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Found 87 with Last Name = 'igarashi' and Initial = 'y'
TargetMuscarinic acetylcholine receptor M3(Homo sapiens (Human))
Mitsubishi Pharma

Curated by ChEMBL
LigandPNGBDBM50241913(CHEMBL499519 | GNF-PF-5618 | nocardimicin B)
Affinity DataKi:  130nMAssay Description:Displacement of [3H]NMS from human muscarinic M3 receptor expressed in insect Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M4(Homo sapiens (Human))
Mitsubishi Pharma

Curated by ChEMBL
LigandPNGBDBM50241913(CHEMBL499519 | GNF-PF-5618 | nocardimicin B)
Affinity DataKi:  140nMAssay Description:Binding affinity to human muscarinic M4 receptor expressed in insect Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M3(Homo sapiens (Human))
Mitsubishi Pharma

Curated by ChEMBL
LigandPNGBDBM50241915(CHEMBL450986 | nocardimicin D)
Affinity DataKi:  230nMAssay Description:Displacement of [3H]NMS from human muscarinic M3 receptor expressed in insect Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1(Homo sapiens (Human))
Mitsubishi Pharma

Curated by ChEMBL
LigandPNGBDBM50241913(CHEMBL499519 | GNF-PF-5618 | nocardimicin B)
Affinity DataKi:  490nMAssay Description:Binding affinity to human muscarinic M1 receptor expressed in insect Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(Homo sapiens (Human))
Mitsubishi Pharma

Curated by ChEMBL
LigandPNGBDBM50241913(CHEMBL499519 | GNF-PF-5618 | nocardimicin B)
Affinity DataKi:  630nMAssay Description:Binding affinity to human muscarinic M2 receptor expressed in insect Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M3(Homo sapiens (Human))
Mitsubishi Pharma

Curated by ChEMBL
LigandPNGBDBM50241916(CHEMBL510340 | Noccardimicin E)
Affinity DataKi:  970nMAssay Description:Displacement of [3H]NMS from human muscarinic M3 receptor expressed in insect Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M3(Homo sapiens (Human))
Mitsubishi Pharma

Curated by ChEMBL
LigandPNGBDBM50241914(CHEMBL507760 | nocardimicin C)
Affinity DataKi:  1.00E+3nMAssay Description:Displacement of [3H]NMS from human muscarinic M3 receptor expressed in insect Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M5(Homo sapiens (Human))
Mitsubishi Pharma

Curated by ChEMBL
LigandPNGBDBM50241913(CHEMBL499519 | GNF-PF-5618 | nocardimicin B)
Affinity DataKi:  1.18E+3nMAssay Description:Binding affinity to human muscarinic M5 receptor expressed in insect Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M3(Homo sapiens (Human))
Mitsubishi Pharma

Curated by ChEMBL
LigandPNGBDBM50241912(CHEMBL505197 | Nocardimicin A)
Affinity DataKi:  1.25E+3nMAssay Description:Displacement of [3H]NMS from human muscarinic M3 receptor expressed in insect Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M3(Homo sapiens (Human))
Mitsubishi Pharma

Curated by ChEMBL
LigandPNGBDBM50241917(CHEMBL508807 | Nocardimicin F)
Affinity DataKi:  1.33E+3nMAssay Description:Displacement of [3H]NMS from human muscarinic M3 receptor expressed in insect Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTissue alpha-L-fucosidase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50104412((S)-5-Methyl-piperidine-3,4-diol | CHEMBL86305)
Affinity DataKi:  8.40E+3nMpH: 6.8Assay Description:Compound was evaluated for inhibition of alpha-fucosidase from bovine kidney(sigma F 5884) at pH 6.8More data for this Ligand-Target Pair
In DepthDetails Article
TargetMuscarinic acetylcholine receptor M3(Homo sapiens (Human))
Mitsubishi Pharma

Curated by ChEMBL
LigandPNGBDBM50259847(CHEMBL480464 | cremastrine)
Affinity DataIC50:  126nMAssay Description:Displacement of [3H]NMS from human cloned muscarinic M3 receptor expressed in insect Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAccessory gene regulator protein A(Staphylococcus aureus)
Toyama Prefectural University

Curated by ChEMBL
LigandPNGBDBM50499936(CHEMBL3742171)
Affinity DataIC50:  300nMAssay Description:Inhibition of agr-mediated quorum sensing in Staphylococcus aureus after 5 hrs by luminescence analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M4(Homo sapiens (Human))
Mitsubishi Pharma

Curated by ChEMBL
LigandPNGBDBM50259847(CHEMBL480464 | cremastrine)
Affinity DataIC50:  498nMAssay Description:Displacement of [3H]NMS from human cloned muscarinic M4 receptor expressed in insect Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1(Homo sapiens (Human))
Mitsubishi Pharma

Curated by ChEMBL
LigandPNGBDBM50259847(CHEMBL480464 | cremastrine)
Affinity DataIC50:  505nMAssay Description:Displacement of [3H]NMS from human cloned muscarinic M1 receptor expressed in insect Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M3(Homo sapiens (Human))
Mitsubishi Pharma

Curated by ChEMBL
LigandPNGBDBM50241913(CHEMBL499519 | GNF-PF-5618 | nocardimicin B)
Affinity DataIC50:  630nMAssay Description:Displacement of [3H]NMS from human muscarinic M3 receptor expressed in insect Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAccessory gene regulator protein A(Staphylococcus aureus)
Toyama Prefectural University

Curated by ChEMBL
LigandPNGBDBM50499937(CHEBI:67522 | Turnagainolide A)
Affinity DataIC50:  800nMAssay Description:Inhibition of agr-mediated quorum sensing in Staphylococcus aureus after 5 hrs by luminescence analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Toyama Prefectural University

Curated by ChEMBL
LigandPNGBDBM50481798(Amo-01 | BU-4664L | Diazepinomicin | ECO-4601 | TL...)
Affinity DataIC50:  994nMAssay Description:Inhibition of MMP2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylcholine:ceramide cholinephosphotransferase 2(Homo sapiens (Human))
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM50182491(CHEBI:69015 | Malabaricone C)
Affinity DataIC50:  1.00E+3nMAssay Description:Noncompetitive inhibition of SMS2 (unknown origin) stably expressed in mouse ZS cells using 5 to 50 uM C6-NBD-ceramide as substrate preincubated for ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylcholine:ceramide cholinephosphotransferase 2(Homo sapiens (Human))
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM50182487(Malabaricone A)
Affinity DataIC50:  1.00E+3nMAssay Description:Noncompetitive inhibition of SMS2 (unknown origin) stably expressed in mouse ZS cells using 5 to 50 uM C6-NBD-ceramide as substrate preincubated for ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylcholine:ceramide cholinephosphotransferase 2(Homo sapiens (Human))
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM50182486(MALABARICONE B)
Affinity DataIC50:  1.00E+3nMAssay Description:Noncompetitive inhibition of SMS2 (unknown origin) stably expressed in mouse ZS cells using 5 to 50 uM C6-NBD-ceramide as substrate preincubated for ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M4(Homo sapiens (Human))
Mitsubishi Pharma

Curated by ChEMBL
LigandPNGBDBM50241913(CHEMBL499519 | GNF-PF-5618 | nocardimicin B)
Affinity DataIC50:  1.04E+3nMAssay Description:Binding affinity to human muscarinic M4 receptor expressed in insect Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M3(Homo sapiens (Human))
Mitsubishi Pharma

Curated by ChEMBL
LigandPNGBDBM50241915(CHEMBL450986 | nocardimicin D)
Affinity DataIC50:  1.10E+3nMAssay Description:Displacement of [3H]NMS from human muscarinic M3 receptor expressed in insect Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M5(Homo sapiens (Human))
Mitsubishi Pharma

Curated by ChEMBL
LigandPNGBDBM50259847(CHEMBL480464 | cremastrine)
Affinity DataIC50:  1.22E+3nMAssay Description:Displacement of [3H]NMS from human cloned muscarinic M5 receptor expressed in insect Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Toyama Prefectural University

Curated by ChEMBL
LigandPNGBDBM50481798(Amo-01 | BU-4664L | Diazepinomicin | ECO-4601 | TL...)
Affinity DataIC50:  1.29E+3nMAssay Description:Inhibition of MMP9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylcholine:ceramide cholinephosphotransferase 2(Homo sapiens (Human))
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM50182491(CHEBI:69015 | Malabaricone C)
Affinity DataIC50:  1.50E+3nMAssay Description:Inhibition of SMS2 (unknown origin) stably expressed in mouse ZS cells using C6-NBD-ceramide as substrate preincubated for 30 mins followed by substr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylcholine:ceramide cholinephosphotransferase 2(Homo sapiens (Human))
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM50242188(6-(8'Z-pentadecenyl)-salicylicacid | 6-[8'(Z)-pent...)
Affinity DataIC50:  1.50E+3nMAssay Description:Inhibition of SMS2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylcholine:ceramide cholinephosphotransferase 1(Homo sapiens (Human))
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM50242188(6-(8'Z-pentadecenyl)-salicylicacid | 6-[8'(Z)-pent...)
Affinity DataIC50:  1.50E+3nMAssay Description:Inhibition of SMS1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M5(Homo sapiens (Human))
Mitsubishi Pharma

Curated by ChEMBL
LigandPNGBDBM50241913(CHEMBL499519 | GNF-PF-5618 | nocardimicin B)
Affinity DataIC50:  1.64E+3nMAssay Description:Binding affinity to human muscarinic M5 receptor expressed in insect Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(Homo sapiens (Human))
Mitsubishi Pharma

Curated by ChEMBL
LigandPNGBDBM50241913(CHEMBL499519 | GNF-PF-5618 | nocardimicin B)
Affinity DataIC50:  1.78E+3nMAssay Description:Binding affinity to human muscarinic M2 receptor expressed in insect Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylcholine:ceramide cholinephosphotransferase 1(Homo sapiens (Human))
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM50182491(CHEBI:69015 | Malabaricone C)
Affinity DataIC50:  2.00E+3nMAssay Description:Noncompetitive inhibition of SMS1 (unknown origin) stably expressed in mouse ZS cells using 5 to 50 uM C6-NBD-ceramide as substrate preincubated for ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylcholine:ceramide cholinephosphotransferase 1(Homo sapiens (Human))
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM50182487(Malabaricone A)
Affinity DataIC50:  2.00E+3nMAssay Description:Noncompetitive inhibition of SMS1 (unknown origin) stably expressed in mouse ZS cells using 5 to 50 uM C6-NBD-ceramide as substrate preincubated for ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylcholine:ceramide cholinephosphotransferase 1(Homo sapiens (Human))
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM50182486(MALABARICONE B)
Affinity DataIC50:  2.00E+3nMAssay Description:Noncompetitive inhibition of SMS1 (unknown origin) stably expressed in mouse ZS cells using 5 to 50 uM C6-NBD-ceramide as substrate preincubated for ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1(Homo sapiens (Human))
Mitsubishi Pharma

Curated by ChEMBL
LigandPNGBDBM50241913(CHEMBL499519 | GNF-PF-5618 | nocardimicin B)
Affinity DataIC50:  2.03E+3nMAssay Description:Binding affinity to human muscarinic M1 receptor expressed in insect Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAccessory gene regulator protein A(Staphylococcus aureus)
Toyama Prefectural University

Curated by ChEMBL
LigandPNGBDBM50499939(CHEMBL3740058)
Affinity DataIC50:  2.50E+3nMAssay Description:Inhibition of agr-mediated quorum sensing in Staphylococcus aureus after 5 hrs by luminescence analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPhosphatidylcholine:ceramide cholinephosphotransferase 2(Homo sapiens (Human))
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM50182486(MALABARICONE B)
Affinity DataIC50:  2.50E+3nMAssay Description:Inhibition of SMS2 (unknown origin) stably expressed in mouse ZS cells using C6-NBD-ceramide as substrate preincubated for 30 mins followed by substr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylcholine:ceramide cholinephosphotransferase 1(Homo sapiens (Human))
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM50182491(CHEBI:69015 | Malabaricone C)
Affinity DataIC50:  3.00E+3nMAssay Description:Inhibition of SMS1 (unknown origin) stably expressed in mouse ZS cells using C6-NBD-ceramide as substrate preincubated for 30 mins followed by substr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylcholine:ceramide cholinephosphotransferase 1(Homo sapiens (Human))
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM50182486(MALABARICONE B)
Affinity DataIC50:  3.50E+3nMAssay Description:Inhibition of SMS1 (unknown origin) stably expressed in mouse ZS cells using C6-NBD-ceramide as substrate preincubated for 30 mins followed by substr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylcholine:ceramide cholinephosphotransferase 1(Homo sapiens (Human))
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM50182487(Malabaricone A)
Affinity DataIC50:  4.00E+3nMAssay Description:Inhibition of SMS1 (unknown origin) stably expressed in mouse ZS cells using C6-NBD-ceramide as substrate preincubated for 30 mins followed by substr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylcholine:ceramide cholinephosphotransferase 2(Homo sapiens (Human))
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM50182487(Malabaricone A)
Affinity DataIC50:  4.00E+3nMAssay Description:Inhibition of SMS2 (unknown origin) stably expressed in mouse ZS cells using C6-NBD-ceramide as substrate preincubated for 30 mins followed by substr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAccessory gene regulator protein A(Staphylococcus aureus)
Toyama Prefectural University

Curated by ChEMBL
LigandPNGBDBM50499938(CHEMBL3741390)
Affinity DataIC50:  4.40E+3nMAssay Description:Inhibition of agr-mediated quorum sensing in Staphylococcus aureus after 5 hrs by luminescence analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPhosphatidylcholine:ceramide cholinephosphotransferase 2(Homo sapiens (Human))
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM50182488(CHEMBL3819036)
Affinity DataIC50:  4.50E+3nMAssay Description:Inhibition of SMS2 (unknown origin) stably expressed in mouse ZS cells using C6-NBD-ceramide as substrate preincubated for 30 mins followed by substr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M3(Homo sapiens (Human))
Mitsubishi Pharma

Curated by ChEMBL
LigandPNGBDBM50241916(CHEMBL510340 | Noccardimicin E)
Affinity DataIC50:  4.56E+3nMAssay Description:Displacement of [3H]NMS from human muscarinic M3 receptor expressed in insect Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M3(Homo sapiens (Human))
Mitsubishi Pharma

Curated by ChEMBL
LigandPNGBDBM50241914(CHEMBL507760 | nocardimicin C)
Affinity DataIC50:  4.70E+3nMAssay Description:Displacement of [3H]NMS from human muscarinic M3 receptor expressed in insect Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(Homo sapiens (Human))
Mitsubishi Pharma

Curated by ChEMBL
LigandPNGBDBM50259847(CHEMBL480464 | cremastrine)
Affinity DataIC50: >5.52E+3nMAssay Description:Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in insect Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M3(Homo sapiens (Human))
Mitsubishi Pharma

Curated by ChEMBL
LigandPNGBDBM50241912(CHEMBL505197 | Nocardimicin A)
Affinity DataIC50:  5.89E+3nMAssay Description:Displacement of [3H]NMS from human muscarinic M3 receptor expressed in insect Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylcholine:ceramide cholinephosphotransferase 1(Homo sapiens (Human))
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM50182488(CHEMBL3819036)
Affinity DataIC50:  6.00E+3nMAssay Description:Inhibition of SMS1 (unknown origin) stably expressed in mouse ZS cells using C6-NBD-ceramide as substrate preincubated for 30 mins followed by substr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M3(Homo sapiens (Human))
Mitsubishi Pharma

Curated by ChEMBL
LigandPNGBDBM50241917(CHEMBL508807 | Nocardimicin F)
Affinity DataIC50:  6.29E+3nMAssay Description:Displacement of [3H]NMS from human muscarinic M3 receptor expressed in insect Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50182798((3R,4r,5S)-piperidine-3,4,5-triol | 1,5-Dideoxy-1,...)
Affinity DataIC50:  8.80E+3nMAssay Description:Compound was evaluated for inhibition of beta-glucosidase from almonds(sigma G 4511).More data for this Ligand-Target Pair
In DepthDetails Article
TargetCholesterol side-chain cleavage enzyme, mitochondrial(Rattus norvegicus)
Kyushu University

Curated by ChEMBL
LigandPNGBDBM50483195(Ambuic Acid)
Affinity DataIC50:  1.00E+4nMAssay Description:Inhibition of gelatinase production in Enterococcus faecalis OG1RF after 5 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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