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Found 38 with Last Name = 'hoffmann' and Initial = 'j'
TargetProgesterone receptor(Homo sapiens (Human))
Schering

Curated by ChEMBL
LigandPNGBDBM50409115(LONAPRISAN)
Affinity DataIC50:  0.00250nMAssay Description:In vitro antagonist potency in transactivation assay in neuroblastoma cells expressing human PR-B progesterone receptorMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Schering

Curated by ChEMBL
LigandPNGBDBM50409115(LONAPRISAN)
Affinity DataIC50:  0.00360nMAssay Description:In vitro antagonist potency in transactivation assay in neuroblastoma cells expressing human PR-A progesterone receptorMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Schering

Curated by ChEMBL
LigandPNGBDBM18627((10S,11S,14S,15S,17R)-17-[4-(dimethylamino)phenyl]...)
Affinity DataIC50:  0.0250nMAssay Description:In vitro antagonist potency in transactivation assay in neuroblastoma cells expressing human PR-B progesterone receptorMore data for this Ligand-Target Pair
TargetProgesterone receptor(Homo sapiens (Human))
Schering

Curated by ChEMBL
LigandPNGBDBM18627((10S,11S,14S,15S,17R)-17-[4-(dimethylamino)phenyl]...)
Affinity DataIC50:  0.0280nMAssay Description:In vitro antgonist potency in transactivation assay in neuroblastoma cells expressing human PR-A progesterone receptorMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Bayer Intellectual Property

US Patent
LigandPNGBDBM101232(US8524722, 70)
Affinity DataIC50:  1nMpH: 7.0 T: 2°CAssay Description:EGFR inhibitory activity of compounds of the present invention is quantified employing the EGFR HTRF assay.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Bayer Intellectual Property

US Patent
LigandPNGBDBM101243(US8524722, 143)
Affinity DataIC50:  1nMpH: 7.0 T: 2°CAssay Description:EGFR inhibitory activity of compounds of the present invention is quantified employing the EGFR HTRF assay.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Bayer Intellectual Property

US Patent
LigandPNGBDBM101241(US8524722, 134)
Affinity DataIC50:  1nMpH: 7.0 T: 2°CAssay Description:EGFR inhibitory activity of compounds of the present invention is quantified employing the EGFR HTRF assay.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Bayer Intellectual Property

US Patent
LigandPNGBDBM101240(US8524722, 123)
Affinity DataIC50:  1nMpH: 7.0 T: 2°CAssay Description:EGFR inhibitory activity of compounds of the present invention is quantified employing the EGFR HTRF assay.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Bayer Intellectual Property

US Patent
LigandPNGBDBM101237(US8524722, 90)
Affinity DataIC50:  1nMpH: 7.0 T: 2°CAssay Description:EGFR inhibitory activity of compounds of the present invention is quantified employing the EGFR HTRF assay.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Bayer Intellectual Property

US Patent
LigandPNGBDBM101239(US8524722, 119)
Affinity DataIC50:  1nMpH: 7.0 T: 2°CAssay Description:EGFR inhibitory activity of compounds of the present invention is quantified employing the EGFR HTRF assay.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Bayer Intellectual Property

US Patent
LigandPNGBDBM101230(US8524722, 14)
Affinity DataIC50:  1nMpH: 7.0 T: 2°CAssay Description:EGFR inhibitory activity of compounds of the present invention is quantified employing the EGFR HTRF assay.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Bayer Intellectual Property

US Patent
LigandPNGBDBM101228(US8524722, 12)
Affinity DataIC50:  1nMpH: 7.0 T: 2°CAssay Description:EGFR inhibitory activity of compounds of the present invention is quantified employing the EGFR HTRF assay.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Bayer Intellectual Property

US Patent
LigandPNGBDBM101226(US8524722, 5)
Affinity DataIC50:  1nMpH: 7.0 T: 2°CAssay Description:EGFR inhibitory activity of compounds of the present invention is quantified employing the EGFR HTRF assay.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Bayer Intellectual Property

US Patent
LigandPNGBDBM101231(US8524722, 31)
Affinity DataIC50:  1nMpH: 7.0 T: 2°CAssay Description:EGFR inhibitory activity of compounds of the present invention is quantified employing the EGFR HTRF assay.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Bayer Intellectual Property

US Patent
LigandPNGBDBM101227(US8524722, 10)
Affinity DataIC50:  1.10nMpH: 7.0 T: 2°CAssay Description:EGFR inhibitory activity of compounds of the present invention is quantified employing the EGFR HTRF assay.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Bayer Intellectual Property

US Patent
LigandPNGBDBM101234(US8524722, 84)
Affinity DataIC50:  1.40nMpH: 7.0 T: 2°CAssay Description:EGFR inhibitory activity of compounds of the present invention is quantified employing the EGFR HTRF assay.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Bayer Intellectual Property

US Patent
LigandPNGBDBM101229(US8524722, 13)
Affinity DataIC50:  2nMpH: 7.0 T: 2°CAssay Description:EGFR inhibitory activity of compounds of the present invention is quantified employing the EGFR HTRF assay.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGlucocorticoid receptor(MOUSE)
Schering

Curated by ChEMBL
LigandPNGBDBM18627((10S,11S,14S,15S,17R)-17-[4-(dimethylamino)phenyl]...)
Affinity DataIC50:  2.20nMAssay Description:In vitro antagonist potency in transactivation assay in NIH3T3 cells expressing glucocorticoid receptorMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Bayer Intellectual Property

US Patent
LigandPNGBDBM101244(US8524722, 148)
Affinity DataIC50:  4.30nMpH: 7.0 T: 2°CAssay Description:EGFR inhibitory activity of compounds of the present invention is quantified employing the EGFR HTRF assay.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Bayer Intellectual Property

US Patent
LigandPNGBDBM50330241((E)-4-(Dimethylamino)-1-(4-[(1R)-1-phenylethyl]ami...)
Affinity DataIC50:  4.60nMpH: 7.0 T: 2°CAssay Description:EGFR inhibitory activity of compounds of the present invention is quantified employing the EGFR HTRF assay.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Bayer Intellectual Property

US Patent
LigandPNGBDBM101235(US8524722, 86)
Affinity DataIC50:  5nMpH: 7.0 T: 2°CAssay Description:EGFR inhibitory activity of compounds of the present invention is quantified employing the EGFR HTRF assay.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Bayer Intellectual Property

US Patent
LigandPNGBDBM101245(US8524722, 151)
Affinity DataIC50:  6.40nMpH: 7.0 T: 2°CAssay Description:EGFR inhibitory activity of compounds of the present invention is quantified employing the EGFR HTRF assay.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Bayer Intellectual Property

US Patent
LigandPNGBDBM101242(US8524722, 139)
Affinity DataIC50:  9.20nMpH: 7.0 T: 2°CAssay Description:EGFR inhibitory activity of compounds of the present invention is quantified employing the EGFR HTRF assay.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Bayer Intellectual Property

US Patent
LigandPNGBDBM101238(US8524722, 95)
Affinity DataIC50:  10nMpH: 7.0 T: 2°CAssay Description:EGFR inhibitory activity of compounds of the present invention is quantified employing the EGFR HTRF assay.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAndrogen receptor(Homo sapiens (Human))
Schering

Curated by ChEMBL
LigandPNGBDBM18627((10S,11S,14S,15S,17R)-17-[4-(dimethylamino)phenyl]...)
Affinity DataIC50:  10nMAssay Description:In vitro antagonist potency in transactivation assay in CV-1 cells expressing androgen receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Bayer Intellectual Property

US Patent
LigandPNGBDBM101233(US8524722, 81)
Affinity DataIC50:  12nMpH: 7.0 T: 2°CAssay Description:EGFR inhibitory activity of compounds of the present invention is quantified employing the EGFR HTRF assay.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGlucocorticoid receptor(MOUSE)
Schering

Curated by ChEMBL
LigandPNGBDBM50409115(LONAPRISAN)
Affinity DataIC50:  16nMAssay Description:In vitro antagonist potency in transactivation assay in NIH3T3 cells expressing glucocorticoid receptorMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Bayer Intellectual Property

