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Found 841 with Last Name = 'ho' and Initial = 'es'
TargetKappa-type opioid receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50000296(CHEMBL441765 | CHEMBL482811 | U-50488H | US1149237...)
Affinity DataKi:  0.5nMAssay Description:Displacement of [3H]-U69593 from kappa opioid receptor (unknown origin) assessed as inhibition constant incubated for 180 mins by competitive radioli...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetMu-type opioid receptor(Homo sapiens (Human))TBA
LigandPNGBDBM21015((2S)-2-{2-[(2R)-2-[(2S)-2-amino-3-(4-hydroxyphenyl...)
Affinity DataKi:  0.900nMAssay Description:Displacement of [3H]DAMGO from mu opioid receptor (unknown origin) assessed as inhibition constant incubated for 180 mins by competitive radioligand ...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetProteasome subunit beta type-5(Homo sapiens (Human))
University Of Gdansk

Curated by ChEMBL
LigandPNGBDBM50518157(CHEMBL4522493)
Affinity DataKi:  4.80nMAssay Description:Non-competitive mixed-type inhibition of SDS-activated human erythrocytes 20S proteasome chymotrypsin like activity using Suc-LLVY-AMC as substrate m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProteasome subunit beta type-5(Homo sapiens (Human))
University Of Gdansk

Curated by ChEMBL
LigandPNGBDBM50518161(CHEMBL4473076)
Affinity DataKi:  10nMAssay Description:Non-competitive mixed-type inhibition of SDS-activated human erythrocytes 20S proteasome chymotrypsin like activity using Suc-LLVY-AMC as substrate m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50613007(CHEMBL5290432)
Affinity DataKi:  12nMAssay Description:Displacement of [3H]DAMGO from mu opioid receptor (unknown origin) assessed as inhibition constant incubated for 180 mins by competitive radioligand ...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50613008(CHEMBL5288483)
Affinity DataKi:  49nMAssay Description:Displacement of [3H]-U69593 from kappa opioid receptor (unknown origin) assessed as inhibition constant incubated for 180 mins by competitive radioli...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetMu-type opioid receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50613008(CHEMBL5288483)
Affinity DataKi:  54nMAssay Description:Displacement of [3H]DAMGO from mu opioid receptor (unknown origin) assessed as inhibition constant incubated for 180 mins by competitive radioligand ...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetMu-type opioid receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50613009(CHEMBL5280172)
Affinity DataKi:  100nMAssay Description:Displacement of [3H]DAMGO from mu opioid receptor (unknown origin) assessed as inhibition constant incubated for 180 mins by competitive radioligand ...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetMu-type opioid receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50613011(CHEMBL5291340)
Affinity DataKi:  120nMAssay Description:Displacement of [3H]DAMGO from mu opioid receptor (unknown origin) assessed as inhibition constant incubated for 180 mins by competitive radioligand ...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetMu-type opioid receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50613010(CHEMBL5276128)
Affinity DataKi:  220nMAssay Description:Displacement of [3H]DAMGO from mu opioid receptor (unknown origin) assessed as inhibition constant incubated for 180 mins by competitive radioligand ...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetMu-type opioid receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50568638(CHEMBL4871880)
Affinity DataKi:  300nMAssay Description:Displacement of [3H]DAMGO from mu opioid receptor (unknown origin) assessed as inhibition constant incubated for 180 mins by competitive radioligand ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50613011(CHEMBL5291340)
Affinity DataKi:  330nMAssay Description:Displacement of [3H]-U69593 from kappa opioid receptor (unknown origin) assessed as inhibition constant incubated for 180 mins by competitive radioli...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetMu-type opioid receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50568639(CHEMBL4846243)
Affinity DataKi:  330nMAssay Description:Displacement of [3H]DAMGO from mu opioid receptor (unknown origin) assessed as inhibition constant incubated for 180 mins by competitive radioligand ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50613010(CHEMBL5276128)
Affinity DataKi:  580nMAssay Description:Displacement of [3H]-U69593 from kappa opioid receptor (unknown origin) assessed as inhibition constant incubated for 180 mins by competitive radioli...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50613007(CHEMBL5290432)
Affinity DataKi:  580nMAssay Description:Displacement of [3H]-U69593 from kappa opioid receptor (unknown origin) assessed as inhibition constant incubated for 180 mins by competitive radioli...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50613009(CHEMBL5280172)
Affinity DataKi:  1.17E+3nMAssay Description:Displacement of [3H]-U69593 from kappa opioid receptor (unknown origin) assessed as inhibition constant incubated for 180 mins by competitive radioli...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50568638(CHEMBL4871880)
Affinity DataKi:  1.67E+3nMAssay Description:Displacement of [3H]-U69593 from kappa opioid receptor (unknown origin) assessed as inhibition constant incubated for 180 mins by competitive radioli...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50568639(CHEMBL4846243)
Affinity DataKi:  2.25E+3nMAssay Description:Displacement of [3H]-U69593 from kappa opioid receptor (unknown origin) assessed as inhibition constant incubated for 180 mins by competitive radioli...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetSolute carrier family 22 member 6(Homo sapiens (Human))
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50206509(4-Dipropylsulfamoyl-benzoic acid | 4-Dipropylsulfa...)
Affinity DataKi:  4.30E+3nMAssay Description:TP_TRANSPORTER: inhibition of PAH uptake in OAT1-expressing CHO cellsMore data for this Ligand-Target Pair
TargetAcetylcholinesterase(Rattus norvegicus (rat))
Hong Kong University of Science and Technology

LigandPNGBDBM8963(CHEMBL32823 | Homodimeric Tacrine Analog 3b | N-[7...)
Affinity DataIC50:  1.5nMAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. Enzyme activity was determined by measuring the absorbance at...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetXanthine dehydrogenase/oxidase(Bos taurus (Bovine))
Lg Life Sciences

US Patent
LigandPNGBDBM121552(US8729273, 22)
Affinity DataIC50:  2.10nMAssay Description:Xanthine oxidase originated from bovine milk was incubated for 3 min with test compounds, and the initial velocity of uric acid formation was determi...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetXanthine dehydrogenase/oxidase(Bos taurus (Bovine))
Lg Life Sciences

US Patent
LigandPNGBDBM121532(US8729273, 2)
Affinity DataIC50:  2.80nMAssay Description:Xanthine oxidase originated from bovine milk was incubated for 3 min with test compounds, and the initial velocity of uric acid formation was determi...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetXanthine dehydrogenase/oxidase(Bos taurus (Bovine))
Lg Life Sciences

US Patent
LigandPNGBDBM121531(US8729273, 1)
Affinity DataIC50:  3.40nMAssay Description:Xanthine oxidase originated from bovine milk was incubated for 3 min with test compounds, and the initial velocity of uric acid formation was determi...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAcetylcholinesterase(Rattus norvegicus (rat))
Hong Kong University of Science and Technology

LigandPNGBDBM9047(Bis-THA inhibitor 5 | CHEMBL73800 | Hexylene-Linke...)
Affinity DataIC50:  3.80nMpH: 7.4 T: 2°CAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. Enzyme activity was determined by measuring the absorbance at...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetXanthine dehydrogenase/oxidase(Bos taurus (Bovine))
Lg Life Sciences

US Patent
LigandPNGBDBM121536(US8729273, 6)
Affinity DataIC50:  3.80nMAssay Description:Xanthine oxidase originated from bovine milk was incubated for 3 min with test compounds, and the initial velocity of uric acid formation was determi...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetLysine-specific demethylase 5B(Homo sapiens (Human))
University of Oxford

LigandPNGBDBM191598(2-(((2-((2-(dimethylamino)ethyl)(ethyl)amino)-2-ox...)
Affinity DataIC50:  4nMpH: 7.5Assay Description:The demethylase AlphaScreen assay was performed in 384-well plate format using white proxiplates (PerkinElmer), and transfer of compound (100 nl) was...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetXanthine dehydrogenase/oxidase(Bos taurus (Bovine))
Lg Life Sciences

US Patent
LigandPNGBDBM121534(US8729273, 4)
Affinity DataIC50:  4.5nMAssay Description:Xanthine oxidase originated from bovine milk was incubated for 3 min with test compounds, and the initial velocity of uric acid formation was determi...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetXanthine dehydrogenase/oxidase(Bos taurus (Bovine))
Lg Life Sciences

US Patent
LigandPNGBDBM121539(US8729273, 9)
Affinity DataIC50:  4.60nMAssay Description:Xanthine oxidase originated from bovine milk was incubated for 3 min with test compounds, and the initial velocity of uric acid formation was determi...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetXanthine dehydrogenase/oxidase(Bos taurus (Bovine))
Lg Life Sciences

US Patent
LigandPNGBDBM121547(US8729273, 17)
Affinity DataIC50:  4.60nMAssay Description:Xanthine oxidase originated from bovine milk was incubated for 3 min with test compounds, and the initial velocity of uric acid formation was determi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetXanthine dehydrogenase/oxidase(Bos taurus (Bovine))
Lg Life Sciences

US Patent
LigandPNGBDBM121550(US8729273, 20)
Affinity DataIC50:  4.70nMAssay Description:Xanthine oxidase originated from bovine milk was incubated for 3 min with test compounds, and the initial velocity of uric acid formation was determi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetXanthine dehydrogenase/oxidase(Bos taurus (Bovine))
Lg Life Sciences

US Patent
LigandPNGBDBM121543(US8729273, 13)
Affinity DataIC50:  4.80nMAssay Description:Xanthine oxidase originated from bovine milk was incubated for 3 min with test compounds, and the initial velocity of uric acid formation was determi...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetXanthine dehydrogenase/oxidase(Bos taurus (Bovine))
Lg Life Sciences

US Patent
LigandPNGBDBM121559(US8729273, 29)
Affinity DataIC50:  5nMAssay Description:Xanthine oxidase originated from bovine milk was incubated for 3 min with test compounds, and the initial velocity of uric acid formation was determi...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetXanthine dehydrogenase/oxidase(Bos taurus (Bovine))
Lg Life Sciences

US Patent
LigandPNGBDBM121535(US8729273, 5)
Affinity DataIC50:  5nMAssay Description:Xanthine oxidase originated from bovine milk was incubated for 3 min with test compounds, and the initial velocity of uric acid formation was determi...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetXanthine dehydrogenase/oxidase(Bos taurus (Bovine))
Lg Life Sciences

US Patent
LigandPNGBDBM121540(US8729273, 10)
Affinity DataIC50:  5.20nMAssay Description:Xanthine oxidase originated from bovine milk was incubated for 3 min with test compounds, and the initial velocity of uric acid formation was determi...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetXanthine dehydrogenase/oxidase(Bos taurus (Bovine))
Lg Life Sciences

US Patent
LigandPNGBDBM121541(US8729273, 11)
Affinity DataIC50:  5.40nMAssay Description:Xanthine oxidase originated from bovine milk was incubated for 3 min with test compounds, and the initial velocity of uric acid formation was determi...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetLysine-specific demethylase 5B(Homo sapiens (Human))
University of Oxford

LigandPNGBDBM191598(2-(((2-((2-(dimethylamino)ethyl)(ethyl)amino)-2-ox...)
Affinity DataIC50:  6nMAssay Description:We previously described 4-carboxy-2-triazolopyridines as selective KDM2 inhibitors (England et al., 2014). In efforts to find alternative scaffolds b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetXanthine dehydrogenase/oxidase(Bos taurus (Bovine))
Lg Life Sciences

US Patent
LigandPNGBDBM121533(US8729273, 3)
Affinity DataIC50:  6nMAssay Description:Xanthine oxidase originated from bovine milk was incubated for 3 min with test compounds, and the initial velocity of uric acid formation was determi...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetXanthine dehydrogenase/oxidase(Bos taurus (Bovine))
Lg Life Sciences

US Patent
LigandPNGBDBM121554(US8729273, 24)
Affinity DataIC50:  6.20nMAssay Description:Xanthine oxidase originated from bovine milk was incubated for 3 min with test compounds, and the initial velocity of uric acid formation was determi...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetXanthine dehydrogenase/oxidase(Bos taurus (Bovine))
Lg Life Sciences

