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Found 53 with Last Name = 'holden' and Initial = 'kg'
TargetPhenylethanolamine N-methyltransferase(Homo sapiens (Human))
Smith Kline & French Laboratories

Curated by ChEMBL
LigandPNGBDBM13014(7,8-Dichloro-1,2,3,4-tetrahydro-isoquinoline; hydr...)
Affinity DataKi:  3nMAssay Description:Binding affinity for phenylethanolamine N-methyl-transferase was determined.More data for this Ligand-Target Pair
TargetAlpha-2A/Alpha-2B/Alpha-2C adrenergic receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM31046(3-[4,5-dihydro-1H-imidazol-2-ylmethyl-(4-methylphe...)
Affinity DataKi:  5nMAssay Description:Binding affinity against alpha-2-adrenergic receptor using 10 nM [3H]yohimbine in human platelet membranes from three separate experiments using 10 i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetAlpha-2A/Alpha-2B/Alpha-2C adrenergic receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50225305(CHEMBL433730)
Affinity DataKi:  6.10nMAssay Description:Binding affinity against alpha-2-adrenergic receptor using 10 nM [3H]yohimbine in human platelet membranes from three separate experiments using 10 i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhenylethanolamine N-methyltransferase(Bos taurus (bovine))
Smith Kline & French Laboratories

Curated by ChEMBL
LigandPNGBDBM50018237(6,7,8,9-Tetrahydro-3-thia-1,2,8-triaza-cyclopenta[...)
Affinity DataKi:  8nMAssay Description:Binding affinity for phenylethanolamine N-methyl-transferase was determined.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2A/Alpha-2B/Alpha-2C adrenergic receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM66983(6-chloranyl-3-methyl-1,2,4,5-tetrahydro-3-benzazep...)
Affinity DataKi:  17nMAssay Description:Binding affinity against alpha-2-adrenergic receptor using 10 nM [3H]yohimbine in human platelet membranes from three separate experiments using 10 i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenylate cyclase type 1(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50222264(CHEMBL552736)
Affinity DataKi:  22nMAssay Description:Inhibitory activity against Dopamine sensitive adenylate cyclase in ratsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenylate cyclase type 1(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50222266(CHEMBL369006)
Affinity DataKi:  33nMAssay Description:Inhibitory activity against Dopamine sensitive adenylate cyclase in ratsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2A/Alpha-2B/Alpha-2C adrenergic receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50225307(CHEMBL170660)
Affinity DataKi:  48nMAssay Description:Binding affinity against alpha-2-adrenergic receptor using 10 nM [3H]yohimbine in human platelet membranes from four to five separate experiments usi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenylate cyclase type 1(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50001888((chloropromazine) [3-(2-Chloro-phenothiazin-10-yl)...)
Affinity DataKi:  118nMAssay Description:Inhibitory activity against Dopamine sensitive adenylate cyclase in ratsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2A/Alpha-2B/Alpha-2C adrenergic receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50225306(CHEMBL355527)
Affinity DataKi:  232nMAssay Description:Binding affinity against alpha-2-adrenergic receptor using 10 nM [3H]yohimbine in preparations in human platelet membranes from three separate experi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenylate cyclase type 1(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50222265(CHEMBL541633)
Affinity DataKi:  250nMAssay Description:Inhibitory activity against Dopamine sensitive adenylate cyclase in ratsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2A/Alpha-2B/Alpha-2C adrenergic receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50225308(CHEMBL173581)
Affinity DataKi:  338nMAssay Description:Binding affinity against alpha-2-adrenergic receptor using 10 nM [3H]yohimbine in human platelet membranes from three separate experiments using 10 i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
The University Of Iowa

Curated by ChEMBL
LigandPNGBDBM50185615((2S,4aR,6aR,7R,9S,10aS,10bR)-methyl 9-acetoxy-6a,1...)
Affinity DataKi:  410nMAssay Description:Displacement of [125I]IOXY from human kappa opioid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
The University Of Iowa

