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Found 1776 with Last Name = 'hage' and Initial = 't'
TargetNeuronal acetylcholine receptor subunit alpha-7(Rattus norvegicus (Rat))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50049757(()-2-(6-Chloro-pyridin-3-yl)-7-aza-bicyclo[2.2.1]h...)
Affinity DataKi:  2.70nMAssay Description:Displacement of [3H]585539 from alpha7 nAChR in rat brainMore data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor subunit alpha-7(Rattus norvegicus (Rat))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50305362((3aR,6aS)-2-(6-phenylpyridazin-3-yl)-5-(pyridin-3-...)
Affinity DataKi:  3.60nMAssay Description:Displacement of [3H]585539 from alpha7 nAChR in rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rattus norvegicus (Rat))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50305359(CHEMBL591097 | N-benzyl-N-methyl-1-(6-phenylpyrida...)
Affinity DataKi: >10nMAssay Description:Displacement of [3H]585539 from alpha7 nAChR in rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rattus norvegicus (Rat))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50305363(CHEMBL601061 | N-methyl-1-(6-phenylpyridazin-3-yl)...)
Affinity DataKi: >10nMAssay Description:Displacement of [3H]585539 from alpha7 nAChR in rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rattus norvegicus (Rat))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50305367(CHEMBL590618 | N-((6-chloropyridin-3-yl)methyl)-N-...)
Affinity DataKi: >10nMAssay Description:Displacement of [3H]585539 from alpha7 nAChR in rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rattus norvegicus (Rat))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50305372(CHEMBL589648 | N-methyl-1-(6-phenylpyridazin-3-yl)...)
Affinity DataKi: >10nMAssay Description:Displacement of [3H]585539 from alpha7 nAChR in rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rattus norvegicus (Rat))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50305365(CHEMBL590617 | N-methyl-1-(6-phenylpyridazin-3-yl)...)
Affinity DataKi: >10nMAssay Description:Displacement of [3H]585539 from alpha7 nAChR in rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rattus norvegicus (Rat))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50305361(CHEMBL610751 | N-methyl-1-(6-phenylpyridazin-3-yl)...)
Affinity DataKi: >10nMAssay Description:Displacement of [3H]585539 from alpha7 nAChR in rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rattus norvegicus (Rat))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50278956((3aR,6aS)-2-methyl-5-(6-phenylpyridazin-3-yl)octah...)
Affinity DataKi:  11nMAssay Description:Displacement of [3H]585539 from alpha7 nAChR in rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rattus norvegicus (Rat))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50278955(CHEMBL506103 | CHEMBL610752 | cis-2-(6-Phenyl-pyri...)
Affinity DataKi:  18nMAssay Description:Displacement of [3H]585539 from alpha7 nAChR in rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rattus norvegicus (Rat))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50305369((1S,3aR,6aR)-2-methyl-5-(6-phenylpyridazin-3-yl)-1...)
Affinity DataKi:  42nMAssay Description:Displacement of [3H]585539 from alpha7 nAChR in rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rattus norvegicus (Rat))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50305366((3aR,6aS)-2-((6-chloropyridin-3-yl)methyl)-5-(6-ph...)
Affinity DataKi:  102nMAssay Description:Displacement of [3H]585539 from alpha7 nAChR in rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rattus norvegicus (Rat))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50305368((1R,3aR,6aR)-2-methyl-5-(6-phenylpyridazin-3-yl)-1...)
Affinity DataKi:  320nMAssay Description:Displacement of [3H]585539 from alpha7 nAChR in rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rattus norvegicus (Rat))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50278957(CHEMBL498262 | CHEMBL594590 | cis-2-Ethyl-5-(6-phe...)
Affinity DataKi:  331nMAssay Description:Displacement of [3H]585539 from alpha7 nAChR in rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rattus norvegicus (Rat))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50305358((3aR,6aS)-2-benzyl-5-(6-phenylpyridazin-3-yl)octah...)
Affinity DataKi:  476nMAssay Description:Displacement of [3H]585539 from alpha7 nAChR in rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rattus norvegicus (Rat))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50305355((+/-)-N,N-dimethyl-1-(6-phenylpyridazin-3-yl)pyrro...)
Affinity DataKi:  478nMAssay Description:Displacement of [3H]585539 from alpha7 nAChR in rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rattus norvegicus (Rat))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50305360((3aR,6aS)-2-(6-phenylpyridazin-3-yl)-5-(pyridin-2-...)
Affinity DataKi:  533nMAssay Description:Displacement of [3H]585539 from alpha7 nAChR in rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rattus norvegicus (Rat))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50305364((3aR,6aS)-2-(6-phenylpyridazin-3-yl)-5-(pyridin-4-...)
Affinity DataKi:  541nMAssay Description:Displacement of [3H]585539 from alpha7 nAChR in rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rattus norvegicus (Rat))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50305357(CHEMBL601927 | N-ethyl-N-methyl-1-(6-phenylpyridaz...)
Affinity DataKi:  746nMAssay Description:Displacement of [3H]585539 from alpha7 nAChR in rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-4(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50278956((3aR,6aS)-2-methyl-5-(6-phenylpyridazin-3-yl)octah...)
Affinity DataKi:  4.70E+3nMAssay Description:Inhibition of alpha3beta4 nAChRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rattus norvegicus (Rat))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50278955(CHEMBL506103 | CHEMBL610752 | cis-2-(6-Phenyl-pyri...)
Affinity DataKi:  5.30E+3nMAssay Description:Displacement of [3H]cytisine from rat brain alpha4beta2 nAChRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50278956((3aR,6aS)-2-methyl-5-(6-phenylpyridazin-3-yl)octah...)
Affinity DataKi: >1.00E+5nMAssay Description:Inhibition of alpha4beta2 nAChRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50357868(CHEMBL1916128)
Affinity DataIC50:  0.0500nMAssay Description:Inhibition of N-terminal His-tagged human PDE10A expressed in Escherichia coli using [3H]cAMP after 1 hr by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50357869(CHEMBL1916129)
Affinity DataIC50:  0.0600nMAssay Description:Inhibition of N-terminal His-tagged human PDE10A expressed in Escherichia coli using [3H]cAMP after 1 hr by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50357870(CHEMBL1916130)
Affinity DataIC50:  0.0900nMAssay Description:Inhibition of N-terminal His-tagged human PDE10A expressed in Escherichia coli using [3H]cAMP after 1 hr by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50357867(CHEMBL1916127)
Affinity DataIC50:  0.100nMAssay Description:Inhibition of N-terminal His-tagged human PDE10A expressed in Escherichia coli using [3H]cAMP after 1 hr by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50357865(CHEMBL1916125)
Affinity DataIC50:  0.140nMAssay Description:Inhibition of N-terminal His-tagged human PDE10A expressed in Escherichia coli using [3H]cAMP after 1 hr by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50357864(CHEMBL1916124)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of N-terminal His-tagged human PDE10A expressed in Escherichia coli using [3H]cAMP after 1 hr by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50390812(CHEMBL2069321)
Affinity DataIC50:  0.280nMAssay Description:Inhibition of human recombinant PDE10A-catalyzed cAMP hydrolysisMore data for this Ligand-Target Pair
LigandPNGBDBM50357857(CHEMBL1916117)
Affinity DataIC50:  0.350nMAssay Description:Inhibition of N-terminal His-tagged human PDE10A expressed in Escherichia coli using [3H]cAMP after 1 hr by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50357863(CHEMBL1916123)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of N-terminal His-tagged human PDE10A expressed in Escherichia coli using [3H]cAMP after 1 hr by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50357854(CHEMBL1916114)
Affinity DataIC50:  0.550nMAssay Description:Inhibition of N-terminal His-tagged human PDE10A expressed in Escherichia coli using [3H]cAMP after 1 hr by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50357803(CHEMBL1916113)
Affinity DataIC50:  0.700nMAssay Description:Inhibition of N-terminal His-tagged human PDE10A expressed in Escherichia coli using [3H]cAMP after 1 hr by scintillation proximity assayMore data for this Ligand-Target Pair
LigandPNGBDBM50357872(CHEMBL1916132)
Affinity DataIC50:  0.700nMAssay Description:Inhibition of N-terminal His-tagged human PDE10A expressed in Escherichia coli using [3H]cAMP after 1 hr by scintillation proximity assayMore data for this Ligand-Target Pair
LigandPNGBDBM50357871(CHEMBL1916131)
Affinity DataIC50:  0.800nMAssay Description:Inhibition of N-terminal His-tagged human PDE10A expressed in Escherichia coli using [3H]cAMP after 1 hr by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50357856(CHEMBL1916116)
Affinity DataIC50:  0.850nMAssay Description:Inhibition of N-terminal His-tagged human PDE10A expressed in Escherichia coli using [3H]cAMP after 1 hr by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50390818(CHEMBL2070655)
Affinity DataIC50:  0.850nMAssay Description:Inhibition of human recombinant PDE10A-catalyzed cAMP hydrolysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM31592(PF-2545920 | US9138494, MP-10 | substituted pyraz...)
Affinity DataIC50:  1.30nMAssay Description:Inhibition of human recombinant PDE10A expressed in baculovirus-SF21 cell system assessed as hydrolysis of [3H]cAMP after 1 hr by liquid scintillatio...More data for this Ligand-Target Pair
LigandPNGBDBM50319169(3,4-Dimethoxy-1-isobutyl-8-methoxy-imidazo[1,5-a]p...)
Affinity DataIC50:  1.40nMAssay Description:Inhibition of human recombinant PDE10A expressed in baculovirus-SF21 cell system assessed as hydrolysis of [3H]cAMP after 1 hr by liquid scintillatio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50390834(CHEMBL2070651)
Affinity DataIC50:  1.48nMAssay Description:Inhibition of human recombinant PDE10A-catalyzed cAMP hydrolysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50390829(CHEMBL2070666)
Affinity DataIC50:  1.48nMAssay Description:Inhibition of human recombinant PDE10A-catalyzed cAMP hydrolysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50357855(CHEMBL1916115)
Affinity DataIC50:  1.5nMAssay Description:Inhibition of N-terminal His-tagged human PDE10A expressed in Escherichia coli using [3H]cAMP after 1 hr by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50357875(CHEMBL1916135)
Affinity DataIC50:  1.5nMAssay Description:Inhibition of N-terminal His-tagged human PDE10A expressed in Escherichia coli using [3H]cAMP after 1 hr by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50390817(CHEMBL2070654)
Affinity DataIC50:  1.53nMAssay Description:Inhibition of human recombinant PDE10A-catalyzed cAMP hydrolysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50390827(CHEMBL2070664)
Affinity DataIC50:  1.65nMAssay Description:Inhibition of human recombinant PDE10A-catalyzed cAMP hydrolysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50357866(CHEMBL1916126)
Affinity DataIC50:  1.70nMAssay Description:Inhibition of N-terminal His-tagged human PDE10A expressed in Escherichia coli using [3H]cAMP after 1 hr by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50357806(CHEMBL1915896)
Affinity DataIC50:  1.80nMAssay Description:Inhibition of N-terminal His-tagged human PDE10A expressed in Escherichia coli using [3H]cAMP after 1 hr by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50390831(CHEMBL2070668)
Affinity DataIC50:  1.85nMAssay Description:Inhibition of human recombinant PDE10A-catalyzed cAMP hydrolysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50357824(CHEMBL1915890)
Affinity DataIC50:  1.90nMAssay Description:Inhibition of N-terminal His-tagged human PDE10A expressed in Escherichia coli using [3H]cAMP after 1 hr by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50357858(CHEMBL1916118)
Affinity DataIC50:  1.90nMAssay Description:Inhibition of N-terminal His-tagged human PDE10A expressed in Escherichia coli using [3H]cAMP after 1 hr by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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