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Found 2434 with Last Name = 'heffron' and Initial = 't'
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM598210(US11612606, Compound 546a | trans-4-Methoxytetrahy...)
Affinity DataKi: <0.0130nMAssay Description:TBDMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM598214((1s,3s)-3-(2-Cyanopropan-2- | US11612606, Compound...)
Affinity DataKi: <0.0130nMAssay Description:TBDMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM598215((1r,3r)-3-(2-Cyanopropan-2- yl)cyclobutyl(8-amino-...)
Affinity DataKi: <0.0130nMAssay Description:TBDMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM598216((1r,3r)-3-Morpholinocyclobutyl(8- | US11612606, Co...)
Affinity DataKi: <0.0130nMAssay Description:TBDMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM598218((1s,3s)-3-Cyclopropyl-3- | US11612606, Compound 55...)
Affinity DataKi: <0.0130nMAssay Description:TBDMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM591137(2-((8-amino-6-(5-amino-4- methylpyridin-3-yl)-7- f...)
Affinity DataKi:  0.0130nMAssay Description:To a 384 well Proxiplate with 80 nL compound or DMSO spotted on was added 4 μl/well kinase mix. The mixture was preincubated for 30 minutes and ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM598103(US11612606, Compound 452d | amino-7-fluoro-6-(8-me...)
Affinity DataKi: <0.0130nMAssay Description:TBDMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM598111(US11612606, Compound 467d | azaspiro[4.4]nonan-3-y...)
Affinity DataKi: <0.0130nMAssay Description:TBDMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM598119(US11612606, Compound 478b | amino-7-fluoro-6-(8-me...)
Affinity DataKi: <0.0130nMAssay Description:TBDMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM598122(US11612606, Compound 479b | amino-7-fluoro-6-(8-me...)
Affinity DataKi: <0.0130nMAssay Description:TBDMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM598127((trans)-2-Cyanocyclopentyl(8-amino-7- | US11612606...)
Affinity DataKi: <0.0130nMAssay Description:TBDMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM598128(US11612606, Compound 482b | fluoro-6-(8-methyl-2,3...)
Affinity DataKi: <0.0130nMAssay Description:TBDMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM598129((1s,3s)-3-cyanocyclobutyl (8-amino-7- | US11612606...)
Affinity DataKi: <0.0130nMAssay Description:TBDMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM598130((1s,3s)-3-Cyanocyclobutyl(8-amino-7- | US11612606,...)
Affinity DataKi: <0.0130nMAssay Description:TBDMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM598132((1s,3s)-3-Hydroxycyclobutyl(8-amino-7- | US1161260...)
Affinity DataKi: <0.0130nMAssay Description:TBDMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM598133((1r,3r)-3-Hydroxycyclobutyl(8-amino-7- | US1161260...)
Affinity DataKi: <0.0130nMAssay Description:TBDMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM598134(3-Hydroxy-3-methylcyclobutyl(8-amino- 7-fluoro-6-(...)
Affinity DataKi: <0.0130nMAssay Description:TBDMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM598136(Cyclobutyl(8-amino-7-fluoro-6-(8- methyl-2,3-dihyd...)
Affinity DataKi: <0.0130nMAssay Description:TBDMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM598139(2-(2,2-Difluoroethyl)-2- azaspiro[3.3]heptan-6-yl(...)
Affinity DataKi: <0.0130nMAssay Description:TBDMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM598140((1R,5S,6r)-3-Isopropyl-3- | US11612606, Compound 4...)
Affinity DataKi: <0.0130nMAssay Description:TBDMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM598141((1R,5S,6r)-3-(oxetan-3-yl)-3- | US11612606, Compou...)
Affinity DataKi: <0.0130nMAssay Description:TBDMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM598142((R)-6,7-dihydro-5H-pyrrolo[1,2- | US11612606, Comp...)
Affinity DataKi: <0.0130nMAssay Description:TBDMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM598144((1R,5S,9s)-7-isopropyl-3-oxa-7- | US11612606, Comp...)
Affinity DataKi: <0.0130nMAssay Description:TBDMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM598145((1R,5S,9s)-7-(2,2-difluoroethyl)-3-oxa-7- | US1161...)
Affinity DataKi: <0.0130nMAssay Description:TBDMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM598148(1H-pyrido[2,3-b][1,4]oxazin-7- | US11612606, Compo...)
Affinity DataKi: <0.0130nMAssay Description:TBDMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM591137(2-((8-amino-6-(5-amino-4- methylpyridin-3-yl)-7- f...)
Affinity DataKi:  0.0130nMAssay Description:For the binding assay, 4 ul 2×HPK1 and Eu-anti-GST antibody were added to each well of the assay plate using a Multidrop reagent dispenser. The solut...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM591144((1R,2S,3R)-N-(8-amino-7-fluoro-6-(8-methyl-2,3-dih...)
Affinity DataKi:  0.0130nMAssay Description:To a 384 well Proxiplate with 80 nL compound or DMSO spotted on was added 4 μl/well kinase mix. The mixture was preincubated for 30 minutes and ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM591146(US11566003, Compound 35)
Affinity DataKi:  0.0130nMAssay Description:To a 384 well Proxiplate with 80 nL compound or DMSO spotted on was added 4 μl/well kinase mix. The mixture was preincubated for 30 minutes and ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM591155(US11566003, Compound 111)
Affinity DataKi:  0.0130nMAssay Description:To a 384 well Proxiplate with 80 nL compound or DMSO spotted on was added 4 μl/well kinase mix. The mixture was preincubated for 30 minutes and ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM591217(2-((8-amino-6-(5-amino-4- methylpyridin-3-yl)-7-fl...)
Affinity DataKi:  0.0130nMAssay Description:To a 384 well Proxiplate with 80 nL compound or DMSO spotted on was added 4 μl/well kinase mix. The mixture was preincubated for 30 minutes and ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM591220(2-((8-amino-6-(5-amino-4-ethylpyridin- 3-yl)-7-flu...)
Affinity DataKi:  0.0130nMAssay Description:To a 384 well Proxiplate with 80 nL compound or DMSO spotted on was added 4 μl/well kinase mix. The mixture was preincubated for 30 minutes and ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM591222(2-((8-amino-6-(5-amino-4- methylpyridin-3-yl)-7-fl...)
Affinity DataKi:  0.0130nMAssay Description:To a 384 well Proxiplate with 80 nL compound or DMSO spotted on was added 4 μl/well kinase mix. The mixture was preincubated for 30 minutes and ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM591225(2-((8-amino-6-(5-amino-4- methylpyridin-3-yl)-7-fl...)
Affinity DataKi:  0.0130nMAssay Description:To a 384 well Proxiplate with 80 nL compound or DMSO spotted on was added 4 μl/well kinase mix. The mixture was preincubated for 30 minutes and ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM591240(2-((8-amino-6-(5-amino-4- chloropyridin-3-yl)-7-fl...)
Affinity DataKi:  0.0130nMAssay Description:To a 384 well Proxiplate with 80 nL compound or DMSO spotted on was added 4 μl/well kinase mix. The mixture was preincubated for 30 minutes and ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM591242(2-((8-amino-6-(5-amino-4- methylpyridin-3-yl)-7-fl...)
Affinity DataKi:  0.0130nMAssay Description:To a 384 well Proxiplate with 80 nL compound or DMSO spotted on was added 4 μl/well kinase mix. The mixture was preincubated for 30 minutes and ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM591244((S)-2-((8-amino-6-(5-amino-4- methylpyridin-3-yl)-...)
Affinity DataKi:  0.0130nMAssay Description:To a 384 well Proxiplate with 80 nL compound or DMSO spotted on was added 4 μl/well kinase mix. The mixture was preincubated for 30 minutes and ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM591249(2-((8-amino-6-(5-amino-4- methylpyridin-3-yl)-7-fl...)
Affinity DataKi:  0.0130nMAssay Description:To a 384 well Proxiplate with 80 nL compound or DMSO spotted on was added 4 μl/well kinase mix. The mixture was preincubated for 30 minutes and ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM591250(2'-((8-amino-6-(5-amino-4- methylpyridin-3-yl)-7-f...)
Affinity DataKi:  0.0130nMAssay Description:To a 384 well Proxiplate with 80 nL compound or DMSO spotted on was added 4 μl/well kinase mix. The mixture was preincubated for 30 minutes and ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM591252(2-((8-amino-7-fluoro-6-(4-methyl-6- (oxazol-2-yl)p...)
Affinity DataKi:  0.0130nMAssay Description:To a 384 well Proxiplate with 80 nL compound or DMSO spotted on was added 4 μl/well kinase mix. The mixture was preincubated for 30 minutes and ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM591211(2-((8-amino-6-(5-amino-4- methylpyridin-3-yl)-7-fl...)
Affinity DataKi:  0.0130nMAssay Description:To a 384 well Proxiplate with 80 nL compound or DMSO spotted on was added 4 μl/well kinase mix. The mixture was preincubated for 30 minutes and ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM598329(1-(8-Amino-7-fluoro-6-(8-methyl-2,3-dihydro-1H-pyr...)
Affinity DataKi: <0.0130nMAssay Description:TBDMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM598031((R)-Tetrahydrofuran-3-yl(8-amino-7- | US11612606, ...)
Affinity DataKi: <0.0130nMAssay Description:TBDMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM598220((1s,3s)-3-hydroxycyclobutyl(8-amino-7- | US1161260...)
Affinity DataKi: <0.0130nMAssay Description:TBDMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM598222(US11612606, Compound 555a | trans-4-Methyltetrahyd...)
Affinity DataKi: <0.0130nMAssay Description:TBDMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM598223((3R,4S)-4-Methyltetrahydrofuran-3-yl(8- amino-6-(8...)
Affinity DataKi: <0.0130nMAssay Description:TBDMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM598225((3R,4S)-4-Methyltetrahydrofuran-3-yl(8- amino-6-(8...)
Affinity DataKi: <0.0130nMAssay Description:TBDMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM598226((1s,3s)-3-Cyanocyclobutyl(8-amino-6- | US11612606,...)
Affinity DataKi: <0.0130nMAssay Description:TBDMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM598231(US11612606, Compound 559c | trans-2-Methylcyclobut...)
Affinity DataKi: <0.0130nMAssay Description:TBDMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM598232((1S,2S)-2-Methylcyclobutyl(8-amino-7- fluoro-6-(8-...)
Affinity DataKi: <0.0130nMAssay Description:TBDMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM598249((1s,3s)-3-(Hydroxymethyl)cyclobutyl(8- amino-7-flu...)
Affinity DataKi: <0.0130nMAssay Description:TBDMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
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