Curated by ChEMBL
LigandPNGBDBM50185617((2S,4aR,6aR,7R,9S,10aS,10bR)-methyl 9-acetoxy-6a,1...)
Affinity DataKi:  840nMAssay Description:Displacement of [125I]IOXY from human kappa opioid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
The University Of Iowa

Curated by ChEMBL
LigandPNGBDBM50185616((2S,4aR,6aR,7R,9S,10aS,10bR)-methyl 9-acetoxy-2-(1...)
Affinity DataKi:  1.62E+3nMAssay Description:Displacement of [125I]IOXY from human kappa opioid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
The University Of Iowa

Curated by ChEMBL
LigandPNGBDBM50185614(CHEMBL377182 | methyl 2-((2S,4aR,6aR,7R,9S,10aS,10...)
Affinity DataKi:  8.53E+3nMAssay Description:Displacement of [125I]IOXY from human kappa opioid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
The University Of Iowa

Curated by ChEMBL
LigandPNGBDBM50185615((2S,4aR,6aR,7R,9S,10aS,10bR)-methyl 9-acetoxy-6a,1...)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [125I]IOXY from human mu opioid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
The University Of Iowa

Curated by ChEMBL
LigandPNGBDBM50185616((2S,4aR,6aR,7R,9S,10aS,10bR)-methyl 9-acetoxy-2-(1...)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [125I]IOXY from human mu opioid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
The University Of Iowa

Curated by ChEMBL
LigandPNGBDBM50185617((2S,4aR,6aR,7R,9S,10aS,10bR)-methyl 9-acetoxy-6a,1...)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [125I]IOXY from human mu opioid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
The University Of Iowa

Curated by ChEMBL
LigandPNGBDBM50185614(CHEMBL377182 | methyl 2-((2S,4aR,6aR,7R,9S,10aS,10...)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [125I]IOXY from human mu opioid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
The University Of Iowa

Curated by ChEMBL
LigandPNGBDBM50185615((2S,4aR,6aR,7R,9S,10aS,10bR)-methyl 9-acetoxy-6a,1...)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [125I]IOXY from human delta opioid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
The University Of Iowa

Curated by ChEMBL
LigandPNGBDBM50185614(CHEMBL377182 | methyl 2-((2S,4aR,6aR,7R,9S,10aS,10...)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [125I]IOXY from human delta opioid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
The University Of Iowa

Curated by ChEMBL
LigandPNGBDBM50185617((2S,4aR,6aR,7R,9S,10aS,10bR)-methyl 9-acetoxy-6a,1...)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [125I]IOXY from human delta opioid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
The University Of Iowa

Curated by ChEMBL
LigandPNGBDBM50185616((2S,4aR,6aR,7R,9S,10aS,10bR)-methyl 9-acetoxy-2-(1...)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [125I]IOXY from human delta opioid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenylate cyclase type 1(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50222264(CHEMBL552736)
Affinity DataIC50:  240nMAssay Description:Inhibitory concentration against Dopamine sensitive adenylate cyclase in ratsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenylate cyclase type 1(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50222266(CHEMBL369006)
Affinity DataIC50:  360nMAssay Description:Inhibitory concentration against Dopamine sensitive adenylate cyclase in ratsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50001888((chloropromazine) [3-(2-Chloro-phenothiazin-10-yl)...)
Affinity DataIC50:  1.30E+3nMAssay Description:Inhibitory concentration against Dopamine sensitive adenylate cyclase in ratsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenylate cyclase type 1(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50222265(CHEMBL541633)
Affinity DataIC50:  2.70E+3nMAssay Description:Inhibitory concentration against Dopamine sensitive adenylate cyclase in ratsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase transforming protein Abl(Abelson murine leukemia virus)
Smith Kline & French Laboratories

