TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Merck Frosst Canada
Curated by ChEMBL
Merck Frosst Canada
Curated by ChEMBL
Affinity DataIC50: 7nMAssay Description:Concentration required for 50 % inhibition of leukotriene B4 production in human PMN compared with controls in the absence of compoundMore data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Merck Frosst Canada
Curated by ChEMBL
Merck Frosst Canada
Curated by ChEMBL
Affinity DataIC50: 11nMAssay Description:Concentration required for 50 % inhibition of leukotriene B4 production in human PMN compared with controls in the absence of compoundMore data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Merck Frosst Canada
Curated by ChEMBL
Merck Frosst Canada
Curated by ChEMBL
Affinity DataIC50: 12nMAssay Description:Concentration required for 50 % inhibition of leukotriene B4 production in human PMN compared with controls in the absence of compoundMore data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Merck Frosst Canada
Curated by ChEMBL
Merck Frosst Canada
Curated by ChEMBL
Affinity DataIC50: 13nMAssay Description:Concentration required for 50 % inhibition of leukotriene B4 production in human PMN compared with controls in the absence of compoundMore data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Merck Frosst Canada
Curated by ChEMBL
Merck Frosst Canada
Curated by ChEMBL
Affinity DataIC50: 20nMAssay Description:Concentration required for 50 % inhibition of leukotriene B4 production in human PMN compared with controls in the absence of compoundMore data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Merck Frosst Canada
Curated by ChEMBL
Merck Frosst Canada
Curated by ChEMBL
Affinity DataIC50: 20nMAssay Description:Concentration required for 50 % inhibition of leukotriene B4 production in human PMN compared with controls in the absence of compoundMore data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Merck Frosst Canada
Curated by ChEMBL
Merck Frosst Canada
Curated by ChEMBL
Affinity DataIC50: 26nMAssay Description:Concentration required for 50 % inhibition of leukotriene B4 production in human PMN compared with controls in the absence of compoundMore data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Merck Frosst Canada
Curated by ChEMBL
Merck Frosst Canada
Curated by ChEMBL
Affinity DataIC50: 30nMAssay Description:Concentration required for 50 % inhibition of leukotriene B4 production in human PMN compared with controls in the absence of compoundMore data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Merck Frosst Canada
Curated by ChEMBL
Merck Frosst Canada
Curated by ChEMBL
Affinity DataIC50: 31nMAssay Description:Concentration required for 50 % inhibition of leukotriene B4 production in human PMN compared with controls in the absence of compoundMore data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rattus norvegicus)
Merck Frosst Canada
Curated by ChEMBL
Merck Frosst Canada
Curated by ChEMBL
Affinity DataIC50: 36nMAssay Description:Concentration required for 50 % inhibition of arachidonic acid oxidation by rat 5-lipoxygenaseMore data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Merck Frosst Canada
Curated by ChEMBL
Merck Frosst Canada
Curated by ChEMBL
Affinity DataIC50: 46nMAssay Description:Concentration required for 50 % inhibition of leukotriene B4 production in human PMN compared with controls in the absence of compoundMore data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Merck Frosst Canada
Curated by ChEMBL
Merck Frosst Canada
Curated by ChEMBL
Affinity DataIC50: 76nMAssay Description:Concentration required for 50 % inhibition of leukotriene B4 production in human PMN compared with controls in the absence of compoundMore data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Merck Frosst Canada
Curated by ChEMBL
Merck Frosst Canada
Curated by ChEMBL
Affinity DataIC50: 85nMAssay Description:Concentration required for 50 % inhibition of leukotriene B4 production in human PMN compared with controls in the absence of compoundMore data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Merck Frosst Canada
