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Found 103 with Last Name = 'hirano' and Initial = 'k'
TargetHistamine H3 receptor(Homo sapiens (Human))
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM22904((2R)-1-(1H-imidazol-5-yl)propan-2-amine | (R)-alph...)
Affinity DataKi:  0.880nMAssay Description:Inhibition of Histamine H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Rattus norvegicus (rat))
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM50127610((1S,2S)-2-(2-aminoethyl)-1-(1H-imidazol-4-yl)cyclo...)
Affinity DataKi:  1.30nMAssay Description:Affinity against rat Histamine H3 receptor using [3H]-N-alpha-methyl histamineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Rattus norvegicus (rat))
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM50127604(C-[2-(1H-Imidazol-4-yl)-cyclopropyl]-methylamine |...)
Affinity DataKi:  2.5nMAssay Description:Affinity against rat Histamine H3 receptor using [3H]-N-alpha-methyl histamineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Rattus norvegicus (rat))
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM22914(CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)pi...)
Affinity DataKi:  2.70nMAssay Description:Inhibition of rat Histamine H3 receptor using [3H]-N-alpha-methyl histamineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Rattus norvegicus (rat))
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM50127605((1S,2S)-2-(1H-Imidazol-4-yl)-cyclopropylamine | (1...)
Affinity DataKi:  4.30nMAssay Description:Affinity against rat Histamine H3 receptor using [3H]-N-alpha-methyl histamineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Rattus norvegicus (rat))
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM50127608(2-[2-(1H-Imidazol-4-yl)-cyclopropyl]-ethylamine | ...)
Affinity DataKi:  4.80nMAssay Description:Affinity against rat Histamine H3 receptor using [3H]-N-alpha-methyl histamineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM21398(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)
Affinity DataKi:  5.09nMAssay Description:Displacement of [3H]YM-09151-2 from human dopamine D2S receptor in membrane suspensions by liquid scintillation counterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetHistamine H3 receptor(Rattus norvegicus (rat))
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM50127603(C-[2-(1H-Imidazol-4-yl)-cyclopropyl]-methylamine |...)
Affinity DataKi:  10nMAssay Description:Affinity against rat Histamine H3 receptor using [3H]-N-alpha-methyl histamineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Rattus norvegicus (rat))
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM50127609(C-[2-(1H-Imidazol-4-yl)-cyclopropyl]-methylamine |...)
Affinity DataKi:  23nMAssay Description:Affinity against rat Histamine H3 receptor using [3H]-N-alpha-methyl histamineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Rattus norvegicus (rat))
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM50127607((1R,2R)-2-(1H-Imidazol-4-yl)-cyclopropylamine | (1...)
Affinity DataKi:  42nMAssay Description:Affinity against rat Histamine H3 receptor using [3H]-N-alpha-methyl histamineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Rattus norvegicus (rat))
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM50127602(C-[2-(1H-Imidazol-4-yl)-cyclopropyl]-methylamine |...)
Affinity DataKi:  65nMAssay Description:Affinity against rat Histamine H3 receptor using [3H]-N-alpha-methyl histamineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Rattus norvegicus (rat))
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM50127601(2-(1H-Imidazol-4-yl)-cyclopropylamine | CHEMBL5938...)
Affinity DataKi:  91nMAssay Description:Affinity against rat Histamine H3 receptor using [3H]-N-alpha-methyl histamineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM50264101(1-(2,4-dimethylphenyl)-4-(((1R,2S)-2-phenylcyclopr...)
Affinity DataKi:  515nMAssay Description:Displacement of [3H]YM-09151-2 from human dopamine D2S receptor in membrane suspensions by liquid scintillation counterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM50092744(1-(2,4-Dimethyl-phenyl)-4-(2-phenyl-cyclopropylmet...)
Affinity DataKi:  540nMAssay Description:Displacement of [3H]YM-09151-2 from human dopamine D2S receptor in membrane suspensions by liquid scintillation counterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM50264100(1-(2,4-dimethylphenyl)-4-(((1S,2R)-2-phenylcyclopr...)
Affinity DataKi:  935nMAssay Description:Displacement of [3H]YM-09151-2 from human dopamine D2S receptor in membrane suspensions by liquid scintillation counterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Rattus norvegicus (rat))
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM50127606(2-(1H-Imidazol-4-yl)-cyclopropylamine | CHEMBL2940...)
Affinity DataKi:  1.38E+3nMAssay Description:Affinity against rat Histamine H3 receptor using [3H]-N-alpha-methyl histamineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase kappa(Homo sapiens (Human))
Science University Of Tokyo

Curated by ChEMBL
LigandPNGBDBM50379292(CHEMBL2011646)
Affinity DataKi:  9.85E+3nMAssay Description:Competitive inhibition of human C-terminal-His6-tagged DNA polymerase kappa expressed in Escherichia coli using dTTP as substrate by Dixon plot analy...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM50264102((1S,2S)-1-[4-(2,4-Dimethylphenyl)piperazyl]methyl-...)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]YM-09151-2 from human dopamine D2S receptor in membrane suspensions by liquid scintillation counterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM50264103((1S,2S)-1-[(R)-2-[4-(2,4-Dimethylphenyl)piperazyl]...)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]YM-09151-2 from human dopamine D2S receptor in membrane suspensions by liquid scintillation counterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM50263350((1S,2S)-1-[(S)-2-[4-(2,4-Dimethylphenyl)piperazyl]...)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]YM-09151-2 from human dopamine D2S receptor in membrane suspensions by liquid scintillation counterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase kappa(Homo sapiens (Human))
Science University Of Tokyo

Curated by ChEMBL
LigandPNGBDBM50379292(CHEMBL2011646)
Affinity DataKi:  1.81E+4nMAssay Description:Non-competitive inhibition of human C-terminal-His6-tagged DNA polymerase kappa expressed in Escherichia coli using ploy(dA)/oligo(dT)18 as substrate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase kappa(Homo sapiens (Human))
Science University Of Tokyo

Curated by ChEMBL
LigandPNGBDBM50379292(CHEMBL2011646)
Affinity DataIC50:  4.86E+4nMAssay Description:Inhibition of human C-terminal-His6-tagged DNA polymerase kappa expressed in Escherichia coli assessed as inhibition of incorporation of dTTP into po...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase iota(Mus musculus)
Science University Of Tokyo

Curated by ChEMBL
LigandPNGBDBM50379292(CHEMBL2011646)
Affinity DataIC50:  5.02E+4nMAssay Description:Inhibition of mouse recombinant C-terminal-His6-tagged DNA polymerase iota assessed as inhibition of incorporation of dTTP into poly(dA)/oligo(dT)18 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase nu(Homo sapiens (Human))
Science University Of Tokyo

Curated by ChEMBL
LigandPNGBDBM50379292(CHEMBL2011646)
Affinity DataIC50:  5.09E+4nMAssay Description:Inhibition of C-terminal-His6-tagged human pol nu expressed in Escherichia coli assessed as inhibition of incorporation of dTTP into poly(dA)/oligo(d...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase delta catalytic subunit(Homo sapiens (Human))
Science University Of Tokyo

Curated by ChEMBL
LigandPNGBDBM50379292(CHEMBL2011646)
Affinity DataIC50:  5.45E+4nMAssay Description:Inhibition of human DNA polymerase delta assessed as inhibition of incorporation of dTTP into poly(dA)/oligo(dT)18 after 60 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase kappa(Homo sapiens (Human))
Science University Of Tokyo

Curated by ChEMBL
LigandPNGBDBM50379293(CHEMBL2011648)
Affinity DataIC50:  5.98E+4nMAssay Description:Inhibition of human C-terminal-His6-tagged DNA polymerase kappa expressed in Escherichia coli assessed as inhibition of incorporation of dTTP into po...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase nu(Homo sapiens (Human))
Science University Of Tokyo

Curated by ChEMBL
LigandPNGBDBM50379293(CHEMBL2011648)
Affinity DataIC50:  6.31E+4nMAssay Description:Inhibition of C-terminal-His6-tagged human pol nu expressed in Escherichia coli assessed as inhibition of incorporation of dTTP into poly(dA)/oligo(d...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase iota(Mus musculus)
Science University Of Tokyo

Curated by ChEMBL
LigandPNGBDBM50379293(CHEMBL2011648)
Affinity DataIC50:  6.38E+4nMAssay Description:Inhibition of mouse recombinant C-terminal-His6-tagged DNA polymerase iota assessed as inhibition of incorporation of dTTP into poly(dA)/oligo(dT)18 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase delta catalytic subunit(Homo sapiens (Human))
Science University Of Tokyo

Curated by ChEMBL
LigandPNGBDBM50379293(CHEMBL2011648)
Affinity DataIC50:  6.80E+4nMAssay Description:Inhibition of human DNA polymerase delta assessed as inhibition of incorporation of dTTP into poly(dA)/oligo(dT)18 after 60 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase kappa(Homo sapiens (Human))
Science University Of Tokyo

Curated by ChEMBL
LigandPNGBDBM50379294(CHEMBL2011647)
Affinity DataIC50:  8.89E+4nMAssay Description:Inhibition of human C-terminal-His6-tagged DNA polymerase kappa expressed in Escherichia coli assessed as inhibition of incorporation of dTTP into po...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase iota(Mus musculus)
Science University Of Tokyo

Curated by ChEMBL
LigandPNGBDBM50379294(CHEMBL2011647)
Affinity DataIC50:  9.10E+4nMAssay Description:Inhibition of mouse recombinant C-terminal-His6-tagged DNA polymerase iota assessed as inhibition of incorporation of dTTP into poly(dA)/oligo(dT)18 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase nu(Homo sapiens (Human))
Science University Of Tokyo

Curated by ChEMBL
LigandPNGBDBM50379294(CHEMBL2011647)
Affinity DataIC50:  9.21E+4nMAssay Description:Inhibition of C-terminal-His6-tagged human pol nu expressed in Escherichia coli assessed as inhibition of incorporation of dTTP into poly(dA)/oligo(d...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase delta catalytic subunit(Homo sapiens (Human))
Science University Of Tokyo

Curated by ChEMBL
LigandPNGBDBM50379294(CHEMBL2011647)
Affinity DataIC50:  9.64E+4nMAssay Description:Inhibition of human DNA polymerase delta assessed as inhibition of incorporation of dTTP into poly(dA)/oligo(dT)18 after 60 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase beta(Rattus norvegicus)
Science University Of Tokyo

Curated by ChEMBL
LigandPNGBDBM50379292(CHEMBL2011646)
Affinity DataIC50: >2.00E+5nMAssay Description:Inhibition of rat DNA polymerase beta expressed in Escherichia coli JMpbeta5 assessed as inhibition of incorporation of dTTP into poly(dA)/oligo(dT)1...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase lambda(Homo sapiens (Human))
Science University Of Tokyo

Curated by ChEMBL
LigandPNGBDBM50379292(CHEMBL2011646)
Affinity DataIC50: >2.00E+5nMAssay Description:Inhibition of human recombinant His-tagged DNA polymerase lambda expressed in Escherichia coli assessed as inhibition of incorporation of dTTP into p...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA-directed DNA/RNA polymerase mu(Homo sapiens (Human))
Science University Of Tokyo

Curated by ChEMBL
LigandPNGBDBM50379292(CHEMBL2011646)
Affinity DataIC50: >2.00E+5nMAssay Description:Inhibition of human His-tagged recombinant DNA polymerase mu expressed in Escherichia coli BL21 assessed as inhibition of incorporation of dTTP into ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolynucleotide kinase(Enterobacteria phage T4)
Science University Of Tokyo

Curated by ChEMBL
LigandPNGBDBM50379293(CHEMBL2011648)
Affinity DataIC50: >2.00E+5nMAssay Description:Inhibition of T4 arnN8l pseT 1 polynucleotide kinase assessed as inhibition of Salmon sperm DNA phosphorylation using [gamma32P]ATP by liquid scintil...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDeoxyribonuclease-1(Bos taurus)
Science University Of Tokyo

Curated by ChEMBL
LigandPNGBDBM50379293(CHEMBL2011648)
Affinity DataIC50: >2.00E+5nMAssay Description:Inhibition of bovine deoxyribonuclease 1 using [3H]-labelled DNA after 30 mins by agorose gel electrophoresisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA-directed DNA polymerase(Enterobacteria phage T4)
Science University Of Tokyo

Curated by ChEMBL
LigandPNGBDBM50379292(CHEMBL2011646)
Affinity DataIC50: >2.00E+5nMAssay Description:Inhibition of T4 bacteriophage DNA polymerase assessed as inhibition of incorporation of dTTP into poly(dA)/oligo(dT)18 after 60 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolynucleotide kinase(Enterobacteria phage T4)
Science University Of Tokyo

Curated by ChEMBL
LigandPNGBDBM50379292(CHEMBL2011646)
Affinity DataIC50: >2.00E+5nMAssay Description:Inhibition of T4 arnN8l pseT 1 polynucleotide kinase assessed as inhibition of Salmon sperm DNA phosphorylation using [gamma32P]ATP by liquid scintil...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDeoxyribonuclease-1(Bos taurus)
Science University Of Tokyo

Curated by ChEMBL
LigandPNGBDBM50379292(CHEMBL2011646)
Affinity DataIC50: >2.00E+5nMAssay Description:Inhibition of bovine deoxyribonuclease 1 using [3H]-labelled DNA after 30 mins by agorose gel electrophoresisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase beta(Rattus norvegicus)
Science University Of Tokyo

Curated by ChEMBL
LigandPNGBDBM50379294(CHEMBL2011647)
Affinity DataIC50: >2.00E+5nMAssay Description:Inhibition of rat DNA polymerase beta expressed in Escherichia coli JMpbeta5 assessed as inhibition of incorporation of dTTP into poly(dA)/oligo(dT)1...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA-directed DNA/RNA polymerase mu(Homo sapiens (Human))
Science University Of Tokyo

Curated by ChEMBL
LigandPNGBDBM50379294(CHEMBL2011647)
Affinity DataIC50: >2.00E+5nMAssay Description:Inhibition of human His-tagged recombinant DNA polymerase mu expressed in Escherichia coli BL21 assessed as inhibition of incorporation of dTTP into ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA nucleotidylexotransferase(Bos taurus)
Science University Of Tokyo

Curated by ChEMBL
LigandPNGBDBM50379294(CHEMBL2011647)
Affinity DataIC50: >2.00E+5nMAssay Description:Inhibition of calf TdT assessed as inhibition of incorporation of dTTP into oligo(dT)18(3'OH) after 60 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA-directed DNA polymerase(Enterobacteria phage T4)
Science University Of Tokyo

Curated by ChEMBL
LigandPNGBDBM50379294(CHEMBL2011647)
Affinity DataIC50: >2.00E+5nMAssay Description:Inhibition of T4 bacteriophage DNA polymerase assessed as inhibition of incorporation of dTTP into poly(dA)/oligo(dT)18 after 60 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolynucleotide kinase(Enterobacteria phage T4)
Science University Of Tokyo

Curated by ChEMBL
LigandPNGBDBM50379294(CHEMBL2011647)
Affinity DataIC50: >2.00E+5nMAssay Description:Inhibition of T4 arnN8l pseT 1 polynucleotide kinase assessed as inhibition of Salmon sperm DNA phosphorylation using [gamma32P]ATP by liquid scintil...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDeoxyribonuclease-1(Bos taurus)
Science University Of Tokyo

Curated by ChEMBL
LigandPNGBDBM50379294(CHEMBL2011647)
Affinity DataIC50: >2.00E+5nMAssay Description:Inhibition of bovine deoxyribonuclease 1 using [3H]-labelled DNA after 30 mins by agorose gel electrophoresisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase beta(Rattus norvegicus)
Science University Of Tokyo

Curated by ChEMBL
LigandPNGBDBM50379293(CHEMBL2011648)
Affinity DataIC50: >2.00E+5nMAssay Description:Inhibition of rat DNA polymerase beta expressed in Escherichia coli JMpbeta5 assessed as inhibition of incorporation of dTTP into poly(dA)/oligo(dT)1...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA nucleotidylexotransferase(Bos taurus)
Science University Of Tokyo

Curated by ChEMBL
LigandPNGBDBM50379293(CHEMBL2011648)
Affinity DataIC50: >2.00E+5nMAssay Description:Inhibition of calf TdT assessed as inhibition of incorporation of dTTP into oligo(dT)18(3'OH) after 60 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA-directed DNA polymerase(Enterobacteria phage T4)
Science University Of Tokyo

Curated by ChEMBL
LigandPNGBDBM50379293(CHEMBL2011648)
Affinity DataIC50: >2.00E+5nMAssay Description:Inhibition of T4 bacteriophage DNA polymerase assessed as inhibition of incorporation of dTTP into poly(dA)/oligo(dT)18 after 60 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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