Compile Data Set for Download or QSAR
maximum 50k data
Found 135 with Last Name = 'howe' and Initial = 't'
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical R&D

Curated by ChEMBL
LigandPNGBDBM50278540(1-(6-((diethylamino)methyl)-1,2,3,4-tetrahydronaph...)
Affinity DataKi:  3nMAssay Description:Antagonist activity at MCH1R (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical R&D

Curated by ChEMBL
LigandPNGBDBM50278501(2-(4-chlorophenyl)-5-(1-methyl-3-(2-(pyrrolidin-1-...)
Affinity DataKi:  3.16nMAssay Description:Antagonist activity at MCH1R (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical R&D

Curated by ChEMBL
LigandPNGBDBM50278539((R)-6-(6-(3-(methylamino)pyrrolidin-1-yl)pyridin-3...)
Affinity DataKi:  3.30nMAssay Description:Antagonist activity at MCH1R (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical R&D

Curated by ChEMBL
LigandPNGBDBM50278541(2-(4-chlorophenyl)-6-(3-methoxy-4-(2-(pyrrolidin-1...)
Affinity DataKi:  77nMAssay Description:Antagonist activity at MCH1R (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical R&D

Curated by ChEMBL
LigandPNGBDBM50211166(1-(3-methoxy-4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)-...)
Affinity DataKi:  164nMAssay Description:Antagonist activity at MCH1R (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50117734(8-{5-[4-(2-Hydroxy-ethyl)-piperidine-1-sulfonyl]-2...)
Affinity DataIC50:  3nMAssay Description:Inhibitory activity against human platelet Phosphodiesterase 5 (PDE5)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP04972/P11541/P16586/P22571/P23439/Q95142(Bos taurus)
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50117721(3-Isobutyl-1-methyl-8-[5-(piperazin-1-ylmethanesul...)
Affinity DataIC50:  3nMAssay Description:Inhibitory concentration against bovine retina phosphodiesterase 6 activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50117719(4-[3-(3-Isobutyl-1-methyl-2,6-dioxo-2,3,6,7-tetrah...)
Affinity DataIC50:  3.5nMAssay Description:Inhibitory activity against human platelet Phosphodiesterase 5 (PDE5)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50117711(8-{5-[4-(2-Hydroxy-ethyl)-piperazine-1-sulfonyl]-2...)
Affinity DataIC50:  3.5nMAssay Description:Inhibitory activity against human platelet Phosphodiesterase 5 (PDE5)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50117724(3-(3-Isobutyl-1-methyl-2,6-dioxo-2,3,6,7-tetrahydr...)
Affinity DataIC50:  5nMAssay Description:Inhibitory activity against human platelet Phosphodiesterase 5 (PDE5)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50117721(3-Isobutyl-1-methyl-8-[5-(piperazin-1-ylmethanesul...)
Affinity DataIC50:  5.5nMAssay Description:Inhibitory activity against human platelet Phosphodiesterase 5 (PDE5)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP04972/P11541/P16586/P22571/P23439/Q95142(Bos taurus)
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50117715(3-Isobutyl-1-methyl-8-[5-(4-methyl-piperazine-1-su...)
Affinity DataIC50:  6nMAssay Description:Inhibitory concentration against bovine retina phosphodiesterase 6 activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical R&D

