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Found 569 with Last Name = 'hartl' and Initial = 'ks'
TargetCoagulation factor X(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50175075((S,Z)-4-hydroxybutyl 2-cyano-3-(2-methylbenzofuran...)
Affinity DataKi:  12nMAssay Description:Inhibitory activity against human FXaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTissue-type plasminogen activator(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM35283(CHEMBL551991 | cyanoguanidine, 3)
Affinity DataKi:  3.70E+3nMAssay Description:Inhibition of t-PAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50175075((S,Z)-4-hydroxybutyl 2-cyano-3-(2-methylbenzofuran...)
Affinity DataKi:  6.30E+3nMAssay Description:Binding affinity to thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM35283(CHEMBL551991 | cyanoguanidine, 3)
Affinity DataKi:  6.60E+3nMAssay Description:Inhibition of thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUrokinase-type plasminogen activator(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM35283(CHEMBL551991 | cyanoguanidine, 3)
Affinity DataKi: >7.80E+3nMAssay Description:Inhibition of u-PAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChymotrypsinogen B(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50175075((S,Z)-4-hydroxybutyl 2-cyano-3-(2-methylbenzofuran...)
Affinity DataKi:  9.42E+3nMAssay Description:Binding affinity to chymotrypsinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor IX(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50175075((S,Z)-4-hydroxybutyl 2-cyano-3-(2-methylbenzofuran...)
Affinity DataKi: >1.00E+4nMAssay Description:Binding affinity to factor IXaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUrokinase-type plasminogen activator(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50175075((S,Z)-4-hydroxybutyl 2-cyano-3-(2-methylbenzofuran...)
Affinity DataKi: >1.40E+4nMAssay Description:Binding affinity to urokinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTissue-type plasminogen activator(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50175075((S,Z)-4-hydroxybutyl 2-cyano-3-(2-methylbenzofuran...)
Affinity DataKi:  1.60E+4nMAssay Description:Binding affinity to tPAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasminogen(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM35283(CHEMBL551991 | cyanoguanidine, 3)
Affinity DataKi: >1.60E+4nMAssay Description:Inhibition of plasminMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVitamin K-dependent protein C(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM35283(CHEMBL551991 | cyanoguanidine, 3)
Affinity DataKi: >1.80E+4nMAssay Description:Inhibition of activated protein CMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasma kallikrein(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50175075((S,Z)-4-hydroxybutyl 2-cyano-3-(2-methylbenzofuran...)
Affinity DataKi: >1.94E+4nMAssay Description:Binding affinity to plasma kallikreinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVitamin K-dependent protein C(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50175075((S,Z)-4-hydroxybutyl 2-cyano-3-(2-methylbenzofuran...)
Affinity DataKi: >2.15E+4nMAssay Description:Binding affinity to activated protein CMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasminogen(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50175075((S,Z)-4-hydroxybutyl 2-cyano-3-(2-methylbenzofuran...)
Affinity DataKi: >2.20E+4nMAssay Description:Binding affinity to plasminMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor VII(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50175075((S,Z)-4-hydroxybutyl 2-cyano-3-(2-methylbenzofuran...)
Affinity DataKi: >5.50E+4nMAssay Description:Binding affinity to factor VIIaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptase delta(Homo sapiens (Human))
The Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50217812(CHEMBL322526)
Affinity DataIC50:  0.400nMAssay Description:In vitro inhibition of human tryptase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptase delta(Homo sapiens (Human))
The Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50217626(CHEMBL322538)
Affinity DataIC50:  0.700nMAssay Description:In vitro inhibition of human tryptase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptase delta(Homo sapiens (Human))
The Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50217627(CHEMBL110061)
Affinity DataIC50:  0.700nMAssay Description:In vitro inhibition of human tryptase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptase beta-2/delta/gamma(Homo sapiens (Human))
The Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50144535((2S,3R)-4-Oxo-1-[4-(6-phenyl-hexanoyl)-piperazine-...)
Affinity DataIC50:  1nMAssay Description:Inhibitory activity of compound against human tryptase was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptase delta(Homo sapiens (Human))
The Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50217801(CHEMBL111250)
Affinity DataIC50:  1nMAssay Description:In vitro inhibition of human tryptase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptase delta(Homo sapiens (Human))
The Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50217622(CHEMBL443539)
Affinity DataIC50:  1nMAssay Description:In vitro inhibition of human tryptase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptase delta(Homo sapiens (Human))
The Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50217599(CHEMBL109888)
Affinity DataIC50:  1nMAssay Description:In vitro inhibition of human tryptase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptase beta-2/delta/gamma(Homo sapiens (Human))
The Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50144577((R)-1-[4-(6-Naphthalen-1-yl-hexanoyl)-piperazine-1...)
Affinity DataIC50:  1nMAssay Description:Inhibitory activity against human tryptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptase beta-2/delta/gamma(Homo sapiens (Human))
The Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50144535((2S,3R)-4-Oxo-1-[4-(6-phenyl-hexanoyl)-piperazine-...)
Affinity DataIC50:  1nMAssay Description:Inhibitory activity against human tryptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptase beta-2/delta/gamma(Homo sapiens (Human))
The Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50144555((R)-1-{4-[2-(4-Benzyloxy-phenyl)-acetyl]-piperazin...)
Affinity DataIC50:  1nMAssay Description:Inhibitory activity against human tryptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptase beta-2/delta/gamma(Homo sapiens (Human))
The Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50144586((R)-1-[4-(7-Naphthalen-1-yl-heptanoyl)-piperazine-...)
Affinity DataIC50:  1nMAssay Description:Inhibitory activity against human tryptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptase beta-2/delta/gamma(Homo sapiens (Human))
The Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50144582((R)-1-[4-(6-Naphthalen-2-yl-hexanoyl)-piperazine-1...)
Affinity DataIC50:  1nMAssay Description:Inhibitory activity against human tryptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptase beta-2/delta/gamma(Homo sapiens (Human))
The Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50120387((2S,3R)-3-((R)-1-Carbamimidoyl-piperidin-3-ylmethy...)
Affinity DataIC50: <1.70nMAssay Description:Inhibitory activity of compound against human tryptase was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptase beta-2/delta/gamma(Homo sapiens (Human))
The Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50221046(CHEMBL72282)
Affinity DataIC50: <1.70nMAssay Description:Inhibitory activity of compound against human tryptase was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptase beta-2/delta/gamma(Homo sapiens (Human))
The Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50217824(BMS-363130 | CHEMBL70738)
Affinity DataIC50: <1.70nMAssay Description:Inhibitory activity of compound against human tryptase was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptase delta(Homo sapiens (Human))
The Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50217824(BMS-363130 | CHEMBL70738)
Affinity DataIC50: <1.70nMAssay Description:Inhibitory concentration against human tryptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptase delta(Homo sapiens (Human))
The Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50217823(CHEMBL111630)
Affinity DataIC50: <1.70nMAssay Description:Inhibitory concentration against human tryptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptase delta(Homo sapiens (Human))
The Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50217822(CHEMBL111173)
Affinity DataIC50: <1.70nMAssay Description:Inhibitory concentration against human tryptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptase delta(Homo sapiens (Human))
The Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50217818(CHEMBL440515)
Affinity DataIC50: <1.70nMAssay Description:Inhibitory concentration against human tryptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptase delta(Homo sapiens (Human))
The Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50217817(CHEMBL326209)
Affinity DataIC50: <1.70nMAssay Description:Inhibitory concentration against human tryptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptase delta(Homo sapiens (Human))
The Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50120387((2S,3R)-3-((R)-1-Carbamimidoyl-piperidin-3-ylmethy...)
Affinity DataIC50: <1.70nMAssay Description:Inhibitory concentration against human tryptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptase beta-2/delta/gamma(Homo sapiens (Human))
The Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50120387((2S,3R)-3-((R)-1-Carbamimidoyl-piperidin-3-ylmethy...)
Affinity DataIC50:  1.70nMAssay Description:Inhibitory activity against human tryptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptase beta-2/delta/gamma(Homo sapiens (Human))
The Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50144532((2S,3R)-4-Oxo-1-[4-(6-phenyl-hexanoyl)-piperazine-...)
Affinity DataIC50:  1.80nMAssay Description:Inhibitory activity of compound against human tryptase was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptase delta(Homo sapiens (Human))
The Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50217819(CHEMBL109504)
Affinity DataIC50:  1.90nMAssay Description:Inhibitory concentration against human tryptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM35298(benzoylguanidine, 18)
Affinity DataIC50:  2nMpH: 7.4 T: 2°CAssay Description:Time-dependent optical density change was followed at 405 nm using a kinetic microplate reader at room temperature. Enzyme activity in the presence o...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM26359((2Z)-3-[(3-chloro-1H-indol-7-yl)amino]-2-cyano-N,N...)
Affinity DataIC50:  2.40nMpH: 7.4 T: 2°CAssay Description:Time-dependent optical density change was followed at 405 nm using a kinetic microplate reader at room temperature. Enzyme activity in the presence o...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM35303(isonicotinoyl guanidine, 23)
Affinity DataIC50:  3nMpH: 7.4 T: 2°CAssay Description:Time-dependent optical density change was followed at 405 nm using a kinetic microplate reader at room temperature. Enzyme activity in the presence o...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptase delta(Homo sapiens (Human))
The Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50217628(CHEMBL107493)
Affinity DataIC50:  3nMAssay Description:In vitro inhibition of human tryptase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM35299(benzoylguanidine, 19)
Affinity DataIC50:  3nMpH: 7.4 T: 2°CAssay Description:Time-dependent optical density change was followed at 405 nm using a kinetic microplate reader at room temperature. Enzyme activity in the presence o...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM35300(benzoylguanidine, 20)
Affinity DataIC50:  3nMpH: 7.4 T: 2°CAssay Description:Time-dependent optical density change was followed at 405 nm using a kinetic microplate reader at room temperature. Enzyme activity in the presence o...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM35313(nicotinoyl guanidine, 33)
Affinity DataIC50:  3.30nMT: 2°CAssay Description:Time-dependent optical density change was followed at 405 nm using a kinetic microplate reader at room temperature. Enzyme activity in the presence o...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptase delta(Homo sapiens (Human))
The Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50120368((2S,3R)-1-(4-tert-Butylcarbamoyl-piperazine-1-carb...)
Affinity DataIC50:  4nMAssay Description:In vitro inhibition of human tryptase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptase beta-2/delta/gamma(Homo sapiens (Human))
The Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50120368((2S,3R)-1-(4-tert-Butylcarbamoyl-piperazine-1-carb...)
Affinity DataIC50:  4nMAssay Description:Inhibitory activity against human tryptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptase delta(Homo sapiens (Human))
The Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50217813(CHEMBL302058)
Affinity DataIC50:  4nMAssay Description:Inhibitory concentration against human tryptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM35311(nicotinoyl guanidine, 31)
Affinity DataIC50:  4nMT: 2°CAssay Description:Time-dependent optical density change was followed at 405 nm using a kinetic microplate reader at room temperature. Enzyme activity in the presence o...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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