Found 75 with Last Name = 'ignatev' and Initial = 'a' TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
Leibniz-Forschungsinstitut F�R Molekulare Pharmakologie (Fmp)
Curated by ChEMBL
Leibniz-Forschungsinstitut F�R Molekulare Pharmakologie (Fmp)
Curated by ChEMBL
Affinity DataIC50: 6.30nMAssay Description:Inhibition of TNKS2 (unknown origin) transfected in human SW480 cells assessed as inhibition of Wnt3a-induced Wnt/beta-catenin signaling after 48 hrs...More data for this Ligand-Target Pair
3D Structure (crystal)TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
Leibniz-Forschungsinstitut F�R Molekulare Pharmakologie (Fmp)
Curated by ChEMBL
Leibniz-Forschungsinstitut F�R Molekulare Pharmakologie (Fmp)
Curated by ChEMBL
Affinity DataIC50: 9.80nMAssay Description:Inhibition of human TNKS2 (873 to 1162 residues) assessed as reduction in NAD+ consumption by fluorescence assayMore data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
Leibniz-Forschungsinstitut F�R Molekulare Pharmakologie (Fmp)
Curated by ChEMBL
Leibniz-Forschungsinstitut F�R Molekulare Pharmakologie (Fmp)
Curated by ChEMBL
Affinity DataIC50: 19nMAssay Description:Inhibition of TNKS2 (unknown origin) expressed in HEK293 cells assessed as inhibition of Wnt3a-induced Wnt/beta-catenin signaling after 24 hrs by luc...More data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase tankyrase-1(Homo sapiens (Human))
Leibniz-Forschungsinstitut F�R Molekulare Pharmakologie (Fmp)
Curated by ChEMBL
Leibniz-Forschungsinstitut F�R Molekulare Pharmakologie (Fmp)
Curated by ChEMBL
Affinity DataIC50: 29nMAssay Description:Inhibition of human TNKS2 (873 to 1162 residues) assessed as reduction in NAD+ consumption by fluorescence assayMore data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase tankyrase-1(Homo sapiens (Human))
Leibniz-Forschungsinstitut F�R Molekulare Pharmakologie (Fmp)
Curated by ChEMBL
Leibniz-Forschungsinstitut F�R Molekulare Pharmakologie (Fmp)
Curated by ChEMBL
Affinity DataIC50: 29nMAssay Description:Inhibition of recombinant human 6xHis-tagged TNKS1 ART domain (1030 to 1317 residues) expressed in Escherichia coli Rosetta2 (DE3) cells using NAD+ a...More data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
Leibniz-Forschungsinstitut F�R Molekulare Pharmakologie (Fmp)
Curated by ChEMBL
Leibniz-Forschungsinstitut F�R Molekulare Pharmakologie (Fmp)
Curated by ChEMBL
Affinity DataIC50: 37nMAssay Description:Inhibition of human TNKS2 by fluorescence analysisMore data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
Leibniz-Forschungsinstitut F�R Molekulare Pharmakologie (Fmp)
Curated by ChEMBL
Leibniz-Forschungsinstitut F�R Molekulare Pharmakologie (Fmp)
Curated by ChEMBL
Affinity DataIC50: 37nMAssay Description:Inhibition of human TNKS2 by fluorescence analysisMore data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
Leibniz-Forschungsinstitut F�R Molekulare Pharmakologie (Fmp)
Curated by ChEMBL
Leibniz-Forschungsinstitut F�R Molekulare Pharmakologie (Fmp)
Curated by ChEMBL
Affinity DataIC50: 70nMAssay Description:Inhibition of TNKS2 (unknown origin) transfected in human SW480 cells assessed as inhibition of Wnt3a-induced Wnt/beta-catenin signaling after 48 hrs...More data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
Leibniz-Forschungsinstitut F�R Molekulare Pharmakologie (Fmp)
Curated by ChEMBL
Leibniz-Forschungsinstitut F�R Molekulare Pharmakologie (Fmp)
Curated by ChEMBL
Affinity DataIC50: 120nMAssay Description:Inhibition of TNKS2 (unknown origin) transfected in human SW480 cells assessed as inhibition of Wnt3a-induced Wnt/beta-catenin signaling after 48 hrs...More data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
Leibniz-Forschungsinstitut F�R Molekulare Pharmakologie (Fmp)
Curated by ChEMBL
Leibniz-Forschungsinstitut F�R Molekulare Pharmakologie (Fmp)
Curated by ChEMBL
Affinity DataIC50: 200nMAssay Description:Inhibition of human TNKS2 (873 to 1162 residues) assessed as reduction in NAD+ consumption by fluorescence assayMore data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
Leibniz-Forschungsinstitut F�R Molekulare Pharmakologie (Fmp)
Curated by ChEMBL
Leibniz-Forschungsinstitut F�R Molekulare Pharmakologie (Fmp)
Curated by ChEMBL
Affinity DataIC50: 257nMAssay Description:Inhibition of human TNKS2 by fluorescence analysisMore data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
Leibniz-Forschungsinstitut F�R Molekulare Pharmakologie (Fmp)
Curated by ChEMBL
Leibniz-Forschungsinstitut F�R Molekulare Pharmakologie (Fmp)
Curated by ChEMBL
Affinity DataIC50: 260nMAssay Description:Inhibition of human TNKS2 by fluorescence analysisMore data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
Leibniz-Forschungsinstitut F�R Molekulare Pharmakologie (Fmp)
Curated by ChEMBL
Leibniz-Forschungsinstitut F�R Molekulare Pharmakologie (Fmp)
Curated by ChEMBL
Affinity DataIC50: 330nMAssay Description:Inhibition of human TNKS2 (873 to 1162 residues) assessed as reduction in NAD+ consumption by fluorescence assayMore data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
Leibniz-Forschungsinstitut F�R Molekulare Pharmakologie (Fmp)
Curated by ChEMBL
Leibniz-Forschungsinstitut F�R Molekulare Pharmakologie (Fmp)
Curated by ChEMBL
Affinity DataIC50: 340nMAssay Description:Inhibition of human TNKS2 (873 to 1162 residues) assessed as reduction in NAD+ consumption by fluorescence assayMore data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase tankyrase-1/tankyrase-2(Homo sapiens (Human))
University Of Oulu
Curated by ChEMBL
University Of Oulu
Curated by ChEMBL
Affinity DataIC50: 360nMAssay Description:Inhibition of tankyrase in WNT3a-stimulated human HEK293 cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase tankyrase-1/tankyrase-2(Homo sapiens (Human))
University Of Oulu
Curated by ChEMBL
University Of Oulu
Curated by ChEMBL
Affinity DataIC50: 380nMAssay Description:Inhibition of tankyrase in WNT3a-stimulated human HEK293 cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
Leibniz-Forschungsinstitut F�R Molekulare Pharmakologie (Fmp)
Curated by ChEMBL
Leibniz-Forschungsinstitut F�R Molekulare Pharmakologie (Fmp)
Curated by ChEMBL
Affinity DataIC50: 410nMAssay Description:Inhibition of TNKS2 (unknown origin) expressed in HEK293 cells assessed as inhibition of Wnt3a-induced Wnt/beta-catenin signaling after 24 hrs by luc...More data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
Leibniz-Forschungsinstitut F�R Molekulare Pharmakologie (Fmp)
Curated by ChEMBL
Leibniz-Forschungsinstitut F�R Molekulare Pharmakologie (Fmp)
Curated by ChEMBL
Affinity DataIC50: 430nMAssay Description:Inhibition of recombinant human 6xHis-tagged TNKS1 ART domain (1030 to 1317 residues) expressed in Escherichia coli Rosetta2 (DE3) cells using NAD+ a...More data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase tankyrase-1(Homo sapiens (Human))
