Affinity DataIC50: 2.5nMAssay Description:Inhibition of radio-isotope labeled MIP1-alpha binding to human recombinant CCR5More data for this Ligand-Target Pair
Affinity DataIC50: 4.5nMAssay Description:Inhibition of radio-isotope labeled MIP1-alpha binding to human recombinant CCR5More data for this Ligand-Target Pair
Affinity DataIC50: 6.10nMAssay Description:Inhibition of radio-isotope labeled MIP1-alpha binding to human recombinant CCR5More data for this Ligand-Target Pair
Affinity DataIC50: 8nMAssay Description:Compound was tested for its binding affinity against Prostaglandin I2 receptor using conventional ligand assay by the displacement of [3H]-iloprost f...More data for this Ligand-Target Pair
Affinity DataIC50: 10nMAssay Description:Compound was tested for prostacyclin (PGI-2) binding by displacement of [3H]-iloprost from human platelets using conventional ligand binding assayMore data for this Ligand-Target Pair
Affinity DataIC50: 11nMAssay Description:Inhibition of radio-isotope labeled MIP1-alpha binding to human recombinant CCR5More data for this Ligand-Target Pair
Affinity DataIC50: 11nMAssay Description:Binding affinity towards Thromboxane A2/ Prostaglandin H2 receptor in human platelet membranes using [125I]- as the radioligand.More data for this Ligand-Target Pair
Affinity DataIC50: 11.2nMAssay Description:Binding affinity towards Thromboxane A2/ Prostaglandin H2 receptor in human platelet membranes using [125I]- as the radioligand.More data for this Ligand-Target Pair
Affinity DataIC50: 17nMAssay Description:Inhibition of radio-isotope labeled MIP1-alpha binding to human recombinant CCR5More data for this Ligand-Target Pair
Affinity DataIC50: 18nMAssay Description:Compound was tested for its binding affinity against Prostaglandin I2 receptor using conventional ligand assay by the displacement of [3H]-iloprost f...More data for this Ligand-Target Pair
Affinity DataIC50: 20nMAssay Description:Inhibition of radio-isotope labeled MIP1-alpha binding to human recombinant CCR5More data for this Ligand-Target Pair
Affinity DataIC50: 20nMAssay Description:Compound was tested for prostacyclin (PGI-2) binding by displacement of [3H]-iloprost from human platelets using conventional ligand binding assayMore data for this Ligand-Target Pair
Affinity DataIC50: 20nMAssay Description:Antagonist activity against human recombinant CCR5 expressed in CHO cells assessed as inhibition of human MIP-1-alpha-stimulated calcium mobilizationMore data for this Ligand-Target Pair
Affinity DataIC50: 27nMAssay Description:Displacement of [3H]-iloprost from Prostaglandin I2 receptor of human plateletsMore data for this Ligand-Target Pair
Affinity DataIC50: 27nMAssay Description:Prostaglandin I2 receptor binding by displacement of [3H]-iloprost from human plateletsMore data for this Ligand-Target Pair
Affinity DataIC50: 36nMAssay Description:Binding affinity towards Thromboxane A2 receptor/Prostaglandin receptor in human platelet membranes using [125I]- as the radioligandMore data for this Ligand-Target Pair
Affinity DataIC50: 38nMAssay Description:Inhibition of radio-isotope labeled MIP1-alpha binding to human recombinant CCR5More data for this Ligand-Target Pair
Affinity DataIC50: 40nMAssay Description:Compound was tested for its binding affinity against Prostaglandin I2 receptor using conventional ligand assay by the displacement of [3H]-iloprost f...More data for this Ligand-Target Pair
Affinity DataIC50: 44nMAssay Description:Inhibitory concentration of the compound was tested in vitro against Human neutrophil elastaseMore data for this Ligand-Target Pair
Affinity DataIC50: 50nMAssay Description:Binding affinity towards Thromboxane A2 receptor/Prostaglandin receptor in human platelet membranes using [125I]- as the radioligandMore data for this Ligand-Target Pair
Affinity DataIC50: 50nMAssay Description:Antagonist activity against human recombinant CCR5 expressed in CHO cells assessed as inhibition of human MIP-1-alpha-stimulated calcium mobilizationMore data for this Ligand-Target Pair
Affinity DataIC50: 83nMAssay Description:Inhibition of radio-isotope labeled MIP1-alpha binding to human recombinant CCR5More data for this Ligand-Target Pair
Affinity DataIC50: 120nMAssay Description:Antagonist activity against human recombinant CCR5 expressed in CHO cells assessed as inhibition of human MIP-1-alpha-stimulated calcium mobilizationMore data for this Ligand-Target Pair
Affinity DataIC50: 120nMAssay Description:Antagonist activity against human recombinant CCR5 expressed in CHO cells assessed as inhibition of human MIP-1-alpha-stimulated calcium mobilizationMore data for this Ligand-Target Pair
Affinity DataIC50: 150nMAssay Description:Displacement of [3H]-iloprost from Prostaglandin I2 receptor of human plateletsMore data for this Ligand-Target Pair
