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Found 403 with Last Name = 'hoffman' and Initial = 'jk'
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50084137(2-Methyl-6-(phenylethynyl)pyridine | 2-Methyl-6-ph...)
Affinity DataKi:  5.70nMAssay Description:Displacement of [3H]MPEP from mGlu5 receptor in rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50216746(3-fluoro-5-(2-methylquinolin-7-yl)benzonitrile | C...)
Affinity DataKi:  22nMAssay Description:Displacement of [3H]MPEP from mGlu5 receptor in rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50210964(3-(2-methylquinolin-7-yl)benzonitrile | CHEMBL2447...)
Affinity DataKi:  72nMAssay Description:Displacement of [3H]MPEP from mGlu5 receptor in rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50084137(2-Methyl-6-(phenylethynyl)pyridine | 2-Methyl-6-ph...)
Affinity DataIC50:  0.200nMAssay Description:Activity at rat mGlu5 receptor expressed in CHO cells assessed as inhibition of quisqualate-stimulated calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase receptor TYRO3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50425862(CHEMBL2312654)
Affinity DataIC50:  0.700nMAssay Description:Inhibition of Sky (unknown origin) by ELISA kinase assay in presence of 60 uM ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50216746(3-fluoro-5-(2-methylquinolin-7-yl)benzonitrile | C...)
Affinity DataIC50:  0.800nMAssay Description:Activity at rat mGlu5 receptor expressed in CHO cells assessed as inhibition of quisqualate-stimulated calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50216762(3-chloro-5-(2-methylquinolin-7-yl)benzonitrile | C...)
Affinity DataIC50:  1.40nMAssay Description:Activity at rat mGlu5 receptor expressed in CHO cells assessed as inhibition of quisqualate-stimulated calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50216758(3-methyl-5-(2-methylquinolin-7-yl)benzonitrile | C...)
Affinity DataIC50:  1.60nMAssay Description:Activity at rat mGlu5 receptor expressed in CHO cells assessed as inhibition of quisqualate-stimulated calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor delta(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50212698(2-(7-(2-(4-(trifluoromethyl)benzyloxy)-5-fluoroben...)
Affinity DataIC50:  1.70nMAssay Description:Displacement of [3H]2-(4-(3-(4-acetyl-3-hydroxy-2 propyl-phenoxy)propoxy)phenoxy)acetic acid from human PPARdelta after 30 mins by SPA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor delta(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50212693(2-(4-(4-(4-(trifluoromethyl)benzyloxy)benzylthio)-...)
Affinity DataIC50:  1.70nMAssay Description:Displacement of [3H]2-(4-(3-(4-acetyl-3-hydroxy-2 propyl-phenoxy)propoxy)phenoxy)acetic acid from human PPARdelta after 30 mins by SPA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50216749(3-(methoxymethyl)-5-(2-methylquinolin-7-yl)benzoni...)
Affinity DataIC50:  2nMAssay Description:Activity at rat mGlu5 receptor expressed in CHO cells assessed as inhibition of quisqualate-stimulated calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50216750(5-(2-methylquinolin-7-yl)isophthalonitrile | CHEMB...)
Affinity DataIC50:  2nMAssay Description:Activity at rat mGlu5 receptor expressed in CHO cells assessed as inhibition of quisqualate-stimulated calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase receptor TYRO3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50425864(CHEMBL2312649)
Affinity DataIC50:  2nMAssay Description:Inhibition of Sky (unknown origin) by ELISA kinase assay in presence of 60 uM ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50216761(3-methoxy-5-(2-methylquinolin-7-yl)benzonitrile | ...)
Affinity DataIC50:  2.40nMAssay Description:Activity at rat mGlu5 receptor expressed in CHO cells assessed as inhibition of quisqualate-stimulated calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase receptor TYRO3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50425870(CHEMBL2311550)
Affinity DataIC50:  3nMAssay Description:Inhibition of Sky (unknown origin) by ELISA kinase assay in presence of 60 uM ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor alpha(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50212693(2-(4-(4-(4-(trifluoromethyl)benzyloxy)benzylthio)-...)
Affinity DataIC50:  4.70nMAssay Description:Displacement of [3H]2-(4-(2-(3-(2,4-difluorophenyl)-1-heptylureido)ethyl)phenoxy)-2-methylbutanoic acid from human PPARalpha after 30 mins by SPA ass...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase receptor TYRO3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50425871(CHEMBL2312651)
Affinity DataIC50:  6nMAssay Description:Inhibition of Sky (unknown origin) by ELISA kinase assay in presence of 60 uM ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50210964(3-(2-methylquinolin-7-yl)benzonitrile | CHEMBL2447...)