Curated by ChEMBL
LigandPNGBDBM50278456(5-(5-((4-chlorobenzyloxy)methyl)-1,2,4-oxadiazol-3...)
Affinity DataIC50:  7nMAssay Description:Antagonist activity at MCH1R (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50117707(8-[2-Ethoxy-5-(4-methyl-piperazine-1-sulfonyl)-phe...)
Affinity DataIC50:  9nMAssay Description:Inhibitory activity against human platelet Phosphodiesterase 5 (PDE5)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50117715(3-Isobutyl-1-methyl-8-[5-(4-methyl-piperazine-1-su...)
Affinity DataIC50:  10nMAssay Description:Inhibitory activity against human platelet Phosphodiesterase 5 (PDE5)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50117715(3-Isobutyl-1-methyl-8-[5-(4-methyl-piperazine-1-su...)
Affinity DataIC50:  10nMAssay Description:Inhibitory activity against human platelet Phosphodiesterase 5 (PDE5)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50117714(CHEMBL90164 | N-(2-Dimethylamino-ethyl)-N-ethyl-3-...)
Affinity DataIC50:  11nMAssay Description:Inhibitory activity against human platelet Phosphodiesterase 5 (PDE5)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50117729(3-Isobutyl-8-{5-[4-(2-methoxy-ethyl)-piperazine-1-...)
Affinity DataIC50:  12nMAssay Description:Inhibitory activity against human platelet Phosphodiesterase 5 (PDE5)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP04972/P11541/P16586/P22571/P23439/Q95142(Bos taurus)
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50117719(4-[3-(3-Isobutyl-1-methyl-2,6-dioxo-2,3,6,7-tetrah...)
Affinity DataIC50:  14nMAssay Description:Inhibitory concentration against bovine retina phosphodiesterase 6 activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP04972/P11541/P16586/P22571/P23439/Q95142(Bos taurus)
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50117711(8-{5-[4-(2-Hydroxy-ethyl)-piperazine-1-sulfonyl]-2...)
Affinity DataIC50:  15nMAssay Description:Inhibitory concentration against bovine retina phosphodiesterase 6 activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50117732(3-Isobutyl-8-[2-isopropoxy-5-(4-methyl-piperazine-...)
Affinity DataIC50:  16nMAssay Description:Inhibitory activity against human platelet Phosphodiesterase 5 (PDE5)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50117722(CHEMBL89239 | N-(2-Dimethylamino-ethyl)-3-(3-isobu...)
Affinity DataIC50:  16nMAssay Description:Inhibitory activity against human platelet Phosphodiesterase 5 (PDE5)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP04972/P11541/P16586/P22571/P23439/Q95142(Bos taurus)
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50117724(3-(3-Isobutyl-1-methyl-2,6-dioxo-2,3,6,7-tetrahydr...)
Affinity DataIC50:  16nMAssay Description:Inhibitory concentration against bovine retina phosphodiesterase 6 activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP04972/P11541/P16586/P22571/P23439/Q95142(Bos taurus)
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50117734(8-{5-[4-(2-Hydroxy-ethyl)-piperidine-1-sulfonyl]-2...)
Affinity DataIC50:  17nMAssay Description:Inhibitory concentration against bovine retina phosphodiesterase 6 activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50117736(8-{2-Ethoxy-5-[4-(2-hydroxy-ethyl)-piperazine-1-su...)
Affinity DataIC50:  19nMAssay Description:Inhibitory activity against human platelet Phosphodiesterase 5 (PDE5)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical R&D

Curated by ChEMBL
LigandPNGBDBM50150715(4''-Fluoro-biphenyl-4-carboxylic acid (6-dimethyla...)
Affinity DataIC50:  19nMAssay Description:Antagonist activity at MCH1R (unknown origin) by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical R&D

Curated by ChEMBL
LigandPNGBDBM50278502((R)-7-(4-chlorophenyl)-3-(6-(3-(dimethylamino)pyrr...)
Affinity DataIC50:  20nMAssay Description:Antagonist activity at MCH1R (unknown origin) by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50117701(8-[2-Ethoxy-5-(4-methyl-piperazine-1-sulfonyl)-phe...)
Affinity DataIC50:  20nMAssay Description:Inhibitory activity against human platelet Phosphodiesterase 5 (PDE5)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50117718(8-{5-[4-(2-Dimethylamino-ethyl)-piperazine-1-sulfo...)
Affinity DataIC50:  24nMAssay Description:Inhibitory activity against human platelet Phosphodiesterase 5 (PDE5)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50117708(8-[2-Ethoxy-5-(piperazin-1-ylmethanesulfonyl)-phen...)
Affinity DataIC50:  26nMAssay Description:Inhibitory activity against human platelet Phosphodiesterase 5 (PDE5)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50117704(3-Cyclopropylmethyl-8-[2-ethoxy-5-(4-methyl-pipera...)
Affinity DataIC50:  28nMAssay Description:Inhibitory activity against human platelet Phosphodiesterase 5 (PDE5)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP04972/P11541/P16586/P22571/P23439/Q95142(Bos taurus)
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50117718(8-{5-[4-(2-Dimethylamino-ethyl)-piperazine-1-sulfo...)
Affinity DataIC50:  37nMAssay Description:Inhibitory concentration against bovine retina phosphodiesterase 6 activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50117712(8-[2-Ethoxy-5-(4-methyl-piperazine-1-sulfonyl)-phe...)
Affinity DataIC50:  59nMAssay Description:Inhibitory activity against human platelet Phosphodiesterase 5 (PDE5)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50117731(3-Isobutyl-1-methyl-8-(2-propoxy-phenyl)-3,7-dihyd...)
Affinity DataIC50:  60nMAssay Description:Inhibitory activity against human platelet Phosphodiesterase 5 (PDE5)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50117716(8-{5-[4-(2-Dimethylamino-ethyl)-piperazine-1-sulfo...)
Affinity DataIC50:  63nMAssay Description:Inhibitory activity against human platelet Phosphodiesterase 5 (PDE5)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 3(Homo sapiens (Human))
Novartis Institutes Of Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50355897(CHEMBL1910163)
Affinity DataIC50:  65nMAssay Description:Displacement of [125I]-eotaxin from CCR3 expressed in RBL-2H3 cells by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP04972/P11541/P16586/P22571/P23439/Q95142(Bos taurus)
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50117736(8-{2-Ethoxy-5-[4-(2-hydroxy-ethyl)-piperazine-1-su...)
Affinity DataIC50:  68nMAssay Description:Inhibitory concentration against bovine retina phosphodiesterase 6 activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP04972/P11541/P16586/P22571/P23439/Q95142(Bos taurus)
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50117723(8-(2-Isobutoxy-phenyl)-3-isobutyl-1-methyl-3,7-dih...)
Affinity DataIC50:  73nMAssay Description:Inhibitory concentration against bovine retina phosphodiesterase 6 activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50117725(8-(2-Ethoxy-phenyl)-3-isobutyl-1-methyl-3,7-dihydr...)
Affinity DataIC50:  73nMAssay Description:Inhibitory activity against human platelet Phosphodiesterase 5 (PDE5)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 3(Homo sapiens (Human))
Novartis Institutes Of Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50355899(CHEMBL1910165)
Affinity DataIC50:  76nMAssay Description:Displacement of [125I]-eotaxin from CCR3 expressed in RBL-2H3 cells by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50117717(3-Isobutyl-8-(2-isopropoxy-phenyl)-1-methyl-3,7-di...)
Affinity DataIC50:  77nMAssay Description:Inhibitory activity against human platelet Phosphodiesterase 5 (PDE5)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP04972/P11541/P16586/P22571/P23439/Q95142(Bos taurus)
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50117732(3-Isobutyl-8-[2-isopropoxy-5-(4-methyl-piperazine-...)
Affinity DataIC50:  77nMAssay Description:Inhibitory concentration against bovine retina phosphodiesterase 6 activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 3(Homo sapiens (Human))
Novartis Institutes Of Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50355898(CHEMBL1910164)
Affinity DataIC50:  82nMAssay Description:Displacement of [125I]-eotaxin from CCR3 expressed in RBL-2H3 cells by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP04972/P11541/P16586/P22571/P23439/Q95142(Bos taurus)
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50117707(8-[2-Ethoxy-5-(4-methyl-piperazine-1-sulfonyl)-phe...)
Affinity DataIC50:  83nMAssay Description:Inhibitory concentration against bovine retina phosphodiesterase 6 activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP04972/P11541/P16586/P22571/P23439/Q95142(Bos taurus)
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50117731(3-Isobutyl-1-methyl-8-(2-propoxy-phenyl)-3,7-dihyd...)
Affinity DataIC50:  87nMAssay Description:Inhibitory concentration against bovine retina phosphodiesterase 6 activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP04972/P11541/P16586/P22571/P23439/Q95142(Bos taurus)
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50117729(3-Isobutyl-8-{5-[4-(2-methoxy-ethyl)-piperazine-1-...)
Affinity DataIC50:  91nMAssay Description:Inhibitory concentration against bovine retina phosphodiesterase 6 activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50117728(3-(2,2-Dimethyl-propyl)-8-[2-ethoxy-5-(4-methyl-pi...)
Affinity DataIC50:  91nMAssay Description:Inhibitory activity against human platelet Phosphodiesterase 5 (PDE5)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50117705(8-[2-Isobutoxy-5-(4-methyl-piperazine-1-sulfonyl)-...)
Affinity DataIC50:  93nMAssay Description:Inhibitory activity against human platelet Phosphodiesterase 5 (PDE5)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical R&D

Curated by ChEMBL
LigandPNGBDBM50278457(1-(4-(2-(dimethylamino)ethoxy)phenyl)-3-(4-phenoxy...)
Affinity DataIC50: >100nMAssay Description:Antagonist activity at MCH1R (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50117703(3-But-3-enyl-8-[2-ethoxy-5-(4-methyl-piperazine-1-...)
Affinity DataIC50:  100nMAssay Description:Inhibitory activity against human platelet Phosphodiesterase 5 (PDE5)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Displayed 1 to 50 (of 135 total ) | Next | Last >>
Jump to: