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Found 896 with Last Name = 'haslam' and Initial = 'c'
TargetKynurenine 3-monooxygenase(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50266003(CHEMBL4091152)
Affinity DataKi:  0.0500nMAssay Description:Competitive inhibition of full length human GST-tagged KMO expressed in baculovirus infected Sf9 insect cell membranes using kynurenine as substrate ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetKynurenine 3-monooxygenase(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50266041(CHEMBL4070212)
Affinity DataKi:  0.100nMAssay Description:Inhibition of full length human GST-tagged KMO expressed in baculovirus infected Sf9 insect cell membranes using kynurenine as substrate measured aft...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50264756(CHEMBL485286 | N-(4-methyl-3-(3-(piperidin-4-yl)be...)
Affinity DataKi:  0.800nMAssay Description:Displacement of fluorescent ATP competitive ligand from p38alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM12569(GTC000006A | N-(6-chloronaphthalen-2-yl)-N'-[(3S)-...)
Affinity DataKi:  1nM ΔG°:  -51.4kJ/molepH: 7.8 T: 2°CAssay Description:The inhibitory effect of test compound for human fXa was determined by using the chromogenic substrate. The hydrolysis rates of chromogenic substrate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM12557(6-chloro-N-[(3S)-2-oxo-1-[(2S)-1-oxo-1-(piperidin-...)
Affinity DataKi:  1nM ΔG°:  -51.4kJ/molepH: 7.8 T: 2°CAssay Description:The inhibitory effect of test compound for human fXa was determined by using the chromogenic substrate. The hydrolysis rates of chromogenic substrate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKynurenine 3-monooxygenase(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50266064(CHEMBL4104310)
Affinity DataKi:  1nMAssay Description:Inhibition of full length human GST-tagged KMO expressed in baculovirus infected Sf9 insect cell membranes using kynurenine as substrate measured aft...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50264993(CHEMBL521722 | N-(6-methyl-4'-(5-methyl-1,2,4-oxad...)
Affinity DataKi:  1.10nMAssay Description:Displacement of fluorescent ATP competitive ligand from p38alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50264755(4-methyl-N-(3-morpholin-4-ylphenyl)-3-(3-piperidin...)
Affinity DataKi:  1.40nMAssay Description:Displacement of fluorescent ATP competitive ligand from p38alphaMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50265035(CHEMBL495729 | N-(2',6-dimethyl-4'-(5-methyl-1,3,4...)
Affinity DataKi:  1.70nMAssay Description:Displacement of fluorescent ATP competitive ligand from p38alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM12567(2-[(6-chloronaphthalene-2-)[(3S)-1-[(2S)-1-(morpho...)
Affinity DataKi:  2nM ΔG°:  -49.7kJ/molepH: 7.8 T: 2°CAssay Description:The inhibitory effect of test compound for human fXa was determined by using the chromogenic substrate. The hydrolysis rates of chromogenic substrate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM12558(6-chloro-N-methyl-N-[(3S)-2-oxo-1-[(2S)-1-oxo-1-(p...)
Affinity DataKi:  2nM ΔG°:  -49.7kJ/molepH: 7.8 T: 2°CAssay Description:The inhibitory effect of test compound for human fXa was determined by using the chromogenic substrate. The hydrolysis rates of chromogenic substrate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50265257(CHEMBL498390 | N-(4-methyl-3-(1-oxo-1,2-dihydroiso...)
Affinity DataKi:  2.40nMAssay Description:Displacement of fluorescent ATP competitive ligand from p38alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50265034(2',6-dimethyl-4'-(5-methyl-1,3,4-oxadiazol-2-yl)-N...)
Affinity DataKi:  2.80nMAssay Description:Displacement of fluorescent ATP competitive ligand from p38alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50265109(CHEMBL525727 | N-cyclopropyl-4-methyl-3-(4-oxo-2-(...)
Affinity DataKi:  2.90nMAssay Description:Displacement of fluorescent ATP competitive ligand from p38alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM12561(N-[(3S)-1-[(2S)-1-{2-azabicyclo[2.2.2]octan-2-yl}-...)
Affinity DataKi:  3nM ΔG°:  -48.6kJ/molepH: 7.8 T: 2°CAssay Description:The inhibitory effect of test compound for human fXa was determined by using the chromogenic substrate. The hydrolysis rates of chromogenic substrate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM12568(2-[(6-chloronaphthalene-2-)[(3S)-1-[(2S)-1-(morpho...)
Affinity DataKi:  3nM ΔG°:  -48.6kJ/molepH: 7.8 T: 2°CAssay Description:The inhibitory effect of test compound for human fXa was determined by using the chromogenic substrate. The hydrolysis rates of chromogenic substrate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50265371(CHEMBL497563 | N-cyclopropyl-4-methyl-3-(3-(piperi...)
