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Found 160 with Last Name = 'havlícek' and Initial = 'l'
LigandPNGBDBM50366800(OLOMOUCINE II)
Affinity DataIC50:  20nMAssay Description:Inhibition of recombinant Cyclin-dependent kinase 1-cyclin BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 1(Homo sapiens (Human))
Academy Of Sciences Of The Czech Republic

Curated by ChEMBL
LigandPNGBDBM50132192(CHEMBL102871 | N*2*-(4-Amino-cyclohexyl)-N*6*-(3-c...)
Affinity DataIC50:  30nMAssay Description:Inhibitory concentration against Cyclin dependent kinase 1.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Palacky£? University And Institute Of Experimental Botany Ascr

Curated by ChEMBL
LigandPNGBDBM50341878((2R)-2-{[7-(benzylamino)-3-(propan-2-yl)-1H-pyrazo...)
Affinity DataIC50:  40nMAssay Description:Inhibition of human recombinant CDK2/cyclin EMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM27216((2R)-2-({6-[(3-chlorophenyl)amino]-9-(propan-2-yl)...)
Affinity DataIC50:  50nMAssay Description:Inhibition of recombinant Cyclin-dependent kinase 1-cyclin BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 1(Homo sapiens (Human))
Academy Of Sciences Of The Czech Republic

Curated by ChEMBL
LigandPNGBDBM27216((2R)-2-({6-[(3-chlorophenyl)amino]-9-(propan-2-yl)...)
Affinity DataIC50:  50nMAssay Description:Inhibitory concentration against Cyclin dependent kinase 1.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM10642(2-[({2-[(1-hydroxy-3-methylbutan-2-yl)amino]-9-(pr...)
Affinity DataIC50:  80nMAssay Description:Inhibition of recombinant Cyclin-dependent kinase 1-cyclin BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50120508(2-(3-hydroxypropylamino)-6-(o -hydroxybenzylamino)...)
Affinity DataIC50:  100nMAssay Description:Inhibition of recombinant Cyclin-dependent kinase 1-cyclin BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM10635(3-[({2-[(1-hydroxy-3-methylbutan-2-yl)amino]-9-(pr...)
Affinity DataIC50:  120nMAssay Description:Inhibition of recombinant Cyclin-dependent kinase 1-cyclin BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50120510(4-{[2-(1-Hydroxymethyl-2-methyl-propylamino)-9-iso...)
Affinity DataIC50:  150nMAssay Description:Inhibition of recombinant Cyclin-dependent kinase 1-cyclin BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-H/Cyclin-dependent kinase 7(Homo sapiens (Human))
Palacky£? University And Institute Of Experimental Botany Ascr

Curated by ChEMBL
LigandPNGBDBM50341878((2R)-2-{[7-(benzylamino)-3-(propan-2-yl)-1H-pyrazo...)
Affinity DataIC50:  160nMAssay Description:Inhibition of human recombinant CDK7/cyclin H/MAT1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50120512(3-{[2-(1-Hydroxymethyl-propylamino)-9-isopropyl-9H...)
Affinity DataIC50:  200nMAssay Description:Inhibition of recombinant Cyclin-dependent kinase 1-cyclin BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5 activator 1(Homo sapiens (Human))
Palacky£? University And Institute Of Experimental Botany Ascr

Curated by ChEMBL
LigandPNGBDBM50341878((2R)-2-{[7-(benzylamino)-3-(propan-2-yl)-1H-pyrazo...)
Affinity DataIC50:  200nMAssay Description:Inhibition of human recombinant CDK5/p35More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 1(Homo sapiens (Human))
Academy Of Sciences Of The Czech Republic

Curated by ChEMBL
LigandPNGBDBM7533((2R)-2-[[6-(benzylamino)-9-isopropyl-purin-2-yl]am...)
Affinity DataIC50:  200nMAssay Description:Inhibitory activity against purified cdc2 p34/Cyclin B obtained from M phase oocytes of the starfish Marthasterias glacialis.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Palacky£? University And Institute Of Experimental Botany Ascr

Curated by ChEMBL
LigandPNGBDBM7533((2R)-2-[[6-(benzylamino)-9-isopropyl-purin-2-yl]am...)
Affinity DataIC50:  220nMAssay Description:Inhibition of human recombinant CDK2/cyclin EMore data for this Ligand-Target Pair
LigandPNGBDBM50120507(4-{[2-(1-Hydroxymethyl-propylamino)-9-isopropyl-9H...)
Affinity DataIC50:  300nMAssay Description:Inhibition of recombinant Cyclin-dependent kinase 1-cyclin BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50132175(2-[(3-Isopropyl-1H-pyrazolo[4,3-d]pyrimidin-7-ylam...)
Affinity DataIC50:  440nMAssay Description:Inhibitory concentration against Cyclin-dependent kinase 1-cyclin BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 1(Homo sapiens (Human))
Academy Of Sciences Of The Czech Republic

Curated by ChEMBL
LigandPNGBDBM7533((2R)-2-[[6-(benzylamino)-9-isopropyl-purin-2-yl]am...)
Affinity DataIC50:  450nMAssay Description:Inhibitory concentration against Cyclin dependent kinase 1.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM7533((2R)-2-[[6-(benzylamino)-9-isopropyl-purin-2-yl]am...)
Affinity DataIC50:  450nMAssay Description:Inhibition of recombinant Cyclin-dependent kinase 1-cyclin BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-H/Cyclin-dependent kinase 7(Homo sapiens (Human))
Palacky£? University And Institute Of Experimental Botany Ascr

Curated by ChEMBL
LigandPNGBDBM7533((2R)-2-[[6-(benzylamino)-9-isopropyl-purin-2-yl]am...)
Affinity DataIC50:  480nMAssay Description:Inhibition of human recombinant CDK7/cyclin H/MAT1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 1(Homo sapiens (Human))
Academy Of Sciences Of The Czech Republic

Curated by ChEMBL
LigandPNGBDBM7585((R,S)-Roscovitine | 2,6,9-Trisubstituted purine de...)
Affinity DataIC50:  650nMAssay Description:Inhibitory activity against purified cdc2 p34/Cyclin B obtained from M phase oocytes of the starfish Marthasterias glacialis.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 1(Homo sapiens (Human))
Academy Of Sciences Of The Czech Republic

Curated by ChEMBL
LigandPNGBDBM50056163((S)-2-(6-(benzylamino)-9-isopropyl-9H-purin-2-ylam...)
Affinity DataIC50:  800nMAssay Description:Inhibitory activity against purified cdc2 p34/Cyclin B obtained from M phase oocytes of the starfish Marthasterias glacialis.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50132169((3-Chloro-phenyl)-(3-isopropyl-1H-pyrazolo[4,3-d]p...)
Affinity DataIC50:  900nMAssay Description:Inhibitory concentration against Cyclin-dependent kinase 1-cyclin BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 1(Homo sapiens (Human))
Academy Of Sciences Of The Czech Republic

Curated by ChEMBL
LigandPNGBDBM50056169(1-(6-Benzylamino-9-isopropyl-9H-purin-2-ylamino)-p...)
Affinity DataIC50:  900nMAssay Description:Inhibitory activity against purified cdc2 p34/Cyclin B obtained from M phase oocytes of the starfish Marthasterias glacialis.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5 activator 1(Homo sapiens (Human))
Palacky£? University And Institute Of Experimental Botany Ascr

Curated by ChEMBL
LigandPNGBDBM7533((2R)-2-[[6-(benzylamino)-9-isopropyl-purin-2-yl]am...)
Affinity DataIC50:  940nMAssay Description:Inhibition of human recombinant CDK5/p35More data for this Ligand-Target Pair
TargetCyclin-T1/Cyclin-dependent kinase 9(Homo sapiens (Human))
Palacky£? University And Institute Of Experimental Botany Ascr

Curated by ChEMBL
LigandPNGBDBM50341878((2R)-2-{[7-(benzylamino)-3-(propan-2-yl)-1H-pyrazo...)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of human recombinant CDK9/cyclin T1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytokinin dehydrogenase 2(Arabidopsis thaliana)
Ieb As Cr & Palacký

Curated by ChEMBL
LigandPNGBDBM50274552(2-Fluoro-6-(3-methoxyanilino)purine | CHEMBL483378)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of sArabidopsis thaliana CKX2 expressed in Saccharomyces cerevisiae 23344c ura-More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50120509(3-{[2-(3-Hydroxy-propylamino)-9-isopropyl-9H-purin...)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of recombinant Cyclin-dependent kinase 1-cyclin BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50132178(5-[(3-Isopropyl-1H-pyrazolo[4,3-d]pyrimidin-7-ylam...)
Affinity DataIC50:  1.10E+3nMAssay Description:Inhibitory concentration against Cyclin-dependent kinase 1-cyclin BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM10633(3-{[6-(benzylamino)-9-(propan-2-yl)-9H-purin-2-yl]...)
Affinity DataIC50:  1.10E+3nMAssay Description:Inhibition of recombinant Cyclin-dependent kinase 1-cyclin BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50132185(Benzyl-(3-isopropyl-1H-pyrazolo[4,3-d]pyrimidin-7-...)
Affinity DataIC50:  1.20E+3nMAssay Description:In vitro antiproliferative activity against myeloid leukemia K562 cell lineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50132183((3-Isopropyl-1H-pyrazolo[4,3-d]pyrimidin-7-yl)-pen...)
Affinity DataIC50:  1.20E+3nMAssay Description:Inhibitory concentration against Cyclin-dependent kinase 1-cyclin BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50132172(3-[(3-Isopropyl-1H-pyrazolo[4,3-d]pyrimidin-7-ylam...)
Affinity DataIC50:  1.70E+3nMAssay Description:Inhibitory concentration against Cyclin-dependent kinase 1-cyclin BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-T1/Cyclin-dependent kinase 9(Homo sapiens (Human))
Palacky£? University And Institute Of Experimental Botany Ascr

Curated by ChEMBL
LigandPNGBDBM7533((2R)-2-[[6-(benzylamino)-9-isopropyl-purin-2-yl]am...)
Affinity DataIC50:  1.77E+3nMAssay Description:Inhibition of human recombinant CDK9/cyclin T1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50132179(4-[(3-Isopropyl-1H-pyrazolo[4,3-d]pyrimidin-7-ylam...)
Affinity DataIC50:  1.80E+3nMAssay Description:Inhibitory concentration against Cyclin-dependent kinase 1-cyclin BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytokinin dehydrogenase 2(Arabidopsis thaliana)
Ieb As Cr & Palacký

Curated by ChEMBL
LigandPNGBDBM50274549(2-Chloro-6-(3-methoxyanilino)purine | CHEMBL484383)
Affinity DataIC50:  1.90E+3nMAssay Description:Inhibition of sArabidopsis thaliana CKX2 expressed in Saccharomyces cerevisiae 23344c ura-More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 1(Homo sapiens (Human))
Academy Of Sciences Of The Czech Republic

Curated by ChEMBL
LigandPNGBDBM10636(2-{[6-(benzylamino)-9-(propan-2-yl)-9H-purin-2-yl]...)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibitory activity against purified cdc2 p34/Cyclin B obtained from M phase oocytes of the starfish Marthasterias glacialis.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50132174((3-Isopropyl-1H-pyrazolo[4,3-d]pyrimidin-7-yl)-(4-...)
Affinity DataIC50:  2.30E+3nMAssay Description:In vitro antiproliferative activity against myeloid leukemia K562 cell lineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50132167(CHEMBL103206 | Furan-2-ylmethyl-(3-isopropyl-1H-py...)
Affinity DataIC50:  2.50E+3nMAssay Description:In vitro antiproliferative activity against myeloid leukemia K562 cell lineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50120511(4-{[2-(3-Hydroxy-propylamino)-9-isopropyl-9H-purin...)
Affinity DataIC50:  2.60E+3nMAssay Description:Inhibition of recombinant Cyclin-dependent kinase 1-cyclin BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50132177(3-[(9-Isopropyl-9H-purin-6-ylamino)-methyl]-phenol...)
Affinity DataIC50:  3.10E+3nMAssay Description:In vitro antiproliferative activity against myeloid leukemia K562 cell lineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM10641(6-(benzylamino)-9-isopropylpurine | CHEMBL85015 | ...)
Affinity DataIC50:  3.60E+3nMAssay Description:In vitro antiproliferative activity against myeloid leukemia K562 cell lineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytokinin dehydrogenase 2(Arabidopsis thaliana)
Ieb As Cr & Palacký

Curated by ChEMBL
LigandPNGBDBM50274506(3-(2-chloro-9H-purin-6-ylamino)phenol | CHEMBL4843...)
Affinity DataIC50:  3.75E+3nMAssay Description:Inhibition of sArabidopsis thaliana CKX2 expressed in Saccharomyces cerevisiae 23344c ura-More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50132176((9-Isopropyl-9H-purin-6-yl)-(4-methoxy-benzyl)-ami...)
Affinity DataIC50:  3.80E+3nMAssay Description:Inhibitory concentration against Cyclin-dependent kinase 1-cyclin BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytokinin dehydrogenase 2(Arabidopsis thaliana)
Ieb As Cr & Palacký

Curated by ChEMBL
LigandPNGBDBM50274501(2-chloro-N-(3-chlorophenyl)-9H-purin-6-amine | CHE...)
Affinity DataIC50:  3.90E+3nMAssay Description:Inhibition of sArabidopsis thaliana CKX2 expressed in Saccharomyces cerevisiae 23344c ura-More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50132171(4-[(9-Isopropyl-9H-purin-6-ylamino)-methyl]-phenol...)
Affinity DataIC50:  4.00E+3nMAssay Description:Inhibitory concentration against Cyclin-dependent kinase 1-cyclin BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50132170(2-[(9-Isopropyl-9H-purin-6-ylamino)-methyl]-phenol...)
Affinity DataIC50:  4.40E+3nMAssay Description:In vitro antiproliferative activity against myeloid leukemia K562 cell lineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50132180((3-Isopropyl-1H-pyrazolo[4,3-d]pyrimidin-7-yl)-(3-...)
Affinity DataIC50:  4.50E+3nMAssay Description:In vitro antiproliferative activity against myeloid leukemia K562 cell lineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50132186(5-[(9-Isopropyl-9H-purin-6-ylamino)-methyl]-2-meth...)
Affinity DataIC50:  4.50E+3nMAssay Description:Inhibitory concentration against Cyclin-dependent kinase 1-cyclin BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50132173((3-Chloro-phenyl)-(9-isopropyl-9H-purin-6-yl)-amin...)
Affinity DataIC50:  5.90E+3nMAssay Description:In vitro antiproliferative activity against myeloid leukemia K562 cell lineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 1(Homo sapiens (Human))
Academy Of Sciences Of The Czech Republic

Curated by ChEMBL
LigandPNGBDBM5718(2,6,9-Trisubstituted purine deriv. 26 | 2-{[6-(ben...)
Affinity DataIC50:  6.00E+3nMAssay Description:Inhibitory activity against purified cdc2 p34/Cyclin B obtained from M phase oocytes of the starfish Marthasterias glacialis.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

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