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Found 143 with Last Name = 'hirsch' and Initial = 'ks'
Target3-oxo-5-alpha-steroid 4-dehydrogenase 1(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50368782(Bexlosteride | CHEMBL24955 | LY-191704)
Affinity DataIC50:  8nMAssay Description:In vitro inhibition of DHT production in Hs 68 (human genital fibroblast) cells.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 2(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50031890((10R,13S)-17-tert-Butylcarbamoyl-10,13-dimethyl-2,...)
Affinity DataIC50:  8nMAssay Description:Compound was tested for inhibition of Type II 5-alpha-reductase in Human Prostate Homogenates (HPH)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 2(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50334788((17beta-(N-tert-butylcarbamoyl)-4-aza-5alpha-andro...)
Affinity DataIC50:  10nMAssay Description:Compound was tested for inhibition of Type II 5-alpha-reductase in Human Prostate Homogenates (HPH).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

Target3-oxo-5-alpha-steroid 4-dehydrogenase 1(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50044878(4,8-Dimethyl-1,4,4a,5,6,10b-hexahydro-2H-benzo[f]q...)
Affinity DataIC50:  11nMAssay Description:In vitro inhibition of DHT production in Hs 68 (human genital fibroblast) cells.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 1(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50044879((4aR,10bR)-8-Chloro-4,10b-dimethyl-1,4,4a,5,6,10b-...)
Affinity DataIC50:  17nMAssay Description:In vitro inhibition of DHT production in Hs 68 (human genital fibroblast) cells.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 1(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50044881(8-Chloro-4-methyl-1,4,5,6-tetrahydro-2H-benzo[f]qu...)
Affinity DataIC50:  30nMAssay Description:In vitro inhibition of DHT production in Hs 68 (human genital fibroblast) cells.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 1(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50044891(8-Fluoro-4-methyl-1,4,4a,5,6,10b-hexahydro-2H-benz...)
Affinity DataIC50:  35nMAssay Description:In vitro inhibition of DHT production in Hs 68 (human genital fibroblast) cells.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 1(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50044885((4aS,10bR)-8-Chloro-4-methyl-1,4,4a,5,6,10b-hexahy...)
Affinity DataIC50:  41nMAssay Description:In vitro inhibition of DHT production in Hs 68 (human genital fibroblast) cells.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 1(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50044886(8-Chloro-1,4,4a,5,6,10b-hexahydro-2H-benzo[f]quino...)
Affinity DataIC50:  60nMAssay Description:In vitro inhibition of DHT production in Hs 68 (human genital fibroblast) cells.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 1(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50334788((17beta-(N-tert-butylcarbamoyl)-4-aza-5alpha-andro...)
Affinity DataIC50:  62nMAssay Description:Compound was tested for inhibition of Type I 5-alpha-reductase in Human genital skin (Hs68) foreskin fibroblast cells.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 1(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50044893(8-Chloro-4,10b-dimethyl-1,4,6,10b-tetrahydro-2H-be...)
Affinity DataIC50:  120nMAssay Description:In vitro inhibition of DHT production in Hs 68 (human genital fibroblast) cells.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 1(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50044892(8-Methoxy-4-methyl-1,4,4a,5,6,10b-hexahydro-2H-ben...)
Affinity DataIC50:  120nMAssay Description:In vitro inhibition of DHT production in Hs 68 (human genital fibroblast) cells.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 1(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50044877(8-Fluoro-4-methyl-1,4,4a,5,6,10b-hexahydro-2H-benz...)
Affinity DataIC50:  320nMAssay Description:In vitro inhibition of DHT production in Hs 68 (human genital fibroblast) cells.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 1(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50044890(8-Chloro-1,4,5,6-tetrahydro-2H-benzo[f]quinolin-3-...)
Affinity DataIC50:  460nMAssay Description:In vitro inhibition of DHT production in Hs 68 (human genital fibroblast) cells.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 1(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50044876((4aR,10bR)-4-Methyl-1,4,4a,5,6,10b-hexahydro-2H-be...)
Affinity DataIC50:  560nMAssay Description:In vitro inhibition of DHT production in Hs 68 (human genital fibroblast) cells.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 1(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50044880(8-Fluoro-1,4,5,6-tetrahydro-2H-benzo[f]quinolin-3-...)
Affinity DataIC50:  600nMAssay Description:In vitro inhibition of DHT production in Hs 68 (human genital fibroblast) cells.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 1(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50044888(8-Chloro-10b-methyl-1,4,4a,5,6,10b-hexahydro-2H-be...)
Affinity DataIC50:  1.80E+3nMAssay Description:In vitro inhibition of DHT production in Hs 68 (human genital fibroblast) cells.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 1(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50044894(9-Fluoro-1,4,5,6-tetrahydro-2H-benzo[f]quinolin-3-...)
Affinity DataIC50:  2.30E+3nMAssay Description:In vitro inhibition of DHT production in Hs 68 (human genital fibroblast) cells.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 1(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50044883(7-Fluoro-1,4,5,6-tetrahydro-2H-benzo[f]quinolin-3-...)
Affinity DataIC50:  3.20E+3nMAssay Description:In vitro inhibition of DHT production in Hs 68 (human genital fibroblast) cells.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 1(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50044887(8-Chloro-10b-methyl-1,4,6,10b-tetrahydro-2H-benzo[...)
Affinity DataIC50:  3.60E+3nMAssay Description:In vitro inhibition of DHT production in Hs 68 (human genital fibroblast) cells.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 1(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50044889(1,4,5,6-Tetrahydro-2H-benzo[f]quinolin-3-one | CHE...)
Affinity DataIC50:  6.50E+3nMAssay Description:In vitro inhibition of DHT production in Hs 68 (human genital fibroblast) cells.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 1(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50031890((10R,13S)-17-tert-Butylcarbamoyl-10,13-dimethyl-2,...)
Affinity DataIC50:  7.50E+3nMAssay Description:In vitro inhibition of DHT production in Hs 68 (human genital fibroblast) cells.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 2(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50368782(Bexlosteride | CHEMBL24955 | LY-191704)
Affinity DataIC50:  1.00E+4nMAssay Description:Compound was tested for inhibition of Type II 5-alpha-reductase in Human Prostate Homogenates (HPH)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 1(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50044884(10-Fluoro-1,4,5,6-tetrahydro-2H-benzo[f]quinolin-3...)
Affinity DataIC50:  1.00E+4nMAssay Description:In vitro inhibition of DHT production in Hs 68 (human genital fibroblast) cells.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Rattus norvegicus)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50014749(3-[Bis-(4-chloro-phenyl)-imidazol-1-yl-methyl]-1H-...)
Affinity DataEC50:  61nMAssay Description:In vitro Cytochrome P450 19A1 inhibition concentration to decrease aromatization of androstenedione in rat ovarian microsomeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Rattus norvegicus)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50014750(3-[Bis-(4-chloro-phenyl)-imidazol-1-yl-methyl]-pyr...)
Affinity DataEC50:  50nMAssay Description:In vitro Cytochrome P450 19A1 inhibition concentration to decrease aromatization of androstenedione in rat ovarian microsomeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Rattus norvegicus)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50014752(1-[Bis-(2-chloro-phenyl)-methyl]-1H-imidazole | CH...)
Affinity DataEC50:  76nMAssay Description:In vitro Cytochrome P450 19A1 inhibition concentration to decrease aromatization of androstenedione in rat ovarian microsomeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Rattus norvegicus)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50014751(3-[1,1-Bis-(4-chloro-phenyl)-ethyl]-pyridine | CHE...)
Affinity DataEC50:  145nMAssay Description:In vitro Cytochrome P450 19A1 inhibition concentration to decrease aromatization of androstenedione in rat ovarian microsomeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Rattus norvegicus)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50014753(3-[Chloro-bis-(4-chloro-phenyl)-methyl]-pyridine :...)
Affinity DataEC50:  200nMAssay Description:In vitro Cytochrome P450 19A1 inhibition concentration to decrease aromatization of androstenedione in rat ovarian microsomeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Rattus norvegicus)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50014754(1-[(4-Chloro-phenyl)-(4-methoxy-phenyl)-methyl]-1H...)
Affinity DataEC50:  8.40nMAssay Description:In vitro Cytochrome P450 19A1 inhibition concentration to decrease aromatization of androstenedione in rat ovarian microsomeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Rattus norvegicus)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50014755(1-[Bis-(4-methoxy-phenyl)-methyl]-1H-imidazole | C...)
Affinity DataEC50:  13nMAssay Description:In vitro Cytochrome P450 19A1 inhibition concentration to decrease aromatization of androstenedione in rat ovarian microsomeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Rattus norvegicus)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50014756(1-[Bis-(4-chloro-phenyl)-methyl]-1H-imidazole | CH...)
Affinity DataEC50:  42nMAssay Description:In vitro Cytochrome P450 19A1 inhibition concentration to decrease aromatization of androstenedione in rat ovarian microsomeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Rattus norvegicus)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50014760(Bis-(4-chloro-phenyl)-(1H-tetrazol-5-yl)-methanol ...)
Affinity DataEC50: >5.00E+3nMAssay Description:In vitro Cytochrome P450 19A1 inhibition concentration to decrease aromatization of androstenedione in rat ovarian microsomeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Rattus norvegicus)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50014758(Bis-(4-chloro-phenyl)-pyridin-3-yl-methanol | CHEM...)
Affinity DataEC50:  150nMAssay Description:In vitro Cytochrome P450 19A1 inhibition concentration to decrease aromatization of androstenedione in rat ovarian microsomeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Rattus norvegicus)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50014757((4-Chloro-phenyl)-(2-chloro-phenyl)-pyridin-3-yl-m...)