Leibniz-Forschungsinstitut F�R Molekulare Pharmakologie (Fmp)
Curated by ChEMBL
Leibniz-Forschungsinstitut F�R Molekulare Pharmakologie (Fmp)
Curated by ChEMBL
Affinity DataIC50: 550nMAssay Description:Inhibition of human TNKS1 by fluorescence analysisMore data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase tankyrase-1(Homo sapiens (Human))
Leibniz-Forschungsinstitut F�R Molekulare Pharmakologie (Fmp)
Curated by ChEMBL
Leibniz-Forschungsinstitut F�R Molekulare Pharmakologie (Fmp)
Curated by ChEMBL
Affinity DataIC50: 550nMAssay Description:Inhibition of human TNKS1 by fluorescence analysisMore data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase tankyrase-1(Homo sapiens (Human))
Leibniz-Forschungsinstitut F�R Molekulare Pharmakologie (Fmp)
Curated by ChEMBL
Leibniz-Forschungsinstitut F�R Molekulare Pharmakologie (Fmp)
Curated by ChEMBL
Affinity DataIC50: 562nMAssay Description:Inhibition of human TNKS1 by fluorescence analysisMore data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase tankyrase-1(Homo sapiens (Human))
Leibniz-Forschungsinstitut F�R Molekulare Pharmakologie (Fmp)
Curated by ChEMBL
Leibniz-Forschungsinstitut F�R Molekulare Pharmakologie (Fmp)
Curated by ChEMBL
Affinity DataIC50: 570nMAssay Description:Inhibition of human TNKS1 by fluorescence analysisMore data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase tankyrase-1/tankyrase-2(Homo sapiens (Human))
University Of Oulu
Curated by ChEMBL
University Of Oulu
Curated by ChEMBL
Affinity DataIC50: 690nMAssay Description:Inhibition of tankyrase in WNT3a-stimulated human HEK293 cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase tankyrase-1(Homo sapiens (Human))
Leibniz-Forschungsinstitut F�R Molekulare Pharmakologie (Fmp)
Curated by ChEMBL
Leibniz-Forschungsinstitut F�R Molekulare Pharmakologie (Fmp)
Curated by ChEMBL
Affinity DataIC50: 690nMAssay Description:Inhibition of human TNKS1 by fluorescence analysisMore data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase tankyrase-1(Homo sapiens (Human))
Leibniz-Forschungsinstitut F�R Molekulare Pharmakologie (Fmp)
Curated by ChEMBL
Leibniz-Forschungsinstitut F�R Molekulare Pharmakologie (Fmp)
Curated by ChEMBL
Affinity DataIC50: 692nMAssay Description:Inhibition of human TNKS1 by fluorescence analysisMore data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase tankyrase-1/tankyrase-2(Homo sapiens (Human))
University Of Oulu
Curated by ChEMBL
University Of Oulu
Curated by ChEMBL
Affinity DataIC50: 790nMAssay Description:Inhibition of tankyrase in WNT3a-stimulated human HEK293 cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
Leibniz-Forschungsinstitut F�R Molekulare Pharmakologie (Fmp)
Curated by ChEMBL
Leibniz-Forschungsinstitut F�R Molekulare Pharmakologie (Fmp)
Curated by ChEMBL
Affinity DataIC50: 1.06E+3nMAssay Description:Inhibition of TNKS2 (unknown origin) expressed in HEK293 cells assessed as inhibition of Wnt3a-induced Wnt/beta-catenin signaling after 24 hrs by luc...More data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase tankyrase-1(Homo sapiens (Human))
Leibniz-Forschungsinstitut F�R Molekulare Pharmakologie (Fmp)
Curated by ChEMBL
Leibniz-Forschungsinstitut F�R Molekulare Pharmakologie (Fmp)
Curated by ChEMBL
Affinity DataIC50: 1.12E+3nMAssay Description:Inhibition of human TNKS1 by fluorescence analysisMore data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase tankyrase-1(Homo sapiens (Human))
Leibniz-Forschungsinstitut F�R Molekulare Pharmakologie (Fmp)
Curated by ChEMBL
Leibniz-Forschungsinstitut F�R Molekulare Pharmakologie (Fmp)
Curated by ChEMBL
Affinity DataIC50: 1.13E+3nMAssay Description:Inhibition of human TNKS1 by fluorescence analysisMore data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase tankyrase-1/tankyrase-2(Homo sapiens (Human))
University Of Oulu
Curated by ChEMBL
University Of Oulu
Curated by ChEMBL
Affinity DataIC50: 1.23E+3nMAssay Description:Inhibition of tankyrase in WNT3a-stimulated human HEK293 cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
TargetCytochrome P450 3A4(Homo sapiens (Human))
Leibniz-Forschungsinstitut F�R Molekulare Pharmakologie (Fmp)
Curated by ChEMBL
Leibniz-Forschungsinstitut F�R Molekulare Pharmakologie (Fmp)
Curated by ChEMBL
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using midazolam as substrate after 30 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
Leibniz-Forschungsinstitut F�R Molekulare Pharmakologie (Fmp)
Curated by ChEMBL
Leibniz-Forschungsinstitut F�R Molekulare Pharmakologie (Fmp)
Curated by ChEMBL
Affinity DataIC50: 1.49E+3nMAssay Description:Inhibition of TNKS2 (unknown origin) transfected in human SW480 cells assessed as inhibition of Wnt3a-induced Wnt/beta-catenin signaling after 48 hrs...More data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase tankyrase-1(Homo sapiens (Human))
Leibniz-Forschungsinstitut F�R Molekulare Pharmakologie (Fmp)
Curated by ChEMBL
Leibniz-Forschungsinstitut F�R Molekulare Pharmakologie (Fmp)
Curated by ChEMBL
Affinity DataIC50: 1.80E+3nMAssay Description:Inhibition of human TNKS1 by fluorescence analysisMore data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
Leibniz-Forschungsinstitut F�R Molekulare Pharmakologie (Fmp)
Curated by ChEMBL
Leibniz-Forschungsinstitut F�R Molekulare Pharmakologie (Fmp)
Curated by ChEMBL
Affinity DataIC50: 1.80E+3nMAssay Description:Inhibition of TNKS2 (unknown origin) expressed in HEK293 cells assessed as inhibition of Wnt3a-induced Wnt/beta-catenin signaling after 24 hrs by luc...More data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase tankyrase-1(Homo sapiens (Human))
Leibniz-Forschungsinstitut F�R Molekulare Pharmakologie (Fmp)
Curated by ChEMBL
Leibniz-Forschungsinstitut F�R Molekulare Pharmakologie (Fmp)
Curated by ChEMBL
Affinity DataIC50: 1.82E+3nMAssay Description:Inhibition of human TNKS1 by fluorescence analysisMore data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase tankyrase-1/tankyrase-2(Homo sapiens (Human))
University Of Oulu
Curated by ChEMBL
University Of Oulu
Curated by ChEMBL
Affinity DataIC50: 1.91E+3nMAssay Description:Inhibition of tankyrase in WNT3a-stimulated human HEK293 cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
Leibniz-Forschungsinstitut F�R Molekulare Pharmakologie (Fmp)
Curated by ChEMBL
Leibniz-Forschungsinstitut F�R Molekulare Pharmakologie (Fmp)
Curated by ChEMBL
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of human TNKS2 by fluorescence analysisMore data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
Leibniz-Forschungsinstitut F�R Molekulare Pharmakologie (Fmp)
Curated by ChEMBL
Leibniz-Forschungsinstitut F�R Molekulare Pharmakologie (Fmp)
Curated by ChEMBL
Affinity DataIC50: 2.01E+3nMAssay Description:Inhibition of human TNKS2 by fluorescence analysisMore data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
Leibniz-Forschungsinstitut F�R Molekulare Pharmakologie (Fmp)
Curated by ChEMBL
Leibniz-Forschungsinstitut F�R Molekulare Pharmakologie (Fmp)
Curated by ChEMBL
Affinity DataIC50: 2.14E+3nMAssay Description:Inhibition of human TNKS2 by fluorescence analysisMore data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
Leibniz-Forschungsinstitut F�R Molekulare Pharmakologie (Fmp)
Curated by ChEMBL
Leibniz-Forschungsinstitut F�R Molekulare Pharmakologie (Fmp)
Curated by ChEMBL
Affinity DataIC50: 2.15E+3nMAssay Description:Inhibition of human TNKS2 by fluorescence analysisMore data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
Leibniz-Forschungsinstitut F�R Molekulare Pharmakologie (Fmp)
Curated by ChEMBL
Leibniz-Forschungsinstitut F�R Molekulare Pharmakologie (Fmp)
Curated by ChEMBL
Affinity DataIC50: 2.23E+3nMAssay Description:Inhibition of human TNKS2 by fluorescence analysisMore data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
Leibniz-Forschungsinstitut F�R Molekulare Pharmakologie (Fmp)
Curated by ChEMBL
Leibniz-Forschungsinstitut F�R Molekulare Pharmakologie (Fmp)
Curated by ChEMBL
Affinity DataIC50: 2.24E+3nMAssay Description:Inhibition of human TNKS2 by fluorescence analysisMore data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
Leibniz-Forschungsinstitut F�R Molekulare Pharmakologie (Fmp)
Curated by ChEMBL
Leibniz-Forschungsinstitut F�R Molekulare Pharmakologie (Fmp)
Curated by ChEMBL
Affinity DataIC50: 2.29E+3nMAssay Description:Inhibition of human TNKS2 by fluorescence analysisMore data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
Leibniz-Forschungsinstitut F�R Molekulare Pharmakologie (Fmp)
Curated by ChEMBL
Leibniz-Forschungsinstitut F�R Molekulare Pharmakologie (Fmp)
Curated by ChEMBL
Affinity DataIC50: 2.30E+3nMAssay Description:Inhibition of human TNKS2 by fluorescence analysisMore data for this Ligand-Target Pair
TargetProtein mono-ADP-ribosyltransferase PARP15(Homo sapiens (Human))
University Of Oulu
Curated by ChEMBL
University Of Oulu
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human ARTD7 by fluorescence analysisMore data for this Ligand-Target Pair
TargetProtein mono-ADP-ribosyltransferase PARP14(Homo sapiens (Human))
University Of Oulu
Curated by ChEMBL
University Of Oulu
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human ARTD8 by fluorescence analysisMore data for this Ligand-Target Pair
TargetProtein mono-ADP-ribosyltransferase PARP10(Homo sapiens (Human))
University Of Oulu
Curated by ChEMBL
University Of Oulu
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human ARTD10 by fluorescence analysisMore data for this Ligand-Target Pair
TargetProtein mono-ADP-ribosyltransferase PARP12(Homo sapiens (Human))
University Of Oulu
Curated by ChEMBL
University Of Oulu
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human ARTD12 by fluorescence analysisMore data for this Ligand-Target Pair
TargetProtein mono-ADP-ribosyltransferase PARP15(Homo sapiens (Human))
University Of Oulu
Curated by ChEMBL
University Of Oulu
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human ARTD7 by fluorescence analysisMore data for this Ligand-Target Pair
TargetProtein mono-ADP-ribosyltransferase PARP14(Homo sapiens (Human))
University Of Oulu
Curated by ChEMBL
University Of Oulu
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human ARTD8 by fluorescence analysisMore data for this Ligand-Target Pair