Curated by ChEMBL
LigandPNGBDBM50292494(CHEMBL485064 | {[(2R,3S,4R,5R)-5-(6-amino-9H-purin...)
Affinity DataIC50:  1.30E+4nMAssay Description:Inhibition of p60v-abl tyrosine kinase from Abelson murine leukemia virusMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase transforming protein Abl(Abelson murine leukemia virus)
Smith Kline & French Laboratories

Curated by ChEMBL
LigandPNGBDBM50292480(CHEMBL445698 | {[(2R,3S,4R,5R)-5-(6-amino-9H-purin...)
Affinity DataIC50:  1.60E+4nMAssay Description:Inhibition of p60v-abl tyrosine kinase from Abelson murine leukemia virusMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase transforming protein Abl(Abelson murine leukemia virus)
Smith Kline & French Laboratories

Curated by ChEMBL
LigandPNGBDBM50292496(((2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihyd...)
Affinity DataIC50:  1.90E+4nMAssay Description:Inhibition of p60-vabl tyrosine kinase isolated from Abelson murine leukemia virus (A-MuLV)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase transforming protein Abl(Abelson murine leukemia virus)
Smith Kline & French Laboratories

Curated by ChEMBL
LigandPNGBDBM50292482(({[({[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-...)
Affinity DataIC50:  2.50E+4nMAssay Description:Inhibition of p60v-abl tyrosine kinase from Abelson murine leukemia virusMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase transforming protein Abl(Abelson murine leukemia virus)
Smith Kline & French Laboratories

Curated by ChEMBL
LigandPNGBDBM50292483(CHEMBL520527 | {[(2R,3S,4R,5R)-5-(6-amino-9H-purin...)
Affinity DataIC50:  4.10E+4nMAssay Description:Inhibition of p60v-abl tyrosine kinase from Abelson murine leukemia virusMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase transforming protein Abl(Abelson murine leukemia virus)
Smith Kline & French Laboratories

Curated by ChEMBL
LigandPNGBDBM50292484(CHEMBL509039 | {[(2R,3S,4R,5R)-5-(6-amino-9H-purin...)
Affinity DataIC50:  4.40E+4nMAssay Description:Inhibition of p60v-abl tyrosine kinase from Abelson murine leukemia virusMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase transforming protein Abl(Abelson murine leukemia virus)
Smith Kline & French Laboratories

Curated by ChEMBL
LigandPNGBDBM50292486(((2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihyd...)
Affinity DataIC50:  4.50E+4nMAssay Description:Inhibition of p60-vabl tyrosine kinase isolated from Abelson murine leukemia virus (A-MuLV)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase transforming protein Abl(Abelson murine leukemia virus)
Smith Kline & French Laboratories

Curated by ChEMBL
LigandPNGBDBM50292487(((2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihyd...)
Affinity DataIC50:  5.00E+4nMAssay Description:Inhibition of p60-vabl tyrosine kinase isolated from Abelson murine leukemia virus (A-MuLV)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase transforming protein Abl(Abelson murine leukemia virus)
Smith Kline & French Laboratories

Curated by ChEMBL
LigandPNGBDBM50292489(((2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihyd...)
Affinity DataIC50:  5.60E+4nMAssay Description:Inhibition of p60-vabl tyrosine kinase isolated from Abelson murine leukemia virus (A-MuLV)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase transforming protein Abl(Abelson murine leukemia virus)
Smith Kline & French Laboratories

Curated by ChEMBL
LigandPNGBDBM50292490(((2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihyd...)
Affinity DataIC50:  6.30E+4nMAssay Description:Inhibition of p60-vabl tyrosine kinase isolated from Abelson murine leukemia virus (A-MuLV)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase transforming protein Abl(Abelson murine leukemia virus)
Smith Kline & French Laboratories

Curated by ChEMBL
LigandPNGBDBM50367766(CHEMBL608279)
Affinity DataIC50:  9.00E+4nMAssay Description:Inhibition of p60v-abl tyrosine kinase from Abelson murine leukemia virusMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase transforming protein Abl(Abelson murine leukemia virus)
Smith Kline & French Laboratories

Curated by ChEMBL
LigandPNGBDBM50292493(CHEMBL452973 | {[(2R,3S,4R,5R)-5-(6-amino-9H-purin...)
Affinity DataIC50:  1.10E+5nMAssay Description:Inhibition of p60v-abl tyrosine kinase from Abelson murine leukemia virusMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase transforming protein Abl(Abelson murine leukemia virus)
Smith Kline & French Laboratories

Curated by ChEMBL
LigandPNGBDBM50292491(((2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihyd...)
Affinity DataIC50:  1.20E+5nMAssay Description:Inhibition of p60-vabl tyrosine kinase isolated from Abelson murine leukemia virus (A-MuLV)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase transforming protein Abl(Abelson murine leukemia virus)
Smith Kline & French Laboratories

Curated by ChEMBL
LigandPNGBDBM50292492(((2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihyd...)
Affinity DataIC50:  1.20E+5nMAssay Description:Inhibition of p60-vabl tyrosine kinase isolated from Abelson murine leukemia virus (A-MuLV)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase transforming protein Abl(Abelson murine leukemia virus)
Smith Kline & French Laboratories

Curated by ChEMBL
LigandPNGBDBM50292498(CHEMBL486679 | {[(2R,3S,4R,5R)-5-(6-amino-9H-purin...)
Affinity DataIC50:  1.50E+5nMAssay Description:Inhibition of p60v-abl tyrosine kinase from Abelson murine leukemia virusMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase transforming protein Abl(Abelson murine leukemia virus)
Smith Kline & French Laboratories

Curated by ChEMBL
LigandPNGBDBM50292495(((2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihyd...)
Affinity DataIC50:  1.50E+5nMAssay Description:Inhibition of p60-vabl tyrosine kinase isolated from Abelson murine leukemia virus (A-MuLV)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase transforming protein Abl(Abelson murine leukemia virus)
Smith Kline & French Laboratories

Curated by ChEMBL
LigandPNGBDBM50292497(((2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihyd...)
Affinity DataIC50:  1.70E+5nMAssay Description:Inhibition of p60-vabl tyrosine kinase isolated from Abelson murine leukemia virus (A-MuLV)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
The University Of Iowa

Curated by ChEMBL
LigandPNGBDBM50189145((2S,4aR,6aR,7R,9R,10aS,10bR)-9-(Acetyloxy)-2-(3-fu...)
Affinity DataEC50:  6.5nMAssay Description:Agonist activity at human kappa opioid receptor-Galpha16 fusion protein expressed in CHO cells by calcium flux assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
The University Of Iowa

Curated by ChEMBL
LigandPNGBDBM50159165((2S,4aR,6aR,7R,9S,10aS,10bR)-9-(acetyloxy)-2-(fura...)
Affinity DataEC50:  0.810nMAssay Description:Agonist activity at human kappa opioid receptor-Galpha16 fusion protein expressed in CHO cells by calcium flux assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
The University Of Iowa

Curated by ChEMBL
LigandPNGBDBM50159165((2S,4aR,6aR,7R,9S,10aS,10bR)-9-(acetyloxy)-2-(fura...)
Affinity DataEC50:  45nMAssay Description:Agonist activity at human kappa opioid receptor expressed in CHO cells by [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
The University Of Iowa

Curated by ChEMBL
LigandPNGBDBM50189145((2S,4aR,6aR,7R,9R,10aS,10bR)-9-(Acetyloxy)-2-(3-fu...)
Affinity DataEC50:  385nMAssay Description:Agonist activity at human kappa opioid receptor expressed in CHO cells by [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
The University Of Iowa

Curated by ChEMBL
LigandPNGBDBM50159163((3S,4aR,4bS,6R,8R,8aR,10aR)-6-Acetoxy-3-furan-3-yl...)
Affinity DataEC50:  3.34nMAssay Description:Agonist activity at human kappa opioid receptor assessed as inhibition of Galpha16-induced calcium fluxMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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