US Patent
LigandPNGBDBM101236(US8524722, 87)
Affinity DataIC50:  19nMpH: 7.0 T: 2°CAssay Description:EGFR inhibitory activity of compounds of the present invention is quantified employing the EGFR HTRF assay.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAndrogen receptor(Homo sapiens (Human))
Schering

Curated by ChEMBL
LigandPNGBDBM50409115(LONAPRISAN)
Affinity DataIC50:  54nMAssay Description:In vitro antagonist potency in transactivation assay in CV-1 cells expressing androgen receptorMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDNA polymerase beta(Homo sapiens (Human))
National Center For Scientific Research (Cnrs)-Pierre Fabre

Curated by ChEMBL
LigandPNGBDBM50241922(CHEMBL486991 | ddCTP SODIUM | sodium ((2S,5R)-5-(4...)
Affinity DataIC50:  1.30E+3nMAssay Description:Inhibition of human recombinant DNA polymerase beta assessed as fluorescein-12-dCTP incorporation by fluorimetryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase beta(Homo sapiens (Human))
National Center For Scientific Research (Cnrs)-Pierre Fabre

Curated by ChEMBL
LigandPNGBDBM50241929(CHEMBL520861 | Mahureone D)
Affinity DataIC50:  1.20E+4nMAssay Description:Inhibition of human recombinant DNA polymerase beta assessed as fluorescein-12-dCTP incorporation by fluorimetryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase beta(Homo sapiens (Human))
National Center For Scientific Research (Cnrs)-Pierre Fabre

Curated by ChEMBL
LigandPNGBDBM50241923(CHEMBL521208 | mahureone A)
Affinity DataIC50:  2.80E+4nMAssay Description:Inhibition of human recombinant DNA polymerase beta assessed as fluorescein-12-dCTP incorporation by fluorimetryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase beta(Homo sapiens (Human))
National Center For Scientific Research (Cnrs)-Pierre Fabre

Curated by ChEMBL
LigandPNGBDBM50241924(CHEMBL486797 | Mahureone B)
Affinity DataIC50:  7.30E+4nMAssay Description:Inhibition of human recombinant DNA polymerase beta assessed as fluorescein-12-dCTP incorporation by fluorimetryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase beta(Homo sapiens (Human))
National Center For Scientific Research (Cnrs)-Pierre Fabre

Curated by ChEMBL
LigandPNGBDBM50241930(CHEMBL486194 | Mahureone E)
Affinity DataIC50:  3.42E+5nMAssay Description:Inhibition of human recombinant DNA polymerase beta assessed as fluorescein-12-dCTP incorporation by fluorimetryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAryl hydrocarbon receptor(Homo sapiens (Human))
Max Planck Institute Of Molecular Physiology

Curated by ChEMBL
LigandPNGBDBM50602335(CHEMBL5186309)
Affinity DataEC50:  3.20nMAssay Description:Activation of AhR in human HepG2 cells assessed as induction of XRE-dependent reporter activity incubated for 4 hrs by Renilla/Firefly based dual-luc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetAryl hydrocarbon receptor(Mus musculus (Mouse))
Max Planck Institute Of Molecular Physiology

Curated by ChEMBL
LigandPNGBDBM50602335(CHEMBL5186309)
Affinity DataEC50:  0.0580nMAssay Description:Activation of AhR in mouse NIH3T3 cells assessed as induction of XRE-dependent reporter activity incubated for 4 hrs by Renilla/Firefly based dual-lu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetAryl hydrocarbon receptor(Homo sapiens (Human))
Max Planck Institute Of Molecular Physiology

Curated by ChEMBL
LigandPNGBDBM50602335(CHEMBL5186309)
Affinity DataEC50:  0.700nMAssay Description:Activation of AhR in human HaCaT cells assessed as induction of XRE-dependent reporter activity incubated for 4 hrs by Renilla/Firefly based dual-luc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetAryl hydrocarbon receptor(Mus musculus (Mouse))
Max Planck Institute Of Molecular Physiology

Curated by ChEMBL
LigandPNGBDBM50602335(CHEMBL5186309)
Affinity DataEC50:  71nMAssay Description:Activation of AhR in mouse Hepa1c1c7 cells assessed as induction of XRE-dependent reporter activity incubated for 4 hrs by Renilla/Firefly based dual...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed