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Found 64 with Last Name = 'huang' and Initial = 'hy'
TargetHistone deacetylase 6(Homo sapiens (Human))
Taipei Medical University

Curated by ChEMBL
LigandPNGBDBM50386657(CHEMBL2048746)
Affinity DataIC50:  1nMAssay Description:Inhibition of human recombinant HDAC6 after 30 mins by fluorometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 2(Homo sapiens (Human))
Taipei Medical University

Curated by ChEMBL
LigandPNGBDBM19149(CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...)
Affinity DataIC50:  1.70nMAssay Description:Inhibition of human recombinant HDAC2 after 30 mins by fluorometric assayMore data for this Ligand-Target Pair
TargetHistone deacetylase 2(Homo sapiens (Human))
Taipei Medical University

Curated by ChEMBL
LigandPNGBDBM50386659(CHEMBL2048750)
Affinity DataIC50:  2.30nMAssay Description:Inhibition of human recombinant HDAC2 after 30 mins by fluorometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
Taipei Medical University

Curated by ChEMBL
LigandPNGBDBM50386658(CHEMBL2048749)
Affinity DataIC50:  3.30nMAssay Description:Inhibition of human recombinant HDAC6 after 30 mins by fluorometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 2(Homo sapiens (Human))
Taipei Medical University

Curated by ChEMBL
LigandPNGBDBM50386657(CHEMBL2048746)
Affinity DataIC50:  4nMAssay Description:Inhibition of human recombinant HDAC2 after 30 mins by fluorometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
Taipei Medical University

Curated by ChEMBL
LigandPNGBDBM19149(CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...)
Affinity DataIC50:  5nMAssay Description:Inhibition of human recombinant HDAC6 after 30 mins by fluorometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetHistone deacetylase 1(Homo sapiens (Human))
Taipei Medical University

Curated by ChEMBL
LigandPNGBDBM19149(CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...)
Affinity DataIC50:  8.90nMAssay Description:Inhibition of human recombinant HDAC1 after 30 mins by fluorometric assayMore data for this Ligand-Target Pair
TargetHistone deacetylase 1(Homo sapiens (Human))
Taipei Medical University

Curated by ChEMBL
LigandPNGBDBM50386657(CHEMBL2048746)
Affinity DataIC50:  12.3nMAssay Description:Inhibition of human recombinant HDAC1 after 30 mins by fluorometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Taipei Medical University

Curated by ChEMBL
LigandPNGBDBM50386659(CHEMBL2048750)
Affinity DataIC50:  18.1nMAssay Description:Inhibition of human recombinant HDAC1 after 30 mins by fluorometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
Taipei Medical University

Curated by ChEMBL
LigandPNGBDBM50386661(CHEMBL2048752)
Affinity DataIC50:  18.3nMAssay Description:Inhibition of human recombinant HDAC6 after 30 mins by fluorometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Taipei Medical University

Curated by ChEMBL
LigandPNGBDBM50386660(CHEMBL2048751)
Affinity DataIC50:  33.2nMAssay Description:Inhibition of human recombinant HDAC1 after 30 mins by fluorometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
Taipei Medical University

Curated by ChEMBL
LigandPNGBDBM50386662(CHEMBL2048755)
Affinity DataIC50:  40.4nMAssay Description:Inhibition of human recombinant HDAC6 after 30 mins by fluorometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
Taipei Medical University

Curated by ChEMBL
LigandPNGBDBM50386659(CHEMBL2048750)
Affinity DataIC50:  45.4nMAssay Description:Inhibition of human recombinant HDAC6 after 30 mins by fluorometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
Taipei Medical University

Curated by ChEMBL
LigandPNGBDBM50386660(CHEMBL2048751)
Affinity DataIC50:  59.2nMAssay Description:Inhibition of human recombinant HDAC6 after 30 mins by fluorometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Taipei Medical University

Curated by ChEMBL
LigandPNGBDBM50386661(CHEMBL2048752)
Affinity DataIC50:  69.9nMAssay Description:Inhibition of human recombinant HDAC1 after 30 mins by fluorometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Taipei Medical University

Curated by ChEMBL
LigandPNGBDBM50386662(CHEMBL2048755)
Affinity DataIC50:  71.2nMAssay Description:Inhibition of human recombinant HDAC1 after 30 mins by fluorometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Taipei Medical University

Curated by ChEMBL
LigandPNGBDBM50386658(CHEMBL2048749)
Affinity DataIC50:  125nMAssay Description:Inhibition of human recombinant HDAC1 after 30 mins by fluorometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 2(Homo sapiens (Human))
Taipei Medical University

Curated by ChEMBL
LigandPNGBDBM50386661(CHEMBL2048752)
Affinity DataIC50:  189nMAssay Description:Inhibition of human recombinant HDAC2 after 30 mins by fluorometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 2(Homo sapiens (Human))
Taipei Medical University

Curated by ChEMBL
LigandPNGBDBM50386660(CHEMBL2048751)
Affinity DataIC50:  199nMAssay Description:Inhibition of human recombinant HDAC2 after 30 mins by fluorometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSignal transducer and activator of transcription 3(Homo sapiens (Human))
Taipei Medical University

Curated by ChEMBL
LigandPNGBDBM50109348(CHEMBL3600757)
Affinity DataIC50:  200nMAssay Description:Inhibition of STAT3 tyrosine phosphorylation in human A549 cells by sandwich ELISA methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Mus musculus (mouse))
Kaohsiung Medical University

Curated by ChEMBL
LigandPNGBDBM50359989(CHEMBL1927943)
Affinity DataIC50:  300nMAssay Description:Inhibition of iNOS-mediated NO production in LPS-stimulated mouse RAW264.7 cells after 24 hrs by Griess reagent methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSignal transducer and activator of transcription 3(Homo sapiens (Human))
Taipei Medical University

Curated by ChEMBL
LigandPNGBDBM50109349(CHEMBL3600853)
Affinity DataIC50:  320nMAssay Description:Inhibition of STAT3 tyrosine phosphorylation in human A549 cells by sandwich ELISA methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 2(Homo sapiens (Human))
Taipei Medical University

Curated by ChEMBL
LigandPNGBDBM50386658(CHEMBL2048749)
Affinity DataIC50:  362nMAssay Description:Inhibition of human recombinant HDAC2 after 30 mins by fluorometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 2(Homo sapiens (Human))
Taipei Medical University

Curated by ChEMBL
LigandPNGBDBM50386662(CHEMBL2048755)
Affinity DataIC50:  381nMAssay Description:Inhibition of human recombinant HDAC2 after 30 mins by fluorometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSignal transducer and activator of transcription 3(Homo sapiens (Human))
Taipei Medical University

Curated by ChEMBL
LigandPNGBDBM50109346(CHEMBL3600746)
Affinity DataIC50:  440nMAssay Description:Inhibition of STAT3 tyrosine phosphorylation in human A549 cells by sandwich ELISA methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Taipei Medical University

Curated by ChEMBL
LigandPNGBDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
Affinity DataIC50:  540nMAssay Description:Inhibition of recombinant human full-length C-terminal FLAG-His tagged HDAC1 (1 to 482 residues) expressed in Sf21 insect cells using RHK-K(Ac)-AMC a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 2(Homo sapiens (Human))
Taipei Medical University

Curated by ChEMBL
LigandPNGBDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
Affinity DataIC50:  610nMAssay Description:Inhibition of recombinant human C-terminal GST-tagged HDAC2 (1 to 488 residues) expressed in baculovirus infected insect cells using RHKKAc-AMC as su...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2)(Homo sapiens (Human))
Taipei Medical University

Curated by ChEMBL
LigandPNGBDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
Affinity DataIC50:  620nMAssay Description:Inhibition of human recombinant HDAC3/NCOR2 using RHKKAc-AMC as substrate measured after 60 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 1(Homo sapiens (Human))
National Chiayi University

Curated by ChEMBL
LigandPNGBDBM50418088(7-ETHYL-10-HYDROXY-CAMPTOTHECIN)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of human topoisomerase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Taipei Medical University

Curated by ChEMBL
LigandPNGBDBM50551593(CHEMBL4749443)
Affinity DataIC50:  1.07E+3nMAssay Description:Inhibition of recombinant human full-length C-terminal FLAG-His tagged HDAC1 (1 to 482 residues) expressed in Sf21 insect cells using RHK-K(Ac)-AMC a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Taipei Medical University

Curated by ChEMBL
LigandPNGBDBM50551596(CHEMBL4788251)
Affinity DataIC50:  1.19E+3nMAssay Description:Inhibition of recombinant human full-length C-terminal FLAG-His tagged HDAC1 (1 to 482 residues) expressed in Sf21 insect cells using RHK-K(Ac)-AMC a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 2(Homo sapiens (Human))
Taipei Medical University

Curated by ChEMBL
LigandPNGBDBM50551593(CHEMBL4749443)
Affinity DataIC50:  1.47E+3nMAssay Description:Inhibition of recombinant human C-terminal GST-tagged HDAC2 (1 to 488 residues) expressed in baculovirus infected insect cells using RHKKAc-AMC as su...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2)(Homo sapiens (Human))
Taipei Medical University

Curated by ChEMBL
LigandPNGBDBM50551595(CHEMBL4757836)
Affinity DataIC50:  1.75E+3nMAssay Description:Inhibition of human recombinant HDAC3/NCOR2 using RHKKAc-AMC as substrate measured after 60 mins by fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSimilar to alpha-tubulin isoform 1(Bos taurus)
Taipei Medical University

Curated by ChEMBL
LigandPNGBDBM50005480((-)-combretastatin | (Z)-3'-hydroxy-3,4,4',5-tetra...)
Affinity DataIC50:  1.90E+3nMAssay Description:Inhibition of bovine brain tubulin polymerization measured every 30 sec for 30 mins by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSimilar to alpha-tubulin isoform 1/Tubulin beta-2B chain(Bos taurus)
Taipei Medical University

Curated by ChEMBL
LigandPNGBDBM50014846((S)-N-(5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-...)
Affinity DataIC50:  1.90E+3nMAssay Description:Inhibition of bovine brain tubulin polymerization after 30 minsMore data for this Ligand-Target Pair
TargetHistone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2)(Homo sapiens (Human))
Taipei Medical University

Curated by ChEMBL
LigandPNGBDBM50551593(CHEMBL4749443)
Affinity DataIC50:  2.27E+3nMAssay Description:Inhibition of human recombinant HDAC3/NCOR2 using RHKKAc-AMC as substrate measured after 60 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2)(Homo sapiens (Human))
Taipei Medical University

Curated by ChEMBL
LigandPNGBDBM50551596(CHEMBL4788251)
Affinity DataIC50:  2.55E+3nMAssay Description:Inhibition of human recombinant HDAC3/NCOR2 using RHKKAc-AMC as substrate measured after 60 mins by fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSignal transducer and activator of transcription 3(Homo sapiens (Human))
Taipei Medical University

Curated by ChEMBL
LigandPNGBDBM50109347(CHEMBL3600755)
Affinity DataIC50:  2.75E+3nMAssay Description:Inhibition of STAT3 tyrosine phosphorylation in human A549 cells by sandwich ELISA methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSimilar to alpha-tubulin isoform 1(Bos taurus)
Taipei Medical University

Curated by ChEMBL
LigandPNGBDBM50496931(CHEMBL3234199)
Affinity DataIC50:  3.70E+3nMAssay Description:Inhibition of bovine brain tubulin polymerization measured every 30 sec for 30 mins by spectrophotometryMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSignal transducer and activator of transcription 3(Homo sapiens (Human))
Taipei Medical University

Curated by ChEMBL
LigandPNGBDBM50109345(CHEMBL3600744)
Affinity DataIC50:  4.02E+3nMAssay Description:Inhibition of STAT3 tyrosine phosphorylation in human A549 cells by sandwich ELISA methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSimilar to alpha-tubulin isoform 1(Bos taurus)
Taipei Medical University

Curated by ChEMBL
LigandPNGBDBM50496930(CHEMBL3234197)
Affinity DataIC50:  4.10E+3nMAssay Description:Inhibition of bovine brain tubulin polymerization measured every 30 sec for 30 mins by spectrophotometryMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSimilar to alpha-tubulin isoform 1/Tubulin beta-2B chain(Bos taurus)
Taipei Medical University

Curated by ChEMBL
LigandPNGBDBM50098801(CHEMBL3593873)
Affinity DataIC50:  4.20E+3nMAssay Description:Inhibition of bovine brain tubulin polymerization after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSimilar to alpha-tubulin isoform 1(Bos taurus)
Taipei Medical University

Curated by ChEMBL
LigandPNGBDBM50014846((S)-N-(5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-...)
Affinity DataIC50:  4.90E+3nMAssay Description:Inhibition of bovine brain tubulin polymerization measured every 30 sec for 30 mins by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSimilar to alpha-tubulin isoform 1/Tubulin beta-2B chain(Bos taurus)
Taipei Medical University

Curated by ChEMBL
LigandPNGBDBM50005480((-)-combretastatin | (Z)-3'-hydroxy-3,4,4',5-tetra...)
Affinity DataIC50:  4.90E+3nMAssay Description:Inhibition of bovine brain tubulin polymerization after 30 minsMore data for this Ligand-Target Pair
TargetSimilar to alpha-tubulin isoform 1/Tubulin beta-2B chain(Bos taurus)
Taipei Medical University

Curated by ChEMBL
LigandPNGBDBM50098800(CHEMBL3593872)
Affinity DataIC50:  4.90E+3nMAssay Description:Inhibition of bovine brain tubulin polymerization after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 2(Homo sapiens (Human))
Taipei Medical University

Curated by ChEMBL
LigandPNGBDBM50551594(CHEMBL4777009)
Affinity DataIC50:  4.95E+3nMAssay Description:Inhibition of recombinant human C-terminal GST-tagged HDAC2 (1 to 488 residues) expressed in baculovirus infected insect cells using RHKKAc-AMC as su...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Taipei Medical University

Curated by ChEMBL
LigandPNGBDBM50551594(CHEMBL4777009)
Affinity DataIC50:  5.45E+3nMAssay Description:Inhibition of recombinant human full-length C-terminal FLAG-His tagged HDAC1 (1 to 482 residues) expressed in Sf21 insect cells using RHK-K(Ac)-AMC a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 1(Homo sapiens (Human))
National Chiayi University

Curated by ChEMBL
LigandPNGBDBM50557284(CHEMBL4789468)
Affinity DataIC50:  7.20E+3nMAssay Description:Inhibition of human topoisomerase 1More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2)(Homo sapiens (Human))
Taipei Medical University

Curated by ChEMBL
LigandPNGBDBM50551594(CHEMBL4777009)
Affinity DataIC50:  7.92E+3nMAssay Description:Inhibition of human recombinant HDAC3/NCOR2 using RHKKAc-AMC as substrate measured after 60 mins by fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSimilar to alpha-tubulin isoform 1/Tubulin beta-2B chain(Bos taurus)
Taipei Medical University

Curated by ChEMBL
LigandPNGBDBM50098799(CHEMBL3593871)
Affinity DataIC50:  8.20E+3nMAssay Description:Inhibition of bovine brain tubulin polymerization after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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