Curated by ChEMBL
Merck Frosst Canada
Curated by ChEMBL
Affinity DataIC50: 99nMAssay Description:Concentration required for 50 % inhibition of leukotriene B4 production in human PMN compared with controls in the absence of compoundMore data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Merck Frosst Canada
Curated by ChEMBL
Merck Frosst Canada
Curated by ChEMBL
Affinity DataIC50: 105nMAssay Description:Concentration required for 50 % inhibition of leukotriene B4 production in human PMN compared with controls in the absence of compoundMore data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rattus norvegicus)
Merck Frosst Canada
Curated by ChEMBL
Merck Frosst Canada
Curated by ChEMBL
Affinity DataIC50: 129nMAssay Description:Concentration required for 50 % inhibition of arachidonic acid oxidation by rat 5-lipoxygenaseMore data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rattus norvegicus)
Merck Frosst Canada
Curated by ChEMBL
Merck Frosst Canada
Curated by ChEMBL
Affinity DataIC50: 130nMAssay Description:Concentration required for 50 % inhibition of arachidonic acid oxidation by rat 5-lipoxygenaseMore data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rattus norvegicus)
Merck Frosst Canada
Curated by ChEMBL
Merck Frosst Canada
Curated by ChEMBL
Affinity DataIC50: 140nMAssay Description:Concentration required for 50 % inhibition of arachidonic acid oxidation by rat 5-lipoxygenaseMore data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rattus norvegicus)
Merck Frosst Canada
Curated by ChEMBL
Merck Frosst Canada
Curated by ChEMBL
Affinity DataIC50: 161nMAssay Description:Concentration required for 50 % inhibition of arachidonic acid oxidation by rat 5-lipoxygenaseMore data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Merck Frosst Canada
Curated by ChEMBL
Merck Frosst Canada
Curated by ChEMBL
Affinity DataIC50: 291nMAssay Description:Concentration required for 50 % inhibition of leukotriene B4 production in human PMN compared with controls in the absence of compoundMore data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Merck Frosst Canada
Curated by ChEMBL
Merck Frosst Canada
Curated by ChEMBL
Affinity DataIC50: 376nMAssay Description:Concentration required for 50 % inhibition of leukotriene B4 production in human PMN compared with controls in the absence of compoundMore data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Merck Frosst Canada
Curated by ChEMBL
Merck Frosst Canada
Curated by ChEMBL
Affinity DataIC50: 400nMAssay Description:Inhibition of 5-lipoxygenase reaction catalyzed by purified enzyme from porcine leukocytesMore data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Merck Frosst Canada
Curated by ChEMBL
Merck Frosst Canada
Curated by ChEMBL
Affinity DataIC50: 574nMAssay Description:Concentration required for 50 % inhibition of leukotriene B4 production in human PMN compared with controls in the absence of compoundMore data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Merck Frosst Canada
Curated by ChEMBL
Merck Frosst Canada
Curated by ChEMBL
Affinity DataIC50: 860nMAssay Description:Concentration required for 50 % inhibition of leukotriene B4 production in human PMN compared with controls in the absence of compoundMore data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rattus norvegicus)
Merck Frosst Canada
Curated by ChEMBL
Merck Frosst Canada
Curated by ChEMBL
Affinity DataIC50: 2.00E+3nMAssay Description:Concentration required for 50 % inhibition of arachidonic acid oxidation by rat 5-lipoxygenaseMore data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rattus norvegicus)
Merck Frosst Canada
Curated by ChEMBL
Merck Frosst Canada
Curated by ChEMBL
Affinity DataIC50: 2.07E+3nMAssay Description:Concentration required for 50 % inhibition of arachidonic acid oxidation by rat 5-lipoxygenaseMore data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Merck Frosst Canada
Curated by ChEMBL
Merck Frosst Canada
Curated by ChEMBL
Affinity DataIC50: 2.13E+3nMAssay Description:Concentration required for 50 % inhibition of leukotriene B4 production in human PMN compared with controls in the absence of compoundMore data for this Ligand-Target Pair
TargetP-selectin(Homo sapiens (Human))
Institut De Recherches Cliniques De Montr£Al (Ircm)
Curated by ChEMBL
Institut De Recherches Cliniques De Montr£Al (Ircm)
Curated by ChEMBL
Affinity DataIC50: 8.00E+3nMAssay Description:Antagonist activity at P-selectin (unknown origin) by surface plasmon resonance-based dynamic assayMore data for this Ligand-Target Pair
TargetP-selectin(Homo sapiens (Human))
Institut De Recherches Cliniques De Montr£Al (Ircm)
Curated by ChEMBL
Institut De Recherches Cliniques De Montr£Al (Ircm)
Curated by ChEMBL
Affinity DataIC50: 8.00E+3nMAssay Description:Antagonist activity at P-selectin (unknown origin) by surface plasmon resonance-based dynamic assayMore data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Merck Frosst Canada
Curated by ChEMBL
Merck Frosst Canada
Curated by ChEMBL
Affinity DataIC50: 9.20E+3nMAssay Description:Concentration required for 50 % inhibition of leukotriene B4 production in human PMN compared with controls in the absence of compoundMore data for this Ligand-Target Pair
TargetP-selectin(Homo sapiens (Human))
Institut De Recherches Cliniques De Montr£Al (Ircm)
Curated by ChEMBL
Institut De Recherches Cliniques De Montr£Al (Ircm)
Curated by ChEMBL
Affinity DataIC50: 1.60E+4nMAssay Description:Antagonist activity at P-selectin (unknown origin) by surface plasmon resonance-based dynamic assayMore data for this Ligand-Target Pair
TargetP-selectin(Homo sapiens (Human))
Institut De Recherches Cliniques De Montr£Al (Ircm)
Curated by ChEMBL
Institut De Recherches Cliniques De Montr£Al (Ircm)
Curated by ChEMBL
Affinity DataIC50: 1.80E+4nMAssay Description:Antagonist activity at P-selectin (unknown origin) by surface plasmon resonance-based dynamic assayMore data for this Ligand-Target Pair
TargetP-selectin(Homo sapiens (Human))
Institut De Recherches Cliniques De Montr£Al (Ircm)
Curated by ChEMBL
Institut De Recherches Cliniques De Montr£Al (Ircm)
Curated by ChEMBL
Affinity DataIC50: 1.80E+4nMAssay Description:Antagonist activity at P-selectin (unknown origin) by surface plasmon resonance-based dynamic assayMore data for this Ligand-Target Pair
TargetP-selectin(Homo sapiens (Human))
Institut De Recherches Cliniques De Montr£Al (Ircm)
Curated by ChEMBL
Institut De Recherches Cliniques De Montr£Al (Ircm)
Curated by ChEMBL
Affinity DataIC50: 1.80E+4nMAssay Description:Inhibition of immobilized rhPSGL-Ig binding to soluble P-selectin by surface plasmon resonance competitive binding assayMore data for this Ligand-Target Pair
TargetP-selectin(Homo sapiens (Human))
Institut De Recherches Cliniques De Montr£Al (Ircm)
Curated by ChEMBL
Institut De Recherches Cliniques De Montr£Al (Ircm)
Curated by ChEMBL
Affinity DataIC50: 1.90E+4nMAssay Description:Antagonist activity at P-selectin (unknown origin) by surface plasmon resonance-based dynamic assayMore data for this Ligand-Target Pair
TargetP-selectin(Homo sapiens (Human))
Institut De Recherches Cliniques De Montr£Al (Ircm)
Curated by ChEMBL
Institut De Recherches Cliniques De Montr£Al (Ircm)
Curated by ChEMBL
Affinity DataIC50: 2.10E+4nMAssay Description:Antagonist activity at P-selectin (unknown origin) by surface plasmon resonance-based dynamic assayMore data for this Ligand-Target Pair
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibitory activity of the compound towards soybean lipoxygenaseMore data for this Ligand-Target Pair
TargetP-selectin(Homo sapiens (Human))
Institut De Recherches Cliniques De Montr£Al (Ircm)
Curated by ChEMBL
Institut De Recherches Cliniques De Montr£Al (Ircm)
Curated by ChEMBL
Affinity DataIC50: 3.40E+4nMAssay Description:Antagonist activity at P-selectin (unknown origin) by surface plasmon resonance-based dynamic assayMore data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Homo sapiens (Human))
Merck Frosst Canada
Curated by ChEMBL
Merck Frosst Canada
Curated by ChEMBL
Affinity DataIC50: 4.00E+4nMAssay Description:Inhibition of partially purified 15-lipoxygenase from human leukocytesMore data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Sus scrofa)
Merck Frosst Canada
Curated by ChEMBL
Merck Frosst Canada
Curated by ChEMBL
Affinity DataIC50: 4.00E+4nMAssay Description:Inhibitory activity of the compound towards porcine 12-lipoxygenaseMore data for this Ligand-Target Pair
TargetP-selectin(Homo sapiens (Human))
Institut De Recherches Cliniques De Montr£Al (Ircm)
Curated by ChEMBL
Institut De Recherches Cliniques De Montr£Al (Ircm)
Curated by ChEMBL
Affinity DataIC50: 6.70E+4nMAssay Description:Antagonist activity at P-selectin (unknown origin) assessed as adhesion to [3H]thymidine-labelled human HL60 cells by static assayMore data for this Ligand-Target Pair
TargetE-selectin(Homo sapiens (Human))
Institut De Recherches Cliniques De Montr£Al (Ircm)
Curated by ChEMBL
Institut De Recherches Cliniques De Montr£Al (Ircm)
Curated by ChEMBL
Affinity DataIC50: 7.60E+4nMAssay Description:Antagonist activity at E-selectin (unknown origin) assessed as adhesion to [3H]thymidine-labelled human HL60 cells by static assayMore data for this Ligand-Target Pair
TargetP-selectin(Homo sapiens (Human))
Institut De Recherches Cliniques De Montr£Al (Ircm)
Curated by ChEMBL
Institut De Recherches Cliniques De Montr£Al (Ircm)
Curated by ChEMBL
Affinity DataIC50: 1.10E+5nMAssay Description:Antagonist activity at P-selectin (unknown origin) assessed as adhesion to [3H]thymidine-labelled human HL60 cells by static assayMore data for this Ligand-Target Pair
TargetE-selectin(Homo sapiens (Human))
Institut De Recherches Cliniques De Montr£Al (Ircm)
Curated by ChEMBL
Institut De Recherches Cliniques De Montr£Al (Ircm)
Curated by ChEMBL
Affinity DataIC50: 1.40E+5nMAssay Description:Antagonist activity at E-selectin (unknown origin) assessed as adhesion to [3H]thymidine-labelled human HL60 cells by static assayMore data for this Ligand-Target Pair
TargetP-selectin(Homo sapiens (Human))
Institut De Recherches Cliniques De Montr£Al (Ircm)
Curated by ChEMBL
Institut De Recherches Cliniques De Montr£Al (Ircm)
Curated by ChEMBL
Affinity DataIC50: 1.90E+5nMAssay Description:Antagonist activity at P-selectin (unknown origin) assessed as adhesion to [3H]thymidine-labelled human HL60 cells by static assayMore data for this Ligand-Target Pair
TargetE-selectin(Homo sapiens (Human))
Institut De Recherches Cliniques De Montr£Al (Ircm)
Curated by ChEMBL
Institut De Recherches Cliniques De Montr£Al (Ircm)
Curated by ChEMBL
Affinity DataIC50: 2.20E+5nMAssay Description:Antagonist activity at E-selectin (unknown origin) assessed as adhesion to [3H]thymidine-labelled human HL60 cells by static assayMore data for this Ligand-Target Pair
TargetP-selectin(Homo sapiens (Human))
Institut De Recherches Cliniques De Montr£Al (Ircm)
Curated by ChEMBL
Institut De Recherches Cliniques De Montr£Al (Ircm)
Curated by ChEMBL
Affinity DataIC50: 5.20E+5nMAssay Description:Antagonist activity at P-selectin (unknown origin) by surface plasmon resonance-based dynamic assayMore data for this Ligand-Target Pair
TargetP-selectin(Homo sapiens (Human))
Institut De Recherches Cliniques De Montr£Al (Ircm)
Curated by ChEMBL
Institut De Recherches Cliniques De Montr£Al (Ircm)
Curated by ChEMBL
Affinity DataIC50: 8.80E+5nMAssay Description:Inhibition of immobilized rhPSGL-Ig binding to soluble P-selectin by surface plasmon resonance competitive binding assayMore data for this Ligand-Target Pair
TargetP-selectin(Homo sapiens (Human))
Institut De Recherches Cliniques De Montr£Al (Ircm)
Curated by ChEMBL
Institut De Recherches Cliniques De Montr£Al (Ircm)
Curated by ChEMBL
Affinity DataIC50: 8.80E+5nMAssay Description:Antagonist activity at P-selectin (unknown origin) by surface plasmon resonance-based dynamic assayMore data for this Ligand-Target Pair
TargetP-selectin(Homo sapiens (Human))
Institut De Recherches Cliniques De Montr£Al (Ircm)
Curated by ChEMBL
Institut De Recherches Cliniques De Montr£Al (Ircm)
Curated by ChEMBL
Affinity DataIC50: >1.00E+6nMAssay Description:Inhibition of immobilized rhPSGL-Ig binding to soluble P-selectin by surface plasmon resonance competitive binding assayMore data for this Ligand-Target Pair