimethyl-propionic acid 4-[2-(carboxymethyl-ca...)
Affinity DataIC50: >2.00E+3nMAssay Description:Inhibition of human kallikrein using H-Pro-Phe-Arg-AMC acetate salt as substrate measured for 30 mins by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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