Affinity DataEC50: >2.00E+3nMAssay Description:In vitro Cytochrome P450 19A1 inhibition concentration to decrease aromatization of androstenedione in rat ovarian microsomeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Rattus norvegicus)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50014759(5-[Bis-(4-chloro-phenyl)-imidazol-1-yl-methyl]-thi...)
Affinity DataEC50:  17nMAssay Description:In vitro Cytochrome P450 19A1 inhibition concentration to decrease aromatization of androstenedione in rat ovarian microsomeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Rattus norvegicus)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50014761(Bis-(4-chloro-phenyl)-(2H-[1,2,3]triazol-4-yl)-met...)
Affinity DataEC50:  2.00E+3nMAssay Description:In vitro Cytochrome P450 19A1 inhibition concentration to decrease aromatization of androstenedione in rat ovarian microsomeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Rattus norvegicus)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50014762(Bis-(4-chloro-phenyl)-piperidin-3-yl-methanol | CH...)
Affinity DataEC50: >5.00E+3nMAssay Description:In vitro Cytochrome P450 19A1 inhibition concentration to decrease aromatization of androstenedione in rat ovarian microsomeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Rattus norvegicus)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50014766(Bis-(4-chloro-phenyl)-pyrimidin-4-yl-methanol | CH...)
Affinity DataEC50:  322nMAssay Description:In vitro Cytochrome P450 19A1 inhibition concentration to decrease aromatization of androstenedione in rat ovarian microsomeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Rattus norvegicus)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50014764(5-[Bis-(4-chloro-phenyl)-imidazol-1-yl-methyl]-1H-...)
Affinity DataEC50:  11nMAssay Description:In vitro Cytochrome P450 19A1 inhibition concentration to decrease aromatization of androstenedione in rat ovarian microsomeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Rattus norvegicus)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50014765(1-[Bis-(4-chloro-phenyl)-methyl]-piperidine | CHEM...)
Affinity DataEC50: >5.00E+3nMAssay Description:In vitro Cytochrome P450 19A1 inhibition concentration to decrease aromatization of androstenedione in rat ovarian microsomeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Rattus norvegicus)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50014767(2-[Bis-(4-chloro-phenyl)-methyl]-1H-pyrrole | CHEM...)
Affinity DataEC50: >5.00E+3nMAssay Description:In vitro Cytochrome P450 19A1 inhibition concentration to decrease aromatization of androstenedione in rat ovarian microsomeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Rattus norvegicus)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50014763(4-[Bis-(4-chloro-phenyl)-imidazol-1-yl-methyl]-1H-...)
Affinity DataEC50:  11nMAssay Description:In vitro Cytochrome P450 19A1 inhibition concentration to decrease aromatization of androstenedione in rat ovarian microsomeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Rattus norvegicus)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50014768((4-Chloro-2-methoxy-phenyl)-phenyl-pyridin-3-yl-me...)
Affinity DataEC50:  1.80E+3nMAssay Description:In vitro Cytochrome P450 19A1 inhibition concentration to decrease aromatization of androstenedione in rat ovarian microsomeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Rattus norvegicus)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50014769(1-[Bis-(4-chloro-phenyl)-methyl]-1H-pyrazole | CHE...)
Affinity DataEC50: >2.00E+3nMAssay Description:In vitro Cytochrome P450 19A1 inhibition concentration to decrease aromatization of androstenedione in rat ovarian microsomeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Rattus norvegicus)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50014771(Bis-(4-chloro-phenyl)-thiazol-5-yl-methanol | CHEM...)
Affinity DataEC50:  9.60nMAssay Description:In vitro Cytochrome P450 19A1 inhibition concentration to decrease aromatization of androstenedione in rat ovarian microsomeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Rattus norvegicus)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50014770(Bis-(4-chloro-phenyl)-(1H-imidazol-2-yl)-methanol ...)
Affinity DataEC50:  670nMAssay Description:In vitro Cytochrome P450 19A1 inhibition concentration to decrease aromatization of androstenedione in rat ovarian microsomeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Rattus norvegicus)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50014773(1-[Bis-(4-bromo-phenyl)-methyl]-1H-imidazole | CHE...)
Affinity DataEC50:  8.90nMAssay Description:In vitro Cytochrome P450 19A1 inhibition concentration to decrease aromatization of androstenedione in rat ovarian microsomeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Rattus norvegicus)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50014772(3-[Bis-(4-chloro-phenyl)-fluoro-methyl]-pyridine |...)
Affinity DataEC50:  200nMAssay Description:In vitro Cytochrome P450 19A1 inhibition concentration to decrease aromatization of androstenedione in rat ovarian microsomeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Rattus norvegicus)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50014775(5-[Bis-(4-chloro-phenyl)-imidazol-1-yl-methyl]-pyr...)
Affinity DataEC50:  26nMAssay Description:In vitro Cytochrome P450 19A1 inhibition concentration to decrease aromatization of androstenedione in rat ovarian microsomeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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