Affinity DataIC50: 150nMAssay Description:Displacement of [3H]-iloprost from Prostaglandin I2 receptor of human plateletsMore data for this Ligand-Target Pair
Affinity DataIC50: 170nMAssay Description:Antagonist activity against human recombinant CCR5 expressed in CHO cells assessed as inhibition of human MIP-1-alpha-stimulated calcium mobilizationMore data for this Ligand-Target Pair
Affinity DataIC50: 170nMAssay Description:Antagonist activity against human recombinant CCR5 expressed in CHO cells assessed as inhibition of human MIP-1-alpha-stimulated calcium mobilizationMore data for this Ligand-Target Pair
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
Ono Pharmaceutical
Curated by ChEMBL
Ono Pharmaceutical
Curated by ChEMBL
Affinity DataIC50: 183nMAssay Description:Binding affinity to sigma receptorMore data for this Ligand-Target Pair
Affinity DataIC50: 210nMAssay Description:Compound was tested for prostacyclin (PGI-2) binding by displacement of [3H]-iloprost from human platelets using conventional ligand binding assayMore data for this Ligand-Target Pair
Affinity DataIC50: 220nMAssay Description:Displacement of [3H]-iloprost from Prostaglandin I2 receptor of human plateletsMore data for this Ligand-Target Pair
Affinity DataIC50: 270nMAssay Description:Antagonist activity against human recombinant CCR5 expressed in CHO cells assessed as inhibition of human MIP-1-alpha-stimulated calcium mobilizationMore data for this Ligand-Target Pair
Affinity DataIC50: 270nMAssay Description:Antagonist activity against human recombinant CCR5 expressed in CHO cells assessed as inhibition of human MIP-1-alpha-stimulated calcium mobilizationMore data for this Ligand-Target Pair
Affinity DataIC50: 300nMAssay Description:Antagonist activity against human recombinant CCR5 expressed in CHO cells assessed as inhibition of human MIP-1-alpha-stimulated calcium mobilizationMore data for this Ligand-Target Pair
Affinity DataIC50: 380nMAssay Description:Displacement of [3H]-iloprost from Prostaglandin I2 receptor of human plateletsMore data for this Ligand-Target Pair
Affinity DataIC50: 460nMAssay Description:Compound was tested for prostacyclin (PGI-2) binding by displacement of [3H]-iloprost from human platelets using conventional ligand binding assayMore data for this Ligand-Target Pair
Affinity DataIC50: 500nMAssay Description:Antagonist activity against human recombinant CCR5 expressed in CHO cells assessed as inhibition of human MIP-1-alpha-stimulated calcium mobilizationMore data for this Ligand-Target Pair
Affinity DataIC50: 560nMAssay Description:Inhibition of radio-isotope labeled MIP1-alpha binding to human recombinant CCR5More data for this Ligand-Target Pair
Affinity DataIC50: 600nMAssay Description:Prostaglandin I2 receptor binding by displacement of [3H]-iloprost from human plateletsMore data for this Ligand-Target Pair
Affinity DataIC50: 600nMAssay Description:Displacement of [3H]-iloprost from Prostaglandin I2 receptor of human plateletsMore data for this Ligand-Target Pair
Affinity DataIC50: 610nMAssay Description:Inhibition of radio-isotope labeled MIP1-alpha binding to human recombinant CCR5More data for this Ligand-Target Pair
Affinity DataIC50: 650nMAssay Description:Displacement of [3H]-iloprost from Prostaglandin I2 receptor of human plateletsMore data for this Ligand-Target Pair
Affinity DataIC50: 650nMAssay Description:Prostaglandin I2 receptor binding by displacement of [3H]-iloprost from human plateletsMore data for this Ligand-Target Pair
Affinity DataIC50: 860nMAssay Description:Inhibition of radio-isotope labeled MIP1-alpha binding to human recombinant CCR5More data for this Ligand-Target Pair
Affinity DataIC50: 900nMAssay Description:Antagonist activity against human recombinant CCR5 expressed in CHO cells assessed as inhibition of human MIP-1-alpha-stimulated calcium mobilizationMore data for this Ligand-Target Pair
Affinity DataIC50: 1.40E+3nMAssay Description:Displacement of [3H]-iloprost from Prostaglandin I2 receptor of human plateletsMore data for this Ligand-Target Pair
Affinity DataIC50: 2.00E+3nMAssay Description:Compound was tested for its binding affinity against Prostaglandin I2 receptor using conventional ligand assay by the displacement of [3H]-iloprost f...More data for this Ligand-Target Pair
Affinity DataIC50: 2.00E+3nMAssay Description:Antagonist activity against human recombinant CCR5 expressed in CHO cells assessed as inhibition of human MIP-1-alpha-stimulated calcium mobilizationMore data for this Ligand-Target Pair
Affinity DataIC50: 2.07E+3nMAssay Description:Binding affinity to muscarinic M3 receptorMore data for this Ligand-Target Pair
Affinity DataIC50: 2.10E+3nMAssay Description:Displacement of [3H]-iloprost from Prostaglandin I2 receptor of human plateletsMore data for this Ligand-Target Pair