Affinity DataIC50:  7.70nMAssay Description:Activity at rat mGlu5 receptor expressed in CHO cells assessed as inhibition of quisqualate-stimulated calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase receptor TYRO3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50425872(CHEMBL2312650)
Affinity DataIC50:  9nMAssay Description:Inhibition of Sky (unknown origin) by ELISA kinase assay in presence of 60 uM ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor delta(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50212708(2-(7-(4-(4-(trifluoromethyl)benzyloxy)benzylthio)-...)
Affinity DataIC50:  10nMAssay Description:Displacement of [3H]2-(4-(3-(4-acetyl-3-hydroxy-2 propyl-phenoxy)propoxy)phenoxy)acetic acid from human PPARdelta after 30 mins by SPA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase receptor TYRO3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50425863(CHEMBL2312652)
Affinity DataIC50:  10nMAssay Description:Inhibition of Sky (unknown origin) by ELISA kinase assay in presence of 60 uM ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor delta(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50212696(2-(7-(2-(4-(trifluoromethyl)benzyloxy)benzylthio)-...)
Affinity DataIC50:  10.4nMAssay Description:Displacement of [3H]2-(4-(3-(4-acetyl-3-hydroxy-2 propyl-phenoxy)propoxy)phenoxy)acetic acid from human PPARdelta after 30 mins by SPA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50216741(3-bromo-5-(2-methylquinolin-7-yl)benzonitrile | CH...)
Affinity DataIC50:  13nMAssay Description:Activity at rat mGlu5 receptor expressed in CHO cells assessed as inhibition of quisqualate-stimulated calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase receptor TYRO3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50425866(CHEMBL2312657)
Affinity DataIC50:  15nMAssay Description:Inhibition of Sky (unknown origin) by ELISA kinase assay in presence of 60 uM ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50216770(3-ethoxy-5-(2-methylquinolin-7-yl)benzonitrile | C...)
Affinity DataIC50:  17nMAssay Description:Activity at rat mGlu5 receptor expressed in CHO cells assessed as inhibition of quisqualate-stimulated calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase kinase 4(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50425862(CHEMBL2312654)
Affinity DataIC50:  18nMAssay Description:Inhibition of MAP4K4 (unknown origin) in presence of ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor delta(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50212707(2-(4-(4-(4-(trifluoromethyl)benzyloxy)benzylthio)-...)
Affinity DataIC50:  19nMAssay Description:Displacement of [3H]2-(4-(3-(4-acetyl-3-hydroxy-2 propyl-phenoxy)propoxy)phenoxy)acetic acid from human PPARdelta after 30 mins by SPA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor delta(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50212701(2-(4-(4-(4-(trifluoromethyl)benzyloxy)benzylthio)-...)
Affinity DataIC50:  20nMAssay Description:Displacement of [3H]2-(4-(3-(4-acetyl-3-hydroxy-2 propyl-phenoxy)propoxy)phenoxy)acetic acid from human PPARdelta after 30 mins by SPA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50216745(5-(2-methylquinolin-7-yl)nicotinonitrile | CHEMBL2...)
Affinity DataIC50:  23nMAssay Description:Activity at rat mGlu5 receptor expressed in CHO cells assessed as inhibition of quisqualate-stimulated calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase receptor TYRO3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50425842(CHEMBL2312292)
Affinity DataIC50:  35nMAssay Description:Inhibition of Sky (unknown origin) in presence of 60 uM ATP by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase receptor TYRO3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50425844(CHEMBL2312318)
Affinity DataIC50:  37nMAssay Description:Inhibition of Sky (unknown origin) in presence of 60 uM ATP by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase receptor TYRO3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50425873(CHEMBL2312648)
Affinity DataIC50:  41nMAssay Description:Inhibition of Sky (unknown origin) by ELISA kinase assay in presence of 60 uM ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase receptor TYRO3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50425868(CHEMBL2312655)
Affinity DataIC50:  44nMAssay Description:Inhibition of Sky (unknown origin) by ELISA kinase assay in presence of 60 uM ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase receptor UFO(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50425832(CHEMBL2312290)
Affinity DataIC50:  61nMAssay Description:Inhibition of Axl (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor delta(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50212694(2-(7-(2-(4-(trifluoromethyl)benzyloxy)-4-fluoroben...)
Affinity DataIC50:  62nMAssay Description:Displacement of [3H]2-(4-(3-(4-acetyl-3-hydroxy-2 propyl-phenoxy)propoxy)phenoxy)acetic acid from human PPARdelta after 30 mins by SPA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase receptor TYRO3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50425843(CHEMBL2312291)
Affinity DataIC50:  68nMAssay Description:Inhibition of Sky (unknown origin) in presence of 60 uM ATP by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor delta(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50212710(2-(7-(4-(2,5-dichlorobenzyloxy)benzylthio)-2,3-dih...)
Affinity DataIC50:  69nMAssay Description:Displacement of [3H]2-(4-(3-(4-acetyl-3-hydroxy-2 propyl-phenoxy)propoxy)phenoxy)acetic acid from human PPARdelta after 30 mins by SPA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase receptor TYRO3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50425829(CHEMBL2312304)
Affinity DataIC50:  70nMAssay Description:Inhibition of Sky (unknown origin) by ELISA kinase assay in presence of 60 uM ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase receptor TYRO3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50425829(CHEMBL2312304)
Affinity DataIC50:  70nMAssay Description:Inhibition of Sky (unknown origin) in presence of 60 uM ATP by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50216752(3-(ethylthio)-5-(2-methylquinolin-7-yl)benzonitril...)
Affinity DataIC50:  72nMAssay Description:Activity at rat mGlu5 receptor expressed in CHO cells assessed as inhibition of quisqualate-stimulated calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50216766(3-(2-methylquinolin-7-yl)-5-(trifluoromethoxy)benz...)
Affinity DataIC50:  75nMAssay Description:Activity at rat mGlu5 receptor expressed in CHO cells assessed as inhibition of quisqualate-stimulated calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor delta(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50212712(2-(7-(4-(4-(trifluoromethoxy)benzyloxy)benzylthio)...)
Affinity DataIC50:  76nMAssay Description:Displacement of [3H]2-(4-(3-(4-acetyl-3-hydroxy-2 propyl-phenoxy)propoxy)phenoxy)acetic acid from human PPARdelta after 30 mins by SPA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50216768(3-(2-methoxyethoxy)-5-(2-methylquinolin-7-yl)benzo...)
Affinity DataIC50:  82nMAssay Description:Activity at rat mGlu5 receptor expressed in CHO cells assessed as inhibition of quisqualate-stimulated calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor delta(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50212704(2-(7-(4-(4-chlorobenzyloxy)benzylthio)-2,3-dihydro...)
Affinity DataIC50:  89nMAssay Description:Displacement of [3H]2-(4-(3-(4-acetyl-3-hydroxy-2 propyl-phenoxy)propoxy)phenoxy)acetic acid from human PPARdelta after 30 mins by SPA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase receptor TYRO3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50425869(CHEMBL2312653)
Affinity DataIC50:  92nMAssay Description:Inhibition of Sky (unknown origin) by ELISA kinase assay in presence of 60 uM ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCasein kinase I isoform delta(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50425862(CHEMBL2312654)
Affinity DataIC50:  110nMAssay Description:Inhibition of CK1-delta (unknown origin) in presence of ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase receptor TYRO3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50425849(CHEMBL2312313)
Affinity DataIC50:  110nMAssay Description:Inhibition of Sky (unknown origin) in presence of 60 uM ATP by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor delta(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50212709(2-(7-(2-(4-(trifluoromethyl)benzyloxy)-3-fluoroben...)
Affinity DataIC50:  111nMAssay Description:Displacement of [3H]2-(4-(3-(4-acetyl-3-hydroxy-2 propyl-phenoxy)propoxy)phenoxy)acetic acid from human PPARdelta after 30 mins by SPA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase kinase 4(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50425864(CHEMBL2312649)
Affinity DataIC50:  120nMAssay Description:Inhibition of MAP4K4 (unknown origin) in presence of ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor delta(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50212697(2-(7-(4-(4-methoxybenzyloxy)benzylthio)-2,3-dihydr...)
Affinity DataIC50:  120nMAssay Description:Displacement of [3H]2-(4-(3-(4-acetyl-3-hydroxy-2 propyl-phenoxy)propoxy)phenoxy)acetic acid from human PPARdelta after 30 mins by SPA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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