BindingDB PrimarySearch

Found 191 with Last Name = 'heffernan' and Initial = 'tp'

Macrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
University Of Texas Md Anderson Cancer Center

Curated by ChEMBL

BDBM50560806(CHEMBL4758092)

IC50: 0.800nMAssay Description:Inhibition of AlexaFluor-labeled tracer 236 binding to recombinant human His-tagged CSF1R (538 to 910 residues) preincubated for 20 mins followed by ...More data for this Ligand-Target Pair

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Macrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
University Of Texas Md Anderson Cancer Center

Curated by ChEMBL

BDBM50560807(CHEMBL4751287)

IC50: 1nMAssay Description:Inhibition of AlexaFluor-labeled tracer 236 binding to recombinant human His-tagged CSF1R (538 to 910 residues) preincubated for 20 mins followed by ...More data for this Ligand-Target Pair

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Macrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
University Of Texas Md Anderson Cancer Center

Curated by ChEMBL

BDBM50560804(CHEMBL4763875)

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Macrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
University Of Texas Md Anderson Cancer Center

Curated by ChEMBL

BDBM50460035(CHEMBL4227505)

IC50: 1nMAssay Description:Inhibition of CSF1R (unknown origin)More data for this Ligand-Target Pair

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Macrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
University Of Texas Md Anderson Cancer Center

Curated by ChEMBL

BDBM50560786(CHEMBL4798876)

IC50: 1.10nMAssay Description:Inhibition of AlexaFluor-labeled tracer 236 binding to recombinant human His-tagged CSF1R (538 to 910 residues) preincubated for 20 mins followed by ...More data for this Ligand-Target Pair

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Macrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
University Of Texas Md Anderson Cancer Center

Curated by ChEMBL

BDBM50560798(CHEMBL4795462)

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Macrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
University Of Texas Md Anderson Cancer Center

Curated by ChEMBL

BDBM50560791(CHEMBL4740157)

IC50: 1.20nMAssay Description:Inhibition of AlexaFluor-labeled tracer 236 binding to recombinant human His-tagged CSF1R (538 to 910 residues) preincubated for 20 mins followed by ...More data for this Ligand-Target Pair

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Macrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
University Of Texas Md Anderson Cancer Center

Curated by ChEMBL

BDBM50560801(CHEMBL4798601)

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Macrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
University Of Texas Md Anderson Cancer Center

Curated by ChEMBL

BDBM50560788(CHEMBL4759047)

IC50: 1.40nMAssay Description:Inhibition of AlexaFluor-labeled tracer 236 binding to recombinant human His-tagged CSF1R (538 to 910 residues) preincubated for 20 mins followed by ...More data for this Ligand-Target Pair

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Macrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
University Of Texas Md Anderson Cancer Center

Curated by ChEMBL

BDBM50560812(CHEMBL4748740)

IC50: 1.70nMAssay Description:Inhibition of AlexaFluor-labeled tracer 236 binding to recombinant human His-tagged CSF1R (538 to 910 residues) preincubated for 20 mins followed by ...More data for this Ligand-Target Pair

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Macrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
University Of Texas Md Anderson Cancer Center

Curated by ChEMBL

BDBM50560790(CHEMBL4741283)

IC50: 2nMAssay Description:Inhibition of AlexaFluor-labeled tracer 236 binding to recombinant human His-tagged CSF1R (538 to 910 residues) preincubated for 20 mins followed by ...More data for this Ligand-Target Pair

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Macrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
University Of Texas Md Anderson Cancer Center

Curated by ChEMBL

BDBM50560789(CHEMBL4779878)

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Macrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
University Of Texas Md Anderson Cancer Center

Curated by ChEMBL

BDBM50560816(CHEMBL4756510)

IC50: 2.40nMAssay Description:Inhibition of AlexaFluor-labeled tracer 236 binding to recombinant human His-tagged CSF1R (538 to 910 residues) preincubated for 20 mins followed by ...More data for this Ligand-Target Pair

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Macrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
University Of Texas Md Anderson Cancer Center

Curated by ChEMBL

BDBM50560800(CHEMBL4779197)

IC50: 2.60nMAssay Description:Inhibition of AlexaFluor-labeled tracer 236 binding to recombinant human His-tagged CSF1R (538 to 910 residues) preincubated for 20 mins followed by ...More data for this Ligand-Target Pair

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Macrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
University Of Texas Md Anderson Cancer Center

Curated by ChEMBL

BDBM50560793(CHEMBL4788945)

IC50: 4nMAssay Description:Inhibition of AlexaFluor-labeled tracer 236 binding to recombinant human His-tagged CSF1R (538 to 910 residues) preincubated for 20 mins followed by ...More data for this Ligand-Target Pair

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Macrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
University Of Texas Md Anderson Cancer Center

Curated by ChEMBL

BDBM50560785(CHEMBL4754431)

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Macrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
University Of Texas Md Anderson Cancer Center

Curated by ChEMBL

BDBM50560813(CHEMBL4746711)

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Macrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
University Of Texas Md Anderson Cancer Center

Curated by ChEMBL

BDBM50560797(CHEMBL4763289)

IC50: 5.70nMAssay Description:Inhibition of AlexaFluor-labeled tracer 236 binding to recombinant human His-tagged CSF1R (538 to 910 residues) preincubated for 20 mins followed by ...More data for this Ligand-Target Pair

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Glutaminase kidney isoform, mitochondrial(Homo sapiens (Human))
The University Of Texas Md Anderson Cancer Center

Curated by ChEMBL

BDBM404825(1-(4-{6-[2-(pyridin-2- yl)acetamido]pyridazin-3-yl...)

IC50: 6nMAssay Description:Inhibition of recombinant human GLS1 using glutamine as substrate preincubated for 10 mins followed by substrate addition and measured after 20 mins ...More data for this Ligand-Target Pair

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Glutaminase kidney isoform, mitochondrial(Homo sapiens (Human))
The University Of Texas Md Anderson Cancer Center

Curated by ChEMBL

BDBM109086(US10793535, Cmpd ID 727 | US8604016, 670 | US99382...)

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Macrophage colony-stimulating factor 1 receptor(Mus musculus (Mouse))
University Of Texas Md Anderson Cancer Center

Curated by ChEMBL

BDBM50560806(CHEMBL4758092)

IC50: 7nMAssay Description:Inhibition of CSF1R in mouse NFS-60 cells assessed as reduction in CSF-induced cell proliferation after 72 hrs by CellTiter-Glo assayMore data for this Ligand-Target Pair

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Macrophage colony-stimulating factor 1 receptor(Mus musculus (Mouse))
University Of Texas Md Anderson Cancer Center

Curated by ChEMBL

BDBM50560812(CHEMBL4748740)

IC50: 7nMAssay Description:Inhibition of CSF1R in mouse NFS-60 cells assessed as reduction in CSF-induced cell proliferation after 72 hrs by CellTiter-Glo assayMore data for this Ligand-Target Pair

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Macrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
University Of Texas Md Anderson Cancer Center

Curated by ChEMBL

BDBM50560792(CHEMBL4762843)

IC50: 7nMAssay Description:Inhibition of AlexaFluor-labeled tracer 236 binding to recombinant human His-tagged CSF1R (538 to 910 residues) preincubated for 20 mins followed by ...More data for this Ligand-Target Pair

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Macrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
University Of Texas Md Anderson Cancer Center

Curated by ChEMBL

BDBM50560809(CHEMBL4787609)

IC50: 9nMAssay Description:Inhibition of AlexaFluor-labeled tracer 236 binding to recombinant human His-tagged CSF1R (538 to 910 residues) preincubated for 20 mins followed by ...More data for this Ligand-Target Pair

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Glutaminase kidney isoform, mitochondrial(Homo sapiens (Human))
The University Of Texas Md Anderson Cancer Center

Curated by ChEMBL

BDBM404848(N-methyl-1-{4-[6-(2-{4-[3- (trifluoromethoxy)pheny...)

IC50: 10nMAssay Description:Inhibition of recombinant human GLS1 using glutamine as substrate preincubated for 10 mins followed by substrate addition and measured after 20 mins ...More data for this Ligand-Target Pair

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Glutaminase kidney isoform, mitochondrial(Homo sapiens (Human))
The University Of Texas Md Anderson Cancer Center

Curated by ChEMBL

BDBM404911((R)-1-(2-fluoro-4-(6-(2-(4-(3- (trifluoromethoxy)p...)

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Macrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
University Of Texas Md Anderson Cancer Center

Curated by ChEMBL

BDBM50560815(CHEMBL4790139)

IC50: 11nMAssay Description:Inhibition of AlexaFluor-labeled tracer 236 binding to recombinant human His-tagged CSF1R (538 to 910 residues) preincubated for 20 mins followed by ...More data for this Ligand-Target Pair

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Glutaminase kidney isoform, mitochondrial(Homo sapiens (Human))
The University Of Texas Md Anderson Cancer Center

Curated by ChEMBL

BDBM404666(US10344025, Example 5 | US11370786, Example 5)

IC50: 14nMAssay Description:Inhibition of recombinant human GLS1 using glutamine as substrate preincubated for 10 mins followed by substrate addition and measured after 20 mins ...More data for this Ligand-Target Pair

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Glutaminase kidney isoform, mitochondrial(Homo sapiens (Human))
The University Of Texas Md Anderson Cancer Center

Curated by ChEMBL

BDBM405185(N-(pyridin-2-ylmethyl)-1-[4-(6-{2-[3- (trifluorome...)

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Glutaminase kidney isoform, mitochondrial(Homo sapiens (Human))
The University Of Texas Md Anderson Cancer Center

Curated by ChEMBL

BDBM405183(N-(cyanomethyl)-1-[4-(6-{2-[3- (trifluoromethoxy)p...)

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Macrophage colony-stimulating factor 1 receptor(Mus musculus (Mouse))
University Of Texas Md Anderson Cancer Center

Curated by ChEMBL

BDBM50560791(CHEMBL4740157)

IC50: 14nMAssay Description:Inhibition of CSF1R in mouse NFS-60 cells assessed as reduction in CSF-induced cell proliferation after 72 hrs by CellTiter-Glo assayMore data for this Ligand-Target Pair

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Glutaminase kidney isoform, mitochondrial(Homo sapiens (Human))
The University Of Texas Md Anderson Cancer Center

Curated by ChEMBL

BDBM50548670(CHEMBL4741924)

IC50: 16nMAssay Description:Inhibition of GLS1 in human A549 cells assessed as reduction in conversion of glutamine to glutamate measured after 24 hrsMore data for this Ligand-Target Pair

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Macrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
University Of Texas Md Anderson Cancer Center

Curated by ChEMBL

BDBM50560812(CHEMBL4748740)

IC50: 17nMAssay Description:Inhibition of CSF1R phosphorylation in M-CSF induced human THP1 cells incubated for 30 mins by ELISA assayMore data for this Ligand-Target Pair

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Macrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
University Of Texas Md Anderson Cancer Center

Curated by ChEMBL

BDBM50560810(CHEMBL4798920)

IC50: 17nMAssay Description:Inhibition of AlexaFluor-labeled tracer 236 binding to recombinant human His-tagged CSF1R (538 to 910 residues) preincubated for 20 mins followed by ...More data for this Ligand-Target Pair

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Macrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
University Of Texas Md Anderson Cancer Center

Curated by ChEMBL

BDBM50560795(CHEMBL4788832)

IC50: 21nMAssay Description:Inhibition of AlexaFluor-labeled tracer 236 binding to recombinant human His-tagged CSF1R (538 to 910 residues) preincubated for 20 mins followed by ...More data for this Ligand-Target Pair

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Glutaminase kidney isoform, mitochondrial(Homo sapiens (Human))
The University Of Texas Md Anderson Cancer Center

Curated by ChEMBL

BDBM404924((R)-1-(2-fluoro-4-(6-(2-(6-methyl-4- (trifluoromet...)

IC50: 21nMAssay Description:Inhibition of recombinant human GLS1 using glutamine as substrate preincubated for 10 mins followed by substrate addition and measured after 20 mins ...More data for this Ligand-Target Pair

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Glutaminase kidney isoform, mitochondrial(Homo sapiens (Human))
The University Of Texas Md Anderson Cancer Center

Curated by ChEMBL

BDBM50548671(CHEMBL4797071)

IC50: 22nMAssay Description:Inhibition of recombinant human GLS1 using glutamine as substrate preincubated for 10 mins followed by substrate addition and measured after 20 mins ...More data for this Ligand-Target Pair

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Glutaminase kidney isoform, mitochondrial(Homo sapiens (Human))
The University Of Texas Md Anderson Cancer Center

Curated by ChEMBL

BDBM405207(N-(2-methoxyethyl)-1-[4-(6-{2-[3- (trifluoromethox...)

IC50: 23nMAssay Description:Inhibition of recombinant human GLS1 using glutamine as substrate preincubated for 10 mins followed by substrate addition and measured after 20 mins ...More data for this Ligand-Target Pair

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Glutaminase kidney isoform, mitochondrial(Homo sapiens (Human))
The University Of Texas Md Anderson Cancer Center

Curated by ChEMBL

BDBM404928((R)-1-(4-(6-(2-(4-(3,3- difluorocyclobutoxy)pyridi...)

IC50: 25nMAssay Description:Inhibition of recombinant human GLS1 using glutamine as substrate preincubated for 10 mins followed by substrate addition and measured after 20 mins ...More data for this Ligand-Target Pair

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Glutaminase kidney isoform, mitochondrial(Homo sapiens (Human))
The University Of Texas Md Anderson Cancer Center

Curated by ChEMBL

BDBM50400050(CHEMBL2177757 | US10793535, Cmpd ID 1 | US11191732...)

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Macrophage colony-stimulating factor 1 receptor(Mus musculus (Mouse))
University Of Texas Md Anderson Cancer Center

Curated by ChEMBL

BDBM50560800(CHEMBL4779197)

IC50: 26nMAssay Description:Inhibition of CSF1R in mouse NFS-60 cells assessed as reduction in CSF-induced cell proliferation after 72 hrs by CellTiter-Glo assayMore data for this Ligand-Target Pair

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Macrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
University Of Texas Md Anderson Cancer Center

Curated by ChEMBL

BDBM50560796(CHEMBL4764974)

IC50: 30nMAssay Description:Inhibition of AlexaFluor-labeled tracer 236 binding to recombinant human His-tagged CSF1R (538 to 910 residues) preincubated for 20 mins followed by ...More data for this Ligand-Target Pair

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Macrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
University Of Texas Md Anderson Cancer Center

Curated by ChEMBL

BDBM32362(5-[[3-methoxy-4-[(4-methoxyphenyl)methoxy]phenyl]m...)

IC50: 30nMAssay Description:Inhibition of CSF1R (unknown origin)More data for this Ligand-Target Pair

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Glutaminase kidney isoform, mitochondrial(Homo sapiens (Human))
The University Of Texas Md Anderson Cancer Center

Curated by ChEMBL

BDBM50548670(CHEMBL4741924)

IC50: 31nMAssay Description:Inhibition of recombinant human GLS1 using glutamine as substrate preincubated for 10 mins followed by substrate addition and measured after 20 mins ...More data for this Ligand-Target Pair

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Glutaminase kidney isoform, mitochondrial(Homo sapiens (Human))
The University Of Texas Md Anderson Cancer Center

Curated by ChEMBL

BDBM404813(N-methyl-1-[4-(6-{2-[3- (trifluoromethoxy)phenyl]a...)

IC50: 32nMAssay Description:Inhibition of recombinant human GLS1 using glutamine as substrate preincubated for 10 mins followed by substrate addition and measured after 20 mins ...More data for this Ligand-Target Pair

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Glutaminase kidney isoform, mitochondrial(Homo sapiens (Human))
The University Of Texas Md Anderson Cancer Center

Curated by ChEMBL

BDBM404910((R)-1-(2-fluoro-4-(6-(2-(pyridin-2- yl)acetamido)p...)

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Glutaminase kidney isoform, mitochondrial(Homo sapiens (Human))
The University Of Texas Md Anderson Cancer Center

Curated by ChEMBL

BDBM404866(N-methyl-1-(4-(6-(2-(4- (trifluoromethyl)pyridin-2...)

IC50: 42nMAssay Description:Inhibition of recombinant human GLS1 using glutamine as substrate preincubated for 10 mins followed by substrate addition and measured after 20 mins ...More data for this Ligand-Target Pair

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Glutaminase kidney isoform, mitochondrial(Homo sapiens (Human))
The University Of Texas Md Anderson Cancer Center

Curated by ChEMBL

BDBM404915((R)-1-(2-fluoro-4-(6-(2-(4- (trifluoromethyl)pyrid...)

IC50: 44nMAssay Description:Inhibition of recombinant human GLS1 using glutamine as substrate preincubated for 10 mins followed by substrate addition and measured after 20 mins ...More data for this Ligand-Target Pair

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Glutaminase kidney isoform, mitochondrial(Homo sapiens (Human))
The University Of Texas Md Anderson Cancer Center

Curated by ChEMBL

BDBM404917(1-(4-(6-(2-(4-(3,3- difluorocyclobutoxy)pyridin-2-...)

IC50: 46nMAssay Description:Inhibition of recombinant human GLS1 using glutamine as substrate preincubated for 10 mins followed by substrate addition and measured after 20 mins ...More data for this Ligand-Target Pair

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Macrophage colony-stimulating factor 1 receptor(Mus musculus (Mouse))
University Of Texas Md Anderson Cancer Center

Curated by ChEMBL

BDBM50560797(CHEMBL4763289)

IC50: 48nMAssay Description:Inhibition of CSF1R in mouse NFS-60 cells assessed as reduction in CSF-induced cell proliferation after 72 hrs by CellTiter-Glo assayMore data for this Ligand-Target Pair

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Displayed 1 to 50 (of 191 total ) | Next | Last >>

Filter my 191 hits

Targets 14▿
- Macrophage colony-stimulating factor 1 receptor 87
- Glutaminase kidney isoform, mitochondrial 26
- Platelet-derived growth factor receptor beta 25
- Receptor-type tyrosine-protein kinase FLT3 15
- Mast/stem cell growth factor receptor Kit 15
- Platelet-derived growth factor receptor alpha 15
- Tyrosine-protein kinase JAK3 1
- Cytochrome P450 1A2 1
- Cytochrome P450 2C9 1
- Glutaminase liver isoform, mitochondrial 1
- Cytochrome P450 2C19 1
- Cytochrome P450 2D6 1
- Potassium voltage-gated channel subfamily H member 2 1
- Cytochrome P450 3A4 1
Publications 2▿
- J Med Chem 63: 9888-9911 (2020) 157
- J Med Chem 63: 12957-12977 (2020) 34
Institutions 2▿
- University Of Texas Md Anderson Cancer Center 157
- The University Of Texas Md Anderson Cancer Center 34
Affinity: 0.60 to 5.0E+4 nM▿
- IC50 115
- Kd 76
- Affinity ≤ nM
Xtal structures: 2
Docked structures: 0
Catalog Cmpds: 5