US Patent
LigandPNGBDBM121551(US8729273, 21)
Affinity DataIC50:  6.20nMAssay Description:Xanthine oxidase originated from bovine milk was incubated for 3 min with test compounds, and the initial velocity of uric acid formation was determi...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetXanthine dehydrogenase/oxidase(Bos taurus (Bovine))
Lg Life Sciences

US Patent
LigandPNGBDBM121537(US8729273, 7)
Affinity DataIC50:  6.70nMAssay Description:Xanthine oxidase originated from bovine milk was incubated for 3 min with test compounds, and the initial velocity of uric acid formation was determi...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetXanthine dehydrogenase/oxidase(Bos taurus (Bovine))
Lg Life Sciences

US Patent
LigandPNGBDBM121538(US8729273, 8)
Affinity DataIC50:  6.90nMAssay Description:Xanthine oxidase originated from bovine milk was incubated for 3 min with test compounds, and the initial velocity of uric acid formation was determi...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetLysine-specific demethylase 5B(Homo sapiens (Human))
University of Oxford

LigandPNGBDBM191598(2-(((2-((2-(dimethylamino)ethyl)(ethyl)amino)-2-ox...)
Affinity DataIC50:  7nMAssay Description:We previously described 4-carboxy-2-triazolopyridines as selective KDM2 inhibitors (England et al., 2014). In efforts to find alternative scaffolds b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific demethylase 5A [1-801](Homo sapiens (Human))
University of Oxford

LigandPNGBDBM191598(2-(((2-((2-(dimethylamino)ethyl)(ethyl)amino)-2-ox...)
Affinity DataIC50:  7nMpH: 7.5Assay Description:The demethylase AlphaScreen assay was performed in 384-well plate format using white proxiplates (PerkinElmer), and transfer of compound (100 nl) was...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Rattus norvegicus (rat))
Hong Kong University of Science and Technology

LigandPNGBDBM8964(CHEMBL75274 | Homodimeric Tacrine Analog 3c | N-[8...)
Affinity DataIC50:  7.80nMAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. Enzyme activity was determined by measuring the absorbance at...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetXanthine dehydrogenase/oxidase(Bos taurus (Bovine))
Lg Life Sciences

US Patent
LigandPNGBDBM121555(US8729273, 25)
Affinity DataIC50:  8.5nMAssay Description:Xanthine oxidase originated from bovine milk was incubated for 3 min with test compounds, and the initial velocity of uric acid formation was determi...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAcetylcholinesterase(Rattus norvegicus (rat))
Hong Kong University of Science and Technology

LigandPNGBDBM9441(CHEMBL1082738 | Heterodimeric Tacrine-Based Inhibi...)
Affinity DataIC50:  8.80nMAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. Enzyme activity was determined by measuring the absorbance at...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetXanthine dehydrogenase/oxidase(Bos taurus (Bovine))
Lg Life Sciences

US Patent
LigandPNGBDBM121553(US8729273, 23)
Affinity DataIC50:  10nMAssay Description:Xanthine oxidase originated from bovine milk was incubated for 3 min with test compounds, and the initial velocity of uric acid formation was determi...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetLysine-specific demethylase 5A(Homo sapiens (Human))
University of Oxford

LigandPNGBDBM191598(2-(((2-((2-(dimethylamino)ethyl)(ethyl)amino)-2-ox...)
Affinity DataIC50:  10nMAssay Description:We previously described 4-carboxy-2-triazolopyridines as selective KDM2 inhibitors (England et al., 2014). In efforts to find alternative scaffolds b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Rattus norvegicus (rat))
Hong Kong University of Science and Technology

LigandPNGBDBM9440(CHEMBL1084775 | Heterodimeric Tacrine-Based Inhibi...)
Affinity DataIC50:  10.1nMAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. Enzyme activity was determined by measuring the absorbance at...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetXanthine dehydrogenase/oxidase(Bos taurus (Bovine))
Lg Life Sciences

US Patent
LigandPNGBDBM121557(US8729273, 27)
Affinity DataIC50:  11nMAssay Description:Xanthine oxidase originated from bovine milk was incubated for 3 min with test compounds, and the initial velocity of uric acid formation was determi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
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