Affinity DataKi:  4nMAssay Description:Displacement of fluorescent ATP competitive ligand from p38alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50265260(3-(isoquinolin-7-yl)-4-methyl-N-(3-morpholinopheny...)
Affinity DataKi:  4.5nMAssay Description:Displacement of fluorescent ATP competitive ligand from p38alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50265071(3-(2-amino-4-oxo-3,4-dihydroquinazolin-6-yl)-4-met...)
Affinity DataKi:  4.70nMAssay Description:Displacement of fluorescent ATP competitive ligand from p38alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50265154(CHEMBL521734 | N-cyclopropyl-3-(3-(cyclopropylmeth...)
Affinity DataKi:  6nMAssay Description:Displacement of fluorescent ATP competitive ligand from p38alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM12538(6-chloro-N-[(3S)-1-[(2S)-1-(morpholin-4-yl)-1-oxop...)
Affinity DataKi:  6nM ΔG°:  -46.9kJ/molepH: 7.8 T: 2°CAssay Description:The inhibitory effect of test compound for human fXa was determined by using the chromogenic substrate. The hydrolysis rates of chromogenic substrate...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50264958(CHEMBL526452 | N-(4'-(2-aminothiazol-4-yl)-6-methy...)
Affinity DataKi:  6.70nMAssay Description:Displacement of fluorescent ATP competitive ligand from p38alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50265155(CHEMBL496528 | N-cyclopropyl-4-methyl-3-(4-oxo-2-(...)
Affinity DataKi:  6.70nMAssay Description:Displacement of fluorescent ATP competitive ligand from p38alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50265072(CHEMBL521548 | N-(3-(2-amino-4-oxo-3,4-dihydroquin...)
Affinity DataKi:  6.80nMAssay Description:Displacement of fluorescent ATP competitive ligand from p38alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50265033(CHEMBL522579 | N-cyclopropyl-2',6-dimethyl-4'-(5-m...)
Affinity DataKi:  10nMAssay Description:Displacement of fluorescent ATP competitive ligand from p38alphaMore data for this Ligand-Target Pair
TargetCoagulation factor X(Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM12566(6-chloro-N-methyl-N-[(3S)-1-[(2S)-1-(morpholin-4-y...)
Affinity DataKi:  10nM ΔG°:  -45.7kJ/molepH: 7.8 T: 2°CAssay Description:The inhibitory effect of test compound for human fXa was determined by using the chromogenic substrate. The hydrolysis rates of chromogenic substrate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50265112(CHEMBL496943 | N-(3-(3-butyl-2,4-dioxo-1,2,3,4-tet...)
Affinity DataKi:  11nMAssay Description:Displacement of fluorescent ATP competitive ligand from p38alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50265259(CHEMBL526639 | N-cyclopropyl-3-(isoquinolin-7-yl)-...)
Affinity DataKi:  11nMAssay Description:Displacement of fluorescent ATP competitive ligand from p38alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50265369(CHEMBL497352 | N-(3-(3-aminobenzo[d]isoxazol-6-yl)...)
Affinity DataKi:  12nMAssay Description:Displacement of fluorescent ATP competitive ligand from p38alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM12562(6-chloro-N-[(3S)-1-[(2S)-1-[(1R,5S)-3,7-diazabicyc...)
Affinity DataKi:  13nM ΔG°:  -45.0kJ/molepH: 7.8 T: 2°CAssay Description:The inhibitory effect of test compound for human fXa was determined by using the chromogenic substrate. The hydrolysis rates of chromogenic substrate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50377985(CHEMBL1964268)
Affinity DataKi:  14nMAssay Description:Displacement of fluorescent ATP competitive ligand from p38alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM12574(6-chloro-N-[(3R)-2-oxo-1-[(2S)-1-oxo-1-(piperidin-...)
Affinity DataKi:  16nM ΔG°:  -44.5kJ/molepH: 7.8 T: 2°CAssay Description:The inhibitory effect of test compound for human fXa was determined by using the chromogenic substrate. The hydrolysis rates of chromogenic substrate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50264992(6-methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)-N-(3-m...)
Affinity DataKi:  17nMAssay Description:Displacement of fluorescent ATP competitive ligand from p38alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50265110(3-(3-butyl-2,4-dioxo-1,2,3,4-tetrahydroquinazolin-...)
Affinity DataKi:  18nMAssay Description:Displacement of fluorescent ATP competitive ligand from p38alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50265198(4-methyl-N-(3-morpholinophenyl)-3-(1-oxo-1,2-dihyd...)
Affinity DataKi:  18nMAssay Description:Displacement of fluorescent ATP competitive ligand from p38alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50265368(3-(3-aminobenzo[d]isoxazol-6-yl)-4-methyl-N-(3-mor...)
Affinity DataKi:  19nMAssay Description:Displacement of fluorescent ATP competitive ligand from p38alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50265111(3-(3-butyl-2,4-dioxo-1,2,3,4-tetrahydroquinazolin-...)
Affinity DataKi:  19nMAssay Description:Displacement of fluorescent ATP competitive ligand from p38alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50264957(4'-(2-aminothiazol-4-yl)-6-methyl-N-(3-morpholinop...)
Affinity DataKi:  20nMAssay Description:Displacement of fluorescent ATP competitive ligand from p38alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM12573(6-chloro-N-[(3R)-2-oxo-1-[(2R)-1-oxo-1-(piperidin-...)
Affinity DataKi:  40nM ΔG°:  -42.2kJ/molepH: 7.8 T: 2°CAssay Description:The inhibitory effect of test compound for human fXa was determined by using the chromogenic substrate. The hydrolysis rates of chromogenic substrate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKynurenine 3-monooxygenase(Rattus norvegicus)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50266003(CHEMBL4091152)
Affinity DataKi:  45nMAssay Description:Inhibition of rat KMO expressed in HEK293 cells using kynurenine as substrate measured after 20 hrs by LC-MS/MS analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50265070(3-(2-amino-4-oxo-3,4-dihydroquinazolin-6-yl)-N-cyc...)
Affinity DataKi:  49nMAssay Description:Displacement of fluorescent ATP competitive ligand from p38alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50265195(CHEMBL495917 | N-(4-methyl-3-(2-oxo-1,2-dihydroqui...)
Affinity DataKi:  49nMAssay Description:Displacement of fluorescent ATP competitive ligand from p38alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM12560(6-chloro-N-[(3S)-2-oxo-1-[(2S)-1-oxo-1-(pyrrolidin...)
Affinity DataKi:  50nM ΔG°:  -41.7kJ/molepH: 7.8 T: 2°CAssay Description:The inhibitory effect of test compound for human fXa was determined by using the chromogenic substrate. The hydrolysis rates of chromogenic substrate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM12571(6-chloro-N-[(3R)-1-[(2S)-1-(morpholin-4-yl)-1-oxop...)
Affinity DataKi:  53nM ΔG°:  -41.5kJ/molepH: 7.8 T: 2°CAssay Description:The inhibitory effect of test compound for human fXa was determined by using the chromogenic substrate. The hydrolysis rates of chromogenic substrate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM12554(N-[(3S)-1-[2-(azepan-1-yl)-2-oxoethyl]-2-oxopyrrol...)
Affinity DataKi:  60nM ΔG°:  -41.2kJ/molepH: 7.8 T: 2°CAssay Description:The inhibitory effect of test compound for human fXa was determined by using the chromogenic substrate. The hydrolysis rates of chromogenic substrate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM12556(6-chloro-N-[(3S)-2-oxo-1-[2-oxo-2-(piperidin-1-yl)...)
Affinity DataKi:  63nM ΔG°:  -41.1kJ/molepH: 7.8 T: 2°CAssay Description:The inhibitory effect of test compound for human fXa was determined by using the chromogenic substrate. The hydrolysis rates of chromogenic substrate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM12555(6-chloro-N-methyl-N-[(3S)-2-oxo-1-[2-oxo-2-(piperi...)
Affinity DataKi:  72nM ΔG°:  -40.8kJ/molepH: 7.8 T: 2°CAssay Description:The inhibitory effect of test compound for human fXa was determined by using the chromogenic substrate. The hydrolysis rates of chromogenic substrate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM12570(6-chloro-N-[(3R)-1-[(2R)-1-(morpholin-4-yl)-1-oxop...)
Affinity DataKi:  82nM ΔG°:  -40.4kJ/molepH: 7.8 T: 2°CAssay Description:The inhibitory effect of test compound for human fXa was determined by using the chromogenic substrate. The hydrolysis rates of chromogenic substrate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM12575(6-chloro-N-[(3S)-2-oxo-1-[(2R)-1-oxo-1-(piperidin-...)
Affinity DataKi:  82nM ΔG°:  -40.4kJ/molepH: 7.8 T: 2°CAssay Description:The inhibitory effect of test compound for human fXa was determined by using the chromogenic substrate. The hydrolysis rates of chromogenic substrate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50265325(CHEMBL495902 | N-cyclopropyl-3-(1H-indazol-5-yl)-4...)
Affinity DataKi:  87nMAssay Description:Displacement of fluorescent ATP competitive ligand from p38alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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